Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000137462 Gene ID 7097 Accession 11848
Symbol TLR2 Alias TIL4;CD282 Full Name toll like receptor 2
Status Confidence Length 22191 bases Strand Plus strand
Position 4 : 153684070 - 153706260 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33073244 Imperfect storm: is interleukin-33 the Achilles heel of COVID-19? Gaetano Zizzo 2020-12-01 The Lancet. Rheumatology
33940513 Mechanistic understanding of innate and adaptive immune responses in SARS-CoV-2 infection. Y Mumtaz Balkhi 2021-07-01 Molecular immunology
34468896 TLR4 gene polymorphisms in Egyptian vitiligo patients: insights into emerging association with clinical activity, family history, and response to therapy. Maha Abdelsalam 2021-09-01 Journal, genetic engineering & biotechnology
32102344 Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment. Massimo M De 2020-02-24 International journal of molecular sciences
20414330 Kaposi's sarcoma-associated herpesvirus and innate immunity. A John West 2010-03-01 Future virology
19635908 Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway. Yung-Cheng Chiu 2009-08-15 Journal of immunology (Baltimore, Md. : 1950)
23282714 Staphylococcus aureus and Chronic Airway Disease. Lara Derycke 2010-08-01 The World Allergy Organization journal

Transcripts

Name Transcript ID bp Protein Translation ID
TLR2-208 ENST00000646900 3227 784aa ENSP00000493968
TLR2-207 ENST00000646219 3899 784aa ENSP00000496676
TLR2-202 ENST00000642580 2979 784aa ENSP00000495339
TLR2-203 ENST00000642700 3596 784aa ENSP00000494425
TLR2-205 ENST00000643501 3806 784aa ENSP00000496208
TLR2-206 ENST00000645889 735 No protein -
TLR2-201 ENST00000260010 4200 784aa ENSP00000260010
TLR2-204 ENST00000643087 630 210aa ENSP00000494668

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
38644Platelet Function Tests6.0600000E-006-
38876Platelet Function Tests8.0900000E-007-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137462homo_sapiensENSP0000037003428.503316.6826homo_sapiensENSP0000049442538.137822.3214
ENSG00000137462homo_sapiensENSP0000030686426.151614.7103homo_sapiensENSP0000049442522.44912.6276
ENSG00000137462homo_sapiensENSP0000021553932.396717.686homo_sapiensENSP000004944252513.648
ENSG00000137462homo_sapiensENSP0000036308935.399322.5268homo_sapiensENSP0000049442537.882724.1071
ENSG00000137462homo_sapiensENSP0000034424234.013617.6871homo_sapiensENSP0000049442519.13279.94898
ENSG00000137462homo_sapiensENSP0000021803229.68317.3871homo_sapiensENSP0000049442539.413323.0867
ENSG00000137462homo_sapiensENSP0000029159234.630420.2335homo_sapiensENSP0000049442511.3526.63265
ENSG00000137462homo_sapiensENSP0000036715732.363618.5455homo_sapiensENSP0000049442511.3526.5051
ENSG00000137462homo_sapiensENSP0000037988034.74917.7606homo_sapiensENSP0000049442511.47965.86735
ENSG00000137462homo_sapiensENSP0000032862530.057816.185homo_sapiensENSP0000049442526.530614.2857
ENSG00000137462homo_sapiensENSP0000030892546.115927.4969homo_sapiensENSP0000049442547.704128.4439
ENSG00000137462homo_sapiensENSP0000029679532.964617.6991homo_sapiensENSP0000049442538.010220.4082
ENSG00000137462homo_sapiensENSP0000049635532.051317.5991homo_sapiensENSP0000049442535.076519.2602
ENSG00000137462homo_sapiensENSP0000033266830.594915.864homo_sapiensENSP0000049442513.77557.14286
ENSG00000137462homo_sapiensENSP0000029838626.525213.3952homo_sapiensENSP0000049442525.510212.8827
ENSG00000137462homo_sapiensENSP0000026006131.117817.8248homo_sapiensENSP0000049442526.275515.051
ENSG00000137462homo_sapiensENSP0000035493247.582727.4809homo_sapiensENSP0000049442547.704127.551
ENSG00000137462homo_sapiensENSP0000036118528.363615.4545homo_sapiensENSP0000049442519.89810.8418
ENSG00000137462homo_sapiensENSP0000030324828.533714.531homo_sapiensENSP0000049442527.55114.0306
ENSG00000137462homo_sapiensENSP0000029463511.86857.05694homo_sapiensENSP0000049442518.877611.2245
ENSG00000137462homo_sapiensENSP0000042471848.241228.7688homo_sapiensENSP0000049442548.979629.2092
ENSG00000137462homo_sapiensENSP0000025644729.803317.0953homo_sapiensENSP0000049442525.127614.4133

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137462homo_sapiensENSP0000049442598.85296.5561nomascus_leucogenysENSNLEP0000002278998.85296.5561
ENSG00000137462homo_sapiensENSP0000049442599.744999.3622pan_paniscusENSPPAP0000000712399.744999.3622
ENSG00000137462homo_sapiensENSP0000049442599.107197.9592pongo_abeliiENSPPYP0000001691099.233798.0843
ENSG00000137462homo_sapiensENSP0000049442599.744999.4898pan_troglodytesENSPTRP0000002837999.744999.4898
ENSG00000137462homo_sapiensENSP0000049442510099.8725gorilla_gorillaENSGGOP0000000301210099.8725
ENSG00000137462homo_sapiensENSP0000049442578.188861.8622sarcophilus_harrisiiENSSHAP0000004568478.288661.9412
ENSG00000137462homo_sapiensENSP0000049442562.627651.7857notamacropus_eugeniiENSMEUP0000000733365.641754.2781
ENSG00000137462homo_sapiensENSP0000049442563.392956.8878choloepus_hoffmanniENSCHOP0000000290987.578.5211
ENSG00000137462homo_sapiensENSP0000049442588.265379.5918dasypus_novemcinctusENSDNOP0000002599488.152979.4904
ENSG00000137462homo_sapiensENSP0000049442596.045992.2194callithrix_jacchusENSCJAP0000008808696.045992.2194
ENSG00000137462homo_sapiensENSP0000049442598.469496.4286cercocebus_atysENSCATP0000000762998.469496.4286
ENSG00000137462homo_sapiensENSP0000049442597.959295.7908macaca_fascicularisENSMFAP0000006181297.959295.7908
ENSG00000137462homo_sapiensENSP0000049442598.086795.7908macaca_mulattaENSMMUP0000002083498.086795.7908
ENSG00000137462homo_sapiensENSP0000049442598.341896.4286macaca_nemestrinaENSMNEP0000000157398.341896.4286
ENSG00000137462homo_sapiensENSP0000049442596.811294.5153papio_anubisENSPANP0000001067497.432695.1219
ENSG00000137462homo_sapiensENSP0000049442598.214395.9184mandrillus_leucophaeusENSMLEP0000000018398.214395.9184
ENSG00000137462homo_sapiensENSP0000049442588.520478.9541tursiops_truncatusENSTTRP0000000426488.407678.8535
ENSG00000137462homo_sapiensENSP0000049442588.520477.2959vulpes_vulpesENSVVUP0000003465784.634173.9024
ENSG00000137462homo_sapiensENSP0000049442583.80171.1735mus_spretusMGP_SPRETEiJ_P006047583.80171.1735
ENSG00000137462homo_sapiensENSP0000049442589.668482.1429equus_asinusENSEASP0000504627088.427781.0063
ENSG00000137462homo_sapiensENSP0000049442586.35275.7653capra_hircusENSCHIP0000003161985.264574.8111
ENSG00000137462homo_sapiensENSP0000049442589.285780.7398loxodonta_africanaENSLAFP0000002855589.399780.8429
ENSG00000137462homo_sapiensENSP0000049442588.392979.8469panthera_leoENSPLOP0000001078188.392979.8469
ENSG00000137462homo_sapiensENSP0000049442588.137878.1888ailuropoda_melanoleucaENSAMEP0000001950575.934167.3626
ENSG00000137462homo_sapiensENSP0000049442587.117377.2959bos_indicus_hybridENSBIXP0000504416387.117377.2959
ENSG00000137462homo_sapiensENSP0000049442586.096976.2755oryctolagus_cuniculusENSOCUP0000000291886.096976.2755
ENSG00000137462homo_sapiensENSP0000049442585.331677.9337equus_caballusENSECAP0000007844688.142380.5007
ENSG00000137462homo_sapiensENSP0000049442589.668482.0153equus_caballusENSECAP0000008892688.427780.8805
ENSG00000137462homo_sapiensENSP0000049442588.265377.0408canis_lupus_familiarisENSCAFP0084501287581.796771.3948
ENSG00000137462homo_sapiensENSP0000049442588.392979.8469panthera_pardusENSPPRP0000002705288.392979.8469
ENSG00000137462homo_sapiensENSP0000049442589.158280.9949marmota_marmota_marmotaENSMMMP0000000419389.158280.9949
ENSG00000137462homo_sapiensENSP0000049442589.158279.4643balaenoptera_musculusENSBMSP0001000153989.044679.3631
ENSG00000137462homo_sapiensENSP0000049442583.673572.0663cavia_porcellusENSCPOP0000001996183.887572.2506
ENSG00000137462homo_sapiensENSP0000049442588.520479.4643felis_catusENSFCAP0000002012788.520479.4643
ENSG00000137462homo_sapiensENSP0000049442588.265377.9337ursus_americanusENSUAMP0000002215487.928877.6366
ENSG00000137462homo_sapiensENSP0000049442577.423562.7551monodelphis_domesticaENSMODP0000003636477.324862.6752
ENSG00000137462homo_sapiensENSP0000049442587.117377.2959bison_bison_bisonENSBBBP0000000615787.117377.2959
ENSG00000137462homo_sapiensENSP0000049442560.969452.8061monodon_monocerosENSMMNP0001502639285.357173.9286
ENSG00000137462homo_sapiensENSP0000049442588.392978.5714sus_scrofaENSSSCP0000006795488.280378.4713
ENSG00000137462homo_sapiensENSP0000049442582.908272.9592ursus_maritimusENSUMAP0000002225487.483276.9852
ENSG00000137462homo_sapiensENSP0000049442587.372575.7653ochotona_princepsENSOPRP0000000798087.595975.9591
ENSG00000137462homo_sapiensENSP0000049442588.392978.699delphinapterus_leucasENSDLEP0000002048188.280378.5987
ENSG00000137462homo_sapiensENSP0000049442583.035773.9796physeter_catodonENSPCTP0000500455488.09278.4844
ENSG00000137462homo_sapiensENSP0000049442583.928671.1735mus_caroliMGP_CAROLIEiJ_P005815183.928671.1735
ENSG00000137462homo_sapiensENSP0000049442583.928670.9184mus_musculusENSMUSP0000002962383.928670.9184
ENSG00000137462homo_sapiensENSP0000049442587.244976.6582mustela_putorius_furoENSMPUP0000001877487.133876.5605
ENSG00000137462homo_sapiensENSP0000049442587.882778.3163vicugna_pacosENSVPAP0000000593187.770778.2166
ENSG00000137462homo_sapiensENSP0000049442598.596996.1735chlorocebus_sabaeusENSCSAP0000001761798.596996.1735
ENSG00000137462homo_sapiensENSP0000049442583.418472.7041mesocricetus_auratusENSMAUP0000000140383.418472.7041
ENSG00000137462homo_sapiensENSP0000049442588.64879.2092phocoena_sinusENSPSNP0000000945788.53579.1083
ENSG00000137462homo_sapiensENSP0000049442586.607178.0612panthera_tigris_altaicaENSPTIP0000000305387.953479.2746
ENSG00000137462homo_sapiensENSP0000049442583.418471.6837rattus_norvegicusENSRNOP0000009576783.418471.6837
ENSG00000137462homo_sapiensENSP0000049442589.285783.1633prolemur_simusENSPSMP0000003136589.285783.1633
ENSG00000137462homo_sapiensENSP0000049442582.780671.4286microtus_ochrogasterENSMOCP0000000469682.886371.5198
ENSG00000137462homo_sapiensENSP0000049442561.734753.1888sorex_araneusENSSARP0000000240662.130953.5302
ENSG00000137462homo_sapiensENSP0000049442583.290871.6837peromyscus_maniculatus_bairdiiENSPEMP0000000771883.290871.6837
ENSG00000137462homo_sapiensENSP0000049442586.096976.2755bos_mutusENSBMUP0000001174284.37574.75
ENSG00000137462homo_sapiensENSP0000049442584.311271.0459mus_spicilegusENSMSIP0000002315883.249470.1511
ENSG00000137462homo_sapiensENSP0000049442582.015371.0459cricetulus_griseus_chok1gshdENSCGRP0000101172184.052372.8105
ENSG00000137462homo_sapiensENSP0000049442586.862277.2959myotis_lucifugusENSMLUP0000001997386.973277.3946
ENSG00000137462homo_sapiensENSP0000049442578.571463.7755vombatus_ursinusENSVURP0001001602978.772463.9386
ENSG00000137462homo_sapiensENSP0000049442587.117376.6582neovison_visonENSNVIP0000001859787.006476.5605
ENSG00000137462homo_sapiensENSP0000049442587.117377.4235bos_taurusENSBTAP0000001053087.117377.4235
ENSG00000137462homo_sapiensENSP0000049442556.122448.5969heterocephalus_glaber_femaleENSHGLP0000004353182.39771.3483
ENSG00000137462homo_sapiensENSP0000049442597.704195.4082rhinopithecus_bietiENSRBIP0000000046497.704195.4082
ENSG00000137462homo_sapiensENSP0000049442588.265377.0408canis_lupus_dingoENSCAFP0002000273288.152976.9427
ENSG00000137462homo_sapiensENSP0000049442588.392980.2296sciurus_vulgarisENSSVLP0000502024788.392980.2296
ENSG00000137462homo_sapiensENSP0000049442579.209264.6684phascolarctos_cinereusENSPCIP0000004051778.409164.0152
ENSG00000137462homo_sapiensENSP0000049442578.954168.4949nannospalax_galiliENSNGAP0000000714288.176676.4957
ENSG00000137462homo_sapiensENSP0000049442586.989877.0408bos_grunniensENSBGRP0000002784185.570975.7842
ENSG00000137462homo_sapiensENSP0000049442584.311273.2143chinchilla_lanigeraENSCLAP0000002553384.526973.4015
ENSG00000137462homo_sapiensENSP0000049442586.989876.7857cervus_hanglu_yarkandensisENSCHYP0000000612086.989876.7857
ENSG00000137462homo_sapiensENSP0000049442584.566372.8316catagonus_wagneriENSCWAP0000002014284.458672.7389
ENSG00000137462homo_sapiensENSP0000049442588.903180.3571ictidomys_tridecemlineatusENSSTOP0000002215288.903180.3571
ENSG00000137462homo_sapiensENSP0000049442587.580.6122otolemur_garnettiiENSOGAP0000001559187.388580.5096
ENSG00000137462homo_sapiensENSP0000049442595.918492.3469cebus_imitatorENSCCAP0000003601792.044188.6169
ENSG00000137462homo_sapiensENSP0000049442588.520480.3571urocitellus_parryiiENSUPAP0001002263288.520480.3571
ENSG00000137462homo_sapiensENSP0000049442585.204175.3827moschus_moschiferusENSMMSP0000001184784.13174.4333
ENSG00000137462homo_sapiensENSP0000049442597.704195.4082rhinopithecus_roxellanaENSRROP0000000699897.704195.4082
ENSG00000137462homo_sapiensENSP0000049442583.163370.9184mus_pahariMGP_PahariEiJ_P006911483.163370.9184
ENSG00000137462homo_sapiensENSP0000049442550.510232.5255petromyzon_marinusENSPMAP0000001139951.22932.9884
ENSG00000137462homo_sapiensENSP0000049442551.785732.6531petromyzon_marinusENSPMAP0000001140051.19832.2825
ENSG00000137462homo_sapiensENSP0000049442543.112224.7449eptatretus_burgeriENSEBUP0000002209944.35725.4593
ENSG00000137462homo_sapiensENSP0000049442565.816345.4082callorhinchus_miliiENSCMIP0000002185866.153845.641
ENSG00000137462homo_sapiensENSP0000049442566.964345.6633callorhinchus_miliiENSCMIP0000002186765.707144.806
ENSG00000137462homo_sapiensENSP0000049442563.775545.4082latimeria_chalumnaeENSLACP0000001430562.656644.6115
ENSG00000137462homo_sapiensENSP0000049442564.158245.6633lepisosteus_oculatusENSLOCP0000002232162.953744.806
ENSG00000137462homo_sapiensENSP0000049442559.056138.648clupea_harengusENSCHAP0000003855859.28338.7964
ENSG00000137462homo_sapiensENSP0000049442560.076541.199danio_rerioENSDARP0000005500559.771640.9898
ENSG00000137462homo_sapiensENSP0000049442558.673540.6888carassius_auratusENSCARP0000005156458.823540.7928
ENSG00000137462homo_sapiensENSP0000049442559.94942.3469carassius_auratusENSCARP0000006336254.778638.6946
ENSG00000137462homo_sapiensENSP0000049442559.183740.6888astyanax_mexicanusENSAMXP0000005360760.259741.4286
ENSG00000137462homo_sapiensENSP0000049442560.204141.8367astyanax_mexicanusENSAMXP0000002628760.668442.1594
ENSG00000137462homo_sapiensENSP0000049442560.076541.3265ictalurus_punctatusENSIPUP0000000195159.620341.0127
ENSG00000137462homo_sapiensENSP0000049442559.183741.199esox_luciusENSELUP0000000803654.26937.7778
ENSG00000137462homo_sapiensENSP0000049442535.586722.8316electrophorus_electricusENSEEEP0000003665850.543532.4275
ENSG00000137462homo_sapiensENSP0000049442551.785735.8418electrophorus_electricusENSEEEP0000004020558.585940.5483
ENSG00000137462homo_sapiensENSP0000049442560.586740.9439oncorhynchus_kisutchENSOKIP0000507749057.022838.5354
ENSG00000137462homo_sapiensENSP0000049442560.586741.0714oncorhynchus_mykissENSOMYP0000013508658.93339.9504
ENSG00000137462homo_sapiensENSP0000049442549.489832.2704salmo_salarENSSSAP0000000782055.270736.0399
ENSG00000137462homo_sapiensENSP0000049442554.464334.949salmo_truttaENSSTUP0000000999452.264433.5373
ENSG00000137462homo_sapiensENSP0000049442528.69918.4949salmo_truttaENSSTUP0000010259059.681738.4615
ENSG00000137462homo_sapiensENSP0000049442548.596929.5918gadus_morhuaENSGMOP0000003857745.95927.9855
ENSG00000137462homo_sapiensENSP0000049442548.086729.7194gadus_morhuaENSGMOP0000003094246.031728.4493
ENSG00000137462homo_sapiensENSP0000049442549.107129.3367gadus_morhuaENSGMOP0000006478146.441527.7443
ENSG00000137462homo_sapiensENSP0000049442548.341829.7194gadus_morhuaENSGMOP0000006823946.163228.38
ENSG00000137462homo_sapiensENSP0000049442548.469429.5918gadus_morhuaENSGMOP0000006252346.568628.4314
ENSG00000137462homo_sapiensENSP0000049442549.362230.2296gadus_morhuaENSGMOP0000004732945.907528.1139
ENSG00000137462homo_sapiensENSP0000049442548.724529.9745gadus_morhuaENSGMOP0000005742646.415628.5541
ENSG00000137462homo_sapiensENSP0000049442548.979628.9541gadus_morhuaENSGMOP0000003639446.545527.5152
ENSG00000137462homo_sapiensENSP0000049442546.428629.9745fundulus_heteroclitusENSFHEP0000000491650.415532.5485
ENSG00000137462homo_sapiensENSP0000049442556.760239.4133fundulus_heteroclitusENSFHEP0000001194854.070537.5456
ENSG00000137462homo_sapiensENSP0000049442556.2538.648fundulus_heteroclitusENSFHEP0000001246354.444437.4074
ENSG00000137462homo_sapiensENSP0000049442551.785736.7347poecilia_reticulataENSPREP0000001177452.864637.5
ENSG00000137462homo_sapiensENSP0000049442554.336737.2449poecilia_reticulataENSPREP0000000882152.657636.0939
ENSG00000137462homo_sapiensENSP0000049442557.015338.9031xiphophorus_maculatusENSXMAP0000000828155.117137.6079
ENSG00000137462homo_sapiensENSP0000049442557.270440.3061xiphophorus_maculatusENSXMAP0000000827654.756138.5366
ENSG00000137462homo_sapiensENSP0000049442558.035740.5612oryzias_latipesENSORLP0000000316354.753338.2671
ENSG00000137462homo_sapiensENSP0000049442558.290841.199cyclopterus_lumpusENSCLMP0000503415955.461239.199
ENSG00000137462homo_sapiensENSP0000049442552.423536.0969cyclopterus_lumpusENSCLMP0000503880659.565241.0145
ENSG00000137462homo_sapiensENSP0000049442560.331641.8367oreochromis_niloticusENSONIP0000002592560.101741.6773
ENSG00000137462homo_sapiensENSP000004944259.821437.39796oreochromis_niloticusENSONIP0000005826748.734236.7089
ENSG00000137462homo_sapiensENSP0000049442558.80141.3265oreochromis_niloticusENSONIP0000004408456.15139.4641
ENSG00000137462homo_sapiensENSP0000049442560.076542.0918oreochromis_niloticusENSONIP0000002972659.923741.9847
ENSG00000137462homo_sapiensENSP0000049442546.30130.4847oreochromis_niloticusENSONIP0000005443954.179135.6716
ENSG00000137462homo_sapiensENSP0000049442540.561228.699haplochromis_burtoniENSHBUP0000001747155.691839.4046
ENSG00000137462homo_sapiensENSP0000049442560.459241.7092haplochromis_burtoniENSHBUP0000003321559.398540.9774
ENSG00000137462homo_sapiensENSP0000049442520.790813.0102astatotilapia_callipteraENSACLP0000004087152.580632.9032
ENSG00000137462homo_sapiensENSP0000049442516.071410.0765astatotilapia_callipteraENSACLP0000004086751.851932.5103
ENSG00000137462homo_sapiensENSP0000049442560.076541.7092astatotilapia_callipteraENSACLP0000000005359.847541.5502
ENSG00000137462homo_sapiensENSP0000049442558.545941.3265astatotilapia_callipteraENSACLP0000002310955.907439.4641
ENSG00000137462homo_sapiensENSP0000049442515.433710.2041astatotilapia_callipteraENSACLP0000004087455.251136.5297
ENSG00000137462homo_sapiensENSP0000049442559.693941.3265astatotilapia_callipteraENSACLP0000000006559.466341.169
ENSG00000137462homo_sapiensENSP0000049442557.780640.3061sparus_aurataENSSAUP0001001272755.243938.5366
ENSG00000137462homo_sapiensENSP0000049442560.459241.199sparus_aurataENSSAUP0001004890759.547740.5779
ENSG00000137462homo_sapiensENSP0000049442557.780639.1582lates_calcariferENSLCAP0001000085455.176637.3934
ENSG00000137462homo_sapiensENSP0000049442554.591839.0306lates_calcariferENSLCAP0001004129962.11944.4122
ENSG00000137462homo_sapiensENSP0000049442555.994937.7551lates_calcariferENSLCAP0001000162454.331736.6337
ENSG00000137462homo_sapiensENSP0000049442557.780639.2857lates_calcariferENSLCAP0001004994555.176637.5152
ENSG00000137462homo_sapiensENSP0000049442564.158248.5969xenopus_tropicalisENSXETP0000010787764.487248.8462
ENSG00000137462homo_sapiensENSP0000049442563.392946.301xenopus_tropicalisENSXETP0000000382262.911445.9494
ENSG00000137462homo_sapiensENSP0000049442573.979656.1224chrysemys_picta_belliiENSCPBP0000001235474.074156.1941
ENSG00000137462homo_sapiensENSP0000049442573.469455.2296chrysemys_picta_belliiENSCPBP0000001235672.452854.4654
ENSG00000137462homo_sapiensENSP0000049442571.811254.4643sphenodon_punctatusENSSPUP0000001928472.551555.0258
ENSG00000137462homo_sapiensENSP0000049442566.836750.6378sphenodon_punctatusENSSPUP0000001932171.48754.161
ENSG00000137462homo_sapiensENSP0000049442566.19950crocodylus_porosusENSCPRP0000501295873.305155.3672
ENSG00000137462homo_sapiensENSP0000049442564.923548.7245crocodylus_porosusENSCPRP0000501294573.132254.8851
ENSG00000137462homo_sapiensENSP0000049442563.137845.4082laticauda_laticaudataENSLLTP0000000785068.941549.5822
ENSG00000137462homo_sapiensENSP0000049442538.520422.449notechis_scutatusENSNSUP0000000718735.86720.9026
ENSG00000137462homo_sapiensENSP0000049442563.392945.6633pseudonaja_textilisENSPTXP0000000870268.93249.6533
ENSG00000137462homo_sapiensENSP0000049442563.137846.0459anas_platyrhynchos_platyrhynchosENSAPLP0000001113169.42550.6311
ENSG00000137462homo_sapiensENSP0000049442570.280652.6786gallus_gallusENSGALP0001002074570.550652.8809
ENSG00000137462homo_sapiensENSP0000049442570.153152.4235gallus_gallusENSGALP0001002065769.356951.8285
ENSG00000137462homo_sapiensENSP0000049442571.428653.0612meleagris_gallopavoENSMGAP0000001854271.702953.265
ENSG00000137462homo_sapiensENSP0000049442555.612242.602meleagris_gallopavoENSMGAP0000002982857.595844.1215
ENSG00000137462homo_sapiensENSP0000049442571.045952.2959meleagris_gallopavoENSMGAP0000000069971.87152.9032
ENSG00000137462homo_sapiensENSP0000049442514.923512.7551serinus_canariaENSSCAP0000000194392.857179.3651
ENSG00000137462homo_sapiensENSP0000049442536.479625.2551serinus_canariaENSSCAP0000001630158.012240.1623
ENSG00000137462homo_sapiensENSP0000049442569.89851.6582parus_majorENSPMJP0000001409669.104751.0719
ENSG00000137462homo_sapiensENSP0000049442566.964349.6173anolis_carolinensisENSACAP0000001775767.829550.2584
ENSG00000137462homo_sapiensENSP0000049442567.60248.7245anolis_carolinensisENSACAP0000001930666.002547.5716
ENSG00000137462homo_sapiensENSP0000049442514.030610.8418neolamprologus_brichardiENSNBRP0000000956880.882462.5
ENSG00000137462homo_sapiensENSP0000049442519.89815.1786neolamprologus_brichardiENSNBRP0000000958377.227758.9109
ENSG00000137462homo_sapiensENSP0000049442556.887839.9235neolamprologus_brichardiENSNBRP0000000056756.59939.7208
ENSG00000137462homo_sapiensENSP0000049442567.857148.7245naja_najaENSNNAP0000002946067.427148.4157
ENSG00000137462homo_sapiensENSP0000049442534.438822.1939podarcis_muralisENSPMRP0000000283741.095926.484
ENSG00000137462homo_sapiensENSP0000049442566.454149.6173geospiza_fortisENSGFOP0000000757869.652452.0053
ENSG00000137462homo_sapiensENSP0000049442566.581650geospiza_fortisENSGFOP0000000756870.350452.8302
ENSG00000137462homo_sapiensENSP0000049442566.454149.1071taeniopygia_guttataENSTGUP0000000532571.174952.5956
ENSG00000137462homo_sapiensENSP0000049442546.556130.8673erpetoichthys_calabaricusENSECRP0000002169754.969936.4458
ENSG00000137462homo_sapiensENSP0000049442557.39838.5204kryptolebias_marmoratusENSKMAP0000002056855.487137.238
ENSG00000137462homo_sapiensENSP0000049442558.673540.5612kryptolebias_marmoratusENSKMAP0000000927257.57239.7998
ENSG00000137462homo_sapiensENSP0000049442567.857147.9592salvator_merianaeENSSMRP0000000149968.822848.6417
ENSG00000137462homo_sapiensENSP0000049442557.525540.5612oryzias_javanicusENSOJAP0000000721955.747839.3078
ENSG00000137462homo_sapiensENSP0000049442558.928640.3061amphilophus_citrinellusENSACIP0000001366656.479238.6308
ENSG00000137462homo_sapiensENSP0000049442558.290841.8367amphilophus_citrinellusENSACIP0000001904857.77541.4665
ENSG00000137462homo_sapiensENSP0000049442559.821442.4745dicentrarchus_labraxENSDLAP0000508165358.993741.8868
ENSG00000137462homo_sapiensENSP0000049442557.015339.7959dicentrarchus_labraxENSDLAP0000507069750.281235.0956
ENSG00000137462homo_sapiensENSP0000049442558.545939.5408amphiprion_perculaENSAPEP0000002522752.040835.1474
ENSG00000137462homo_sapiensENSP0000049442572.066353.8265pelodiscus_sinensisENSPSIP0000000053772.158453.8953
ENSG00000137462homo_sapiensENSP0000049442573.086755.7398pelodiscus_sinensisENSPSIP0000000053073.180155.811
ENSG00000137462homo_sapiensENSP0000049442567.857150.7653gopherus_evgoodeiENSGEVP0000501408272.086753.9295
ENSG00000137462homo_sapiensENSP0000049442572.066354.7194gopherus_evgoodeiENSGEVP0000501413872.343154.9296
ENSG00000137462homo_sapiensENSP0000049442553.571438.1378chelonoidis_abingdoniiENSCABP0000000120366.56147.3851
ENSG00000137462homo_sapiensENSP0000049442561.989842.9847seriola_dumeriliENSSDUP0000002414260.7542.125
ENSG00000137462homo_sapiensENSP0000049442558.035738.9031seriola_dumeriliENSSDUP0000000618855.285537.0595
ENSG00000137462homo_sapiensENSP0000049442540.816328.0612seriola_dumeriliENSSDUP0000000553157.761739.7112
ENSG00000137462homo_sapiensENSP0000049442559.566342.3469cottoperca_gobioENSCGOP0000000512858.890341.8663
ENSG00000137462homo_sapiensENSP0000049442556.2539.0306cottoperca_gobioENSCGOP0000003170056.683839.3316
ENSG00000137462homo_sapiensENSP0000049442571.938853.5714struthio_camelus_australisENSSCUP0000001263768.363650.9091
ENSG00000137462homo_sapiensENSP0000049442571.811253.3163anser_brachyrhynchusENSABRP0000001680970.996252.7112
ENSG00000137462homo_sapiensENSP0000049442557.780640.3061gasterosteus_aculeatusENSGACP0000002468155.651138.8206
ENSG00000137462homo_sapiensENSP0000049442556.122440.1786poecilia_formosaENSPFOP0000000066754.187238.7931
ENSG00000137462homo_sapiensENSP0000049442559.566339.1582myripristis_murdjanENSMMDP0000504637055.794536.6786
ENSG00000137462homo_sapiensENSP0000049442557.270439.7959sander_luciopercaENSSLUP0000001255454.8938.1418
ENSG00000137462homo_sapiensENSP0000049442558.418441.3265sander_luciopercaENSSLUP0000000698758.269741.2214
ENSG00000137462homo_sapiensENSP0000049442571.556153.5714strigops_habroptilaENSSHBP0000501123670.833353.0303
ENSG00000137462homo_sapiensENSP0000049442566.836749.7449strigops_habroptilaENSSHBP0000501122271.584753.2787
ENSG00000137462homo_sapiensENSP0000049442558.673539.4133amphiprion_ocellarisENSAOCP0000001093654.309336.4817
ENSG00000137462homo_sapiensENSP0000049442513.137811.8622terrapene_carolina_triunguisENSTMTP0000001728697.169887.7358
ENSG00000137462homo_sapiensENSP0000049442513.010211.7347terrapene_carolina_triunguisENSTMTP0000001388296.226486.7924
ENSG00000137462homo_sapiensENSP0000049442542.984731.3776hucho_huchoENSHHUP0000002323858.203842.487
ENSG00000137462homo_sapiensENSP0000049442552.040834.3112betta_splendensENSBSLP0000000023556.353637.1547
ENSG00000137462homo_sapiensENSP0000049442559.438841.9643pygocentrus_nattereriENSPNAP0000000910058.39641.2281
ENSG00000137462homo_sapiensENSP0000049442558.545940.051anabas_testudineusENSATEP0000001627755.301237.8313
ENSG00000137462homo_sapiensENSP0000049442560.076541.8367anabas_testudineusENSATEP0000001340259.245341.2579
ENSG00000137462homo_sapiensENSP0000049442542.346929.2092seriola_lalandi_dorsalisENSSLDP0000003035854.785537.7888
ENSG00000137462homo_sapiensENSP0000049442557.908239.0306seriola_lalandi_dorsalisENSSLDP0000002334855.77437.5921
ENSG00000137462homo_sapiensENSP0000049442558.673539.9235labrus_bergyltaENSLBEP0000000563460.846641.4021
ENSG00000137462homo_sapiensENSP0000049442553.69935.7143labrus_bergyltaENSLBEP0000001872753.022735.2645
ENSG00000137462homo_sapiensENSP0000049442517.474513.2653pundamilia_nyerereiENSPNYP0000001876973.655955.914
ENSG00000137462homo_sapiensENSP0000049442520.280612.5pundamilia_nyerereiENSPNYP0000000773058.455936.0294
ENSG00000137462homo_sapiensENSP0000049442558.418440.4337mastacembelus_armatusENSMAMP0000006629755.990238.7531
ENSG00000137462homo_sapiensENSP0000049442560.076541.199stegastes_partitusENSSPAP0000001595059.319940.6801
ENSG00000137462homo_sapiensENSP0000049442557.525540.8163stegastes_partitusENSSPAP0000001414355.20239.1677
ENSG00000137462homo_sapiensENSP0000049442553.571435.5867oncorhynchus_tshawytschaENSOTSP0000509994253.915335.8151
ENSG00000137462homo_sapiensENSP0000049442533.290821.301oncorhynchus_tshawytschaENSOTSP0000509518955.769235.6838
ENSG00000137462homo_sapiensENSP0000049442534.183721.6837acanthochromis_polyacanthusENSAPOP0000001055647.686830.2491
ENSG00000137462homo_sapiensENSP0000049442558.80140.6888acanthochromis_polyacanthusENSAPOP0000000752057.62539.875
ENSG00000137462homo_sapiensENSP0000049442571.173552.2959aquila_chrysaetos_chrysaetosENSACCP0002000491471.264452.3627
ENSG00000137462homo_sapiensENSP0000049442571.30151.7857aquila_chrysaetos_chrysaetosENSACCP0002000493370.491851.198
ENSG00000137462homo_sapiensENSP0000049442555.484738.648cyprinodon_variegatusENSCVAP0000003192653.571437.3153
ENSG00000137462homo_sapiensENSP0000049442555.867338.2653cyprinodon_variegatusENSCVAP0000003171254.207937.1287
ENSG00000137462homo_sapiensENSP0000049442561.35241.5816denticeps_clupeoidesENSDCDP0000001465661.273941.5287
ENSG00000137462homo_sapiensENSP0000049442560.331641.3265larimichthys_croceaENSLCRP0000504614258.830840.2985
ENSG00000137462homo_sapiensENSP0000049442557.780639.7959larimichthys_croceaENSLCRP0000500192455.514738.2353
ENSG00000137462homo_sapiensENSP0000049442556.632738.1378takifugu_rubripesENSTRUP0000000745454.814836.9136
ENSG00000137462homo_sapiensENSP0000049442569.515352.2959ficedula_albicollisENSFALP0000001470169.604152.3627
ENSG00000137462homo_sapiensENSP0000049442569.89852.0408ficedula_albicollisENSFALP0000001365664.093647.7193
ENSG00000137462homo_sapiensENSP0000049442559.94942.2194cyprinus_carpio_carpioENSCCRP0000014112154.398138.3102
ENSG00000137462homo_sapiensENSP0000049442558.163340.1786cyprinus_carpio_carpioENSCCRP0000013453758.762940.5928
ENSG00000137462homo_sapiensENSP0000049442570.153151.9133coturnix_japonicaENSCJPP0000500032370.332552.046
ENSG00000137462homo_sapiensENSP0000049442570.408252.2959coturnix_japonicaENSCJPP0000500032169.609151.7024
ENSG00000137462homo_sapiensENSP0000049442557.015339.0306poecilia_latipinnaENSPLAP0000000181554.779437.5
ENSG00000137462homo_sapiensENSP0000049442555.994940.3061poecilia_latipinnaENSPLAP0000002020254.60239.3035
ENSG00000137462homo_sapiensENSP0000049442559.821442.0918sinocyclocheilus_grahamiENSSGRP0000003736159.367141.7722
ENSG00000137462homo_sapiensENSP0000049442560.331641.3265maylandia_zebraENSMZEP0000501516860.101741.169
ENSG00000137462homo_sapiensENSP0000049442558.673541.3265maylandia_zebraENSMZEP0000503733456.511139.8034
ENSG00000137462homo_sapiensENSP0000049442560.331641.8367maylandia_zebraENSMZEP0000501515560.101741.6773
ENSG00000137462homo_sapiensENSP0000049442545.408228.1888maylandia_zebraENSMZEP0000501509349.859930.9524
ENSG00000137462homo_sapiensENSP0000049442546.30129.9745maylandia_zebraENSMZEP0000501496754.017934.9702
ENSG00000137462homo_sapiensENSP0000049442545.408230.3571tetraodon_nigroviridisENSTNIP0000000568153.134335.5224
ENSG00000137462homo_sapiensENSP0000049442548.214329.2092paramormyrops_kingsleyaeENSPKIP0000002789945.873827.7913
ENSG00000137462homo_sapiensENSP0000049442548.724529.9745paramormyrops_kingsleyaeENSPKIP0000003416046.928728.8698
ENSG00000137462homo_sapiensENSP0000049442563.903145.2806leptobrachium_leishanenseENSLLEP0000003495263.337544.8799
ENSG00000137462homo_sapiensENSP0000049442556.2539.0306scophthalmus_maximusENSSMAP0000002759554.044137.5
ENSG00000137462homo_sapiensENSP0000049442557.39840.8163scophthalmus_maximusENSSMAP0000000380855.079639.1677
ENSG00000137462homo_sapiensENSP0000049442557.525539.4133oryzias_melastigmaENSOMEP0000002086956.164438.4807
ENSG00000137462homo_sapiensENSP0000049442558.035741.3265oryzias_melastigmaENSOMEP0000003547456.311940.099

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001530enables lipopolysaccharide binding1IDAHomo_sapiens(9606)Function
GO:0001540enables amyloid-beta binding2IDA,ISSHomo_sapiens(9606)Function
GO:0001666involved_in response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0001774involved_in microglial cell activation1IEAHomo_sapiens(9606)Process
GO:0001875enables lipopolysaccharide immune receptor activity1TASHomo_sapiens(9606)Function
GO:0002224involved_in toll-like receptor signaling pathway3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0004888enables transmembrane signaling receptor activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005794located_in Golgi apparatus1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2IDA,TASHomo_sapiens(9606)Component
GO:0006691involved_in leukotriene metabolic process1IEAHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1TASHomo_sapiens(9606)Process
GO:0006954involved_in inflammatory response1IBAHomo_sapiens(9606)Process
GO:0006955involved_in immune response1TASHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007252involved_in I-kappaB phosphorylation1IDAHomo_sapiens(9606)Process
GO:0007612involved_in learning1ISSHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IEAHomo_sapiens(9606)Process
GO:0009636involved_in response to toxic substance1IEAHomo_sapiens(9606)Process
GO:0009986located_in cell surface1IDAHomo_sapiens(9606)Component
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0014005involved_in microglia development1ISSHomo_sapiens(9606)Process
GO:0030177involved_in positive regulation of Wnt signaling pathway1IMPHomo_sapiens(9606)Process
GO:0030667located_in secretory granule membrane1TASHomo_sapiens(9606)Component
GO:0030670located_in phagocytic vesicle membrane1IEAHomo_sapiens(9606)Component
GO:0031663involved_in lipopolysaccharide-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0032289involved_in central nervous system myelin formation1IEAHomo_sapiens(9606)Process
GO:0032570involved_in response to progesterone1IEAHomo_sapiens(9606)Process
GO:0032722involved_in positive regulation of chemokine production1IDAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production1ISSHomo_sapiens(9606)Process
GO:0032733involved_in positive regulation of interleukin-10 production1IEAHomo_sapiens(9606)Process
GO:0032735involved_in positive regulation of interleukin-12 production1ISSHomo_sapiens(9606)Process
GO:0032741involved_in positive regulation of interleukin-18 production1ISSHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production2IDA,IGIHomo_sapiens(9606)Process
GO:0032757acts_upstream_of positive regulation of interleukin-8 production3IDA,IGIHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1ISSHomo_sapiens(9606)Process
GO:0032868involved_in response to insulin1IEAHomo_sapiens(9606)Process
GO:0034134involved_in toll-like receptor 2 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0035325enables Toll-like receptor binding1IPIHomo_sapiens(9606)Function
GO:0035354part_of Toll-like receptor 1-Toll-like receptor 2 protein complex2IDA,IPIHomo_sapiens(9606)Component
GO:0035355part_of Toll-like receptor 2-Toll-like receptor 6 protein complex1IPIHomo_sapiens(9606)Component
GO:0038023enables signaling receptor activity1IBAHomo_sapiens(9606)Function
GO:0038124involved_in toll-like receptor TLR6:TLR2 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0038187enables pattern recognition receptor activity1IDAHomo_sapiens(9606)Function
GO:0042495acts_upstream_of_or_within detection of triacyl bacterial lipopeptide1IDAHomo_sapiens(9606)Process
GO:0042496acts_upstream_of_or_within detection of diacyl bacterial lipopeptide1IDAHomo_sapiens(9606)Process
GO:0042497enables triacyl lipopeptide binding2IBA,IDAHomo_sapiens(9606)Function
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042834enables peptidoglycan binding1IDAHomo_sapiens(9606)Function
GO:0042995located_in cell projection1IEAHomo_sapiens(9606)Component
GO:0043235part_of receptor complex1IPIHomo_sapiens(9606)Component
GO:0044297located_in cell body1IEAHomo_sapiens(9606)Component
GO:0044877enables protein-containing complex binding1IPIHomo_sapiens(9606)Function
GO:0045087involved_in innate immune response2NAS,TASHomo_sapiens(9606)Process
GO:0045121located_in membrane raft1IDAHomo_sapiens(9606)Component
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0046209involved_in nitric oxide metabolic process1IEAHomo_sapiens(9606)Process
GO:0048714involved_in positive regulation of oligodendrocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0050135enables NAD(P)+ nucleosidase activity1IEAHomo_sapiens(9606)Function
GO:0050729involved_in positive regulation of inflammatory response2IC,IGIHomo_sapiens(9606)Process
GO:0050765involved_in negative regulation of phagocytosis1ISSHomo_sapiens(9606)Process
GO:0050830involved_in defense response to Gram-positive bacterium1IDAHomo_sapiens(9606)Process
GO:0051092acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity2IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IEPHomo_sapiens(9606)Process
GO:0051770involved_in positive regulation of nitric-oxide synthase biosynthetic process1ISSHomo_sapiens(9606)Process
GO:0051964involved_in negative regulation of synapse assembly1ISSHomo_sapiens(9606)Process
GO:0061809enables NAD+ nucleotidase, cyclic ADP-ribose generating1IEAHomo_sapiens(9606)Function
GO:0070542involved_in response to fatty acid1IEAHomo_sapiens(9606)Process
GO:0071221involved_in cellular response to bacterial lipopeptide1TASHomo_sapiens(9606)Process
GO:0071223acts_upstream_of_or_within cellular response to lipoteichoic acid2IDA,IMPHomo_sapiens(9606)Process
GO:0071346involved_in cellular response to type II interferon1IDAHomo_sapiens(9606)Process
GO:0071726acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide2IDAHomo_sapiens(9606)Process
GO:0071727acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide2IDAHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:1903974involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus1IDAHomo_sapiens(9606)Process
GO:1904466involved_in positive regulation of matrix metallopeptidase secretion1IGIHomo_sapiens(9606)Process

Expression