RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000137411	Gene ID	57176	Accession	21642
Symbol	VARS2	Alias		Full Name
Status	Confidence	Length	12255 bases	Strand	Plus strand
Position	6 : 30914205 - 30926459	RNA binding domain	tRNA-synt_1g , tRNA-synt_1 , Anticodon_1
Summary

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000316092	tRNA-synt_1g	PF09334	1.7e-14	1
ENSP00000316092	Anticodon_1	PF08264	1.5e-30	2
ENSP00000316092	tRNA-synt_1	PF00133	8.9e-180	3
ENSP00000403749	tRNA-synt_1g	PF09334	1.2e-07	1
ENSP00000403749	tRNA-synt_1	PF00133	4.8e-63	2
ENSP00000441000	tRNA-synt_1g	PF09334	1.7e-14	1
ENSP00000441000	Anticodon_1	PF08264	1.5e-30	2
ENSP00000441000	tRNA-synt_1	PF00133	8.9e-180	3
ENSP00000485818	tRNA-synt_1g	PF09334	9.8e-15	1
ENSP00000485818	Anticodon_1	PF08264	1.2e-30	2
ENSP00000485818	tRNA-synt_1	PF00133	1.6e-174	3
ENSP00000500615	tRNA-synt_1g	PF09334	1.7e-14	1
ENSP00000500615	Anticodon_1	PF08264	1.5e-30	2
ENSP00000500615	tRNA-synt_1	PF00133	7.6e-176	3
ENSP00000502585	tRNA-synt_1g	PF09334	1.7e-14	1
ENSP00000502585	Anticodon_1	PF08264	1.5e-30	2
ENSP00000502585	tRNA-synt_1	PF00133	8.9e-180	3

Showing 1 to 17 of 17 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
30607034	RIC_PMID30607034_Hs_OOPS_U2OS		Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y
33693821	PP.enrichment.RIC_PMID33693821_Hela_human	Hela	Zheng Zhang	2021 Jun 21	doi: 10.1093/nar/gkab156
35451177	PhotoCAX.MS_PMID35451177_293T_human	293T	Huixin Luo	2022 Jul 4	doi: 10.1002/anie.202202008
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

Showing 1 to 9 of 9 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
30709774	The nuclear background influences the penetrance of the near-homoplasmic m.1630 A > G MELAS variant in a symptomatic proband and asymptomatic mother.	Martine Uittenbogaard	2019-04-01	Molecular genetics and metabolism

Showing 1 to 1 of 1 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
No data available in table

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Gene Model

Click here to download ENSG00000137411's gene model file

Phenotypes

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Search:

ensgID	Trait	pValue	Pubmed ID
12208	Lupus Erythematosus, Systemic	4.5908E-13	18204098
13681	Leprosy	1.0480000E-005	20018961
13690	Leprosy	8.7830000E-006	20018961
13691	Leprosy	8.7830000E-006	20018961
16174	Behcet Syndrome	2.01439166442782E-05	20622878
16181	Behcet Syndrome	7.62403948573418E-06	20622878
16182	Behcet Syndrome	7.62403948573418E-06	20622878
16183	Behcet Syndrome	7.38917590543696E-06	20622878
16184	Behcet Syndrome	7.62403948573418E-06	20622878
16212	Behcet Syndrome	5.70739897355508E-06	20622878

Showing 1 to 10 of 16 entries

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000137411's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000137411	homo_sapiens	ENSP00000406448	28.8431	16.6403	homo_sapiens	ENSP00000502585	34.2427	19.7554
ENSG00000137411	homo_sapiens	ENSP00000282276	32.3777	20.2361	homo_sapiens	ENSP00000502585	18.0621	11.2888
ENSG00000137411	homo_sapiens	ENSP00000262027	26.5556	14.8889	homo_sapiens	ENSP00000502585	22.4835	12.6058
ENSG00000137411	homo_sapiens	ENSP00000377954	25.8503	15.051	homo_sapiens	ENSP00000502585	28.5983	16.651
ENSG00000137411	homo_sapiens	ENSP00000495093	30.897	17.7187	homo_sapiens	ENSP00000502585	26.2465	15.0517
ENSG00000137411	homo_sapiens	ENSP00000364815	54.1139	41.4557	homo_sapiens	ENSP00000502585	64.3462	49.2944
ENSG00000137411	homo_sapiens	ENSP00000355889	37.6482	22.1344	homo_sapiens	ENSP00000502585	35.842	21.0724
ENSG00000137411	homo_sapiens	ENSP00000447141	97.2553	97.1638	homo_sapiens	ENSP00000502585	100	99.9059
ENSG00000137411	homo_sapiens	ENSP00000446839	97.2553	97.2553	homo_sapiens	ENSP00000502585	100	100
ENSG00000137411	homo_sapiens	ENSP00000447179	97.1638	97.0723	homo_sapiens	ENSP00000502585	99.9059	99.8119

Showing 1 to 10 of 12 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000137411	homo_sapiens	ENSP00000502585	95.6726	94.7319	nomascus_leucogenys	ENSNLEP00000006871	95.4034	94.4653
ENSG00000137411	homo_sapiens	ENSP00000502585	99.5296	99.2474	pan_paniscus	ENSPPAP00000037059	96.357	96.0838
ENSG00000137411	homo_sapiens	ENSP00000502585	98.8711	98.4948	pongo_abelii	ENSPPYP00000018364	96.1574	95.7914
ENSG00000137411	homo_sapiens	ENSP00000502585	99.5296	99.2474	pan_troglodytes	ENSPTRP00000056402	96.357	96.0838
ENSG00000137411	homo_sapiens	ENSP00000502585	97.0837	96.4252	gorilla_gorilla	ENSGGOP00000046773	95.1152	94.47
ENSG00000137411	homo_sapiens	ENSP00000502585	83.349	74.0358	ornithorhynchus_anatinus	ENSOANP00000000646	82.1131	72.9379
ENSG00000137411	homo_sapiens	ENSP00000502585	83.6312	75.4468	sarcophilus_harrisii	ENSSHAP00000010796	84.0265	75.8034
ENSG00000137411	homo_sapiens	ENSP00000502585	62.1825	56.2559	notamacropus_eugenii	ENSMEUP00000013221	71.692	64.859
ENSG00000137411	homo_sapiens	ENSP00000502585	54.1863	49.5767	erinaceus_europaeus	ENSEEUP00000011548	54.9618	50.2863
ENSG00000137411	homo_sapiens	ENSP00000502585	78.8335	74.0358	echinops_telfairi	ENSETEP00000012033	78.8335	74.0358

Showing 1 to 10 of 179 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002161	enables aminoacyl-tRNA editing activity	1	IEA	Homo_sapiens(9606)	Function
GO:0004832	enables valine-tRNA ligase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	1	IBA	Homo_sapiens(9606)	Component
GO:0006438	involved_in valyl-tRNA aminoacylation	1	IBA	Homo_sapiens(9606)	Process
GO:0106074	involved_in aminoacyl-tRNA metabolism involved in translational fidelity	1	IEA	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression