RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzymeTF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000134852	Gene ID	9575	Accession	2082
Symbol	CLOCK	Alias	KAT13D;bHLHe8	Full Name	clock circadian regulator
Status	Confidence	Length	119007 bases	Strand	Minus strand
Position	4 : 55427903 - 55546909	RNA binding domain	N.A.
Summary	The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
27108448	Post-transcriptional control of the mammalian circadian clock: implications for health and disease.	Marco Preußner	2016-06-01	Pflugers Archiv : European journal of physiology
33295874	PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock.	M Christina Kelliher	2020-12-09	eLife
34046015	Epigenetics of Hepatic Insulin Resistance.	Hannah Maude	2021-01-01	Frontiers in endocrinology
23916625	Molecular architecture of the mammalian circadian clock.	L Carrie Partch	2014-02-01	Trends in cell biology
28008157	The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation.	Cristina Pagano	2017-01-24	Oncotarget
23698761	Ribonucleoprotein complexes that control circadian clocks.	Dongni Wang	2013-04-25	International journal of molecular sciences
24964051	The Trichoderma reesei Cry1 protein is a member of the cryptochrome/photolyase family with 6-4 photoproduct repair activity.	Jesús Guzmán-Moreno	2014-01-01	PloS one
29658882	Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.	Laurent Perrin	2018-04-16	eLife
35463437	Role of Circadian Rhythms in Major Plant Metabolic and Signaling Pathways.	Ajila Venkat	2022-01-01	Frontiers in plant science
24160700	Chronopharmacology: new insights and therapeutic implications.	Robert Dallmann	2014-01-01	Annual review of pharmacology and toxicology

Name	Transcript ID	bp	Protein	Translation ID
CLOCK-201	ENST00000309964	10304	846aa	ENSP00000308741
CLOCK-209	ENST00000511124	3932	No protein	-
CLOCK-202	ENST00000381322	4059	846aa	ENSP00000370723
CLOCK-211	ENST00000513440	10470	846aa	ENSP00000426983
CLOCK-204	ENST00000479384	426	No protein	-
CLOCK-205	ENST00000506747	1337	No protein	-
CLOCK-203	ENST00000435527	746	182aa	ENSP00000396649
CLOCK-207	ENST00000508049	401	No protein	-
CLOCK-206	ENST00000506923	616	No protein	-
CLOCK-208	ENST00000509151	476	No protein	-
CLOCK-210	ENST00000513033	567	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
58350	Respiratory Function Tests	4.2750000E-007	20010835
62106	Personality	2E-6	18957941
74424	Body Height	8E-9	25282103

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000077	involved_in DNA damage checkpoint signaling	1	IMP	Homo_sapiens(9606)	Process
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	2	IDA,ISS	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	3	IBA,ISA,ISS	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	ISS	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003700	enables DNA-binding transcription factor activity	1	ISS	Homo_sapiens(9606)	Function
GO:0004402	enables histone acetyltransferase activity	1	IMP	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	1	IEA	Homo_sapiens(9606)	Process
GO:0006355	involved_in regulation of DNA-templated transcription	1	ISS	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006473	involved_in protein acetylation	1	IDA	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0007283	involved_in spermatogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0007623	involved_in circadian rhythm	1	TAS	Homo_sapiens(9606)	Process
GO:0009648	involved_in photoperiodism	1	TAS	Homo_sapiens(9606)	Process
GO:0031490	enables chromatin DNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0032922	involved_in circadian regulation of gene expression	4	IBA,IDA,IMP,ISS	Homo_sapiens(9606)	Process
GO:0033391	located_in chromatoid body	1	ISS	Homo_sapiens(9606)	Component
GO:0042634	involved_in regulation of hair cycle	1	IMP	Homo_sapiens(9606)	Process
GO:0042752	involved_in regulation of circadian rhythm	1	ISS	Homo_sapiens(9606)	Process
GO:0042753	involved_in positive regulation of circadian rhythm	1	IDA	Homo_sapiens(9606)	Process
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0043565	enables sequence-specific DNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	ISS	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0046983	enables protein dimerization activity	1	IEA	Homo_sapiens(9606)	Function
GO:0050729	involved_in positive regulation of inflammatory response	1	IEA	Homo_sapiens(9606)	Process
GO:0050796	involved_in regulation of insulin secretion	1	ISS	Homo_sapiens(9606)	Process
GO:0051092	involved_in positive regulation of NF-kappaB transcription factor activity	1	ISS	Homo_sapiens(9606)	Process
GO:0051775	involved_in response to redox state	1	IDA	Homo_sapiens(9606)	Process
GO:0070888	enables E-box binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0071479	involved_in cellular response to ionizing radiation	1	IDA	Homo_sapiens(9606)	Process
GO:1990513	part_of CLOCK-BMAL transcription complex	2	IBA,IPI	Homo_sapiens(9606)	Component
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:2000074	involved_in regulation of type B pancreatic cell development	1	ISS	Homo_sapiens(9606)	Process
GO:2000323	involved_in negative regulation of glucocorticoid receptor signaling pathway	1	ISS	Homo_sapiens(9606)	Process