RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000133794	Gene ID	406	Accession	701
Symbol	BMAL1	Alias	TIC;JAP3;MOP3;ARNTL;PASD3;ARNTL1;BMAL1c;bHLHe5	Full Name	basic helix-loop-helix ARNT like 1
Status	Confidence	Length	110615 bases	Strand	Plus strand
Position	11 : 13276652 - 13387266	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]