Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000143153 Gene ID 481 Accession 804
Symbol ATP1B1 Alias ATP1B Full Name ATPase Na+/K+ transporting subunit beta 1
Status Confidence Length 205296 bases Strand Plus strand
Position 1 : 169105697 - 169310992 RNA binding domain N.A.
Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ATP1B1-202 ENST00000367816 2608 303aa ENSP00000356790
ATP1B1-214 ENST00000690184 1330 303aa ENSP00000509517
ATP1B1-211 ENST00000688406 4082 No protein -
ATP1B1-219 ENST00000692003 4817 No protein -
ATP1B1-212 ENST00000688755 1520 318aa ENSP00000508725
ATP1B1-213 ENST00000689522 4435 303aa ENSP00000509039
ATP1B1-216 ENST00000691106 2071 183aa ENSP00000508710
ATP1B1-201 ENST00000367815 2216 303aa ENSP00000356789
ATP1B1-207 ENST00000686702 2012 247aa ENSP00000509060
ATP1B1-204 ENST00000685155 2055 247aa ENSP00000508678
ATP1B1-206 ENST00000685792 2119 247aa ENSP00000508616
ATP1B1-217 ENST00000691753 2183 247aa ENSP00000509877
ATP1B1-203 ENST00000494797 2229 247aa ENSP00000477015
ATP1B1-218 ENST00000691802 2254 183aa ENSP00000510565
ATP1B1-210 ENST00000687745 1570 247aa ENSP00000509323
ATP1B1-205 ENST00000685762 2464 247aa ENSP00000508918
ATP1B1-209 ENST00000687182 657 No protein -
ATP1B1-215 ENST00000690604 3933 No protein -
ATP1B1-208 ENST00000687013 6406 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
4375Cholesterol, LDL5.5540043690146E-517903299
38035Platelet Function Tests1.6145800E-005-
70987Electrocardiography1E-1024952745
81081Electrocardiography1E-625055868
96188Electrocardiography1E-3124952745
103707Electrocardiography1E-1519305409

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001671enables ATPase activator activity3IBA,IDA,IGIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005886located_in plasma membrane3IDA,IGI,TASHomo_sapiens(9606)Component
GO:0005890part_of sodium:potassium-exchanging ATPase complex6IBA,IDA,IGI,IPI,ISO,ISSHomo_sapiens(9606)Component
GO:0006874involved_in intracellular calcium ion homeostasis1ISSHomo_sapiens(9606)Process
GO:0006883involved_in intracellular sodium ion homeostasis3IBA,IDA,ISOHomo_sapiens(9606)Process
GO:0007155involved_in cell adhesion1IEAHomo_sapiens(9606)Process
GO:0010248involved_in establishment or maintenance of transmembrane electrochemical gradient2NAS,TASHomo_sapiens(9606)Process
GO:0010468involved_in regulation of gene expression1ISSHomo_sapiens(9606)Process
GO:0010882involved_in regulation of cardiac muscle contraction by calcium ion signaling1ISSHomo_sapiens(9606)Process
GO:0014704located_in intercalated disc1ISSHomo_sapiens(9606)Component
GO:0016020located_in membrane1IDAHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IEAHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane2IDA,ISSHomo_sapiens(9606)Component
GO:0016328located_in lateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0019901enables protein kinase binding1IEAHomo_sapiens(9606)Function
GO:0023026enables MHC class II protein complex binding1HDAHomo_sapiens(9606)Function
GO:0030007involved_in intracellular potassium ion homeostasis3IBA,IDA,ISOHomo_sapiens(9606)Process
GO:0030315located_in T-tubule1IGIHomo_sapiens(9606)Component
GO:0030674enables protein-macromolecule adaptor activity2IDA,IGIHomo_sapiens(9606)Function
GO:0031090located_in organelle membrane1IGIHomo_sapiens(9606)Component
GO:0032781involved_in positive regulation of ATP-dependent activity1IDAHomo_sapiens(9606)Process
GO:0035725involved_in sodium ion transmembrane transport1IGIHomo_sapiens(9606)Process
GO:0036126located_in sperm flagellum1IDAHomo_sapiens(9606)Component
GO:0036376involved_in sodium ion export across plasma membrane4IBA,IDA,ISO,ISSHomo_sapiens(9606)Process
GO:0042383located_in sarcolemma1ISSHomo_sapiens(9606)Component
GO:0044861involved_in protein transport into plasma membrane raft1TASHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0046034involved_in ATP metabolic process1IDAHomo_sapiens(9606)Process
GO:0046982enables protein heterodimerization activity1ISSHomo_sapiens(9606)Function
GO:0050821involved_in protein stabilization2IDA,ISSHomo_sapiens(9606)Process
GO:0051117enables ATPase binding1IPIHomo_sapiens(9606)Function
GO:0055119involved_in relaxation of cardiac muscle1ISSHomo_sapiens(9606)Process
GO:0060048involved_in cardiac muscle contraction1ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0072659involved_in protein localization to plasma membrane1IDAHomo_sapiens(9606)Process
GO:0086009involved_in membrane repolarization1IDAHomo_sapiens(9606)Process
GO:0086013involved_in membrane repolarization during cardiac muscle cell action potential1ICHomo_sapiens(9606)Process
GO:0086064involved_in cell communication by electrical coupling involved in cardiac conduction1TASHomo_sapiens(9606)Process
GO:0098655involved_in monoatomic cation transmembrane transport1IGIHomo_sapiens(9606)Process
GO:1901018involved_in positive regulation of potassium ion transmembrane transporter activity1IDAHomo_sapiens(9606)Process
GO:1902600involved_in proton transmembrane transport1NASHomo_sapiens(9606)Process
GO:1903278involved_in positive regulation of sodium ion export across plasma membrane3IDA,IGI,ISSHomo_sapiens(9606)Process
GO:1903281involved_in positive regulation of calcium:sodium antiporter activity1ISSHomo_sapiens(9606)Process
GO:1903288involved_in positive regulation of potassium ion import across plasma membrane2IDA,IGIHomo_sapiens(9606)Process
GO:1903408involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity3IDA,IGI,ISSHomo_sapiens(9606)Process
GO:1903561located_in extracellular vesicle1HDAHomo_sapiens(9606)Component
GO:1990573involved_in potassium ion import across plasma membrane3IBA,ISO,ISSHomo_sapiens(9606)Process

Expression