Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzymeTransmemebrane
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000136960 Gene ID 5168 Accession 3357
Symbol ENPP2 Alias ATX;NPP2;ATX-X;PDNP2;LysoPLD;AUTOTAXIN;PD-IALPHA Full Name ectonucleotide pyrophosphatase/phosphodiesterase 2
Status Confidence Length 116368 bases Strand Minus strand
Position 8 : 119557086 - 119673453 RNA binding domain Endonuclease_NS
Summary The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

RNA binding domains (RBDs)

Transcripts

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression