Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions Kinase
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000135828 Gene ID 6041 Accession 10050
Symbol RNASEL Alias RNS4;PRCA1 Full Name ribonuclease L
Status Confidence Length 15623 bases Strand Minus strand
Position 1 : 182573634 - 182589256 RNA binding domain Ribonuc_2-5A
Summary This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Orthologs

Gene Ontology

Expression