Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000134627 Gene ID 143689 Accession 18444
Symbol PIWIL4 Alias HIWI2;MIWI2 Full Name piwi like RNA-mediated gene silencing 4
Status Confidence Length 77582 bases Strand Plus strand
Position 11 : 94543840 - 94621421 RNA binding domain Piwi , PAZ
Summary PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000299001 Piwi PF02171 4e-88 1
ENSP00000299001 PAZ PF02170 2.2e-31 2
ENSP00000439710 Piwi PF02171 2.7e-56 1
ENSP00000444575 PAZ PF02170 8.4e-32 1
ENSP00000413838 PAZ PF02170 9.9e-32 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32267490 Small nucleolar RNAs: continuing identification of novel members and increasing diversity of their molecular mechanisms of action. Danny Bergeron 2020-04-29 Biochemical Society transactions
36930678 PCB: A pseudotemporal causality-based Bayesian approach to identify EMT-associated regulatory relationships of AS events and RBPs during breast cancer progression. Liangjie Sun 2023-03-01 PLoS computational biology
25779046 An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Xin He 2015-04-20 Nucleic acids research
37146239 A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Shiva Bamezai 2023-07-06 Blood
31019967 A Simple Competing Endogenous RNA Network Identifies Novel mRNA, miRNA, and lncRNA Markers in Human Cholangiocarcinoma. Cheng Zhang 2019-01-01 BioMed research international
34876138 PIWIL4 and SUPT5H combine to predict prognosis and immune landscape in intrahepatic cholangiocarcinoma. Wenbo Zou 2021-12-07 Cancer cell international

Transcripts

Name Transcript ID bp Protein Translation ID
PIWIL4-204 ENST00000543336 1901 453aa ENSP00000444575
PIWIL4-202 ENST00000446230 3759 495aa ENSP00000413838
PIWIL4-201 ENST00000299001 3139 852aa ENSP00000299001
PIWIL4-205 ENST00000545603 587 118aa ENSP00000440499
PIWIL4-203 ENST00000537419 831 203aa ENSP00000439710

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17596Alcoholism8.05812e-00522978509
54338Fructose-Bisphosphate Aldolase6.7720000E-005-
76088Attention Deficit Disorder with Hyperactivity9E-718846501
84256Prion Diseases4E-625897833
84257Mood Disorders4E-625897833
103077Prion Diseases8E-625897833
103078Mood Disorders8E-625897833

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134627homo_sapiensENSP0000047952457.388338.9462homo_sapiensENSP0000029900158.802839.9061
ENSG00000134627homo_sapiensENSP0000024525567.131249.1289homo_sapiensENSP0000029900167.840449.6479
ENSG00000134627homo_sapiensENSP0000034920849.229231.963homo_sapiensENSP0000029900156.220736.5023

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134627homo_sapiensENSP0000029900194.483694.0141nomascus_leucogenysENSNLEP0000000867499.260298.767
ENSG00000134627homo_sapiensENSP0000029900110099.5305pan_paniscusENSPPAP0000001620010099.5305
ENSG00000134627homo_sapiensENSP0000029900199.178498.5916pongo_abeliiENSPPYP0000000432799.178498.5916
ENSG00000134627homo_sapiensENSP0000029900199.882699.4131pan_troglodytesENSPTRP0000008762599.882699.4131
ENSG00000134627homo_sapiensENSP0000029900199.765399.1784gorilla_gorillaENSGGOP0000001588699.765399.1784
ENSG00000134627homo_sapiensENSP0000029900182.629169.4836sarcophilus_harrisiiENSSHAP0000002053981.012768.1243
ENSG00000134627homo_sapiensENSP0000029900163.61554.5775notamacropus_eugeniiENSMEUP0000000468768.090558.4171
ENSG00000134627homo_sapiensENSP0000029900167.488361.5023choloepus_hoffmanniENSCHOP0000000711667.806661.7925
ENSG00000134627homo_sapiensENSP0000029900180.633871.1268dasypus_novemcinctusENSDNOP0000001302689.336878.8036
ENSG00000134627homo_sapiensENSP0000029900146.596238.615erinaceus_europaeusENSEEUP0000000460352.513243.5185
ENSG00000134627homo_sapiensENSP0000029900147.652642.2535echinops_telfairiENSETEP0000000041158.585951.9481
ENSG00000134627homo_sapiensENSP0000029900196.009492.4883callithrix_jacchusENSCJAP0000000748395.896892.3798
ENSG00000134627homo_sapiensENSP0000029900199.295898.0047cercocebus_atysENSCATP0000001222599.295898.0047
ENSG00000134627homo_sapiensENSP0000029900199.295897.5352macaca_fascicularisENSMFAP0000003097499.295897.5352
ENSG00000134627homo_sapiensENSP0000029900199.295897.5352macaca_mulattaENSMMUP0000001174799.295897.5352
ENSG00000134627homo_sapiensENSP0000029900199.295897.6526macaca_nemestrinaENSMNEP0000002810999.295897.6526
ENSG00000134627homo_sapiensENSP0000029900199.178497.77papio_anubisENSPANP0000000964199.178497.77
ENSG00000134627homo_sapiensENSP0000029900199.06197.5352mandrillus_leucophaeusENSMLEP0000001116699.06197.5352
ENSG00000134627homo_sapiensENSP0000029900191.431982.1596tursiops_truncatusENSTTRP0000001001191.647182.3529
ENSG00000134627homo_sapiensENSP0000029900188.61579.8122vulpes_vulpesENSVVUP0000001579091.626282.5243
ENSG00000134627homo_sapiensENSP0000029900179.10869.2488mus_spretusMGP_SPRETEiJ_P009029276.765467.1982
ENSG00000134627homo_sapiensENSP0000029900192.136184.1549equus_asinusENSEASP0000506139092.136184.1549
ENSG00000134627homo_sapiensENSP0000029900189.084581.1033capra_hircusENSCHIP0000000405588.875980.9133
ENSG00000134627homo_sapiensENSP0000029900191.197282.277loxodonta_africanaENSLAFP0000000706689.826681.0405
ENSG00000134627homo_sapiensENSP0000029900190.258282.5117panthera_leoENSPLOP0000002492791.113783.2938
ENSG00000134627homo_sapiensENSP0000029900189.906181.2207ailuropoda_melanoleucaENSAMEP0000000801389.48680.8411
ENSG00000134627homo_sapiensENSP0000029900183.21676.1737bos_indicus_hybridENSBIXP0000501421791.839484.0674
ENSG00000134627homo_sapiensENSP0000029900191.197282.9812oryctolagus_cuniculusENSOCUP0000000248490.877282.6901
ENSG00000134627homo_sapiensENSP0000029900188.849880.7512equus_caballusENSECAP0000004325682.193374.7014
ENSG00000134627homo_sapiensENSP0000029900190.727781.8075canis_lupus_familiarisENSCAFP0084502752190.727781.8075
ENSG00000134627homo_sapiensENSP0000029900190.375682.5117panthera_pardusENSPPRP0000001455891.232283.2938
ENSG00000134627homo_sapiensENSP0000029900190.258282.277marmota_marmota_marmotaENSMMMP0000000414990.577182.5677
ENSG00000134627homo_sapiensENSP0000029900121.713619.8357balaenoptera_musculusENSBMSP0001001096691.13383.2512
ENSG00000134627homo_sapiensENSP0000029900174.882667.1361cavia_porcellusENSCPOP0000000006187.878878.7879
ENSG00000134627homo_sapiensENSP0000029900190.023581.5728felis_catusENSFCAP0000001013890.876882.346
ENSG00000134627homo_sapiensENSP0000029900186.737178.169ursus_americanusENSUAMP0000002733890.563781.6176
ENSG00000134627homo_sapiensENSP0000029900183.450770.6573monodelphis_domesticaENSMODP0000000025883.352970.5744
ENSG00000134627homo_sapiensENSP0000029900188.967180.8685bison_bison_bisonENSBBBP0000001290789.492381.3459
ENSG00000134627homo_sapiensENSP0000029900191.549382.1596monodon_monocerosENSMMNP0001502713191.549382.1596
ENSG00000134627homo_sapiensENSP0000029900190.375681.338sus_scrofaENSSSCP0000006883590.269681.2427
ENSG00000134627homo_sapiensENSP0000029900193.66286.8545microcebus_murinusENSMICP0000000582293.77286.9565
ENSG00000134627homo_sapiensENSP0000029900186.150277.4648octodon_degusENSODEP0000001764888.009679.1367
ENSG00000134627homo_sapiensENSP0000029900188.849881.1033ovis_aries_rambouilletENSOARP0002003137388.954281.1986
ENSG00000134627homo_sapiensENSP0000029900190.610381.9249ursus_maritimusENSUMAP0000000945391.037782.3113
ENSG00000134627homo_sapiensENSP0000029900180.633871.9484ochotona_princepsENSOPRP0000000392881.301872.5444
ENSG00000134627homo_sapiensENSP0000029900186.854578.169delphinapterus_leucasENSDLEP0000001177592.154482.939
ENSG00000134627homo_sapiensENSP0000029900191.901483.8028physeter_catodonENSPCTP0000501733891.901483.8028
ENSG00000134627homo_sapiensENSP0000029900179.694869.6009mus_caroliMGP_CAROLIEiJ_P008674877.334967.5399
ENSG00000134627homo_sapiensENSP0000029900187.910877.4648mus_musculusENSMUSP0000011130882.217372.4479
ENSG00000134627homo_sapiensENSP0000029900119.835717.9577dipodomys_ordiiENSDORP0000001809290.860282.2581
ENSG00000134627homo_sapiensENSP0000029900184.741875.5869mustela_putorius_furoENSMPUP0000001215990.2580.5
ENSG00000134627homo_sapiensENSP0000029900192.253588.7324aotus_nancymaaeENSANAP0000002686696.560292.8747
ENSG00000134627homo_sapiensENSP0000029900196.596292.8404saimiri_boliviensis_boliviensisENSSBOP0000001562696.48392.7315
ENSG00000134627homo_sapiensENSP0000029900182.981274.5305vicugna_pacosENSVPAP0000000542383.078774.6181
ENSG00000134627homo_sapiensENSP0000029900198.708997.3005chlorocebus_sabaeusENSCSAP0000001472298.708997.3005
ENSG00000134627homo_sapiensENSP0000029900176.760670.5399tupaia_belangeriENSTBEP0000001158776.401970.2103
ENSG00000134627homo_sapiensENSP0000029900185.798175.5869mesocricetus_auratusENSMAUP0000001060486.714176.3938
ENSG00000134627homo_sapiensENSP0000029900191.431981.9249phocoena_sinusENSPSNP0000001725791.431981.9249
ENSG00000134627homo_sapiensENSP0000029900191.314682.6291camelus_dromedariusENSCDRP0000502255091.421982.7262
ENSG00000134627homo_sapiensENSP0000029900181.220772.5352carlito_syrichtaENSTSYP0000000511591.292981.5303
ENSG00000134627homo_sapiensENSP0000029900188.732480.9859panthera_tigris_altaicaENSPTIP0000002502691.194283.2328
ENSG00000134627homo_sapiensENSP0000029900185.680776.1737rattus_norvegicusENSRNOP0000003946087.740478.0048
ENSG00000134627homo_sapiensENSP0000029900193.427287.0892prolemur_simusENSPSMP0000003053793.53787.1915
ENSG00000134627homo_sapiensENSP0000029900186.502373.8263microtus_ochrogasterENSMOCP0000002360586.80874.0872
ENSG00000134627homo_sapiensENSP0000029900151.408545.0704sorex_araneusENSSARP0000000891956.010249.1049
ENSG00000134627homo_sapiensENSP0000029900186.032975.2347peromyscus_maniculatus_bairdiiENSPEMP0000002829186.336975.5006
ENSG00000134627homo_sapiensENSP0000029900189.201981.1033bos_mutusENSBMUP0000001234189.306781.1986
ENSG00000134627homo_sapiensENSP0000029900179.225369.6009mus_spicilegusENSMSIP0000001982276.966967.6169
ENSG00000134627homo_sapiensENSP0000029900185.798175.5869cricetulus_griseus_chok1gshdENSCGRP0000101799587.544977.1257
ENSG00000134627homo_sapiensENSP0000029900184.976578.169pteropus_vampyrusENSPVAP0000000683784.579477.8037
ENSG00000134627homo_sapiensENSP0000029900190.845182.7465myotis_lucifugusENSMLUP0000000183890.951882.8437
ENSG00000134627homo_sapiensENSP0000029900184.50772.0657vombatus_ursinusENSVURP0001001384484.50772.0657
ENSG00000134627homo_sapiensENSP0000029900190.727784.1549rhinolophus_ferrumequinumENSRFEP0001003110986.368780.1117
ENSG00000134627homo_sapiensENSP0000029900190.140880.1643neovison_visonENSNVIP0000000702990.140880.1643
ENSG00000134627homo_sapiensENSP0000029900187.910879.8122bos_taurusENSBTAP0000001985186.790378.7949
ENSG00000134627homo_sapiensENSP0000029900190.375682.1596heterocephalus_glaber_femaleENSHGLP0000004035590.163981.9672
ENSG00000134627homo_sapiensENSP0000029900120.539918.662heterocephalus_glaber_femaleENSHGLP0000005737187.579.5
ENSG00000134627homo_sapiensENSP0000029900198.591697.3005rhinopithecus_bietiENSRBIP0000003187098.591697.3005
ENSG00000134627homo_sapiensENSP0000029900189.084580.3991canis_lupus_dingoENSCAFP0002002088490.357181.5476
ENSG00000134627homo_sapiensENSP0000029900190.610382.7465sciurus_vulgarisENSSVLP0000501219090.716882.8437
ENSG00000134627homo_sapiensENSP0000029900183.920271.2441phascolarctos_cinereusENSPCIP0000004194183.920271.2441
ENSG00000134627homo_sapiensENSP0000029900187.793479.4601nannospalax_galiliENSNGAP000000238758879.6471
ENSG00000134627homo_sapiensENSP0000029900189.084581.2207bos_grunniensENSBGRP0000001689089.294181.4118
ENSG00000134627homo_sapiensENSP0000029900148.591544.2488chinchilla_lanigeraENSCLAP0000000044890.590882.4945
ENSG00000134627homo_sapiensENSP0000029900189.201981.1033cervus_hanglu_yarkandensisENSCHYP0000000374089.201981.1033
ENSG00000134627homo_sapiensENSP0000029900190.727780.3991catagonus_wagneriENSCWAP0000000242290.621380.3048
ENSG00000134627homo_sapiensENSP0000029900149.765345.7746ictidomys_tridecemlineatusENSSTOP0000000621192.982585.5263
ENSG00000134627homo_sapiensENSP0000029900192.72385.446otolemur_garnettiiENSOGAP0000001087692.074684.8485
ENSG00000134627homo_sapiensENSP0000029900196.713693.5446cebus_imitatorENSCCAP0000000316996.600293.4349
ENSG00000134627homo_sapiensENSP0000029900190.023581.8075urocitellus_parryiiENSUPAP0001000239189.812681.6159
ENSG00000134627homo_sapiensENSP0000029900189.084580.1643moschus_moschiferusENSMMSP0000002287189.084580.1643
ENSG00000134627homo_sapiensENSP0000029900198.826397.6526rhinopithecus_roxellanaENSRROP0000000377798.826397.6526
ENSG00000134627homo_sapiensENSP0000029900188.028277.3474mus_pahariMGP_PahariEiJ_P002240888.443477.7123
ENSG00000134627homo_sapiensENSP0000029900194.366287.9108propithecus_coquereliENSPCOP0000002057394.477188.0141
ENSG00000134627homo_sapiensENSP0000029900149.882630.3991caenorhabditis_elegansD2030.6.151.577731.432
ENSG00000134627homo_sapiensENSP0000029900150.93932.6291drosophila_melanogasterFBpp007975551.482832.9775
ENSG00000134627homo_sapiensENSP0000029900152.112732.0423drosophila_melanogasterFBpp007975451.270231.5243
ENSG00000134627homo_sapiensENSP0000029900164.671445.4225petromyzon_marinusENSPMAP0000001023363.699444.7399
ENSG00000134627homo_sapiensENSP0000029900164.436643.1925eptatretus_burgeriENSEBUP0000000550763.321842.4452
ENSG00000134627homo_sapiensENSP0000029900169.131554.8122callorhinchus_miliiENSCMIP0000002946572.447757.4416
ENSG00000134627homo_sapiensENSP0000029900174.178457.7465xenopus_tropicalisENSXETP0000001401874.091457.6788
ENSG00000134627homo_sapiensENSP0000029900176.995362.9108chrysemys_picta_belliiENSCPBP0000003446084.864269.3402
ENSG00000134627homo_sapiensENSP0000029900178.286463.3803sphenodon_punctatusENSSPUP0000000564575.197360.8794
ENSG00000134627homo_sapiensENSP0000029900176.995362.4413crocodylus_porosusENSCPRP0000502189183.460667.6845
ENSG00000134627homo_sapiensENSP0000029900166.314652.23laticauda_laticaudataENSLLTP0000002476176.766360.462
ENSG00000134627homo_sapiensENSP0000029900172.300556.9249notechis_scutatusENSNSUP0000000726479.689562.7426
ENSG00000134627homo_sapiensENSP0000029900173.474257.8638pseudonaja_textilisENSPTXP0000000654178.841362.0907
ENSG00000134627homo_sapiensENSP0000029900175.352157.6291anolis_carolinensisENSACAP0000001382075.886558.0378
ENSG00000134627homo_sapiensENSP0000029900169.95354.5775naja_najaENSNNAP0000000586677.705360.6258
ENSG00000134627homo_sapiensENSP0000029900175.469559.6244podarcis_muralisENSPMRP0000001295877.469961.2048
ENSG00000134627homo_sapiensENSP0000029900118.66214.3192podarcis_muralisENSPMRP0000003505578.712960.396
ENSG00000134627homo_sapiensENSP0000029900177.816961.385salvator_merianaeENSSMRP0000001306580.266363.3172
ENSG00000134627homo_sapiensENSP0000029900182.042366.6667pelodiscus_sinensisENSPSIP0000001595581.658966.3551
ENSG00000134627homo_sapiensENSP0000029900180.633866.0798gopherus_evgoodeiENSGEVP0000501006981.205766.5485
ENSG00000134627homo_sapiensENSP0000029900182.394466.9014chelonoidis_abingdoniiENSCABP0000003082684.172768.3453
ENSG00000134627homo_sapiensENSP0000029900183.802868.5446terrapene_carolina_triunguisENSTMTP0000002851683.023367.907
ENSG00000134627homo_sapiensENSP0000029900155.985938.7324ciona_savignyiENSCSAVP0000000536260.841842.0918
ENSG00000134627homo_sapiensENSP0000029900171.009455.2817leptobrachium_leishanenseENSLLEP0000000152775.530658.8015

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0004521enables RNA endonuclease activity2IBA,ISSHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,ISSHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0006417involved_in regulation of translation1IEAHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis1ISSHomo_sapiens(9606)Process
GO:0010669involved_in epithelial structure maintenance1IMPHomo_sapiens(9606)Process
GO:0031047involved_in regulatory ncRNA-mediated gene silencing2IBA,ISSHomo_sapiens(9606)Process
GO:0034584enables piRNA binding3IBA,IDA,ISSHomo_sapiens(9606)Function
GO:0043186is_active_in P granule2IBA,ISSHomo_sapiens(9606)Component
GO:0051321involved_in meiotic cell cycle1IEAHomo_sapiens(9606)Process
GO:0071514involved_in genomic imprinting1ISSHomo_sapiens(9606)Process
GO:0071547located_in piP-body1ISSHomo_sapiens(9606)Component
GO:0140965involved_in secondary piRNA processing1ISSHomo_sapiens(9606)Process
GO:0141005acts_upstream_of_positive_effect retrotransposon silencing by heterochromatin formation1ISSHomo_sapiens(9606)Process

Expression