RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000134440	Gene ID	4677	Accession	7643
Symbol	NARS1	Alias	NARS;ASNRS;NEDMILG;NEDMILEG	Full Name	asparaginyl-tRNA synthetase 1
Status	Confidence	Length	21558 bases	Strand	Minus strand
Position	18 : 57600656 - 57622213	RNA binding domain	tRNA_anti-codon , tRNA-synt_2
Summary	Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000256854	tRNA_anti-codon	PF01336	1.2e-09	1
ENSP00000256854	tRNA-synt_2	PF00152	1.4e-107	2
ENSP00000466606	tRNA_anti-codon	PF01336	1e-09	1
ENSP00000467421	tRNA_anti-codon	PF01336	1.7e-09	1
ENSP00000467651	tRNA_anti-codon	PF01336	1.8e-09	1

Showing 1 to 5 of 5 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
29431736	RICK_PMID29431736_Hela_human	Hela	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_MCF7	MCF7	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30607034	RIC_PMID_30607034_Hs_HEK293	HEK293	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30607034	RIC_PMID30607034_Hs_OOPS_MCF10A	MCF10A	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3

Showing 1 to 10 of 23 entries

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Pubmed ID	Title	Author	Time	Journal
No data available in table

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
NARS1-201	ENST00000256854	2762	548aa	ENSP00000256854
NARS1-202	ENST00000411676	1097	No protein	-
NARS1-203	ENST00000540592	937	174aa	ENSP00000442496
NARS1-204	ENST00000586807	1608	136aa	ENSP00000464988
NARS1-205	ENST00000587194	562	162aa	ENSP00000464899
NARS1-206	ENST00000587366	515	No protein	-
NARS1-207	ENST00000587675	1002	128aa	ENSP00000466606
NARS1-208	ENST00000588661	582	163aa	ENSP00000467421
NARS1-209	ENST00000589001	612	No protein	-
NARS1-210	ENST00000589314	1036	No protein	-

Showing 1 to 10 of 12 entries

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Gene Model

Click here to download ENSG00000134440's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
23614	Body Height	4.6370000E-005	-

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000134440's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000134440	homo_sapiens	ENSP00000281038	48.6373	29.7694	homo_sapiens	ENSP00000256854	42.3358	25.9124
ENSG00000134440	homo_sapiens	ENSP00000264161	43.3134	24.5509	homo_sapiens	ENSP00000256854	39.5985	22.4453
ENSG00000134440	homo_sapiens	ENSP00000303043	29.6482	16.0804	homo_sapiens	ENSP00000256854	32.2993	17.5182
ENSG00000134440	homo_sapiens	ENSP00000497569	31.3178	17.0543	homo_sapiens	ENSP00000256854	36.8613	20.073

Showing 1 to 4 of 4 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000134440	homo_sapiens	ENSP00000256854	99.2701	98.9051	nomascus_leucogenys	ENSNLEP00000009876	99.2701	98.9051
ENSG00000134440	homo_sapiens	ENSP00000256854	99.8175	99.4526	pan_paniscus	ENSPPAP00000032110	99.8175	99.4526
ENSG00000134440	homo_sapiens	ENSP00000256854	99.635	99.0876	pongo_abelii	ENSPPYP00000024159	99.635	99.0876
ENSG00000134440	homo_sapiens	ENSP00000256854	99.635	99.2701	pan_troglodytes	ENSPTRP00000017072	97.8495	97.491
ENSG00000134440	homo_sapiens	ENSP00000256854	99.635	99.4526	gorilla_gorilla	ENSGGOP00000009207	99.635	99.4526
ENSG00000134440	homo_sapiens	ENSP00000256854	96.8978	91.9708	ornithorhynchus_anatinus	ENSOANP00000002741	94.9911	90.161
ENSG00000134440	homo_sapiens	ENSP00000256854	97.6277	92.8832	sarcophilus_harrisii	ENSSHAP00000045231	95.7066	91.0555
ENSG00000134440	homo_sapiens	ENSP00000256854	91.6058	83.9416	notamacropus_eugenii	ENSMEUP00000014782	94.1839	86.3039
ENSG00000134440	homo_sapiens	ENSP00000256854	51.4599	48.7226	notamacropus_eugenii	ENSMEUP00000000713	97.2414	92.069
ENSG00000134440	homo_sapiens	ENSP00000256854	70.8029	68.0657	choloepus_hoffmanni	ENSCHOP00000006062	71.3235	68.5662

Showing 1 to 10 of 230 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004816	enables asparagine-tRNA ligase activity	3	IBA,IMP,TAS	Homo_sapiens(9606)	Function
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006421	involved_in asparaginyl-tRNA aminoacylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0006418	involved_in tRNA aminoacylation for protein translation	1	TAS	Homo_sapiens(9606)	Process
GO:0016477	involved_in cell migration	1	IDA	Homo_sapiens(9606)	Process
GO:0021987	involved_in cerebral cortex development	1	IMP	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression