Functions and Diseases

RBP Type Canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000137265 Gene ID 3662 Accession 6119
Symbol IRF4 Alias MUM1;LSIRF;SHEP8;NF-EM5 Full Name interferon regulatory factor 4
Status Confidence Length 19705 bases Strand Plus strand
Position 6 : 391739 - 411443 RNA binding domain IRF-3
Summary The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000370343 IRF-3 PF10401 1.9e-64 1
ENSP00000512940 IRF-3 PF10401 1.9e-64 1
ENSP00000436094 IRF-3 PF10401 3.7e-60 1
ENSP00000512942 IRF-3 PF10401 2.2e-43 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34547461 Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation. Haoyu Song 2022-02-02 Molecular therapy : the journal of the American Society of Gene Therapy
26103097 New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA. K Nicholas Conrad 2016-01-02 Virus research
21919915 Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis. S Bruhn 2012-01-01 Allergy
36129197 Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase. Takeshi Harada 2023-03-28 Blood advances

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
16992Neuroblastoma4.9e-00523222812
21849Personality4.911e-005-
35564Platelet Function Tests8.7600000E-006-
63183Hair Color1E-1326184321
63802Skin Pigmentation5E-823548203
65585Hair Color4E-720585627
66299Skin Pigmentation3E-925963972
67006Leukemia, Lymphocytic, Chronic, B-Cell3E-1624292274
67258Leukemia, Lymphocytic, Chronic, B-Cell6E-2023770605
68025Melanoma9E-1428212542
70320Melanosis2E-9120585627
70476Eye Color2E-1520585627
70836Eyebrows1E-1027182965
71384Leukemia, Lymphocytic, Chronic, B-Cell2E-2018758461
71759Hair Color2E-2820585627
72793Carcinoma, Basal Cell1E-921700618
72878Hodgkin Disease6E-928112199
72879Multiple Myeloma6E-928112199
72880Leukemia, Lymphocytic, Chronic, B-Cell6E-928112199
75107Supranuclear Palsy, Progressive6E-1521685912
75543Schizophrenia4E-622885689
77123Hair Color1E-1326926045
81116Alopecia4E-1127182965
81676Melanosis4E-1817952075
82547Leukemia, Lymphocytic, Chronic, B-Cell1E-2828165464
84331Suntan5E-1419340012
85699Hair Color3E-1226184321
86898Leukemia, Lymphocytic, Chronic, B-Cell2E-621131588
88573Skin Neoplasms3E-11127424798
89512Lymphoma, Large B-Cell, Diffuse2E-2125261932
90158Arthritis, Rheumatoid2E-1024390342
90175Arthritis, Rheumatoid1E-724390342
90532Hair Color3E-1326926045
92270Carcinoma, Basal Cell1E-5127539887
94293Hair Color9E-2818483556
94721Hair Color7E-12718483556
94963Carcinoma, Squamous Cell8E-9726829030
96112Leukemia, Lymphocytic, Chronic, B-Cell9E-2226956414
97045Hair Color5E-826184321
98186Skin Pigmentation2E-2725705849
98374Sunburn2E-623548203
99014Hair Color1E-2823548203
99058Schizophrenia3E-622885689
99096Suntan3E-2323548203
102338Skin Pigmentation7E-1423548203
103713Carcinoma, Basal Cell2E-15227539887
106295Leukemia, Lymphocytic, Chronic, B-Cell8E-1422700719

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000786part_of nucleosome1IEAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific2IBA,ISAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IDAHomo_sapiens(9606)Function
GO:0002376involved_in immune system process1IBAHomo_sapiens(9606)Process
GO:0003700enables DNA-binding transcription factor activity1ISSHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,ICHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0032733involved_in positive regulation of interleukin-10 production1IDAHomo_sapiens(9606)Process
GO:0032736involved_in positive regulation of interleukin-13 production1IDAHomo_sapiens(9606)Process
GO:0032743involved_in positive regulation of interleukin-2 production1IDAHomo_sapiens(9606)Process
GO:0032753involved_in positive regulation of interleukin-4 production1IDAHomo_sapiens(9606)Process
GO:0034122involved_in negative regulation of toll-like receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0042110involved_in T cell activation1NASHomo_sapiens(9606)Process
GO:0042832involved_in defense response to protozoan1ISSHomo_sapiens(9606)Process
GO:0043011involved_in myeloid dendritic cell differentiation1IEAHomo_sapiens(9606)Process
GO:0043388involved_in positive regulation of DNA binding1IEAHomo_sapiens(9606)Process
GO:0043565enables sequence-specific DNA binding1ISSHomo_sapiens(9606)Function
GO:0045622involved_in regulation of T-helper cell differentiation1NASHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0072540involved_in T-helper 17 cell lineage commitment1ISSHomo_sapiens(9606)Process
GO:0120162involved_in positive regulation of cold-induced thermogenesis1ISSHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function

Expression