RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000138071	Gene ID	10097	Accession	169
Symbol	ACTR2	Alias	ARP2	Full Name	actin related protein 2
Status	Confidence	Length	43466 bases	Strand	Plus strand
Position	2 : 65227788 - 65271253	RNA binding domain	N.A.
Summary	The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ACTR2-204	ENST00000476840	587	53aa	ENSP00000490877
ACTR2-201	ENST00000260641	3783	394aa	ENSP00000260641
ACTR2-203	ENST00000471552	554	65aa	ENSP00000490923
ACTR2-202	ENST00000377982	2685	399aa	ENSP00000367220

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005200	enables structural constituent of cytoskeleton	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005885	part_of Arp2/3 protein complex	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005925	located_in focal adhesion	1	HDA	Homo_sapiens(9606)	Component
GO:0007163	involved_in establishment or maintenance of cell polarity	1	IEA	Homo_sapiens(9606)	Process
GO:0008356	involved_in asymmetric cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0010592	involved_in positive regulation of lamellipodium assembly	1	IDA	Homo_sapiens(9606)	Process
GO:0015629	located_in actin cytoskeleton	1	TAS	Homo_sapiens(9606)	Component
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016344	involved_in meiotic chromosome movement towards spindle pole	1	IEA	Homo_sapiens(9606)	Process
GO:0016482	involved_in cytosolic transport	1	IEA	Homo_sapiens(9606)	Process
GO:0030478	located_in actin cap	1	IEA	Homo_sapiens(9606)	Component
GO:0033206	involved_in meiotic cytokinesis	1	IEA	Homo_sapiens(9606)	Process
GO:0034314	involved_in Arp2/3 complex-mediated actin nucleation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0035578	located_in azurophil granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0035861	located_in site of double-strand break	1	IDA	Homo_sapiens(9606)	Component
GO:0042995	located_in cell projection	1	IEA	Homo_sapiens(9606)	Component
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0051015	contributes_to actin filament binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0051653	involved_in spindle localization	1	IEA	Homo_sapiens(9606)	Process
GO:0060271	acts_upstream_of_or_within cilium assembly	1	IMP	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0071346	involved_in cellular response to type II interferon	1	IEA	Homo_sapiens(9606)	Process
GO:1904813	located_in ficolin-1-rich granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:1905168	involved_in positive regulation of double-strand break repair via homologous recombination	1	IDA	Homo_sapiens(9606)	Process
GO:2001032	NOT involved_in regulation of double-strand break repair via nonhomologous end joining	1	IDA	Homo_sapiens(9606)	Process