Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq

Description

Ensembl ID ENSG00000136874 Gene ID 55014 Accession 11432
Symbol STX17 Alias NA Full Name syntaxin 17
Status Confidence Length 67881 bases Strand Plus strand
Position 9 : 99906654 - 99974534 RNA binding domain N.A.
Summary Enables SNAP receptor activity; SNARE binding activity; and protein phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane. Part of SNARE complex. Colocalizes with HOPS complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
STX17-201 ENST00000259400 6885 302aa ENSP00000259400
STX17-208 ENST00000529340 858 45aa ENSP00000434323
STX17-211 ENST00000533696 611 No protein -
STX17-210 ENST00000531035 568 41aa ENSP00000433694
STX17-203 ENST00000525342 675 68aa ENSP00000433701
STX17-202 ENST00000524405 941 141aa ENSP00000436666
STX17-205 ENST00000525640 2523 302aa ENSP00000435981
STX17-212 ENST00000534052 2424 302aa ENSP00000433484
STX17-207 ENST00000526607 542 41aa ENSP00000434547
STX17-204 ENST00000525579 342 No protein -
STX17-206 ENST00000525847 828 No protein -
STX17-209 ENST00000529385 858 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
26512Blood Pressure8.9290000E-005-
98168Alopecia Areata4E-720596022

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000149enables SNARE binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000421is_active_in autophagosome membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0005484enables SNAP receptor activity2IBA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005739NOT located_in mitochondrion2IDAHomo_sapiens(9606)Component
GO:0005765NOT located_in lysosomal membrane1IDAHomo_sapiens(9606)Component
GO:0005776located_in autophagosome1IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1IDAHomo_sapiens(9606)Component
GO:0005791NOT located_in rough endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005793located_in endoplasmic reticulum-Golgi intermediate compartment1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1ISSHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane1IBAHomo_sapiens(9606)Component
GO:0006886involved_in intracellular protein transport1IBAHomo_sapiens(9606)Process
GO:0006887involved_in exocytosis1IBAHomo_sapiens(9606)Process
GO:0006888involved_in endoplasmic reticulum to Golgi vesicle-mediated transport1IMPHomo_sapiens(9606)Process
GO:0006906involved_in vesicle fusion1IBAHomo_sapiens(9606)Process
GO:0007030involved_in Golgi organization1IMPHomo_sapiens(9606)Process
GO:0012505is_active_in endomembrane system1IBAHomo_sapiens(9606)Component
GO:0012507located_in ER to Golgi transport vesicle membrane1IEAHomo_sapiens(9606)Component
GO:0016240involved_in autophagosome membrane docking1IDAHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IEAHomo_sapiens(9606)Function
GO:0019903enables protein phosphatase binding1IPIHomo_sapiens(9606)Function
GO:0030134located_in COPII-coated ER to Golgi transport vesicle1ISSHomo_sapiens(9606)Component
GO:0030868located_in smooth endoplasmic reticulum membrane1ISSHomo_sapiens(9606)Component
GO:0031201part_of SNARE complex2IBA,IDAHomo_sapiens(9606)Component
GO:0033116located_in endoplasmic reticulum-Golgi intermediate compartment membrane1IEAHomo_sapiens(9606)Component
GO:0034497acts_upstream_of_or_within protein localization to phagophore assembly site1IDAHomo_sapiens(9606)Process
GO:0044233located_in mitochondria-associated endoplasmic reticulum membrane1IDAHomo_sapiens(9606)Component
GO:0048278involved_in vesicle docking1IBAHomo_sapiens(9606)Process
GO:0097111involved_in endoplasmic reticulum-Golgi intermediate compartment organization1IMPHomo_sapiens(9606)Process
GO:0097352involved_in autophagosome maturation2IDA,IMPHomo_sapiens(9606)Process

Expression