RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000138617	Gene ID	54956	Accession	26040
Symbol	PARP16	Alias	ARTD15;pART15;C15orf30	Full Name	poly(ADP-ribose) polymerase family member 16
Status	Confidence	Length	52424 bases	Strand	Minus strand
Position	15 : 65234460 - 65286883	RNA binding domain	PARP
Summary	Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of protein serine/threonine kinase activity; and protein ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000496935	PARP	PF00644	9.6e-34	1
ENSP00000261888	PARP	PF00644	9.7e-34	1
ENSP00000396118	PARP	PF00644	1.7e-15	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
37163422	PARP16-Mediated Stabilization of Amyloid Precursor Protein mRNA Exacerbates Alzheimer's Disease Pathogenesis.	Jinghuan Wang	2023-08-01	Aging and disease

Name	Transcript ID	bp	Protein	Translation ID
PARP16-204	ENST00000559805	678	72aa	ENSP00000457982
PARP16-201	ENST00000261888	2731	323aa	ENSP00000261888
PARP16-202	ENST00000444347	2352	207aa	ENSP00000396118
PARP16-206	ENST00000649807	2734	322aa	ENSP00000496935
PARP16-205	ENST00000560149	823	No protein	-
PARP16-203	ENST00000558873	838	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	3	IBA,IMP,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005635	is_active_in nuclear envelope	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	IMP	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0019082	involved_in viral protein processing	1	TAS	Homo_sapiens(9606)	Process
GO:0019900	enables kinase binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0030968	involved_in endoplasmic reticulum unfolded protein response	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0034356	involved_in NAD biosynthesis via nicotinamide riboside salvage pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0036498	involved_in IRE1-mediated unfolded protein response	1	IMP	Homo_sapiens(9606)	Process
GO:0043539	enables protein serine/threonine kinase activator activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0070213	involved_in protein auto-ADP-ribosylation	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0071782	is_active_in endoplasmic reticulum tubular network	2	IBA,IMP	Homo_sapiens(9606)	Component
GO:0140804	enables NAD+- protein-lysine ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140806	enables NAD+- protein-aspartate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140807	enables NAD+-protein-glutamate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:1990830	involved_in cellular response to leukemia inhibitory factor	1	IEA	Homo_sapiens(9606)	Process
GO:2000766	involved_in negative regulation of cytoplasmic translation	1	IDA	Homo_sapiens(9606)	Process