RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000139767	Gene ID	84530	Accession	29389
Symbol	SRRM4	Alias	nSR100;KIAA1853;MU-MB-2.76	Full Name	serine/arginine repetitive matrix 4
Status	Confidence	Length	181511 bases	Strand	Plus strand
Position	12 : 118981541 - 119163051	RNA binding domain	SRRM_C
Summary	SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000267260	SRRM_C	PF15230	5.2e-24	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28673540	Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.	Yan Song	2017-07-06	Molecular cell
30417466	Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.	R Ahn Lee	2019-01-01	Cancer science
29666783	Development of Neuroendocrine Prostate Cancers by the Ser/Arg Repetitive Matrix 4-Mediated RNA Splicing Network.	R Ahn Lee	2018-01-01	Frontiers in oncology
34566717	Do Fragile X Syndrome and Other Intellectual Disorders Converge at Aberrant Pre-mRNA Splicing?	Sneha Shah	2021-01-01	Frontiers in psychiatry
32086391	Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers.	W John Phillips	2020-03-10	Proceedings of the National Academy of Sciences of the United States of America
34100419	Genes for RNA-binding proteins involved in neural-specific functions and diseases are downregulated in Rubinstein-Taybi iNeurons.	Lidia Larizza	2022-01-01	Neural regeneration research
30177243	'Splice' a way towards neuroendocrine prostate cancer.	Dingxiao Zhang	2018-09-01	EBioMedicine
29759485	Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.	Yu Gan	2018-05-01	EBioMedicine

Name	Transcript ID	bp	Protein	Translation ID
SRRM4-201	ENST00000267260	8431	611aa	ENSP00000267260
SRRM4-207	ENST00000651431	2944	No protein	-
SRRM4-206	ENST00000641910	848	No protein	-
SRRM4-202	ENST00000534886	455	No protein	-
SRRM4-204	ENST00000545224	461	No protein	-
SRRM4-203	ENST00000537597	561	No protein	-
SRRM4-205	ENST00000641899	682	66aa	ENSP00000493188

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
42825	Platelet Function Tests	2.1215831E-006	-
42826	Platelet Function Tests	2.1110239E-006	-
103983	Autosomal dominant compelling helio ophthalmic outburst syndrome	3E-12	27182965

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000139767

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000139767	homo_sapiens	ENSP00000267260	99.3453	99.018	nomascus_leucogenys	ENSNLEP00000000249	98.6992	98.374
ENSG00000139767	homo_sapiens	ENSP00000267260	92.7987	92.4714	pan_paniscus	ENSPPAP00000009808	99.6485	99.297
ENSG00000139767	homo_sapiens	ENSP00000267260	98.6907	98.1997	pongo_abelii	ENSPPYP00000005716	98.0488	97.561
ENSG00000139767	homo_sapiens	ENSP00000267260	99.8363	99.6727	pan_troglodytes	ENSPTRP00000009365	99.8363	99.6727
ENSG00000139767	homo_sapiens	ENSP00000267260	100	99.509	gorilla_gorilla	ENSGGOP00000005229	99.6737	99.1843
ENSG00000139767	homo_sapiens	ENSP00000267260	42.0622	38.2979	notamacropus_eugenii	ENSMEUP00000009501	50.4912	45.9725
ENSG00000139767	homo_sapiens	ENSP00000267260	67.2668	64.6481	choloepus_hoffmanni	ENSCHOP00000002843	74.4565	71.558
ENSG00000139767	homo_sapiens	ENSP00000267260	89.689	85.761	dasypus_novemcinctus	ENSDNOP00000000196	92.4115	88.3643
ENSG00000139767	homo_sapiens	ENSP00000267260	44.3535	42.7169	erinaceus_europaeus	ENSEEUP00000001371	46.8858	45.1557
ENSG00000139767	homo_sapiens	ENSP00000267260	56.3011	53.3552	echinops_telfairi	ENSETEP00000002746	63.8219	60.4824
ENSG00000139767	homo_sapiens	ENSP00000267260	97.7087	96.7267	callithrix_jacchus	ENSCJAP00000016805	90.1813	89.2749
ENSG00000139767	homo_sapiens	ENSP00000267260	98.6907	97.545	cercocebus_atys	ENSCATP00000025778	98.3687	97.2268
ENSG00000139767	homo_sapiens	ENSP00000267260	98.6907	97.545	macaca_fascicularis	ENSMFAP00000041047	97.731	96.5964
ENSG00000139767	homo_sapiens	ENSP00000267260	98.036	97.054	macaca_mulatta	ENSMMUP00000076693	96.769	95.7997
ENSG00000139767	homo_sapiens	ENSP00000267260	98.527	97.3813	macaca_nemestrina	ENSMNEP00000042878	97.5689	96.4344
ENSG00000139767	homo_sapiens	ENSP00000267260	99.018	97.8723	papio_anubis	ENSPANP00000006334	98.0551	96.9206
ENSG00000139767	homo_sapiens	ENSP00000267260	98.8543	98.036	mandrillus_leucophaeus	ENSMLEP00000020465	98.2114	97.3984
ENSG00000139767	homo_sapiens	ENSP00000267260	75.1227	71.6858	tursiops_truncatus	ENSTTRP00000013848	67.2035	64.1288
ENSG00000139767	homo_sapiens	ENSP00000267260	54.0098	53.3552	vulpes_vulpes	ENSVVUP00000018095	89.1892	88.1081
ENSG00000139767	homo_sapiens	ENSP00000267260	89.689	84.9427	mus_spretus	MGP_SPRETEiJ_P0072918	89.8361	85.082
ENSG00000139767	homo_sapiens	ENSP00000267260	91.9804	89.689	equus_asinus	ENSEASP00005012548	93.5108	91.1814
ENSG00000139767	homo_sapiens	ENSP00000267260	76.1047	72.5041	capra_hircus	ENSCHIP00000020523	83.4829	79.5332
ENSG00000139767	homo_sapiens	ENSP00000267260	91.9804	87.8887	loxodonta_africana	ENSLAFP00000003111	92.2824	88.1773
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	90.18	panthera_leo	ENSPLOP00000015532	90.9238	89.3031
ENSG00000139767	homo_sapiens	ENSP00000267260	92.635	90.18	ailuropoda_melanoleuca	ENSAMEP00000016969	93.7086	91.2252
ENSG00000139767	homo_sapiens	ENSP00000267260	79.0507	73.3224	bos_indicus_hybrid	ENSBIXP00005020372	75.2336	69.7819
ENSG00000139767	homo_sapiens	ENSP00000267260	90.671	87.0704	oryctolagus_cuniculus	ENSOCUP00000023794	92.1797	88.5191
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	89.689	equus_caballus	ENSECAP00000019201	93.3444	91.1814
ENSG00000139767	homo_sapiens	ENSP00000267260	85.1064	82.4877	canis_lupus_familiaris	ENSCAFP00845039806	81.761	79.2453
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	90.0164	panthera_pardus	ENSPPRP00000007549	90.6301	88.853
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	89.3617	marmota_marmota_marmota	ENSMMMP00000024432	93.5	91
ENSG00000139767	homo_sapiens	ENSP00000267260	90.18	87.234	balaenoptera_musculus	ENSBMSP00010021497	90.7743	87.8089
ENSG00000139767	homo_sapiens	ENSP00000267260	93.2897	90.0164	cavia_porcellus	ENSCPOP00000003204	93.75	90.4605
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	90.0164	felis_catus	ENSFCAP00000009783	89.76	88
ENSG00000139767	homo_sapiens	ENSP00000267260	91.9804	88.8707	bison_bison_bison	ENSBBBP00000021883	93.2007	90.0498
ENSG00000139767	homo_sapiens	ENSP00000267260	89.198	85.1064	monodon_monoceros	ENSMMNP00015003130	91.1371	86.9565
ENSG00000139767	homo_sapiens	ENSP00000267260	91.4894	88.707	sus_scrofa	ENSSSCP00000010509	91.4894	88.707
ENSG00000139767	homo_sapiens	ENSP00000267260	94.599	92.4714	microcebus_murinus	ENSMICP00000011278	94.2904	92.1697
ENSG00000139767	homo_sapiens	ENSP00000267260	92.4714	89.8527	octodon_degus	ENSODEP00000008428	92.6229	90
ENSG00000139767	homo_sapiens	ENSP00000267260	84.4517	80.6874	jaculus_jaculus	ENSJJAP00000013837	86.4322	82.5796
ENSG00000139767	homo_sapiens	ENSP00000267260	91.4894	88.5434	ovis_aries_rambouillet	ENSOARP00020012815	92.7031	89.7181
ENSG00000139767	homo_sapiens	ENSP00000267260	86.252	82.1604	ochotona_princeps	ENSOPRP00000015508	76.4877	72.8592
ENSG00000139767	homo_sapiens	ENSP00000267260	84.4517	80.3601	delphinapterus_leucas	ENSDLEP00000010278	84.0391	79.9674
ENSG00000139767	homo_sapiens	ENSP00000267260	89.8527	85.2701	mus_caroli	MGP_CAROLIEiJ_P0070232	90.5941	85.9736
ENSG00000139767	homo_sapiens	ENSP00000267260	89.198	84.6154	mus_musculus	ENSMUSP00000075488	89.6382	85.0329
ENSG00000139767	homo_sapiens	ENSP00000267260	83.9607	80.0327	dipodomys_ordii	ENSDORP00000014349	87.5427	83.4471
ENSG00000139767	homo_sapiens	ENSP00000267260	92.144	90.0164	mustela_putorius_furo	ENSMPUP00000002901	93.3665	91.2106
ENSG00000139767	homo_sapiens	ENSP00000267260	80.1964	77.0867	aotus_nancymaae	ENSANAP00000004467	89.2532	85.7924
ENSG00000139767	homo_sapiens	ENSP00000267260	83.7971	82.6514	saimiri_boliviensis_boliviensis	ENSSBOP00000038484	92.4188	91.1552
ENSG00000139767	homo_sapiens	ENSP00000267260	62.5205	60.7201	vicugna_pacos	ENSVPAP00000007384	61.3162	59.5506
ENSG00000139767	homo_sapiens	ENSP00000267260	97.7087	96.7267	chlorocebus_sabaeus	ENSCSAP00000015738	97.3899	96.4111
ENSG00000139767	homo_sapiens	ENSP00000267260	66.6121	65.3028	tupaia_belangeri	ENSTBEP00000008275	80.1181	78.5433
ENSG00000139767	homo_sapiens	ENSP00000267260	89.689	85.1064	mesocricetus_auratus	ENSMAUP00000013081	91.4858	86.8114
ENSG00000139767	homo_sapiens	ENSP00000267260	92.4714	90.18	camelus_dromedarius	ENSCDRP00005024761	93.3884	91.0744
ENSG00000139767	homo_sapiens	ENSP00000267260	88.8707	86.0884	carlito_syrichta	ENSTSYP00000011240	95.2632	92.2807
ENSG00000139767	homo_sapiens	ENSP00000267260	62.8478	59.4108	panthera_tigris_altaica	ENSPTIP00000010733	80.167	75.7829
ENSG00000139767	homo_sapiens	ENSP00000267260	89.3617	84.6154	rattus_norvegicus	ENSRNOP00000001507	90.6977	85.8804
ENSG00000139767	homo_sapiens	ENSP00000267260	93.126	91.162	prolemur_simus	ENSPSMP00000011169	93.7397	91.7628
ENSG00000139767	homo_sapiens	ENSP00000267260	88.8707	84.4517	microtus_ochrogaster	ENSMOCP00000007008	90.8027	86.2876
ENSG00000139767	homo_sapiens	ENSP00000267260	69.2308	65.3028	sorex_araneus	ENSSARP00000011423	75.5357	71.25
ENSG00000139767	homo_sapiens	ENSP00000267260	90.0164	85.5974	peromyscus_maniculatus_bairdii	ENSPEMP00000001915	91.6667	87.1667
ENSG00000139767	homo_sapiens	ENSP00000267260	54.5008	53.1915	bos_mutus	ENSBMUP00000029019	93.5393	91.2921
ENSG00000139767	homo_sapiens	ENSP00000267260	89.8527	85.1064	mus_spicilegus	ENSMSIP00000014213	90.2961	85.5263
ENSG00000139767	homo_sapiens	ENSP00000267260	89.5254	85.5974	cricetulus_griseus_chok1gshd	ENSCGRP00001000691	91.015	87.0216
ENSG00000139767	homo_sapiens	ENSP00000267260	84.7791	82.8151	pteropus_vampyrus	ENSPVAP00000016496	92.9982	90.8438
ENSG00000139767	homo_sapiens	ENSP00000267260	70.5401	65.4664	myotis_lucifugus	ENSMLUP00000016112	78.7934	73.1261
ENSG00000139767	homo_sapiens	ENSP00000267260	91.653	88.707	rhinolophus_ferrumequinum	ENSRFEP00010021239	92.869	89.8839
ENSG00000139767	homo_sapiens	ENSP00000267260	91.653	89.3617	neovison_vison	ENSNVIP00000017423	93.8023	91.4573
ENSG00000139767	homo_sapiens	ENSP00000267260	91.653	88.5434	bos_taurus	ENSBTAP00000011438	92.869	89.7181
ENSG00000139767	homo_sapiens	ENSP00000267260	93.9444	90.9984	heterocephalus_glaber_female	ENSHGLP00000010917	92.5806	89.6774
ENSG00000139767	homo_sapiens	ENSP00000267260	84.6154	81.5057	rhinopithecus_bieti	ENSRBIP00000032647	90.2269	86.911
ENSG00000139767	homo_sapiens	ENSP00000267260	81.0147	78.7234	canis_lupus_dingo	ENSCAFP00020023678	86.8421	84.386
ENSG00000139767	homo_sapiens	ENSP00000267260	91.162	87.725	sciurus_vulgaris	ENSSVLP00005012682	94.7279	91.1565
ENSG00000139767	homo_sapiens	ENSP00000267260	77.5777	73.9771	procavia_capensis	ENSPCAP00000015385	69.1971	65.9854
ENSG00000139767	homo_sapiens	ENSP00000267260	91.3257	87.234	nannospalax_galili	ENSNGAP00000021705	92.3841	88.245
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	88.5434	bos_grunniens	ENSBGRP00000027158	93.0348	89.7181
ENSG00000139767	homo_sapiens	ENSP00000267260	93.4534	90.671	chinchilla_lanigera	ENSCLAP00000014143	93.6066	90.8197
ENSG00000139767	homo_sapiens	ENSP00000267260	91.8167	88.707	cervus_hanglu_yarkandensis	ENSCHYP00000003098	93.0348	89.8839
ENSG00000139767	homo_sapiens	ENSP00000267260	90.8347	88.0524	catagonus_wagneri	ENSCWAP00000009826	92.3461	89.5175
ENSG00000139767	homo_sapiens	ENSP00000267260	76.7594	73.8134	ictidomys_tridecemlineatus	ENSSTOP00000023179	90.7157	87.234
ENSG00000139767	homo_sapiens	ENSP00000267260	94.4353	92.7987	otolemur_garnettii	ENSOGAP00000013820	94.1272	92.4959
ENSG00000139767	homo_sapiens	ENSP00000267260	97.2177	96.2357	cebus_imitator	ENSCCAP00000009491	97.5369	96.5517
ENSG00000139767	homo_sapiens	ENSP00000267260	91.4894	89.198	urocitellus_parryii	ENSUPAP00010022012	92.8571	90.5316
ENSG00000139767	homo_sapiens	ENSP00000267260	91.4894	88.707	moschus_moschiferus	ENSMMSP00000027325	93.0117	90.183
ENSG00000139767	homo_sapiens	ENSP00000267260	84.4517	81.8331	rhinopithecus_roxellana	ENSRROP00000024101	90.6854	87.8735
ENSG00000139767	homo_sapiens	ENSP00000267260	89.0344	83.3061	mus_pahari	MGP_PahariEiJ_P0058451	90.0662	84.2715
ENSG00000139767	homo_sapiens	ENSP00000267260	93.7807	91.8167	propithecus_coquereli	ENSPCOP00000005658	95.0249	93.0348
ENSG00000139767	homo_sapiens	ENSP00000267260	62.1931	51.7185	xenopus_tropicalis	ENSXETP00000107723	64.4068	53.5593
ENSG00000139767	homo_sapiens	ENSP00000267260	68.5761	58.4288	chrysemys_picta_bellii	ENSCPBP00000016711	67.1474	57.2115
ENSG00000139767	homo_sapiens	ENSP00000267260	43.8625	38.2979	crocodylus_porosus	ENSCPRP00005008966	71.0875	62.069
ENSG00000139767	homo_sapiens	ENSP00000267260	49.0998	36.0065	notechis_scutatus	ENSNSUP00000028180	53.9568	39.5683
ENSG00000139767	homo_sapiens	ENSP00000267260	45.9902	34.2062	pseudonaja_textilis	ENSPTXP00000027054	49.3849	36.7311
ENSG00000139767	homo_sapiens	ENSP00000267260	46.3175	40.2619	anas_platyrhynchos_platyrhynchos	ENSAPLP00000027566	68.8564	59.854
ENSG00000139767	homo_sapiens	ENSP00000267260	70.7038	61.2111	gallus_gallus	ENSGALP00010034684	71.1697	61.6145
ENSG00000139767	homo_sapiens	ENSP00000267260	52.0458	45.9902	meleagris_gallopavo	ENSMGAP00000003438	68.8312	60.8225
ENSG00000139767	homo_sapiens	ENSP00000267260	52.5368	46.1538	serinus_canaria	ENSSCAP00000005312	69.181	60.7759
ENSG00000139767	homo_sapiens	ENSP00000267260	69.7218	60.8838	parus_major	ENSPMJP00000023489	70.7641	61.794
ENSG00000139767	homo_sapiens	ENSP00000267260	63.1751	54.5008	geospiza_fortis	ENSGFOP00000002041	68.3186	58.9381
ENSG00000139767	homo_sapiens	ENSP00000267260	69.8854	61.2111	taeniopygia_guttata	ENSTGUP00000009512	71.2855	62.4374
ENSG00000139767	homo_sapiens	ENSP00000267260	41.8985	36.1702	chelonoidis_abingdonii	ENSCABP00000029167	71.5084	61.7318
ENSG00000139767	homo_sapiens	ENSP00000267260	42.2259	35.8429	struthio_camelus_australis	ENSSCUP00000007627	55.0107	46.6951
ENSG00000139767	homo_sapiens	ENSP00000267260	55.8101	47.9542	anser_brachyrhynchus	ENSABRP00000021617	64.4613	55.3875
ENSG00000139767	homo_sapiens	ENSP00000267260	41.4075	36.0065	strigops_habroptila	ENSSHBP00005018479	67.4667	58.6667
ENSG00000139767	homo_sapiens	ENSP00000267260	58.2651	50.2455	terrapene_carolina_triunguis	ENSTMTP00000008985	70.495	60.7921
ENSG00000139767	homo_sapiens	ENSP00000267260	40.7529	35.8429	aquila_chrysaetos_chrysaetos	ENSACCP00020011914	69.3593	61.0028
ENSG00000139767	homo_sapiens	ENSP00000267260	64.1571	54.5008	ficedula_albicollis	ENSFALP00000008036	67.2384	57.1184
ENSG00000139767	homo_sapiens	ENSP00000267260	42.3895	35.8429	coturnix_japonica	ENSCJPP00005017907	67.0984	56.7358
ENSG00000139767	homo_sapiens	ENSP00000267260	60.5565	50.9002	leptobrachium_leishanense	ENSLLEP00000000199	62.0805	52.1812

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000381	involved_in regulation of alternative mRNA splicing, via spliceosome	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0003729	enables mRNA binding	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0007399	involved_in nervous system development	1	ISS	Homo_sapiens(9606)	Process
GO:0007605	involved_in sensory perception of sound	1	IEA	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	IEA	Homo_sapiens(9606)	Process
GO:0030154	involved_in cell differentiation	1	ISS	Homo_sapiens(9606)	Process
GO:0042551	involved_in neuron maturation	1	IBA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043484	involved_in regulation of RNA splicing	2	IBA,ISS	Homo_sapiens(9606)	Process