RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000135241	Gene ID	50640	Accession	28900
Symbol	PNPLA8	Alias	MMLA;IPLA2G;IPLA2-2;iPLA2gamma;PNPLA-gamma	Full Name	patatin like phospholipase domain containing 8
Status	Confidence	Length	57745 bases	Strand	Minus strand
Position	7 : 108470417 - 108528161	RNA binding domain	N.A.
Summary	This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PNPLA8-204	ENST00000426128	4268	720aa	ENSP00000394988
PNPLA8-201	ENST00000257694	4569	782aa	ENSP00000257694
PNPLA8-203	ENST00000422087	3530	782aa	ENSP00000410804
PNPLA8-208	ENST00000453144	3366	682aa	ENSP00000387789
PNPLA8-206	ENST00000436062	3462	782aa	ENSP00000406779
PNPLA8-207	ENST00000453085	2326	639aa	ENSP00000402274
PNPLA8-211	ENST00000483879	711	No protein	-
PNPLA8-210	ENST00000476592	660	No protein	-
PNPLA8-209	ENST00000462466	557	No protein	-
PNPLA8-212	ENST00000489738	426	No protein	-
PNPLA8-205	ENST00000427008	735	192aa	ENSP00000406033
PNPLA8-202	ENST00000415498	568	55aa	ENSP00000391872

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
50755	Child Development Disorders, Pervasive	5.9112000E-006	-
51472	Child Development Disorders, Pervasive	5.0153000E-006	-
101669	Bronchodilator Agents	8E-7	26634245
101670	Lung Volume Measurements	8E-7	26634245

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001516	involved_in prostaglandin biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0004622	enables lysophospholipase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	NAS	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	ISS	Homo_sapiens(9606)	Component
GO:0005777	located_in peroxisome	1	IDA	Homo_sapiens(9606)	Component
GO:0005778	located_in peroxisomal membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006631	involved_in fatty acid metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0008970	enables phospholipase A1 activity	1	IEA	Homo_sapiens(9606)	Function
GO:0016020	is_active_in membrane	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0019369	involved_in arachidonic acid metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0031966	located_in mitochondrial membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0032048	involved_in cardiolipin metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0034638	involved_in phosphatidylcholine catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IDA	Homo_sapiens(9606)	Process
GO:0043651	involved_in linoleic acid metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0046338	involved_in phosphatidylethanolamine catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0047499	enables calcium-independent phospholipase A2 activity	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:0050482	involved_in arachidonic acid secretion	1	IDA	Homo_sapiens(9606)	Process
GO:0055088	involved_in lipid homeostasis	1	IMP	Homo_sapiens(9606)	Process
GO:0070328	involved_in triglyceride homeostasis	1	IMP	Homo_sapiens(9606)	Process
GO:0102545	enables phosphatidyl phospholipase B activity	1	IEA	Homo_sapiens(9606)	Function
GO:1900407	involved_in regulation of cellular response to oxidative stress	1	IEA	Homo_sapiens(9606)	Process