RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000134046	Gene ID	8932	Accession	6917
Symbol	MBD2	Alias	DMTase;NY-CO-41	Full Name	methyl-CpG binding domain protein 2
Status	Confidence	Length	73064 bases	Strand	Minus strand
Position	18 : 54151606 - 54224669	RNA binding domain	MBD
Summary	DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000256429	MBD	PF01429	5.3e-27	1
ENSP00000381435	MBD	PF01429	1.2e-22	1
ENSP00000464554	MBD	PF01429	1.7e-22	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32176734	Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation.	Weili Kong	2020-03-01	PLoS pathogens
35051313	circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis.	Donghong Liu	2022-01-01	Clinical and translational medicine
26007656	Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.	Guillaume Devailly	2015-07-13	Nucleic acids research
23955541	Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2.	Barbara Stefanska	2013-12-01	Carcinogenesis
24927503	Genome-wide binding of MBD2 reveals strong preference for highly methylated loci.	Roberta Menafra	2014-01-01	PloS one
33876188	Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia.	Panpan Han	2021-08-26	Blood

Name	Transcript ID	bp	Protein	Translation ID
MBD2-201	ENST00000256429	5064	411aa	ENSP00000256429
MBD2-204	ENST00000579025	241	No protein	-
MBD2-203	ENST00000578272	701	72aa	ENSP00000462393
MBD2-202	ENST00000398398	1237	241aa	ENSP00000381435
MBD2-205	ENST00000583046	1182	302aa	ENSP00000464554

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000134046	homo_sapiens	ENSP00000269468	21.3223	14.5455	homo_sapiens	ENSP00000256429	31.3869	21.4112
ENSG00000134046	homo_sapiens	ENSP00000412302	79.0378	65.9794	homo_sapiens	ENSP00000256429	55.9611	46.7153
ENSG00000134046	homo_sapiens	ENSP00000331435	44.7115	29.8077	homo_sapiens	ENSP00000256429	22.6277	15.0852
ENSG00000134046	homo_sapiens	ENSP00000370800	45.1923	29.8077	homo_sapiens	ENSP00000256429	22.871	15.0852
ENSG00000134046	homo_sapiens	ENSP00000471575	56.1856	35.567	homo_sapiens	ENSP00000256429	26.5207	16.7883
ENSG00000134046	homo_sapiens	ENSP00000489619	46.0784	30.3922	homo_sapiens	ENSP00000256429	22.871	15.0852
ENSG00000134046	homo_sapiens	ENSP00000370801	44.7115	29.8077	homo_sapiens	ENSP00000256429	22.6277	15.0852
ENSG00000134046	homo_sapiens	ENSP00000333183	45.1923	29.8077	homo_sapiens	ENSP00000256429	22.871	15.0852

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	55.9611	nomascus_leucogenys	ENSNLEP00000042351	100	100
ENSG00000134046	homo_sapiens	ENSP00000256429	75.4258	73.9659	pan_paniscus	ENSPPAP00000014317	84.9315	83.2877
ENSG00000134046	homo_sapiens	ENSP00000256429	100	100	pongo_abelii	ENSPPYP00000010299	100	100
ENSG00000134046	homo_sapiens	ENSP00000256429	84.9148	83.9416	pan_troglodytes	ENSPTRP00000049369	91.3613	90.3141
ENSG00000134046	homo_sapiens	ENSP00000256429	99.7567	99.7567	gorilla_gorilla	ENSGGOP00000013077	99.7567	99.7567
ENSG00000134046	homo_sapiens	ENSP00000256429	83.2117	80.0487	ornithorhynchus_anatinus	ENSOANP00000002857	64.6503	62.1928
ENSG00000134046	homo_sapiens	ENSP00000256429	49.635	47.9319	sarcophilus_harrisii	ENSSHAP00000010098	96.6825	93.3649
ENSG00000134046	homo_sapiens	ENSP00000256429	54.0146	51.3382	sarcophilus_harrisii	ENSSHAP00000018503	92.887	88.2845
ENSG00000134046	homo_sapiens	ENSP00000256429	91.9708	91.2409	sarcophilus_harrisii	ENSSHAP00000040756	91.5254	90.799
ENSG00000134046	homo_sapiens	ENSP00000256429	58.6375	57.4209	notamacropus_eugenii	ENSMEUP00000015066	97.9675	95.935
ENSG00000134046	homo_sapiens	ENSP00000256429	43.309	42.3358	choloepus_hoffmanni	ENSCHOP00000010839	77.7293	75.9825
ENSG00000134046	homo_sapiens	ENSP00000256429	97.0803	97.0803	dasypus_novemcinctus	ENSDNOP00000032156	97.0803	97.0803
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	53.528	erinaceus_europaeus	ENSEEUP00000000140	55.122	53.6585
ENSG00000134046	homo_sapiens	ENSP00000256429	59.3674	58.1509	echinops_telfairi	ENSETEP00000016362	59.2233	58.0097
ENSG00000134046	homo_sapiens	ENSP00000256429	99.7567	99.7567	callithrix_jacchus	ENSCJAP00000065488	99.0338	99.0338
ENSG00000134046	homo_sapiens	ENSP00000256429	95.3771	95.3771	cercocebus_atys	ENSCATP00000035326	99.2405	99.2405
ENSG00000134046	homo_sapiens	ENSP00000256429	64.9635	64.9635	macaca_fascicularis	ENSMFAP00000015039	100	100
ENSG00000134046	homo_sapiens	ENSP00000256429	99.7567	99.7567	macaca_mulatta	ENSMMUP00000041217	99.5146	99.5146
ENSG00000134046	homo_sapiens	ENSP00000256429	90.2676	90.0243	macaca_nemestrina	ENSMNEP00000007996	98.1481	97.8836
ENSG00000134046	homo_sapiens	ENSP00000256429	79.0754	78.8321	papio_anubis	ENSPANP00000004479	80.0493	79.803
ENSG00000134046	homo_sapiens	ENSP00000256429	69.5864	69.0998	mandrillus_leucophaeus	ENSMLEP00000008214	97.9452	97.2603
ENSG00000134046	homo_sapiens	ENSP00000256429	60.0973	60.0973	tursiops_truncatus	ENSTTRP00000009125	60.0973	60.0973
ENSG00000134046	homo_sapiens	ENSP00000256429	73.7226	72.7494	vulpes_vulpes	ENSVVUP00000020096	89.3805	88.2006
ENSG00000134046	homo_sapiens	ENSP00000256429	98.0535	97.0803	mus_spretus	MGP_SPRETEiJ_P0049043	97.8155	96.8447
ENSG00000134046	homo_sapiens	ENSP00000256429	40.6326	38.6861	equus_asinus	ENSEASP00005047624	60.9489	58.0292
ENSG00000134046	homo_sapiens	ENSP00000256429	96.837	96.3504	capra_hircus	ENSCHIP00000008412	96.1353	95.6522
ENSG00000134046	homo_sapiens	ENSP00000256429	71.5328	71.2895	loxodonta_africana	ENSLAFP00000011833	99.661	99.322
ENSG00000134046	homo_sapiens	ENSP00000256429	99.2701	99.2701	panthera_leo	ENSPLOP00000015773	99.5122	99.5122
ENSG00000134046	homo_sapiens	ENSP00000256429	71.2895	70.5596	ailuropoda_melanoleuca	ENSAMEP00000023172	66.7426	66.0592
ENSG00000134046	homo_sapiens	ENSP00000256429	97.3236	96.1071	bos_indicus_hybrid	ENSBIXP00005022192	96.6184	95.4106
ENSG00000134046	homo_sapiens	ENSP00000256429	76.6423	75.4258	oryctolagus_cuniculus	ENSOCUP00000041460	90.7781	89.3372
ENSG00000134046	homo_sapiens	ENSP00000256429	96.5937	96.3504	equus_caballus	ENSECAP00000040297	91.055	90.8257
ENSG00000134046	homo_sapiens	ENSP00000256429	98.7835	98.7835	canis_lupus_familiaris	ENSCAFP00845004131	98.3051	98.3051
ENSG00000134046	homo_sapiens	ENSP00000256429	99.2701	99.2701	panthera_pardus	ENSPPRP00000006191	99.5122	99.5122
ENSG00000134046	homo_sapiens	ENSP00000256429	71.0462	70.073	marmota_marmota_marmota	ENSMMMP00000006006	94.4984	93.2039
ENSG00000134046	homo_sapiens	ENSP00000256429	98.7835	98.7835	balaenoptera_musculus	ENSBMSP00010013708	99.2665	99.2665
ENSG00000134046	homo_sapiens	ENSP00000256429	75.1825	74.4526	cavia_porcellus	ENSCPOP00000006158	92.7928	91.8919
ENSG00000134046	homo_sapiens	ENSP00000256429	99.2701	99.2701	felis_catus	ENSFCAP00000021321	99.5122	99.5122
ENSG00000134046	homo_sapiens	ENSP00000256429	83.9416	83.6983	ursus_americanus	ENSUAMP00000023658	99.711	99.422
ENSG00000134046	homo_sapiens	ENSP00000256429	96.5937	95.6204	monodelphis_domestica	ENSMODP00000013828	95.4327	94.4712
ENSG00000134046	homo_sapiens	ENSP00000256429	55.4745	54.5012	bison_bison_bison	ENSBBBP00000023882	55.4745	54.5012
ENSG00000134046	homo_sapiens	ENSP00000256429	98.5401	98.5401	monodon_monoceros	ENSMMNP00015009932	99.022	99.022
ENSG00000134046	homo_sapiens	ENSP00000256429	60.5839	58.1509	sus_scrofa	ENSSSCP00000071505	83.2776	79.9331
ENSG00000134046	homo_sapiens	ENSP00000256429	90.5109	90.5109	microcebus_murinus	ENSMICP00000008165	93.4673	93.4673
ENSG00000134046	homo_sapiens	ENSP00000256429	82.2384	81.9951	octodon_degus	ENSODEP00000025169	98.8304	98.538
ENSG00000134046	homo_sapiens	ENSP00000256429	74.4526	73.7226	jaculus_jaculus	ENSJJAP00000025078	84.5304	83.7017
ENSG00000134046	homo_sapiens	ENSP00000256429	97.3236	96.837	ovis_aries_rambouillet	ENSOARP00020021711	96.6184	96.1353
ENSG00000134046	homo_sapiens	ENSP00000256429	68.1265	67.8832	ursus_maritimus	ENSUMAP00000004231	98.2456	97.8947
ENSG00000134046	homo_sapiens	ENSP00000256429	29.927	29.4404	ochotona_princeps	ENSOPRP00000006992	53.4783	52.6087
ENSG00000134046	homo_sapiens	ENSP00000256429	98.5401	98.5401	delphinapterus_leucas	ENSDLEP00000005622	99.022	99.022
ENSG00000134046	homo_sapiens	ENSP00000256429	98.2968	98.0535	physeter_catodon	ENSPCTP00005021271	98.7775	98.533
ENSG00000134046	homo_sapiens	ENSP00000256429	97.8102	96.3504	mus_caroli	MGP_CAROLIEiJ_P0047092	97.3366	95.8838
ENSG00000134046	homo_sapiens	ENSP00000256429	98.5401	97.5669	mus_musculus	ENSMUSP00000073701	97.8261	96.8599
ENSG00000134046	homo_sapiens	ENSP00000256429	72.2628	71.2895	dipodomys_ordii	ENSDORP00000025162	81.3699	80.274
ENSG00000134046	homo_sapiens	ENSP00000256429	16.545	16.545	mustela_putorius_furo	ENSMPUP00000010437	98.5507	98.5507
ENSG00000134046	homo_sapiens	ENSP00000256429	89.5377	89.0511	aotus_nancymaae	ENSANAP00000024711	98.6595	98.1233
ENSG00000134046	homo_sapiens	ENSP00000256429	75.1825	73.9659	saimiri_boliviensis_boliviensis	ENSSBOP00000002242	85.8333	84.4444
ENSG00000134046	homo_sapiens	ENSP00000256429	50.1217	49.8783	vicugna_pacos	ENSVPAP00000011431	90.3509	89.9123
ENSG00000134046	homo_sapiens	ENSP00000256429	63.747	63.747	chlorocebus_sabaeus	ENSCSAP00000014123	100	100
ENSG00000134046	homo_sapiens	ENSP00000256429	70.3163	69.3431	tupaia_belangeri	ENSTBEP00000013266	95.3795	94.0594
ENSG00000134046	homo_sapiens	ENSP00000256429	89.781	88.5645	mesocricetus_auratus	ENSMAUP00000013249	89.5631	88.3495
ENSG00000134046	homo_sapiens	ENSP00000256429	98.5401	98.5401	phocoena_sinus	ENSPSNP00000009852	99.022	99.022
ENSG00000134046	homo_sapiens	ENSP00000256429	81.9951	80.292	camelus_dromedarius	ENSCDRP00005031816	88.4514	86.6142
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	55.4745	carlito_syrichta	ENSTSYP00000012259	61.828	61.2903
ENSG00000134046	homo_sapiens	ENSP00000256429	69.3431	69.0998	panthera_tigris_altaica	ENSPTIP00000010871	69.3431	69.0998
ENSG00000134046	homo_sapiens	ENSP00000256429	97.5669	96.1071	rattus_norvegicus	ENSRNOP00000016112	97.3301	95.8738
ENSG00000134046	homo_sapiens	ENSP00000256429	64.7202	64.7202	prolemur_simus	ENSPSMP00000036098	91.7241	91.7241
ENSG00000134046	homo_sapiens	ENSP00000256429	84.4282	83.455	microtus_ochrogaster	ENSMOCP00000018822	99.4269	98.2808
ENSG00000134046	homo_sapiens	ENSP00000256429	78.5888	77.6156	peromyscus_maniculatus_bairdii	ENSPEMP00000023796	79.5566	78.5714
ENSG00000134046	homo_sapiens	ENSP00000256429	61.5572	60.5839	bos_mutus	ENSBMUP00000025198	61.5572	60.5839
ENSG00000134046	homo_sapiens	ENSP00000256429	75.1825	72.5061	mus_spicilegus	ENSMSIP00000013854	81.3158	78.4211
ENSG00000134046	homo_sapiens	ENSP00000256429	98.2968	97.3236	cricetulus_griseus_chok1gshd	ENSCGRP00001017310	98.0583	97.0874
ENSG00000134046	homo_sapiens	ENSP00000256429	76.6423	76.6423	pteropus_vampyrus	ENSPVAP00000008081	77.0171	77.0171
ENSG00000134046	homo_sapiens	ENSP00000256429	81.0219	78.3455	myotis_lucifugus	ENSMLUP00000009104	81.6176	78.9216
ENSG00000134046	homo_sapiens	ENSP00000256429	84.6715	83.9416	vombatus_ursinus	ENSVURP00010002288	98.3051	97.4576
ENSG00000134046	homo_sapiens	ENSP00000256429	99.5134	99.2701	rhinolophus_ferrumequinum	ENSRFEP00010026740	99.2718	99.0291
ENSG00000134046	homo_sapiens	ENSP00000256429	71.0462	71.0462	neovison_vison	ENSNVIP00000003684	70.8738	70.8738
ENSG00000134046	homo_sapiens	ENSP00000256429	97.3236	96.3504	bos_taurus	ENSBTAP00000048789	95.9233	94.964
ENSG00000134046	homo_sapiens	ENSP00000256429	97.8102	97.5669	heterocephalus_glaber_female	ENSHGLP00000030079	99.0148	98.7685
ENSG00000134046	homo_sapiens	ENSP00000256429	85.1581	85.1581	rhinopithecus_bieti	ENSRBIP00000036992	91.1458	91.1458
ENSG00000134046	homo_sapiens	ENSP00000256429	88.8078	88.8078	canis_lupus_dingo	ENSCAFP00020027534	98.1183	98.1183
ENSG00000134046	homo_sapiens	ENSP00000256429	99.2701	99.2701	sciurus_vulgaris	ENSSVLP00005030785	99.0291	99.0291
ENSG00000134046	homo_sapiens	ENSP00000256429	96.1071	95.1338	phascolarctos_cinereus	ENSPCIP00000004340	96.577	95.599
ENSG00000134046	homo_sapiens	ENSP00000256429	73.9659	72.9927	nannospalax_galili	ENSNGAP00000018124	99.6721	98.3607
ENSG00000134046	homo_sapiens	ENSP00000256429	96.5937	95.6204	bos_grunniens	ENSBGRP00000040222	96.5937	95.6204
ENSG00000134046	homo_sapiens	ENSP00000256429	82.9684	82.9684	chinchilla_lanigera	ENSCLAP00000015205	99.7076	99.7076
ENSG00000134046	homo_sapiens	ENSP00000256429	55.4745	54.7445	cervus_hanglu_yarkandensis	ENSCHYP00000038530	87.6923	86.5385
ENSG00000134046	homo_sapiens	ENSP00000256429	98.2968	98.2968	catagonus_wagneri	ENSCWAP00000022366	98.0583	98.0583
ENSG00000134046	homo_sapiens	ENSP00000256429	68.1265	67.8832	ictidomys_tridecemlineatus	ENSSTOP00000010090	100	99.6429
ENSG00000134046	homo_sapiens	ENSP00000256429	71.0462	70.3163	otolemur_garnettii	ENSOGAP00000007183	98.3165	97.3064
ENSG00000134046	homo_sapiens	ENSP00000256429	99.7567	99.7567	cebus_imitator	ENSCCAP00000040230	98.5577	98.5577
ENSG00000134046	homo_sapiens	ENSP00000256429	99.2701	99.0268	urocitellus_parryii	ENSUPAP00010000772	98.3133	98.0723
ENSG00000134046	homo_sapiens	ENSP00000256429	96.5937	95.3771	moschus_moschiferus	ENSMMSP00000008579	96.1259	94.9153
ENSG00000134046	homo_sapiens	ENSP00000256429	71.0462	70.3163	rhinopithecus_roxellana	ENSRROP00000020693	91.536	90.5956
ENSG00000134046	homo_sapiens	ENSP00000256429	98.5401	97.0803	mus_pahari	MGP_PahariEiJ_P0039664	97.8261	96.3768
ENSG00000134046	homo_sapiens	ENSP00000256429	99.0268	98.7835	propithecus_coquereli	ENSPCOP00000005073	99.2683	99.0244
ENSG00000134046	homo_sapiens	ENSP00000256429	39.4161	26.764	drosophila_melanogaster	FBpp0306716	47.6471	32.3529
ENSG00000134046	homo_sapiens	ENSP00000256429	47.6886	39.9027	petromyzon_marinus	ENSPMAP00000002686	82.3529	68.9076
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	46.7153	eptatretus_burgeri	ENSEBUP00000008209	85.9316	73.0038
ENSG00000134046	homo_sapiens	ENSP00000256429	61.5572	58.6375	latimeria_chalumnae	ENSLACP00000018207	94.7566	90.2622
ENSG00000134046	homo_sapiens	ENSP00000256429	58.6375	54.2579	lepisosteus_oculatus	ENSLOCP00000003987	90.6015	83.8346
ENSG00000134046	homo_sapiens	ENSP00000256429	34.0633	30.1703	danio_rerio	ENSDARP00000136077	73.2984	64.9215
ENSG00000134046	homo_sapiens	ENSP00000256429	55.7178	48.4185	carassius_auratus	ENSCARP00000054275	87.0722	75.6654
ENSG00000134046	homo_sapiens	ENSP00000256429	39.9027	34.5499	carassius_auratus	ENSCARP00000049008	24.8862	21.5478
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	48.6618	astyanax_mexicanus	ENSAMXP00000031606	86.7924	75.4717
ENSG00000134046	homo_sapiens	ENSP00000256429	56.4477	49.635	ictalurus_punctatus	ENSIPUP00000027786	87.5472	76.9811
ENSG00000134046	homo_sapiens	ENSP00000256429	56.2044	48.9051	electrophorus_electricus	ENSEEEP00000008646	87.1698	75.8491
ENSG00000134046	homo_sapiens	ENSP00000256429	56.2044	47.9319	oncorhynchus_kisutch	ENSOKIP00005031938	87.1698	74.3396
ENSG00000134046	homo_sapiens	ENSP00000256429	47.2019	39.6594	oncorhynchus_kisutch	ENSOKIP00005003282	78.2258	65.7258
ENSG00000134046	homo_sapiens	ENSP00000256429	38.6861	26.764	oncorhynchus_mykiss	ENSOMYP00000114557	33.9019	23.4542
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	47.9319	oncorhynchus_mykiss	ENSOMYP00000016361	85.3383	74.0602
ENSG00000134046	homo_sapiens	ENSP00000256429	33.5766	24.3309	salmo_salar	ENSSSAP00000177129	24.1259	17.4825
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	47.4453	salmo_salar	ENSSSAP00000044634	85.9316	74.1445
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	47.2019	salmo_trutta	ENSSTUP00000036235	85.9316	73.7643
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	48.1752	salmo_trutta	ENSSTUP00000052133	85.3383	74.4361
ENSG00000134046	homo_sapiens	ENSP00000256429	47.9319	39.4161	gadus_morhua	ENSGMOP00000000288	77.2549	63.5294
ENSG00000134046	homo_sapiens	ENSP00000256429	54.0146	47.4453	fundulus_heteroclitus	ENSFHEP00000012906	83.7736	73.5849
ENSG00000134046	homo_sapiens	ENSP00000256429	50.6083	45.2555	poecilia_reticulata	ENSPREP00000019886	68.8742	61.5894
ENSG00000134046	homo_sapiens	ENSP00000256429	50.365	44.0389	xiphophorus_maculatus	ENSXMAP00000031093	70.1695	61.3559
ENSG00000134046	homo_sapiens	ENSP00000256429	53.2847	45.4988	oryzias_latipes	ENSORLP00000034270	56.7358	48.4456
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	48.4185	cyclopterus_lumpus	ENSCLMP00005048700	86.4662	74.812
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	oreochromis_niloticus	ENSONIP00000015903	86.4662	76.6917
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	haplochromis_burtoni	ENSHBUP00000013076	86.4662	76.6917
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.3917	astatotilapia_calliptera	ENSACLP00000006712	86.4662	76.3158
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	48.6618	sparus_aurata	ENSSAUP00010022397	86.4662	75.188
ENSG00000134046	homo_sapiens	ENSP00000256429	56.2044	49.8783	lates_calcarifer	ENSLCAP00010045579	86.8421	77.0677
ENSG00000134046	homo_sapiens	ENSP00000256429	60.8273	55.7178	xenopus_tropicalis	ENSXETP00000029954	94.3396	86.4151
ENSG00000134046	homo_sapiens	ENSP00000256429	63.2603	60.5839	chrysemys_picta_bellii	ENSCPBP00000036905	93.8628	89.8917
ENSG00000134046	homo_sapiens	ENSP00000256429	50.6083	47.2019	sphenodon_punctatus	ENSSPUP00000022894	87.395	81.5126
ENSG00000134046	homo_sapiens	ENSP00000256429	37.4696	35.5231	sphenodon_punctatus	ENSSPUP00000018020	98.0892	92.9936
ENSG00000134046	homo_sapiens	ENSP00000256429	32.6034	29.6837	laticauda_laticaudata	ENSLLTP00000021210	85.8974	78.2051
ENSG00000134046	homo_sapiens	ENSP00000256429	34.0633	30.6569	notechis_scutatus	ENSNSUP00000017886	54.2636	48.8372
ENSG00000134046	homo_sapiens	ENSP00000256429	54.5012	48.6618	pseudonaja_textilis	ENSPTXP00000025619	49.7778	44.4444
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	52.0681	anas_platyrhynchos_platyrhynchos	ENSAPLP00000009775	94.9791	89.5397
ENSG00000134046	homo_sapiens	ENSP00000256429	67.8832	63.9903	anolis_carolinensis	ENSACAP00000039623	58.4906	55.1363
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	neolamprologus_brichardi	ENSNBRP00000004762	86.7924	76.9811
ENSG00000134046	homo_sapiens	ENSP00000256429	51.0949	44.7689	naja_naja	ENSNNAP00000018750	57.2207	50.1362
ENSG00000134046	homo_sapiens	ENSP00000256429	71.5328	66.6667	podarcis_muralis	ENSPMRP00000015827	79.6748	74.2547
ENSG00000134046	homo_sapiens	ENSP00000256429	58.8808	53.2847	erpetoichthys_calabaricus	ENSECRP00000006155	90.2985	81.7164
ENSG00000134046	homo_sapiens	ENSP00000256429	54.7445	48.4185	kryptolebias_marmoratus	ENSKMAP00000008676	84.5865	74.812
ENSG00000134046	homo_sapiens	ENSP00000256429	73.236	67.1533	salvator_merianae	ENSSMRP00000021225	74.6898	68.4864
ENSG00000134046	homo_sapiens	ENSP00000256429	54.7445	48.6618	oryzias_javanicus	ENSOJAP00000027405	86.2069	76.6283
ENSG00000134046	homo_sapiens	ENSP00000256429	49.635	44.7689	amphilophus_citrinellus	ENSACIP00000016182	78.1609	70.4981
ENSG00000134046	homo_sapiens	ENSP00000256429	50.6083	45.2555	dicentrarchus_labrax	ENSDLAP00005067875	67.9739	60.7843
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	48.6618	amphiprion_percula	ENSAPEP00000030154	85.6061	75.7576
ENSG00000134046	homo_sapiens	ENSP00000256429	47.4453	45.2555	pelodiscus_sinensis	ENSPSIP00000019229	93.75	89.4231
ENSG00000134046	homo_sapiens	ENSP00000256429	62.0438	59.854	gopherus_evgoodei	ENSGEVP00005027543	88.5417	85.4167
ENSG00000134046	homo_sapiens	ENSP00000256429	54.9878	53.0414	chelonoidis_abingdonii	ENSCABP00000011501	95.3587	91.9831
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	seriola_dumerili	ENSSDUP00000024330	86.4662	76.6917
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	47.6886	cottoperca_gobio	ENSCGOP00000025501	85.3383	73.6842
ENSG00000134046	homo_sapiens	ENSP00000256429	58.3942	54.5012	struthio_camelus_australis	ENSSCUP00000001989	87.9121	82.0513
ENSG00000134046	homo_sapiens	ENSP00000256429	50.6083	47.4453	anser_brachyrhynchus	ENSABRP00000024930	98.1132	91.9811
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	47.9319	gasterosteus_aculeatus	ENSGACP00000024186	86.7924	74.3396
ENSG00000134046	homo_sapiens	ENSP00000256429	55.4745	47.4453	cynoglossus_semilaevis	ENSCSEP00000026629	85.3933	73.0337
ENSG00000134046	homo_sapiens	ENSP00000256429	54.5012	48.1752	poecilia_formosa	ENSPFOP00000003850	84.5283	74.717
ENSG00000134046	homo_sapiens	ENSP00000256429	52.7981	46.2287	myripristis_murdjan	ENSMMDP00005024052	84.7656	74.2188
ENSG00000134046	homo_sapiens	ENSP00000256429	56.2044	48.6618	sander_lucioperca	ENSSLUP00000041148	86.8421	75.188
ENSG00000134046	homo_sapiens	ENSP00000256429	44.0389	40.6326	strigops_habroptila	ENSSHBP00005013977	89.1626	82.266
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	48.6618	amphiprion_ocellaris	ENSAOCP00000000746	85.9848	75.7576
ENSG00000134046	homo_sapiens	ENSP00000256429	51.3382	48.6618	terrapene_carolina_triunguis	ENSTMTP00000000671	89.0295	84.3882
ENSG00000134046	homo_sapiens	ENSP00000256429	25.3041	20.9246	hucho_hucho	ENSHHUP00000011821	65	53.75
ENSG00000134046	homo_sapiens	ENSP00000256429	36.983	30.1703	hucho_hucho	ENSHHUP00000066071	71.3615	58.216
ENSG00000134046	homo_sapiens	ENSP00000256429	25.5474	20.6813	hucho_hucho	ENSHHUP00000018194	60	48.5714
ENSG00000134046	homo_sapiens	ENSP00000256429	50.365	44.7689	betta_splendens	ENSBSLP00000030931	74.1936	65.9498
ENSG00000134046	homo_sapiens	ENSP00000256429	56.4477	49.3917	pygocentrus_nattereri	ENSPNAP00000003508	87.5472	76.6038
ENSG00000134046	homo_sapiens	ENSP00000256429	55.7178	48.4185	anabas_testudineus	ENSATEP00000010457	86.0902	74.812
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	seriola_lalandi_dorsalis	ENSSLDP00000021216	86.4662	76.6917
ENSG00000134046	homo_sapiens	ENSP00000256429	51.0949	44.2822	labrus_bergylta	ENSLBEP00000028995	78.9474	68.4211
ENSG00000134046	homo_sapiens	ENSP00000256429	50.6083	45.7421	pundamilia_nyererei	ENSPNYP00000004968	79.6935	72.0307
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	mastacembelus_armatus	ENSMAMP00000027956	86.7924	76.9811
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.635	stegastes_partitus	ENSSPAP00000018180	86.7924	76.9811
ENSG00000134046	homo_sapiens	ENSP00000256429	25.5474	19.4647	oncorhynchus_tshawytscha	ENSOTSP00005086086	53.8462	41.0256
ENSG00000134046	homo_sapiens	ENSP00000256429	55.2311	48.6618	acanthochromis_polyacanthus	ENSAPOP00000010203	85.9848	75.7576
ENSG00000134046	homo_sapiens	ENSP00000256429	53.2847	51.3382	aquila_chrysaetos_chrysaetos	ENSACCP00020014241	93.9914	90.5579
ENSG00000134046	homo_sapiens	ENSP00000256429	55.4745	49.1484	nothobranchius_furzeri	ENSNFUP00015006740	86.0377	76.2264
ENSG00000134046	homo_sapiens	ENSP00000256429	48.6618	40.8759	cyprinodon_variegatus	ENSCVAP00000009784	73.2601	61.5385
ENSG00000134046	homo_sapiens	ENSP00000256429	51.8248	47.6886	denticeps_clupeoides	ENSDCDP00000035210	78.8889	72.5926
ENSG00000134046	homo_sapiens	ENSP00000256429	50.8516	45.4988	larimichthys_crocea	ENSLCRP00005006873	76.8382	68.75
ENSG00000134046	homo_sapiens	ENSP00000256429	53.7713	45.9854	takifugu_rubripes	ENSTRUP00000016000	83.3962	71.3208
ENSG00000134046	homo_sapiens	ENSP00000256429	50.1217	44.5255	hippocampus_comes	ENSHCOP00000013224	78.626	69.8473
ENSG00000134046	homo_sapiens	ENSP00000256429	51.5815	43.309	cyprinus_carpio_carpio	ENSCCRP00000081709	74.1259	62.2378
ENSG00000134046	homo_sapiens	ENSP00000256429	51.5815	44.2822	cyprinus_carpio_carpio	ENSCCRP00000081818	79.4007	68.1648
ENSG00000134046	homo_sapiens	ENSP00000256429	54.2579	47.9319	poecilia_latipinna	ENSPLAP00000030110	84.1509	74.3396
ENSG00000134046	homo_sapiens	ENSP00000256429	43.7956	38.4428	sinocyclocheilus_grahami	ENSSGRP00000001598	73.7705	64.7541
ENSG00000134046	homo_sapiens	ENSP00000256429	51.3382	44.0389	sinocyclocheilus_grahami	ENSSGRP00000009813	80.8429	69.3487
ENSG00000134046	homo_sapiens	ENSP00000256429	55.9611	49.3917	maylandia_zebra	ENSMZEP00005001607	86.4662	76.3158
ENSG00000134046	homo_sapiens	ENSP00000256429	55.7178	46.9586	tetraodon_nigroviridis	ENSTNIP00000006308	86.4151	72.8302
ENSG00000134046	homo_sapiens	ENSP00000256429	56.2044	51.0949	paramormyrops_kingsleyae	ENSPKIP00000037667	88.1679	80.1527
ENSG00000134046	homo_sapiens	ENSP00000256429	56.4477	50.8516	scleropages_formosus	ENSSFOP00015032552	86.5672	77.9851
ENSG00000134046	homo_sapiens	ENSP00000256429	60.0973	55.4745	leptobrachium_leishanense	ENSLLEP00000005723	92.5094	85.3933
ENSG00000134046	homo_sapiens	ENSP00000256429	53.2847	47.2019	scophthalmus_maximus	ENSSMAP00000019195	82.6415	73.2076
ENSG00000134046	homo_sapiens	ENSP00000256429	51.0949	45.4988	oryzias_melastigma	ENSOMEP00000003384	77.4908	69.0037

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	2	IBA,IGI	Homo_sapiens(9606)	Process
GO:0000785	part_of chromatin	2	HDA,IDA	Homo_sapiens(9606)	Component
GO:0000792	part_of heterochromatin	1	IEA	Homo_sapiens(9606)	Component
GO:0003696	enables satellite DNA binding	1	TAS	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	2	HDA,IDA	Homo_sapiens(9606)	Process
GO:0006346	involved_in DNA methylation-dependent heterochromatin formation	2	IBA,IGI	Homo_sapiens(9606)	Process
GO:0007507	involved_in heart development	1	IEA	Homo_sapiens(9606)	Process
GO:0008327	enables methyl-CpG binding	3	IBA,IDA,NAS	Homo_sapiens(9606)	Function
GO:0009612	involved_in response to mechanical stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0016055	involved_in Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0016575	involved_in histone deacetylation	1	IDA	Homo_sapiens(9606)	Process
GO:0016581	part_of NuRD complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0019904	enables protein domain specific binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030177	involved_in positive regulation of Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0031492	contributes_to nucleosomal DNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0031667	involved_in response to nutrient levels	1	IEA	Homo_sapiens(9606)	Process
GO:0032355	involved_in response to estradiol	1	IEA	Homo_sapiens(9606)	Process
GO:0032991	part_of protein-containing complex	1	HDA	Homo_sapiens(9606)	Component
GO:0035197	enables siRNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0035563	involved_in positive regulation of chromatin binding	1	IEA	Homo_sapiens(9606)	Process
GO:0042127	involved_in regulation of cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0042711	involved_in maternal behavior	1	IEA	Homo_sapiens(9606)	Process
GO:0044030	involved_in regulation of DNA methylation	1	IEA	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process
GO:0048568	involved_in embryonic organ development	1	IEA	Homo_sapiens(9606)	Process
GO:0060090	enables molecular adaptor activity	1	EXP	Homo_sapiens(9606)	Function
GO:0065003	involved_in protein-containing complex assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0070742	enables C2H2 zinc finger domain binding	1	IPI	Homo_sapiens(9606)	Function
GO:0071407	involved_in cellular response to organic cyclic compound	1	IEA	Homo_sapiens(9606)	Process