Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions Kinase
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000135828 Gene ID 6041 Accession 10050
Symbol RNASEL Alias RNS4;PRCA1 Full Name ribonuclease L
Status Confidence Length 15623 bases Strand Minus strand
Position 1 : 182573634 - 182589256 RNA binding domain Ribonuc_2-5A
Summary This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000356530 Ribonuc_2-5A PF06479 5.3e-26 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37080969 Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. J Oliver Ziff 2023-04-20 Nature communications
36317071 Proposal for the use of an inhalation drug containing 2-5 oligoadenylates for treatment of COVID-19. Gernot Bruchelt 2022-11-01 Medical hypotheses
25668758 Cytoplasmic sensing of viral nucleic acids. Matthias Habjan 2015-04-01 Current opinion in virology
24782340 Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. Jonathan Maelfait 2014-07-01 BioEssays : news and reviews in molecular, cellular and developmental biology
18049472 Interferons at age 50: past, current and future impact on biomedicine. C Ernest Borden 2007-12-01 Nature reviews. Drug discovery
30078389 OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages. Wook-Bin Lee 2019-02-01 BMB reports
34803997 Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors. Miaomiao Zhang 2021-01-01 Frontiers in microbiology
20075243 How the noninflammasome NLRs function in the innate immune system. Y P Jenny Ting 2010-01-15 Science (New York, N.Y.)
35937688 Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use. Aitor Nogales 2022-01-01 Frontiers in cellular and infection microbiology
34101465 A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways. Sarah Wagner-Griffin 2021-06-24 Journal of medicinal chemistry
20079393 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine. H Iana Haralambieva 2010-04-01 Human immunology
30587119 Origin and development of oligoadenylate synthetase immune system. Jiaxiang Hu 2018-12-27 BMC evolutionary biology
30149120 Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90. Maurer Kelly 2018-12-01 Clinical immunology (Orlando, Fla.)
19247438 Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. K Jean Lim 2009-02-01 PLoS pathogens
21222046 Tetherin and its viral antagonists. D Björn Kuhl 2011-06-01 Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
21182542 Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy. K Mostafa MK El 2011-05-01 Journal of gastroenterology and hepatology

Transcripts

Name Transcript ID bp Protein Translation ID
RNASEL-201 ENST00000367559 4238 741aa ENSP00000356530
RNASEL-202 ENST00000539397 4046 652aa ENSP00000440844

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
60945Multiple Sclerosis6E-923412934
76414Circadian Rhythm7E-2827494321
93187Circadian Rhythm3E-1227494321
104517Circadian Rhythm7E-1826835600

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135828

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135828homo_sapiensENSP0000035653097.300995.0067nomascus_leucogenysENSNLEP0000002188197.300995.0067
ENSG00000135828homo_sapiensENSP0000035653098.785497.4359pan_paniscusENSPPAP0000001273098.785497.4359
ENSG00000135828homo_sapiensENSP0000035653097.705895.6815pongo_abeliiENSPPYP0000000049597.705895.6815
ENSG00000135828homo_sapiensENSP0000035653098.785497.3009pan_troglodytesENSPTRP0000000293198.785497.3009
ENSG00000135828homo_sapiensENSP0000035653099.055398.5155gorilla_gorillaENSGGOP0000001972299.055398.5155
ENSG00000135828homo_sapiensENSP0000035653061.268647.2335ornithorhynchus_anatinusENSOANP0000000155466.180851.0204
ENSG00000135828homo_sapiensENSP0000035653069.500751.2821sarcophilus_harrisiiENSSHAP0000002647873.361854.1311
ENSG00000135828homo_sapiensENSP0000035653038.731429.8246notamacropus_eugeniiENSMEUP0000000327360.548546.6245
ENSG00000135828homo_sapiensENSP0000035653081.106669.9055dasypus_novemcinctusENSDNOP0000001373082.216170.8618
ENSG00000135828homo_sapiensENSP0000035653066.531753.0364erinaceus_europaeusENSEEUP0000001046673.802458.8323
ENSG00000135828homo_sapiensENSP0000035653062.88851.417echinops_telfairiENSETEP0000000680063.143651.626
ENSG00000135828homo_sapiensENSP0000035653092.442685.9649callithrix_jacchusENSCJAP0000004786990.848884.4828
ENSG00000135828homo_sapiensENSP0000035653095.951492.8475cercocebus_atysENSCATP0000003136295.951492.8475
ENSG00000135828homo_sapiensENSP0000035653095.951492.0378macaca_fascicularisENSMFAP0000002709695.951492.0378
ENSG00000135828homo_sapiensENSP0000035653095.951492.1727macaca_mulattaENSMMUP0000000744895.951492.1727
ENSG00000135828homo_sapiensENSP0000035653095.951492.3077macaca_nemestrinaENSMNEP0000001749295.951492.3077
ENSG00000135828homo_sapiensENSP0000035653096.086492.7125papio_anubisENSPANP0000001011596.086492.7125
ENSG00000135828homo_sapiensENSP0000035653096.221392.7125mandrillus_leucophaeusENSMLEP0000002634496.221392.7125
ENSG00000135828homo_sapiensENSP0000035653080.296968.2861tursiops_truncatusENSTTRP0000000721880.842468.75
ENSG00000135828homo_sapiensENSP0000035653082.995969.7706vulpes_vulpesENSVVUP0000001203684.944771.4088
ENSG00000135828homo_sapiensENSP0000035653076.248362.753mus_spretusMGP_SPRETEiJ_P002149278.581464.6732
ENSG00000135828homo_sapiensENSP0000035653083.130974.6289equus_asinusENSEASP0000503739885.318676.5928
ENSG00000135828homo_sapiensENSP0000035653080.296969.6356capra_hircusENSCHIP0000002428781.506970.6849
ENSG00000135828homo_sapiensENSP0000035653079.217367.8812loxodonta_africanaENSLAFP0000001713478.475967.246
ENSG00000135828homo_sapiensENSP0000035653083.805773.2794panthera_leoENSPLOP0000001683184.836174.1803
ENSG00000135828homo_sapiensENSP0000035653083.130970.3104ailuropoda_melanoleucaENSAMEP0000000817884.15371.1749
ENSG00000135828homo_sapiensENSP0000035653080.566869.6356bos_indicus_hybridENSBIXP0000504434882.572671.3693
ENSG00000135828homo_sapiensENSP0000035653070.310455.6005oryctolagus_cuniculusENSOCUP0000004302472.260757.1429
ENSG00000135828homo_sapiensENSP0000035653083.265974.8988equus_caballusENSECAP0000006287285.457176.8698
ENSG00000135828homo_sapiensENSP0000035653082.456169.6356canis_lupus_familiarisENSCAFP0084500599484.392371.2707
ENSG00000135828homo_sapiensENSP0000035653083.400873.0094panthera_pardusENSPPRP0000000945985.359174.7238
ENSG00000135828homo_sapiensENSP0000035653082.051372.1997marmota_marmota_marmotaENSMMMP0000001725682.496672.5916
ENSG00000135828homo_sapiensENSP0000035653083.670771.9298balaenoptera_musculusENSBMSP0001000710284.124872.3202
ENSG00000135828homo_sapiensENSP0000035653036.302331.309cavia_porcellusENSCPOP0000001646580.059569.0476
ENSG00000135828homo_sapiensENSP0000035653083.400872.6046felis_catusENSFCAP0000002541385.359174.3094
ENSG00000135828homo_sapiensENSP0000035653073.414363.1579ursus_americanusENSUAMP0000003583785.804473.817
ENSG00000135828homo_sapiensENSP0000035653067.071550.7422monodelphis_domesticaENSMODP0000000846165.052449.2147
ENSG00000135828homo_sapiensENSP0000035653070.580361.6734bison_bison_bisonENSBBBP0000002637382.753272.3101
ENSG00000135828homo_sapiensENSP0000035653042.7837.5169monodon_monocerosENSMMNP0001500119985.675775.1351
ENSG00000135828homo_sapiensENSP0000035653057.08549.1228monodon_monocerosENSMMNP0001500855784.769572.9459
ENSG00000135828homo_sapiensENSP0000035653081.916370.5803sus_scrofaENSSSCP0000005396981.695870.3903
ENSG00000135828homo_sapiensENSP0000035653086.234877.3279microcebus_murinusENSMICP0000002839685.656876.8097
ENSG00000135828homo_sapiensENSP0000035653078.407665.8569octodon_degusENSODEP0000000291878.513565.9459
ENSG00000135828homo_sapiensENSP0000035653069.770658.1646jaculus_jaculusENSJJAP0000000985477.978965.0075
ENSG00000135828homo_sapiensENSP0000035653080.701870.5803ovis_aries_rambouilletENSOARP0002000426782.596772.2376
ENSG00000135828homo_sapiensENSP0000035653082.72670.0405ursus_maritimusENSUMAP0000002256484.551771.5862
ENSG00000135828homo_sapiensENSP0000035653073.954163.2928delphinapterus_leucasENSDLEP0000002866482.40670.5263
ENSG00000135828homo_sapiensENSP0000035653083.400872.1997physeter_catodonENSPCTP0000500309383.853572.5916
ENSG00000135828homo_sapiensENSP0000035653076.518263.8327mus_caroliMGP_CAROLIEiJ_P002042777.991765.0619
ENSG00000135828homo_sapiensENSP0000035653077.19364.1026mus_musculusENSMUSP0000008338577.823164.6258
ENSG00000135828homo_sapiensENSP0000035653076.383363.5628dipodomys_ordiiENSDORP0000000551180.741867.1897
ENSG00000135828homo_sapiensENSP0000035653080.296968.2861mustela_putorius_furoENSMPUP0000001143181.955969.697
ENSG00000135828homo_sapiensENSP0000035653093.927187.5843aotus_nancymaaeENSANAP0000003708593.927187.5843
ENSG00000135828homo_sapiensENSP0000035653093.792287.3144saimiri_boliviensis_boliviensisENSSBOP0000003691493.665887.1968
ENSG00000135828homo_sapiensENSP0000035653052.361744.8043vicugna_pacosENSVPAP0000000992457.652349.3314
ENSG00000135828homo_sapiensENSP0000035653096.086492.9825chlorocebus_sabaeusENSCSAP0000000869696.086492.9825
ENSG00000135828homo_sapiensENSP0000035653069.770660.9986tupaia_belangeriENSTBEP0000000346969.770660.9986
ENSG00000135828homo_sapiensENSP0000035653075.303662.3482mesocricetus_auratusENSMAUP0000002351376.125563.0286
ENSG00000135828homo_sapiensENSP0000035653083.535871.6599phocoena_sinusENSPSNP0000000356283.648771.7568
ENSG00000135828homo_sapiensENSP0000035653082.86171.39camelus_dromedariusENSCDRP0000501978682.526971.1021
ENSG00000135828homo_sapiensENSP0000035653084.210575.0337carlito_syrichtaENSTSYP0000002105284.552875.3388
ENSG00000135828homo_sapiensENSP0000035653081.781471.525panthera_tigris_altaicaENSPTIP0000001915685.232174.5429
ENSG00000135828homo_sapiensENSP0000035653078.542562.6181rattus_norvegicusENSRNOP0000003297578.861862.8726
ENSG00000135828homo_sapiensENSP0000035653088.52981.1066prolemur_simusENSPSMP0000000319988.053780.6711
ENSG00000135828homo_sapiensENSP0000035653076.518263.4278microtus_ochrogasterENSMOCP0000000963877.142963.9456
ENSG00000135828homo_sapiensENSP0000035653060.458848.3131sorex_araneusENSSARP0000000279772.374857.8352
ENSG00000135828homo_sapiensENSP0000035653078.542565.722peromyscus_maniculatus_bairdiiENSPEMP0000001255179.076166.1685
ENSG00000135828homo_sapiensENSP0000035653080.296969.3657bos_mutusENSBMUP0000003625382.29671.0927
ENSG00000135828homo_sapiensENSP0000035653076.788163.8327mus_spicilegusENSMSIP0000001507574.088561.5885
ENSG00000135828homo_sapiensENSP0000035653076.113463.1579cricetulus_griseus_chok1gshdENSCGRP0000100659776.734763.6735
ENSG00000135828homo_sapiensENSP0000035653081.376570.3104pteropus_vampyrusENSPVAP0000000984382.71671.4678
ENSG00000135828homo_sapiensENSP0000035653084.210571.7949myotis_lucifugusENSMLUP0000000920983.983871.6016
ENSG00000135828homo_sapiensENSP0000035653070.310453.5762vombatus_ursinusENSVURP0001001298873.071555.6802
ENSG00000135828homo_sapiensENSP0000035653081.916370.3104rhinolophus_ferrumequinumENSRFEP0001003175283.264771.4678
ENSG00000135828homo_sapiensENSP0000035653080.296969.0958neovison_visonENSNVIP0000001931781.955970.5234
ENSG00000135828homo_sapiensENSP0000035653080.566869.6356bos_taurusENSBTAP0000004175782.572671.3693
ENSG00000135828homo_sapiensENSP0000035653080.836768.556heterocephalus_glaber_femaleENSHGLP0000000675781.165368.8347
ENSG00000135828homo_sapiensENSP0000035653097.03194.197rhinopithecus_bietiENSRBIP0000004307897.03194.197
ENSG00000135828homo_sapiensENSP0000035653082.456169.5007canis_lupus_dingoENSCAFP0002001869984.392371.1326
ENSG00000135828homo_sapiensENSP0000035653083.805773.1444sciurus_vulgarisENSSVLP0000501617283.918973.2432
ENSG00000135828homo_sapiensENSP0000035653070.175454.251phascolarctos_cinereusENSPCIP0000002394773.033756.4607
ENSG00000135828homo_sapiensENSP0000035653046.963638.8664procavia_capensisENSPCAP0000001457047.090738.9716
ENSG00000135828homo_sapiensENSP0000035653055.195746.0189nannospalax_galiliENSNGAP0000001714880.353666.9941
ENSG00000135828homo_sapiensENSP0000035653081.646470.7152bos_grunniensENSBGRP0000002417081.978371.0027
ENSG00000135828homo_sapiensENSP0000035653079.757167.3414chinchilla_lanigeraENSCLAP0000001738979.757167.3414
ENSG00000135828homo_sapiensENSP0000035653079.89270.3104cervus_hanglu_yarkandensisENSCHYP0000002454579.569970.0269
ENSG00000135828homo_sapiensENSP0000035653081.646470.0405catagonus_wagneriENSCWAP0000002527582.876771.0959
ENSG00000135828homo_sapiensENSP0000035653083.535873.2794ictidomys_tridecemlineatusENSSTOP0000000656383.423273.1806
ENSG00000135828homo_sapiensENSP0000035653088.394178.4076otolemur_garnettiiENSOGAP0000000233988.394178.4076
ENSG00000135828homo_sapiensENSP0000035653093.657287.8542cebus_imitatorENSCCAP0000002895393.53187.7358
ENSG00000135828homo_sapiensENSP0000035653082.72671.525urocitellus_parryiiENSUPAP0001000701582.949971.7185
ENSG00000135828homo_sapiensENSP0000035653080.02770.0405moschus_moschiferusENSMMSP0000001878281.906171.6851
ENSG00000135828homo_sapiensENSP0000035653097.03194.0621rhinopithecus_roxellanaENSRROP0000002434397.03194.0621
ENSG00000135828homo_sapiensENSP0000035653076.383362.753mus_pahariMGP_PahariEiJ_P007570877.322463.5246
ENSG00000135828homo_sapiensENSP0000035653088.798980.1619propithecus_coquereliENSPCOP0000000576588.798980.1619
ENSG00000135828homo_sapiensENSP0000035653054.925835.6275callorhinchus_miliiENSCMIP0000000801950.748132.9177
ENSG00000135828homo_sapiensENSP0000035653056.410339.946latimeria_chalumnaeENSLACP0000000089459.885442.4069
ENSG00000135828homo_sapiensENSP0000035653015.789511.471chrysemys_picta_belliiENSCPBP0000002201853.91739.1705
ENSG00000135828homo_sapiensENSP0000035653057.08543.4548chrysemys_picta_belliiENSCPBP0000002202458.104444.2308
ENSG00000135828homo_sapiensENSP0000035653042.645132.6586sphenodon_punctatusENSSPUP0000000529360.190546.0952
ENSG00000135828homo_sapiensENSP0000035653051.41736.3023laticauda_laticaudataENSLLTP0000002055663.079544.5364
ENSG00000135828homo_sapiensENSP0000035653049.527734.1431notechis_scutatusENSNSUP0000001951359.77241.2052
ENSG00000135828homo_sapiensENSP0000035653051.282136.5722pseudonaja_textilisENSPTXP0000000508262.397444.4992
ENSG00000135828homo_sapiensENSP0000035653055.465638.5965anas_platyrhynchos_platyrhynchosENSAPLP0000002980153.238337.0466
ENSG00000135828homo_sapiensENSP0000035653055.600538.4615gallus_gallusENSGALP0001001354358.60640.5405
ENSG00000135828homo_sapiensENSP0000035653053.846236.9771meleagris_gallopavoENSMGAP0000003373657.65939.5954
ENSG00000135828homo_sapiensENSP0000035653055.060739.8111serinus_canariaENSSCAP0000000237053.968339.0212
ENSG00000135828homo_sapiensENSP0000035653051.956836.7072parus_majorENSPMJP0000001399657.807840.8408
ENSG00000135828homo_sapiensENSP0000035653060.998643.0499anolis_carolinensisENSACAP0000000483462.517344.1217
ENSG00000135828homo_sapiensENSP0000035653013.09049.9865naja_najaENSNNAP0000002344975.781257.8125
ENSG00000135828homo_sapiensENSP0000035653058.974444.1296podarcis_muralisENSPMRP0000000139961.636146.1213
ENSG00000135828homo_sapiensENSP0000035653054.520939.5412geospiza_fortisENSGFOP0000000835856.981741.3258
ENSG00000135828homo_sapiensENSP0000035653058.569541.9703salvator_merianaeENSSMRP0000001459160.869643.6185
ENSG00000135828homo_sapiensENSP0000035653055.600541.7004pelodiscus_sinensisENSPSIP0000000887558.439743.8298
ENSG00000135828homo_sapiensENSP0000035653061.943345.614pelodiscus_sinensisENSPSIP0000000855962.876746.3014
ENSG00000135828homo_sapiensENSP0000035653063.157946.9636gopherus_evgoodeiENSGEVP0000501800164.909948.2663
ENSG00000135828homo_sapiensENSP0000035653056.140441.4305chelonoidis_abingdoniiENSCABP0000001919562.275445.9581
ENSG00000135828homo_sapiensENSP0000035653013.90019.58165chelonoidis_abingdoniiENSCABP0000001918948.356833.3333
ENSG00000135828homo_sapiensENSP0000035653054.925841.0256struthio_camelus_australisENSSCUP0000000732757.648743.0595
ENSG00000135828homo_sapiensENSP0000035653055.465639.2713anser_brachyrhynchusENSABRP0000002727347.569433.6806
ENSG00000135828homo_sapiensENSP0000035653055.735541.4305strigops_habroptilaENSSHBP0000501075758.915843.7946
ENSG00000135828homo_sapiensENSP0000035653011.06618.63698terrapene_carolina_triunguisENSTMTP0000002116167.213152.459
ENSG00000135828homo_sapiensENSP0000035653014.03519.58165terrapene_carolina_triunguisENSTMTP0000002112952.525335.8586
ENSG00000135828homo_sapiensENSP0000035653051.686939.8111terrapene_carolina_triunguisENSTMTP0000003123459.013945.4545
ENSG00000135828homo_sapiensENSP0000035653058.569543.1849terrapene_carolina_triunguisENSTMTP0000001504964.487447.5483
ENSG00000135828homo_sapiensENSP0000035653056.275340.8907aquila_chrysaetos_chrysaetosENSACCP0002000276059.656743.3476
ENSG00000135828homo_sapiensENSP0000035653053.171439.1363ficedula_albicollisENSFALP0000000834558.112142.7729
ENSG00000135828homo_sapiensENSP0000035653055.870438.0567coturnix_japonicaENSCJPP0000502768259.058540.2282

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity1NASHomo_sapiens(9606)Function
GO:0004540enables RNA nuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005575is_active_in cellular_component1NDHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006364involved_in rRNA processing1IEAHomo_sapiens(9606)Process
GO:0006396involved_in RNA processing1IBAHomo_sapiens(9606)Process
GO:0006397involved_in mRNA processing1IEAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1NASHomo_sapiens(9606)Process
GO:0016363located_in nuclear matrix1IEAHomo_sapiens(9606)Component
GO:0019843enables rRNA binding1IEAHomo_sapiens(9606)Function
GO:0043021enables ribonucleoprotein complex binding1IEAHomo_sapiens(9606)Function
GO:0043488involved_in regulation of mRNA stability1IEAHomo_sapiens(9606)Process
GO:0045071involved_in negative regulation of viral genome replication2IBA,IDAHomo_sapiens(9606)Process
GO:0045444involved_in fat cell differentiation1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0046326involved_in positive regulation of glucose import1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051607involved_in defense response to virus2IBA,IDAHomo_sapiens(9606)Process

Expression