Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq

Description

Ensembl ID ENSG00000136238 Gene ID 5879 Accession 9801
Symbol RAC1 Alias MIG5;MRD48;Rac-1;TC-25;p21-Rac1 Full Name Rac family small GTPase 1
Status Confidence Length 29441 bases Strand Plus strand
Position 7 : 6374527 - 6403967 RNA binding domain N.A.
Summary The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36823385 A shape-shifting nuclease unravels structured RNA. Katarina Meze 2023-03-01 Nature structural & molecular biology
32433947 The CD47-SIRPα Immune Checkpoint. W E Meike Logtenberg 2020-05-19 Immunity
31294692 In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation. K Alison Gillingham 2019-07-11 eLife
27518042 Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP. Pritha Majumder 2016-11-01 Acta neuropathologica
30639190 The actin cytoskeleton is important for rotavirus internalization and RNA genome replication. Oscar Trejo-Cerro 2019-04-02 Virus research
22345078 Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. Federico Pelisch 2012-07-01 Journal of cellular biochemistry
35726081 Circular RNA hsa_circ_0004381 Promotes Neuronal Injury in Parkinson's Disease Cell Model by miR-185-5p/RAC1 Axis. Hongying Zhang 2022-08-01 Neurotoxicity research

Transcripts

Name Transcript ID bp Protein Translation ID
RAC1-201 ENST00000348035 2309 192aa ENSP00000258737
RAC1-202 ENST00000356142 907 211aa ENSP00000348461
RAC1-208 ENST00000704002 950 225aa ENSP00000515615
RAC1-207 ENST00000696666 5408 No protein -
RAC1-209 ENST00000704003 2369 42aa ENSP00000515616
RAC1-204 ENST00000488373 845 No protein -
RAC1-206 ENST00000497741 651 No protein -
RAC1-203 ENST00000473564 576 No protein -
RAC1-205 ENST00000495499 615 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
49853Child Development Disorders, Pervasive2.9542400E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001764involved_in neuron migration1ISSHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation1IMPHomo_sapiens(9606)Process
GO:0003376involved_in sphingosine-1-phosphate receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0003924enables GTPase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0003925enables G protein activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005525enables GTP binding3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005802located_in trans-Golgi network1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2ISS,TASHomo_sapiens(9606)Component
GO:0005856is_active_in cytoskeleton1IBAHomo_sapiens(9606)Component
GO:0005884colocalizes_with actin filament1IDAHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0005938located_in cell cortex1IDAHomo_sapiens(9606)Component
GO:0006954involved_in inflammatory response1ICHomo_sapiens(9606)Process
GO:0007015involved_in actin filament organization1IBAHomo_sapiens(9606)Process
GO:0007155involved_in cell adhesion1TASHomo_sapiens(9606)Process
GO:0007160involved_in cell-matrix adhesion1NASHomo_sapiens(9606)Process
GO:0007163involved_in establishment or maintenance of cell polarity1IBAHomo_sapiens(9606)Process
GO:0007264involved_in small GTPase mediated signal transduction1IMPHomo_sapiens(9606)Process
GO:0008045involved_in motor neuron axon guidance1IBAHomo_sapiens(9606)Process
GO:0008360involved_in regulation of cell shape1IBAHomo_sapiens(9606)Process
GO:0008361involved_in regulation of cell size2IGI,IMPHomo_sapiens(9606)Process
GO:0009611involved_in response to wounding1TASHomo_sapiens(9606)Process
GO:0009653involved_in anatomical structure morphogenesis1TASHomo_sapiens(9606)Process
GO:0010310involved_in regulation of hydrogen peroxide metabolic process1TASHomo_sapiens(9606)Process
GO:0010591involved_in regulation of lamellipodium assembly1IGIHomo_sapiens(9606)Process
GO:0010592acts_upstream_of_or_within positive regulation of lamellipodium assembly2IDA,IMPHomo_sapiens(9606)Process
GO:0010595involved_in positive regulation of endothelial cell migration1IMPHomo_sapiens(9606)Process
GO:0010764involved_in negative regulation of fibroblast migration1IDAHomo_sapiens(9606)Process
GO:0010811involved_in positive regulation of cell-substrate adhesion1IGIHomo_sapiens(9606)Process
GO:0016020located_in membrane1ISSHomo_sapiens(9606)Component
GO:0016477involved_in cell migration2IDA,IMPHomo_sapiens(9606)Process
GO:0016601involved_in Rac protein signal transduction1IBAHomo_sapiens(9606)Process
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding2IBA,IPIHomo_sapiens(9606)Function
GO:0030027located_in lamellipodium1IDAHomo_sapiens(9606)Component
GO:0030031involved_in cell projection assembly1IBAHomo_sapiens(9606)Process
GO:0030032involved_in lamellipodium assembly1IMPHomo_sapiens(9606)Process
GO:0030036acts_upstream_of_or_within actin cytoskeleton organization1IGIHomo_sapiens(9606)Process
GO:0030041involved_in actin filament polymerization1TASHomo_sapiens(9606)Process
GO:0030334involved_in regulation of cell migration1IMPHomo_sapiens(9606)Process
GO:0030667located_in secretory granule membrane1TASHomo_sapiens(9606)Component
GO:0030865involved_in cortical cytoskeleton organization1IBAHomo_sapiens(9606)Process
GO:0031116involved_in positive regulation of microtubule polymerization1IMPHomo_sapiens(9606)Process
GO:0031410is_active_in cytoplasmic vesicle1IBAHomo_sapiens(9606)Component
GO:0031529acts_upstream_of_or_within ruffle organization2IDA,TASHomo_sapiens(9606)Process
GO:0031996enables thioesterase binding1IPIHomo_sapiens(9606)Function
GO:0032587located_in ruffle membrane1IDAHomo_sapiens(9606)Component
GO:0032707involved_in negative regulation of interleukin-23 production1IDAHomo_sapiens(9606)Process
GO:0032956involved_in regulation of actin cytoskeleton organization1IBAHomo_sapiens(9606)Process
GO:0034446involved_in substrate adhesion-dependent cell spreading1IMPHomo_sapiens(9606)Process
GO:0035025involved_in positive regulation of Rho protein signal transduction1TASHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction1TASHomo_sapiens(9606)Process
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0042470located_in melanosome1IEAHomo_sapiens(9606)Component
GO:0043020part_of NADPH oxidase complex1NASHomo_sapiens(9606)Component
GO:0043197is_active_in dendritic spine2IBA,IDAHomo_sapiens(9606)Component
GO:0043652involved_in engulfment of apoptotic cell1IBAHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IDAHomo_sapiens(9606)Function
GO:0045428involved_in regulation of nitric oxide biosynthetic process1ISSHomo_sapiens(9606)Process
GO:0045730involved_in respiratory burst1NASHomo_sapiens(9606)Process
GO:0048012involved_in hepatocyte growth factor receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0048261involved_in negative regulation of receptor-mediated endocytosis1TASHomo_sapiens(9606)Process
GO:0048870involved_in cell motility1IDAHomo_sapiens(9606)Process
GO:0051022enables Rho GDP-dissociation inhibitor binding1ISSHomo_sapiens(9606)Function
GO:0051179involved_in localization1IDAHomo_sapiens(9606)Process
GO:0051492involved_in regulation of stress fiber assembly1IGIHomo_sapiens(9606)Process
GO:0051496involved_in positive regulation of stress fiber assembly2IDA,IMPHomo_sapiens(9606)Process
GO:0051668involved_in localization within membrane1IMPHomo_sapiens(9606)Process
GO:0051894involved_in positive regulation of focal adhesion assembly1IDAHomo_sapiens(9606)Process
GO:0055038located_in recycling endosome membrane1IDAHomo_sapiens(9606)Component
GO:0060071involved_in Wnt signaling pathway, planar cell polarity pathway1NASHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1IPIHomo_sapiens(9606)Function
GO:0060263involved_in regulation of respiratory burst1IDAHomo_sapiens(9606)Process
GO:0060326involved_in cell chemotaxis1IBAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071526involved_in semaphorin-plexin signaling pathway1ISSHomo_sapiens(9606)Process
GO:0090023involved_in positive regulation of neutrophil chemotaxis1IMPHomo_sapiens(9606)Process
GO:0097178involved_in ruffle assembly1IMPHomo_sapiens(9606)Process
GO:0098794is_active_in postsynapse2IDA,IMPHomo_sapiens(9606)Component
GO:0098978is_active_in glutamatergic synapse2IDA,IMPHomo_sapiens(9606)Component
GO:0101003located_in ficolin-1-rich granule membrane1TASHomo_sapiens(9606)Component
GO:1900026involved_in positive regulation of substrate adhesion-dependent cell spreading1IDAHomo_sapiens(9606)Process
GO:1902622involved_in regulation of neutrophil migration1IBAHomo_sapiens(9606)Process

Expression