Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000138646 Gene ID 51191 Accession 24368
Symbol HERC5 Alias CEB1;CEBP1 Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 5
Status Confidence Length 49045 bases Strand Plus strand
Position 4 : 88457119 - 88506163 RNA binding domain N.A.
Summary This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
HERC5-201 ENST00000264350 3511 1024aa ENSP00000264350
HERC5-204 ENST00000508695 543 No protein -
HERC5-203 ENST00000508159 2243 662aa ENSP00000424129
HERC5-205 ENST00000510223 2925 No protein -
HERC5-202 ENST00000502913 1949 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
59825Hypertension2.6003624E-005-
70240Forced Expiratory Volume9E-622424883

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000138646homo_sapiensENSP0000034059623.127312.2659homo_sapiensENSP0000026435024.121112.793
ENSG00000138646homo_sapiensENSP0000036280452.430933.1745homo_sapiensENSP0000026435053.710933.9844
ENSG00000138646homo_sapiensENSP0000038568451.428633.4286homo_sapiensENSP0000026435052.734434.2773
ENSG00000138646homo_sapiensENSP0000049541818.702310.369homo_sapiensENSP0000026435028.710915.918
ENSG00000138646homo_sapiensENSP0000036399832.250617.5174homo_sapiensENSP0000026435027.148414.7461
ENSG00000138646homo_sapiensENSP0000035532634.062919.2886homo_sapiensENSP0000026435024.316413.7695
ENSG00000138646homo_sapiensENSP0000050271314.65897.35365homo_sapiensENSP0000026435029.589814.8438
ENSG00000138646homo_sapiensENSP0000026434661.056846.771homo_sapiensENSP0000026435060.937546.6797
ENSG00000138646homo_sapiensENSP0000029806831.056717.5258homo_sapiensENSP0000026435023.535213.2812
ENSG00000138646homo_sapiensENSP000002616099.412495.21307homo_sapiensENSP0000026435044.433624.6094
ENSG00000138646homo_sapiensENSP0000037922817.808210.274homo_sapiensENSP0000026435027.929716.1133
ENSG00000138646homo_sapiensENSP0000034871423.572312.8797homo_sapiensENSP0000026435018.945310.3516
ENSG00000138646homo_sapiensENSP0000041061332.333316.6667homo_sapiensENSP0000026435028.41814.6484
ENSG00000138646homo_sapiensENSP0000030919822.5312.1884homo_sapiensENSP0000026435023.828112.8906
ENSG00000138646homo_sapiensENSP0000042779328.416515.5098homo_sapiensENSP0000026435025.585913.9648
ENSG00000138646homo_sapiensENSP000005076878.963335.0249homo_sapiensENSP0000026435038.671921.6797
ENSG00000138646homo_sapiensENSP0000038226913.18016.4751homo_sapiensENSP0000026435033.593816.5039
ENSG00000138646homo_sapiensENSP0000038319929.333316homo_sapiensENSP0000026435027.929715.2344
ENSG00000138646homo_sapiensENSP0000026243534.89319.9198homo_sapiensENSP0000026435025.488314.5508
ENSG00000138646homo_sapiensENSP0000049757232.568818.3486homo_sapiensENSP0000026435027.734415.625
ENSG00000138646homo_sapiensENSP000002628547.224514.04664homo_sapiensENSP0000026435030.859417.2852
ENSG00000138646homo_sapiensENSP0000026290325.962613.9714homo_sapiensENSP0000026435023.046912.4023
ENSG00000138646homo_sapiensENSP0000035206930.114916.092homo_sapiensENSP0000026435025.585913.6719
ENSG00000138646homo_sapiensENSP0000042908410.25374.64452homo_sapiensENSP0000026435028.027312.6953

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000138646homo_sapiensENSP0000026435098.535296.875nomascus_leucogenysENSNLEP0000001186398.535296.875
ENSG00000138646homo_sapiensENSP0000026435098.437597.9492pan_paniscusENSPPAP0000001247899.11598.6234
ENSG00000138646homo_sapiensENSP0000026435098.632897.0703pongo_abeliiENSPPYP0000001666598.632897.0703
ENSG00000138646homo_sapiensENSP0000026435098.535297.9492pan_troglodytesENSPTRP0000002795098.535297.9492
ENSG00000138646homo_sapiensENSP0000026435099.218898.7305gorilla_gorillaENSGGOP0000001067998.164397.6812
ENSG00000138646homo_sapiensENSP0000026435064.843856.1523choloepus_hoffmanniENSCHOP0000000579765.418756.6502
ENSG00000138646homo_sapiensENSP0000026435065.820356.6406dasypus_novemcinctusENSDNOP0000001096579.57568.477
ENSG00000138646homo_sapiensENSP0000026435049.218842.2852erinaceus_europaeusENSEEUP0000001103763.716854.7408
ENSG00000138646homo_sapiensENSP0000026435057.226647.3633echinops_telfairiENSETEP0000000349866.666755.1763
ENSG00000138646homo_sapiensENSP0000026435095.117290.625callithrix_jacchusENSCJAP0000001201483.605179.6567
ENSG00000138646homo_sapiensENSP0000026435096.777394.4336cercocebus_atysENSCATP0000003013896.871994.5259
ENSG00000138646homo_sapiensENSP0000026435096.777394.4336macaca_fascicularisENSMFAP0000000079196.966794.6184
ENSG00000138646homo_sapiensENSP0000026435097.070394.6289macaca_mulattaENSMMUP0000007249797.165294.7214
ENSG00000138646homo_sapiensENSP0000026435088.867286.1328macaca_nemestrinaENSMNEP0000003433896.092993.1362
ENSG00000138646homo_sapiensENSP0000026435096.972794.7266papio_anubisENSPANP0000000366297.067594.8192
ENSG00000138646homo_sapiensENSP0000026435082.714881.1523mandrillus_leucophaeusENSMLEP0000003409297.356395.5172
ENSG00000138646homo_sapiensENSP0000026435082.910273.4375tursiops_truncatusENSTTRP0000000366883.398873.8703
ENSG00000138646homo_sapiensENSP0000026435083.496173.8281vulpes_vulpesENSVVUP0000001104077.235868.2927
ENSG00000138646homo_sapiensENSP0000026435085.937575.7812equus_asinusENSEASP0000501839985.35475.2667
ENSG00000138646homo_sapiensENSP0000026435084.08272.4609capra_hircusENSCHIP0000000595586.969774.9495
ENSG00000138646homo_sapiensENSP0000026435082.519570.8008loxodonta_africanaENSLAFP0000002623081.959370.3201
ENSG00000138646homo_sapiensENSP0000026435086.425876.7578panthera_leoENSPLOP0000000815685.922376.3107
ENSG00000138646homo_sapiensENSP0000026435087.109476.3672ailuropoda_melanoleucaENSAMEP0000003060986.686175.9961
ENSG00000138646homo_sapiensENSP0000026435086.816475.5859bos_indicus_hybridENSBIXP0000501308085.645574.5665
ENSG00000138646homo_sapiensENSP0000026435054.101646.1914oryctolagus_cuniculusENSOCUP0000001364483.685871.4501
ENSG00000138646homo_sapiensENSP0000026435085.937575.5859equus_caballusENSECAP0000001317884.534174.3516
ENSG00000138646homo_sapiensENSP0000026435086.425877.3438canis_lupus_familiarisENSCAFP0084502364886.341577.2683
ENSG00000138646homo_sapiensENSP0000026435086.425876.7578panthera_pardusENSPPRP0000002703786.425876.7578
ENSG00000138646homo_sapiensENSP0000026435085.546975.1953marmota_marmota_marmotaENSMMMP0000000678285.882475.4902
ENSG00000138646homo_sapiensENSP0000026435086.425875.8789balaenoptera_musculusENSBMSP0001000756486.341575.8049
ENSG00000138646homo_sapiensENSP0000026435075.585961.7188cavia_porcellusENSCPOP0000002470575.882461.9608
ENSG00000138646homo_sapiensENSP0000026435086.425876.6602felis_catusENSFCAP0000000572986.341576.5854
ENSG00000138646homo_sapiensENSP0000026435086.718876.4648ursus_americanusENSUAMP0000002954486.381376.1673
ENSG00000138646homo_sapiensENSP0000026435086.816475.5859bison_bison_bisonENSBBBP0000000170186.901375.6598
ENSG00000138646homo_sapiensENSP0000026435085.742276.1719monodon_monocerosENSMMNP0001501442083.698874.3565
ENSG00000138646homo_sapiensENSP0000026435080.95769.6289sus_scrofaENSSSCP0000002091585.640573.657
ENSG00000138646homo_sapiensENSP0000026435048.925842.8711microcebus_murinusENSMICP0000002902081.996771.8494
ENSG00000138646homo_sapiensENSP0000026435087.402375.7812ovis_aries_rambouilletENSOARP0002003056187.487875.8553
ENSG00000138646homo_sapiensENSP0000026435080.859471.2891ursus_maritimusENSUMAP0000000560787.61977.2487
ENSG00000138646homo_sapiensENSP0000026435061.523453.7109ochotona_princepsENSOPRP0000001149179.64669.5322
ENSG00000138646homo_sapiensENSP0000026435086.132876.0742delphinapterus_leucasENSDLEP0000000626486.132876.0742
ENSG00000138646homo_sapiensENSP0000026435086.621176.9531physeter_catodonENSPCTP0000500358186.705877.0284
ENSG00000138646homo_sapiensENSP0000026435086.035275.5859mustela_putorius_furoENSMPUP0000000214786.203575.7339
ENSG00000138646homo_sapiensENSP0000026435093.164188.0859aotus_nancymaaeENSANAP0000001302594.175789.0424
ENSG00000138646homo_sapiensENSP0000026435095.312591.0156saimiri_boliviensis_boliviensisENSSBOP0000004046195.312591.0156
ENSG00000138646homo_sapiensENSP0000026435087.20776.3672vicugna_pacosENSVPAP0000000256787.292376.4418
ENSG00000138646homo_sapiensENSP0000026435087.890686.2305chlorocebus_sabaeusENSCSAP0000000064397.087495.2535
ENSG00000138646homo_sapiensENSP0000026435072.949264.8438tupaia_belangeriENSTBEP0000000946680.582571.6289
ENSG00000138646homo_sapiensENSP000002643509.277347.51953phocoena_sinusENSPSNP0000000208263.333351.3333
ENSG00000138646homo_sapiensENSP0000026435055.468848.5352phocoena_sinusENSPSNP0000000205985.800675.0755
ENSG00000138646homo_sapiensENSP0000026435087.79377.0508camelus_dromedariusENSCDRP0000500068387.878877.1261
ENSG00000138646homo_sapiensENSP0000026435079.589870.8984carlito_syrichtaENSTSYP0000003318479.667670.9677
ENSG00000138646homo_sapiensENSP0000026435056.2549.707panthera_tigris_altaicaENSPTIP0000000099886.877876.7722
ENSG00000138646homo_sapiensENSP0000026435086.621176.3672prolemur_simusENSPSMP0000000286386.705876.4418
ENSG00000138646homo_sapiensENSP0000026435053.12545.2148sorex_araneusENSSARP0000000834765.939456.1212
ENSG00000138646homo_sapiensENSP0000026435085.742274.707bos_mutusENSBMUP0000002756385.575174.5614
ENSG00000138646homo_sapiensENSP0000026435087.402377.0508pteropus_vampyrusENSPVAP0000000337686.977676.6764
ENSG00000138646homo_sapiensENSP0000026435080.078169.3359myotis_lucifugusENSMLUP0000001114987.700575.9358
ENSG00000138646homo_sapiensENSP0000026435038.085933.8867myotis_lucifugusENSMLUP0000002266989.861779.9539
ENSG00000138646homo_sapiensENSP0000026435055.371147.8516rhinolophus_ferrumequinumENSRFEP0001000664186.301474.5814
ENSG00000138646homo_sapiensENSP0000026435056.445349.3164neovison_visonENSNVIP0000002869787.311276.284
ENSG00000138646homo_sapiensENSP0000026435086.914175.4883bos_taurusENSBTAP0000005890685.741874.4701
ENSG00000138646homo_sapiensENSP0000026435076.757862.793heterocephalus_glaber_femaleENSHGLP0000003342977.286163.2252
ENSG00000138646homo_sapiensENSP0000026435083.398474.3164heterocephalus_glaber_femaleENSHGLP0000001056984.387475.1976
ENSG00000138646homo_sapiensENSP0000026435091.015688.1836rhinopithecus_bietiENSRBIP0000001008197.28694.2589
ENSG00000138646homo_sapiensENSP0000026435085.839877.0508canis_lupus_dingoENSCAFP0002000875786.26177.4288
ENSG00000138646homo_sapiensENSP0000026435086.328175.1953sciurus_vulgarisENSSVLP0000501448486.412575.2688
ENSG00000138646homo_sapiensENSP0000026435077.343865.0391procavia_capensisENSPCAP0000000645877.647165.2941
ENSG00000138646homo_sapiensENSP0000026435087.011775.7812bos_grunniensENSBGRP0000003402485.426774.4008
ENSG00000138646homo_sapiensENSP0000026435086.621175.5859cervus_hanglu_yarkandensisENSCHYP0000002140986.28475.2918
ENSG00000138646homo_sapiensENSP0000026435055.566447.9492catagonus_wagneriENSCWAP0000002294285.951774.1692
ENSG00000138646homo_sapiensENSP0000026435031.347726.6602ictidomys_tridecemlineatusENSSTOP0000001412282.945770.5426
ENSG00000138646homo_sapiensENSP0000026435079.199268.2617otolemur_garnettiiENSOGAP0000001543284.832673.1172
ENSG00000138646homo_sapiensENSP0000026435095.703191.3086cebus_imitatorENSCCAP0000000449595.703191.3086
ENSG00000138646homo_sapiensENSP0000026435085.058675.1953urocitellus_parryiiENSUPAP0001001240685.225175.3425
ENSG00000138646homo_sapiensENSP0000026435086.816476.1719moschus_moschiferusENSMMSP0000002357086.478675.8755
ENSG00000138646homo_sapiensENSP0000026435096.972793.9453rhinopithecus_roxellanaENSRROP0000004171597.162494.1292
ENSG00000138646homo_sapiensENSP0000026435086.035276.0742propithecus_coquereliENSPCOP0000001992986.119376.1486
ENSG00000138646homo_sapiensENSP0000026435033.007821.875naja_najaENSNNAP0000001003151.603134.1985
ENSG00000138646homo_sapiensENSP0000026435038.183625.0977podarcis_muralisENSPMRP0000003118556.748937.3004
ENSG00000138646homo_sapiensENSP0000026435013.671910.8398pelodiscus_sinensisENSPSIP0000001826480.924964.1618
ENSG00000138646homo_sapiensENSP000002643508.691416.64062struthio_camelus_australisENSSCUP0000001794976.068458.1197
ENSG00000138646homo_sapiensENSP000002643506.445314.98047anser_brachyrhynchusENSABRP000000088437557.9545

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000079involved_in regulation of cyclin-dependent protein serine/threonine kinase activity1TASHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm3IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006511involved_in ubiquitin-dependent protein catabolic process1IBAHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination2IBA,IDAHomo_sapiens(9606)Process
GO:0032020involved_in ISG15-protein conjugation2IBA,IDAHomo_sapiens(9606)Process
GO:0042296enables ISG15 transferase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0045087involved_in innate immune response1IDAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IEAHomo_sapiens(9606)Component
GO:0050688involved_in regulation of defense response to virus1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IEAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity2IBA,IDAHomo_sapiens(9606)Function

Expression