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RBP World!
Functions and Diseases
| RBP Type | Canonical_RBPs |
| Diseases | SARS-COV-2 |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | N.A. |
| Localizations | Stress granucle |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000140416 | Gene ID | 7168 | Accession | 12010 |
| Symbol | TPM1 | Alias | CMH3;TMSA;CMD1Y;LVNC9;C15orf13;HEL-S-265;HTM-alpha | Full Name | tropomyosin 1 |
| Status | Confidence | Length | 29284 bases | Strand | Plus strand |
| Position | 15 : 63042632 - 63071915 | RNA binding domain | Tropomyosin | ||
| Summary | This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|---|---|---|---|
| ENSP00000453062 | Tropomyosin | PF00261 | 6.6e-100 | 1 |
| ENSP00000385107 | Tropomyosin | PF00261 | 7.9e-100 | 1 |
| ENSP00000453941 | Tropomyosin | PF00261 | 3.8e-97 | 1 |
| ENSP00000288398 | Tropomyosin | PF00261 | 2.5e-94 | 1 |
| ENSP00000452658 | Tropomyosin | PF00261 | 4.3e-94 | 1 |
| ENSP00000452830 | Tropomyosin | PF00261 | 4.5e-94 | 1 |
| ENSP00000350667 | Tropomyosin | PF00261 | 1.2e-93 | 1 |
| ENSP00000453955 | Tropomyosin | PF00261 | 6.3e-92 | 1 |
| ENSP00000351022 | Tropomyosin | PF00261 | 1.5e-91 | 1 |
| ENSP00000267996 | Tropomyosin | PF00261 | 3.1e-89 | 1 |
| ENSP00000334624 | Tropomyosin | PF00261 | 3.2e-87 | 1 |
| ENSP00000384315 | Tropomyosin | PF00261 | 1.1e-85 | 1 |
| ENSP00000498284 | Tropomyosin | PF00261 | 1.8e-85 | 1 |
| ENSP00000452879 | Tropomyosin | PF00261 | 1.1e-83 | 1 |
| ENSP00000322577 | Tropomyosin | PF00261 | 1.2e-81 | 1 |
| ENSP00000453724 | Tropomyosin | PF00261 | 1.4e-78 | 1 |
| ENSP00000516139 | Tropomyosin | PF00261 | 1.9e-75 | 1 |
| ENSP00000498562 | Tropomyosin | PF00261 | 4.2e-60 | 1 |
| ENSP00000498730 | Tropomyosin | PF00261 | 4.2e-60 | 1 |
| ENSP00000452977 | Tropomyosin | PF00261 | 8.6e-52 | 1 |
| ENSP00000453050 | Tropomyosin | PF00261 | 7.9e-39 | 1 |
| ENSP00000452887 | Tropomyosin | PF00261 | 2.5e-27 | 1 |
| ENSP00000453092 | Tropomyosin | PF00261 | 1.1e-22 | 1 |
| ENSP00000498540 | Tropomyosin | PF00261 | 2.7e-22 | 1 |
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| TPM1-221 | ENST00000559831 | 3095 | 218aa | ENSP00000452977 |
| TPM1-202 | ENST00000288398 | 1295 | 284aa | ENSP00000288398 |
| TPM1-234 | ENST00000651344 | 3316 | No protein | - |
| TPM1-227 | ENST00000560975 | 2855 | No protein | - |
| TPM1-206 | ENST00000358278 | 1717 | 284aa | ENSP00000351022 |
| TPM1-232 | ENST00000610733 | 3957 | 106aa | ENSP00000477929 |
| TPM1-230 | ENST00000561395 | 1017 | 155aa | ENSP00000453092 |
| TPM1-207 | ENST00000403994 | 1217 | 284aa | ENSP00000385107 |
| TPM1-205 | ENST00000357980 | 1807 | 326aa | ENSP00000350667 |
| TPM1-231 | ENST00000561425 | 582 | 40aa | ENSP00000453324 |
| TPM1-211 | ENST00000558314 | 1031 | No protein | - |
| TPM1-222 | ENST00000560131 | 2615 | No protein | - |
| TPM1-212 | ENST00000558347 | 1525 | 157aa | ENSP00000452887 |
| TPM1-220 | ENST00000559556 | 977 | 284aa | ENSP00000453941 |
| TPM1-201 | ENST00000267996 | 1670 | 284aa | ENSP00000267996 |
| TPM1-219 | ENST00000559397 | 933 | 284aa | ENSP00000452879 |
| TPM1-229 | ENST00000561266 | 1100 | 284aa | ENSP00000453955 |
| TPM1-226 | ENST00000560970 | 1097 | 284aa | ENSP00000453062 |
| TPM1-233 | ENST00000644204 | 2704 | No protein | - |
| TPM1-238 | ENST00000651704 | 1780 | 155aa | ENSP00000498562 |
| TPM1-237 | ENST00000651622 | 2226 | 248aa | ENSP00000498540 |
| TPM1-204 | ENST00000334895 | 1564 | 245aa | ENSP00000334624 |
| TPM1-215 | ENST00000558868 | 2381 | No protein | - |
| TPM1-208 | ENST00000404484 | 943 | 248aa | ENSP00000384315 |
| TPM1-216 | ENST00000558910 | 1968 | 248aa | ENSP00000452830 |
| TPM1-203 | ENST00000317516 | 1160 | 245aa | ENSP00000322577 |
| TPM1-236 | ENST00000651590 | 1382 | 251aa | ENSP00000498284 |
| TPM1-214 | ENST00000558544 | 1399 | 49aa | ENSP00000453817 |
| TPM1-225 | ENST00000560959 | 925 | 275aa | ENSP00000453724 |
| TPM1-218 | ENST00000559281 | 941 | 248aa | ENSP00000452658 |
| TPM1-223 | ENST00000560615 | 1466 | 158aa | ENSP00000453050 |
| TPM1-235 | ENST00000651577 | 2010 | 155aa | ENSP00000498730 |
| TPM1-224 | ENST00000560679 | 292 | No protein | - |
| TPM1-210 | ENST00000558264 | 2687 | No protein | - |
| TPM1-213 | ENST00000558400 | 658 | No protein | - |
| TPM1-239 | ENST00000705544 | 2754 | 180aa | ENSP00000516139 |
| TPM1-228 | ENST00000561242 | 673 | No protein | - |
| TPM1-209 | ENST00000558072 | 525 | No protein | - |
| TPM1-217 | ENST00000559108 | 437 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 33533 | Blood Pressure | 1.1365794E-005 | - |
| 33534 | Blood Pressure | 9.1989485E-005 | - |
| 33535 | Blood Pressure | 1.3655359E-005 | - |
| 70500 | Cholesterol, HDL | 9E-9 | 20686565 |
| 79397 | Parkinson Disease | 9E-11 | 27402877 |
| 79398 | Age of Onset | 9E-11 | 27402877 |
| 91931 | Mean Platelet Volume | 2E-8 | 19820697 |
| 98896 | Platelet Count | 4E-10 | 22139419 |
| 101833 | Cholesterol, HDL | 4E-11 | 24097068 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0001725 | located_in stress fiber | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0003065 | involved_in positive regulation of heart rate by epinephrine | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0003779 | enables actin binding | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0005200 | enables structural constituent of cytoskeleton | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005829 | located_in cytosol | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005856 | located_in cytoskeleton | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005862 | part_of muscle thin filament tropomyosin | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005884 | is_active_in actin filament | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0006937 | involved_in regulation of muscle contraction | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0007010 | involved_in cytoskeleton organization | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0007015 | involved_in actin filament organization | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0008016 | involved_in regulation of heart contraction | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0008092 | enables cytoskeletal protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0008307 | enables structural constituent of muscle | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0008360 | involved_in regulation of cell shape | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0015629 | located_in actin cytoskeleton | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0030017 | located_in sarcomere | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0030049 | involved_in muscle filament sliding | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0030336 | involved_in negative regulation of cell migration | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0031529 | involved_in ruffle organization | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0032059 | located_in bleb | 1 | IMP | Homo_sapiens(9606) | Component |
| GO:0032587 | located_in ruffle membrane | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0032781 | involved_in positive regulation of ATP-dependent activity | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0034614 | involved_in cellular response to reactive oxygen species | 1 | IEP | Homo_sapiens(9606) | Process |
| GO:0042060 | involved_in wound healing | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0042802 | enables identical protein binding | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0042803 | enables protein homodimerization activity | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0045214 | involved_in sarcomere organization | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0045785 | involved_in positive regulation of cell adhesion | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0046982 | enables protein heterodimerization activity | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0051015 | enables actin filament binding | 2 | IBA,ISS | Homo_sapiens(9606) | Function |
| GO:0051496 | involved_in positive regulation of stress fiber assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0055010 | involved_in ventricular cardiac muscle tissue morphogenesis | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0060048 | involved_in cardiac muscle contraction | 2 | IBA,IMP | Homo_sapiens(9606) | Process |
| GO:1904706 | involved_in negative regulation of vascular associated smooth muscle cell proliferation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1904753 | involved_in negative regulation of vascular associated smooth muscle cell migration | 1 | IMP | Homo_sapiens(9606) | Process |