Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000139160 Gene ID 254013 Accession 28739
Symbol ETFBKMT Alias METTL20;C12orf72;ETFB-KMT Full Name electron transfer flavoprotein subunit beta lysine methyltransferase
Status Confidence Length 25955 bases Strand Plus strand
Position 12 : 31647160 - 31673114 RNA binding domain Met_10
Summary Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of electron transfer activity; negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase; and peptidyl-lysine trimethylation. Located in mitochondrial matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000350353 Met_10 PF02475 0.00069 1
ENSP00000379112 Met_10 PF02475 0.00069 1
ENSP00000396123 Met_10 PF02475 0.00069 1
ENSP00000441421 Met_10 PF02475 0.00069 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ETFBKMT-203 ENST00000412352 1083 262aa ENSP00000396123
ETFBKMT-202 ENST00000395763 2055 262aa ENSP00000379112
ETFBKMT-205 ENST00000538463 1862 262aa ENSP00000441421
ETFBKMT-201 ENST00000357721 6128 262aa ENSP00000350353
ETFBKMT-206 ENST00000539633 554 72aa ENSP00000445165
ETFBKMT-204 ENST00000538391 1067 114aa ENSP00000437442

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000139160homo_sapiensENSP0000030358432.710316.3551homo_sapiensENSP0000035035326.717613.3588
ENSG00000139160homo_sapiensENSP0000023285423.372811.5385homo_sapiensENSP0000035035330.152714.8855

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000139160homo_sapiensENSP0000035035397.709997.7099nomascus_leucogenysENSNLEP0000002004098.084398.0843
ENSG00000139160homo_sapiensENSP0000035035399.236699.2366pan_paniscusENSPPAP0000000935399.236699.2366
ENSG00000139160homo_sapiensENSP0000035035398.473398.0916pongo_abeliiENSPPYP0000003355798.473398.0916
ENSG00000139160homo_sapiensENSP0000035035399.236699.2366pan_troglodytesENSPTRP0000006975899.236699.2366
ENSG00000139160homo_sapiensENSP0000035035398.85598.4733gorilla_gorillaENSGGOP0000000365698.85598.4733
ENSG00000139160homo_sapiensENSP0000035035346.564940.8397notamacropus_eugeniiENSMEUP0000000392884.722274.3056
ENSG00000139160homo_sapiensENSP0000035035358.015354.1985dasypus_novemcinctusENSDNOP0000000134392.682986.5854
ENSG00000139160homo_sapiensENSP0000035035396.183292.7481callithrix_jacchusENSCJAP0000006514196.183292.7481
ENSG00000139160homo_sapiensENSP0000035035398.473397.3282cercocebus_atysENSCATP0000004096798.473397.3282
ENSG00000139160homo_sapiensENSP0000035035398.091695.8015macaca_fascicularisENSMFAP0000004241098.091695.8015
ENSG00000139160homo_sapiensENSP0000035035398.473397.3282macaca_mulattaENSMMUP0000001463698.473397.3282
ENSG00000139160homo_sapiensENSP0000035035398.473396.9466macaca_nemestrinaENSMNEP0000000131998.473396.9466
ENSG00000139160homo_sapiensENSP0000035035371.755767.5573papio_anubisENSPANP0000005836971.482967.3004
ENSG00000139160homo_sapiensENSP0000035035398.091696.9466mandrillus_leucophaeusENSMLEP0000004028098.091696.9466
ENSG00000139160homo_sapiensENSP0000035035391.603186.6412tursiops_truncatusENSTTRP0000000458891.603186.6412
ENSG00000139160homo_sapiensENSP0000035035393.511587.4046vulpes_vulpesENSVVUP0000001698392.105386.0902
ENSG00000139160homo_sapiensENSP0000035035386.641277.8626mus_spretusMGP_SPRETEiJ_P008024689.019680
ENSG00000139160homo_sapiensENSP0000035035345.038242.7481equus_asinusENSEASP0000504918892.187587.5
ENSG00000139160homo_sapiensENSP0000035035392.748187.0229loxodonta_africanaENSLAFP0000002039591.353485.7143
ENSG00000139160homo_sapiensENSP0000035035391.221482.4427panthera_leoENSPLOP0000002546389.849681.203
ENSG00000139160homo_sapiensENSP0000035035393.893187.4046ailuropoda_melanoleucaENSAMEP0000000950392.481286.0902
ENSG00000139160homo_sapiensENSP0000035035389.694783.2061bos_indicus_hybridENSBIXP0000502553688.345981.9549
ENSG00000139160homo_sapiensENSP0000035035392.366486.2595equus_caballusENSECAP0000005497480.936575.5853
ENSG00000139160homo_sapiensENSP0000035035393.511586.6412canis_lupus_familiarisENSCAFP0084502565292.105385.3383
ENSG00000139160homo_sapiensENSP0000035035391.221483.5878panthera_pardusENSPPRP0000001354089.849682.3308
ENSG00000139160homo_sapiensENSP0000035035391.603185.4962marmota_marmota_marmotaENSMMMP0000002510991.603185.4962
ENSG00000139160homo_sapiensENSP0000035035391.603187.7863balaenoptera_musculusENSBMSP0001001765391.603187.7863
ENSG00000139160homo_sapiensENSP0000035035376.717670.229cavia_porcellusENSCPOP0000000356779.133972.4409
ENSG00000139160homo_sapiensENSP0000035035390.839783.9695felis_catusENSFCAP0000003271889.473782.7068
ENSG00000139160homo_sapiensENSP0000035035393.129886.2595ursus_americanusENSUAMP0000000626391.729384.9624
ENSG00000139160homo_sapiensENSP0000035035390.076383.5878bison_bison_bisonENSBBBP0000001193288.721882.3308
ENSG00000139160homo_sapiensENSP0000035035391.984787.0229monodon_monocerosENSMMNP0001502624290.601585.7143
ENSG00000139160homo_sapiensENSP0000035035393.129886.2595ursus_maritimusENSUMAP0000000299491.729384.9624
ENSG00000139160homo_sapiensENSP0000035035391.221486.6412delphinapterus_leucasENSDLEP0000001999489.849685.3383
ENSG00000139160homo_sapiensENSP0000035035392.366487.7863physeter_catodonENSPCTP0000501588990.977486.4662
ENSG00000139160homo_sapiensENSP0000035035386.641277.8626mus_caroliMGP_CAROLIEiJ_P007697389.019680
ENSG00000139160homo_sapiensENSP0000035035386.641277.4809mus_musculusENSMUSP0000013616789.019679.6078
ENSG00000139160homo_sapiensENSP0000035035394.274886.6412mustela_putorius_furoENSMPUP0000000020892.857185.3383
ENSG00000139160homo_sapiensENSP0000035035395.801591.9847aotus_nancymaaeENSANAP0000002164695.801591.9847
ENSG00000139160homo_sapiensENSP0000035035357.633654.9618saimiri_boliviensis_boliviensisENSSBOP0000000985996.178391.7197
ENSG00000139160homo_sapiensENSP0000035035354.580252.6718vicugna_pacosENSVPAP0000000405891.082887.8981
ENSG00000139160homo_sapiensENSP0000035035398.473396.9466chlorocebus_sabaeusENSCSAP0000000367998.473396.9466
ENSG00000139160homo_sapiensENSP0000035035355.343553.0534tupaia_belangeriENSTBEP0000001053992.356788.535
ENSG00000139160homo_sapiensENSP0000035035387.786379.3893mesocricetus_auratusENSMAUP0000000420390.196181.5686
ENSG00000139160homo_sapiensENSP0000035035390.076386.2595camelus_dromedariusENSCDRP0000502042088.721884.9624
ENSG00000139160homo_sapiensENSP0000035035391.603183.9695panthera_tigris_altaicaENSPTIP0000001135190.225682.7068
ENSG00000139160homo_sapiensENSP0000035035385.877978.626rattus_norvegicusENSRNOP0000005230988.235380.7843
ENSG00000139160homo_sapiensENSP0000035035391.603187.4046prolemur_simusENSPSMP0000000405892.664188.417
ENSG00000139160homo_sapiensENSP0000035035390.076382.8244bos_mutusENSBMUP0000001721688.721881.5789
ENSG00000139160homo_sapiensENSP0000035035387.022979.3893cricetulus_griseus_chok1gshdENSCGRP0000101841089.411881.5686
ENSG00000139160homo_sapiensENSP0000035035393.129886.2595pteropus_vampyrusENSPVAP0000001342991.729384.9624
ENSG00000139160homo_sapiensENSP0000035035393.511588.9313rhinolophus_ferrumequinumENSRFEP0001000560592.105387.594
ENSG00000139160homo_sapiensENSP0000035035393.893186.2595neovison_visonENSNVIP0000002608292.481284.9624
ENSG00000139160homo_sapiensENSP0000035035390.076383.5878bos_taurusENSBTAP0000000116788.721882.3308
ENSG00000139160homo_sapiensENSP0000035035398.091696.5649rhinopithecus_bietiENSRBIP0000001743198.091696.5649
ENSG00000139160homo_sapiensENSP0000035035393.511586.6412canis_lupus_dingoENSCAFP0002002424992.105385.3383
ENSG00000139160homo_sapiensENSP0000035035391.221486.2595sciurus_vulgarisENSSVLP0000502489891.221486.2595
ENSG00000139160homo_sapiensENSP0000035035387.404678.626nannospalax_galiliENSNGAP0000002490989.803980.7843
ENSG00000139160homo_sapiensENSP0000035035390.076382.8244bos_grunniensENSBGRP0000000721788.721881.5789
ENSG00000139160homo_sapiensENSP0000035035391.603186.2595ictidomys_tridecemlineatusENSSTOP0000002010591.603186.2595
ENSG00000139160homo_sapiensENSP0000035035391.603187.0229otolemur_garnettiiENSOGAP0000000677292.307787.6923
ENSG00000139160homo_sapiensENSP0000035035396.183292.7481cebus_imitatorENSCCAP0000002989996.183292.7481
ENSG00000139160homo_sapiensENSP0000035035391.221485.8779urocitellus_parryiiENSUPAP0001001758191.221485.8779
ENSG00000139160homo_sapiensENSP0000035035390.45885.1145moschus_moschiferusENSMMSP0000002079177.198772.6384
ENSG00000139160homo_sapiensENSP0000035035398.091696.5649rhinopithecus_roxellanaENSRROP0000002116298.091696.5649
ENSG00000139160homo_sapiensENSP0000035035386.641277.8626mus_pahariMGP_PahariEiJ_P005331789.019680
ENSG00000139160homo_sapiensENSP0000035035392.366488.9313propithecus_coquereliENSPCOP0000000286792.720389.272
ENSG00000139160homo_sapiensENSP0000035035314.88557.63359ciona_intestinalisENSCINP0000001453343.333322.2222
ENSG00000139160homo_sapiensENSP0000035035352.290138.5496neolamprologus_brichardiENSNBRP0000001900059.307443.7229
ENSG00000139160homo_sapiensENSP0000035035338.931329.0076labrus_bergyltaENSLBEP0000001988164.150947.7987
ENSG00000139160homo_sapiensENSP0000035035344.656532.0611cyprinodon_variegatusENSCVAP0000002854365.730347.191

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005759is_active_in mitochondrial matrix3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006479involved_in protein methylation1TASHomo_sapiens(9606)Process
GO:0016279enables protein-lysine N-methyltransferase activity3IBA,IMP,TASHomo_sapiens(9606)Function
GO:0018022involved_in peptidyl-lysine methylation1IMPHomo_sapiens(9606)Process
GO:0018023involved_in peptidyl-lysine trimethylation2IBA,IMPHomo_sapiens(9606)Process
GO:0031072enables heat shock protein binding1IPIHomo_sapiens(9606)Function
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:1904733involved_in negative regulation of electron transfer activity1IMPHomo_sapiens(9606)Process
GO:1904736involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase1IMPHomo_sapiens(9606)Process

Expression