RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeTransmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000136960	Gene ID	5168	Accession	3357
Symbol	ENPP2	Alias	ATX;NPP2;ATX-X;PDNP2;LysoPLD;AUTOTAXIN;PD-IALPHA	Full Name	ectonucleotide pyrophosphatase/phosphodiesterase 2
Status	Confidence	Length	116368 bases	Strand	Minus strand
Position	8 : 119557086 - 119673453	RNA binding domain	Endonuclease_NS
Summary	The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000429476	Endonuclease_NS	PF01223	6.4e-10	1
ENSP00000075322	Endonuclease_NS	PF01223	2.1e-09	1
ENSP00000403315	Endonuclease_NS	PF01223	2.2e-09	1
ENSP00000428291	Endonuclease_NS	PF01223	2.2e-09	1
ENSP00000259486	Endonuclease_NS	PF01223	2.4e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ENPP2-202	ENST00000259486	3233	915aa	ENSP00000259486
ENPP2-203	ENST00000427067	3271	884aa	ENSP00000403315
ENPP2-209	ENST00000523861	3647	No protein	-
ENPP2-207	ENST00000522167	1695	498aa	ENSP00000429476
ENPP2-208	ENST00000522826	2667	888aa	ENSP00000428291
ENPP2-201	ENST00000075322	3086	863aa	ENSP00000075322
ENPP2-204	ENST00000518109	666	No protein	-
ENPP2-206	ENST00000520066	769	245aa	ENSP00000428304
ENPP2-205	ENST00000518958	991	162aa	ENSP00000429447

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
85305	Body Height	6E-6	21998595

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004528	enables phosphodiesterase I activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004622	enables lysophospholipase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005044	enables scavenger receptor activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005509	enables calcium ion binding	3	IBA,IDA,ISS	Homo_sapiens(9606)	Function
GO:0005615	is_active_in extracellular space	3	IBA,IDA,ISS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006897	involved_in endocytosis	1	IEA	Homo_sapiens(9606)	Process
GO:0006935	involved_in chemotaxis	1	NAS	Homo_sapiens(9606)	Process
GO:0006955	involved_in immune response	1	IEA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	3	IBA,IDA,ISS	Homo_sapiens(9606)	Function
GO:0009395	involved_in phospholipid catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0010634	involved_in positive regulation of epithelial cell migration	2	IGI,IMP	Homo_sapiens(9606)	Process
GO:0016787	enables hydrolase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0030149	involved_in sphingolipid catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0030247	enables polysaccharide binding	1	IEA	Homo_sapiens(9606)	Function
GO:0030334	involved_in regulation of cell migration	1	IDA	Homo_sapiens(9606)	Process
GO:0034638	involved_in phosphatidylcholine catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0047391	enables alkylglycerophosphoethanolamine phosphodiesterase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0048870	involved_in cell motility	1	TAS	Homo_sapiens(9606)	Process
GO:0050731	involved_in positive regulation of peptidyl-tyrosine phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:2000394	involved_in positive regulation of lamellipodium morphogenesis	1	IGI	Homo_sapiens(9606)	Process