RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000132837	Gene ID	29958	Accession	24475
Symbol	DMGDH	Alias	DMGDHD;ME2GLYDH	Full Name	dimethylglycine dehydrogenase
Status	Confidence	Length	72111 bases	Strand	Minus strand
Position	5 : 78997564 - 79069674	RNA binding domain	N.A.
Summary	This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
DMGDH-201	ENST00000255189	3173	866aa	ENSP00000255189
DMGDH-209	ENST00000523732	2777	613aa	ENSP00000430972
DMGDH-203	ENST00000518477	1966	98aa	ENSP00000427834
DMGDH-202	ENST00000517853	1517	106aa	ENSP00000428995
DMGDH-208	ENST00000523201	583	No protein	-
DMGDH-207	ENST00000521052	554	50aa	ENSP00000430133
DMGDH-210	ENST00000524206	572	50aa	ENSP00000428092
DMGDH-205	ENST00000520388	661	No protein	-
DMGDH-204	ENST00000518707	455	No protein	-
DMGDH-206	ENST00000520855	550	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8543	Blood Pressure	6.4715298450933E-6	17903302
8561	Blood Pressure	1.87210932337905E-6	17903302
9735	Echocardiography	2.18452592267932E-8	17903301
25670	Arteries	4.0630000E-005	-
40265	Platelet Function Tests	1.0082500E-005	-
55937	Selenium	6.3120000E-005	-
63269	Selenium	2E-11	25343990
78879	Selenium	2E-39	25343990
88976	Selenium	1E-16	25343990
91132	Metabolism	1E-19	24816252
91763	Selenium	3E-13	25343990
96169	Insulin Resistance	2E-9	23378610
97207	Selenium	2E-15	25343990
98195	Selenium	9E-28	23720494

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005759	is_active_in mitochondrial matrix	3	IBA,NAS,TAS	Homo_sapiens(9606)	Component
GO:0006579	involved_in amino-acid betaine catabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0009055	enables electron transfer activity	1	NAS	Homo_sapiens(9606)	Function
GO:0019695	involved_in choline metabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0022900	involved_in electron transport chain	1	IEA	Homo_sapiens(9606)	Process
GO:0042426	involved_in choline catabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0047865	enables dimethylglycine dehydrogenase activity	2	IBA,IMP	Homo_sapiens(9606)	Function