Welcome to
RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | N.A. |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | Metabolic enzyme |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000133794 | Gene ID | 406 | Accession | 701 |
| Symbol | BMAL1 | Alias | TIC;JAP3;MOP3;ARNTL;PASD3;ARNTL1;BMAL1c;bHLHe5 | Full Name | basic helix-loop-helix ARNT like 1 |
| Status | Confidence | Length | 110615 bases | Strand | Plus strand |
| Position | 11 : 13276652 - 13387266 | RNA binding domain | N.A. | ||
| Summary | The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 24449876 | Mistimed sleep disrupts circadian regulation of the human transcriptome. | N Simon Archer | 2014-02-11 | Proceedings of the National Academy of Sciences of the United States of America |
| 33888702 | Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation. | Eleonore Maury | 2021-04-22 | Nature communications |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| BMAL1-213 | ENST00000529050 | 571 | 23aa | ENSP00000434044 |
| BMAL1-221 | ENST00000534544 | 807 | 59aa | ENSP00000431566 |
| BMAL1-212 | ENST00000527998 | 519 | 76aa | ENSP00000433540 |
| BMAL1-214 | ENST00000529388 | 2641 | 626aa | ENSP00000433571 |
| BMAL1-205 | ENST00000403510 | 2728 | 626aa | ENSP00000385581 |
| BMAL1-219 | ENST00000533520 | 567 | 100aa | ENSP00000431488 |
| BMAL1-216 | ENST00000529825 | 551 | 63aa | ENSP00000434263 |
| BMAL1-201 | ENST00000389707 | 2776 | 625aa | ENSP00000374357 |
| BMAL1-228 | ENST00000674108 | 2788 | 66aa | ENSP00000501035 |
| BMAL1-217 | ENST00000530357 | 868 | 63aa | ENSP00000436313 |
| BMAL1-207 | ENST00000480685 | 633 | No protein | - |
| BMAL1-224 | ENST00000673834 | 2786 | 86aa | ENSP00000500983 |
| BMAL1-222 | ENST00000673626 | 2759 | 63aa | ENSP00000500988 |
| BMAL1-223 | ENST00000673817 | 2854 | 630aa | ENSP00000501212 |
| BMAL1-203 | ENST00000403290 | 2787 | 626aa | ENSP00000384517 |
| BMAL1-227 | ENST00000673892 | 2745 | 63aa | ENSP00000501106 |
| BMAL1-226 | ENST00000673888 | 2766 | 63aa | ENSP00000501059 |
| BMAL1-208 | ENST00000482049 | 739 | 70aa | ENSP00000436721 |
| BMAL1-218 | ENST00000531665 | 390 | 60aa | ENSP00000434781 |
| BMAL1-209 | ENST00000485918 | 457 | No protein | - |
| BMAL1-204 | ENST00000403482 | 2389 | 624aa | ENSP00000385897 |
| BMAL1-210 | ENST00000497429 | 764 | No protein | - |
| BMAL1-225 | ENST00000673868 | 1976 | 50aa | ENSP00000500968 |
| BMAL1-220 | ENST00000534102 | 418 | No protein | - |
| BMAL1-215 | ENST00000529390 | 591 | No protein | - |
| BMAL1-211 | ENST00000524392 | 1421 | 171aa | ENSP00000436442 |
| BMAL1-206 | ENST00000472842 | 3862 | No protein | - |
| BMAL1-202 | ENST00000401424 | 2807 | 582aa | ENSP00000385915 |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 15339 | Heart Failure | 1.3448144E-004 | - |
| 15358 | Heart Failure | 3.2582624E-004 | - |
| 29856 | Triglycerides | 6.7970000E-006 | - |
| 36101 | Platelet Function Tests | 2.5700000E-005 | - |
| 36102 | Platelet Function Tests | 2.5700000E-005 | - |
| 60580 | Plasminogen Activator Inhibitor 1 | 4.3680000E-006 | 24578379 |
| 60583 | Plasminogen Activator Inhibitor 1 | 1.3130000E-007 | 24578379 |
| 60592 | Plasminogen Activator Inhibitor 1 | 9.9480000E-008 | 24578379 |
| 60600 | Plasminogen Activator Inhibitor 1 | 5.0160000E-007 | 24578379 |
| 60605 | Plasminogen Activator Inhibitor 1 | 1.2770000E-006 | 24578379 |
| 60613 | Plasminogen Activator Inhibitor 1 | 2.8930000E-006 | 24578379 |
| 60614 | Plasminogen Activator Inhibitor 1 | 3.1140000E-008 | 24578379 |
| 64845 | Body Mass Index | 8E-6 | 25673413 |
| 65916 | Circadian Rhythm | 9E-6 | 26835600 |
| 66167 | Menarche | 7E-20 | 25231870 |
| 67153 | Iron | 4E-10 | 25352340 |
| 67154 | Transferrin | 4E-10 | 25352340 |
| 70964 | Body Mass Index | 6E-6 | 25673413 |
| 84151 | Schizophrenia | 5E-6 | 23358160 |
| 92273 | C-Reactive Protein | 9E-9 | 27286809 |
| 92274 | Triglycerides | 9E-9 | 27286809 |
| 104138 | Plasminogen Activator Inhibitor 1 | 2E-10 | 22990020 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000785 | part_of chromatin | 1 | ISA | Homo_sapiens(9606) | Component |
| GO:0000976 | enables transcription cis-regulatory region binding | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0000978 | enables RNA polymerase II cis-regulatory region sequence-specific DNA binding | 2 | IBA,ISS | Homo_sapiens(9606) | Function |
| GO:0000981 | enables DNA-binding transcription factor activity, RNA polymerase II-specific | 3 | IBA,ISA,ISS | Homo_sapiens(9606) | Function |
| GO:0003677 | enables DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005634 | is_active_in nucleus | 2 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0006355 | involved_in regulation of DNA-templated transcription | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0006357 | involved_in regulation of transcription by RNA polymerase II | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0007283 | involved_in spermatogenesis | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0007623 | involved_in circadian rhythm | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0016605 | located_in PML body | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0017162 | enables aryl hydrocarbon receptor binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0032007 | involved_in negative regulation of TOR signaling | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0032922 | involved_in circadian regulation of gene expression | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0033391 | located_in chromatoid body | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0034751 | part_of aryl hydrocarbon receptor complex | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0042634 | involved_in regulation of hair cycle | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0042753 | involved_in positive regulation of circadian rhythm | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0043161 | involved_in proteasome-mediated ubiquitin-dependent protein catabolic process | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0043231 | located_in intracellular membrane-bounded organelle | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0043565 | enables sequence-specific DNA binding | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0045599 | involved_in negative regulation of fat cell differentiation | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0045892 | involved_in negative regulation of DNA-templated transcription | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0045893 | involved_in positive regulation of DNA-templated transcription | 2 | IDA,IMP | Homo_sapiens(9606) | Process |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0046983 | enables protein dimerization activity | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0050767 | involved_in regulation of neurogenesis | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0050796 | involved_in regulation of insulin secretion | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0051726 | involved_in regulation of cell cycle | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0051775 | involved_in response to redox state | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0051879 | enables Hsp90 protein binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0070888 | enables E-box binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0090263 | involved_in positive regulation of canonical Wnt signaling pathway | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0090403 | involved_in oxidative stress-induced premature senescence | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0120163 | involved_in negative regulation of cold-induced thermogenesis | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0140297 | enables DNA-binding transcription factor binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:1901985 | involved_in positive regulation of protein acetylation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1990513 | part_of CLOCK-BMAL transcription complex | 1 | IPI | Homo_sapiens(9606) | Component |
| GO:1990837 | enables sequence-specific double-stranded DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:2000074 | involved_in regulation of type B pancreatic cell development | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:2000323 | involved_in negative regulation of glucocorticoid receptor signaling pathway | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:2000772 | involved_in regulation of cellular senescence | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:2001016 | involved_in positive regulation of skeletal muscle cell differentiation | 1 | ISS | Homo_sapiens(9606) | Process |