RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	Stress granucleNucleoli rim
BulkPerturb-seq

Description

Ensembl ID	ENSG00000136045	Gene ID	11137	Accession	17015
Symbol	PWP1	Alias	NCLB;IEF-SSP-9502	Full Name	PWP1 homolog, endonuclein
Status	Confidence	Length	27364 bases	Strand	Plus strand
Position	12 : 107685799 - 107713162	RNA binding domain	N.A.
Summary	The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
30361412	PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA.	Ying Liu	2018-11-22	Biology open

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
PWP1-201	ENST00000412830	2549	501aa	ENSP00000387365
PWP1-205	ENST00000552760	851	147aa	ENSP00000448227
PWP1-204	ENST00000547995	569	98aa	ENSP00000447770
PWP1-202	ENST00000541166	1722	439aa	ENSP00000445249
PWP1-203	ENST00000547120	543	No protein	-

Gene Model

Click here to download ENSG00000136045's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000136045's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IEA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0006364	involved_in rRNA processing	1	IEA	Homo_sapiens(9606)	Process
GO:0033140	involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein	1	IEA	Homo_sapiens(9606)	Process
GO:0140713	enables histone chaperone activity	1	IEA	Homo_sapiens(9606)	Function
GO:1901838	involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	1	IDA	Homo_sapiens(9606)	Process
GO:1990889	enables H4K20me3 modified histone binding	1	IEA	Homo_sapiens(9606)	Function
GO:2000738	involved_in positive regulation of stem cell differentiation	1	IEA	Homo_sapiens(9606)	Process

Expression