RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000134046	Gene ID	8932	Accession	6917
Symbol	MBD2	Alias	DMTase;NY-CO-41	Full Name	methyl-CpG binding domain protein 2
Status	Confidence	Length	73064 bases	Strand	Minus strand
Position	18 : 54151606 - 54224669	RNA binding domain	MBD
Summary	DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]