RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Description

Ensembl ID	ENSG00000133316	Gene ID	54663	Accession	25529
Symbol	WDR74	Alias	Nsa1	Full Name	WD repeat domain 74
Status	Confidence	Length	9468 bases	Strand	Minus strand
Position	11 : 62832342 - 62841809	RNA binding domain	N.A.
Summary	Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
WDR74-207	ENST00000536401	371	38aa	ENSP00000439541
WDR74-202	ENST00000311713	1153	366aa	ENSP00000308931
WDR74-201	ENST00000278856	1219	385aa	ENSP00000278856
WDR74-206	ENST00000529106	1366	385aa	ENSP00000435726
WDR74-204	ENST00000525239	1736	385aa	ENSP00000432119
WDR74-205	ENST00000525752	1724	328aa	ENSP00000432113
WDR74-215	ENST00000544831	814	No protein	-
WDR74-214	ENST00000543688	537	No protein	-
WDR74-213	ENST00000542347	988	No protein	-
WDR74-212	ENST00000541930	827	No protein	-
WDR74-211	ENST00000540620	984	No protein	-
WDR74-209	ENST00000538150	487	No protein	-
WDR74-217	ENST00000545112	788	No protein	-
WDR74-203	ENST00000453708	617	No protein	-
WDR74-216	ENST00000544953	796	No protein	-
WDR74-210	ENST00000538277	565	No protein	-
WDR74-208	ENST00000538098	548	57aa	ENSP00000440612

Gene Model

Click here to download ENSG00000133316's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000133316's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001825	involved_in blastocyst formation	1	ISS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	4	IBA,IDA,IMP	Homo_sapiens(9606)	Component
GO:0006364	involved_in rRNA processing	1	IMP	Homo_sapiens(9606)	Process
GO:0016070	involved_in RNA metabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0030687	part_of preribosome, large subunit precursor	1	IBA	Homo_sapiens(9606)	Component
GO:0042273	involved_in ribosomal large subunit biogenesis	2	IBA,IMP	Homo_sapiens(9606)	Process

Expression