Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000141526 Gene ID 9123 Accession 10924
Symbol SLC16A3 Alias MCT3;MCT4;MCT3;MCT4;MCT-3;MCT-4 Full Name solute carrier family 16 member 3
Status Confidence Length 43196 bases Strand Plus strand
Position 17 : 82217934 - 82261129 RNA binding domain N.A.
Summary Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SLC16A3-208 ENST00000580098 2676 410aa ENSP00000463880
SLC16A3-216 ENST00000584689 2667 465aa ENSP00000464625
SLC16A3-202 ENST00000392341 2659 465aa ENSP00000376152
SLC16A3-211 ENST00000581642 557 No protein -
SLC16A3-213 ENST00000582743 2599 465aa ENSP00000462405
SLC16A3-215 ENST00000583444 2882 No protein -
SLC16A3-217 ENST00000584781 562 No protein -
SLC16A3-205 ENST00000578684 2439 417aa ENSP00000463912
SLC16A3-203 ENST00000577650 2503 439aa ENSP00000463063
SLC16A3-204 ENST00000578574 958 No protein -
SLC16A3-207 ENST00000579572 863 No protein -
SLC16A3-212 ENST00000582715 279 79aa ENSP00000464326
SLC16A3-201 ENST00000392339 2662 465aa ENSP00000376150
SLC16A3-210 ENST00000581287 4830 465aa ENSP00000463978
SLC16A3-218 ENST00000617373 2636 465aa ENSP00000483212
SLC16A3-209 ENST00000580189 2711 465aa ENSP00000464112
SLC16A3-219 ENST00000619321 2603 465aa ENSP00000482013
SLC16A3-206 ENST00000578810 678 No protein -
SLC16A3-214 ENST00000583025 955 306aa ENSP00000463005

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005886located_in plasma membrane2IDA,TASHomo_sapiens(9606)Component
GO:0008028enables monocarboxylic acid transmembrane transporter activity1IBAHomo_sapiens(9606)Function
GO:0015650enables lactate:proton symporter activity1IDAHomo_sapiens(9606)Function
GO:0015718involved_in monocarboxylic acid transport1IBAHomo_sapiens(9606)Process
GO:0016020located_in membrane1TASHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016328located_in lateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0030163involved_in protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0031965located_in nuclear membrane1IDAHomo_sapiens(9606)Component
GO:0035873involved_in lactate transmembrane transport1IDAHomo_sapiens(9606)Process
GO:0042867involved_in pyruvate catabolic process1IEAHomo_sapiens(9606)Process
GO:0045202is_active_in synapse1IDAHomo_sapiens(9606)Component
GO:0050833enables pyruvate transmembrane transporter activity1IDAHomo_sapiens(9606)Function
GO:1901475involved_in pyruvate transmembrane transport1IDAHomo_sapiens(9606)Process

Expression