Functions and Diseases

RBP Type Canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000132466 Gene ID 26057 Accession 23575
Symbol ANKRD17 Alias CAGS;GTAR;MASK2;NY-BR-16 Full Name ankyrin repeat domain 17
Status Confidence Length 185423 bases Strand Minus strand
Position 4 : 73073376 - 73258798 RNA binding domain KH_1
Summary The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000332265 KH_1 PF00013 2e-14 1
ENSP00000453434 KH_1 PF00013 2.2e-14 1
ENSP00000427151 KH_1 PF00013 2.2e-14 1
ENSP00000351416 KH_1 PF00013 2.3e-14 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ANKRD17-202 ENST00000358602 10797 2603aa ENSP00000351416
ANKRD17-207 ENST00000558247 8456 2487aa ENSP00000453434
ANKRD17-203 ENST00000509867 8105 2490aa ENSP00000427151
ANKRD17-201 ENST00000330838 7734 2352aa ENSP00000332265
ANKRD17-204 ENST00000510127 504 No protein -
ANKRD17-205 ENST00000513908 852 No protein -
ANKRD17-209 ENST00000560507 563 No protein -
ANKRD17-210 ENST00000561029 2717 862aa ENSP00000453294
ANKRD17-206 ENST00000514252 3259 No protein -
ANKRD17-208 ENST00000559367 539 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
73525Dental Caries7E-724556642

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000132466homo_sapiensENSP0000035408572.73861.605homo_sapiensENSP0000035141671.033460.1614

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000132466homo_sapiensENSP0000035141699.923299.8463nomascus_leucogenysENSNLEP0000003224199.923299.8463
ENSG00000132466homo_sapiensENSP0000035141699.923299.9232pan_paniscusENSPPAP0000002937499.961699.9616
ENSG00000132466homo_sapiensENSP0000035141699.923299.8079pongo_abeliiENSPPYP0000003137199.923299.8079
ENSG00000132466homo_sapiensENSP0000035141699.961699.9616pan_troglodytesENSPTRP0000002775799.961699.9616
ENSG00000132466homo_sapiensENSP0000035141695.428495.3899gorilla_gorillaENSGGOP0000004358099.519299.4792
ENSG00000132466homo_sapiensENSP0000035141686.169884.0569ornithorhynchus_anatinusENSOANP0000004035591.963989.7089
ENSG00000132466homo_sapiensENSP0000035141691.317789.2432sarcophilus_harrisiiENSSHAP0000002438495.194293.0316
ENSG00000132466homo_sapiensENSP0000035141664.809862.9274notamacropus_eugeniiENSMEUP0000001396068.161666.1818
ENSG00000132466homo_sapiensENSP0000035141678.947478.5248choloepus_hoffmanniENSCHOP0000001199780.085779.6571
ENSG00000132466homo_sapiensENSP0000035141672.608572.3012dasypus_novemcinctusENSDNOP0000001849499.056698.6373
ENSG00000132466homo_sapiensENSP0000035141684.44183.6727erinaceus_europaeusENSEEUP0000000921084.376283.6084
ENSG00000132466homo_sapiensENSP0000035141688.282886.8229echinops_telfairiENSETEP0000000888289.277487.8011
ENSG00000132466homo_sapiensENSP0000035141699.53999.2701callithrix_jacchusENSCJAP0000002611499.53999.2701
ENSG00000132466homo_sapiensENSP0000035141699.846399.6927cercocebus_atysENSCATP0000001398699.846399.6927
ENSG00000132466homo_sapiensENSP0000035141695.274795.0442macaca_fascicularisENSMFAP0000000149199.598499.3574
ENSG00000132466homo_sapiensENSP0000035141699.769599.6158macaca_mulattaENSMMUP0000005801499.769599.6158
ENSG00000132466homo_sapiensENSP0000035141699.807999.6542macaca_nemestrinaENSMNEP0000000964399.807999.6542
ENSG00000132466homo_sapiensENSP0000035141699.846399.6542papio_anubisENSPANP0000002930099.846399.6542
ENSG00000132466homo_sapiensENSP0000035141699.807999.6158mandrillus_leucophaeusENSMLEP0000000953299.807999.6158
ENSG00000132466homo_sapiensENSP0000035141691.356190.7415tursiops_truncatusENSTTRP0000001568392.242191.6214
ENSG00000132466homo_sapiensENSP0000035141697.541396.8114vulpes_vulpesENSVVUP0000003063797.691496.9604
ENSG00000132466homo_sapiensENSP0000035141697.925596.5424mus_spretusMGP_SPRETEiJ_P007166797.963196.5796
ENSG00000132466homo_sapiensENSP0000035141697.310896.965equus_asinusENSEASP0000504344499.177898.8254
ENSG00000132466homo_sapiensENSP0000035141699.001298.617capra_hircusENSCHIP0000001943298.963198.5791
ENSG00000132466homo_sapiensENSP0000035141698.079197.5413loxodonta_africanaENSLAFP0000001773698.381597.842
ENSG00000132466homo_sapiensENSP0000035141694.813794.1222panthera_leoENSPLOP0000000497099.076798.3541
ENSG00000132466homo_sapiensENSP0000035141697.23496.9266ailuropoda_melanoleucaENSAMEP0000002753199.21698.9024
ENSG00000132466homo_sapiensENSP0000035141698.15697.7334bos_indicus_hybridENSBIXP0000504279998.801298.3759
ENSG00000132466homo_sapiensENSP0000035141693.545992.8544oryctolagus_cuniculusENSOCUP0000002601397.673596.9515
ENSG00000132466homo_sapiensENSP0000035141698.117697.8102equus_caballusENSECAP0000008607799.107598.7971
ENSG00000132466homo_sapiensENSP0000035141694.775394.1222canis_lupus_familiarisENSCAFP0084501769099.036598.3541
ENSG00000132466homo_sapiensENSP0000035141698.117697.6565panthera_pardusENSPPRP0000001879298.155397.6941
ENSG00000132466homo_sapiensENSP0000035141694.852194.4679marmota_marmota_marmotaENSMMMP0000002832999.236398.8344
ENSG00000132466homo_sapiensENSP0000035141662.812161.5828balaenoptera_musculusENSBMSP0001001339094.508792.659
ENSG00000132466homo_sapiensENSP0000035141693.776492.3934cavia_porcellusENSCPOP0000001207898.268996.8196
ENSG00000132466homo_sapiensENSP0000035141699.270198.8475felis_catusENSFCAP0000001294199.079898.658
ENSG00000132466homo_sapiensENSP0000035141693.584392.7391ursus_americanusENSUAMP0000002399997.51896.6373
ENSG00000132466homo_sapiensENSP0000035141694.045391.5482monodelphis_domesticaENSMODP0000002390693.86591.3727
ENSG00000132466homo_sapiensENSP0000035141694.275893.8917bison_bison_bisonENSBBBP0000000761795.190194.8022
ENSG00000132466homo_sapiensENSP0000035141698.040797.4645monodon_monocerosENSMMNP0001502705198.570997.9915
ENSG00000132466homo_sapiensENSP0000035141699.039698.6554sus_scrofaENSSSCP0000003319698.209597.8286
ENSG00000132466homo_sapiensENSP0000035141694.467993.6612microcebus_murinusENSMICP0000003739898.478297.6372
ENSG00000132466homo_sapiensENSP0000035141697.502996.4656octodon_degusENSODEP0000000116098.219897.1749
ENSG00000132466homo_sapiensENSP0000035141692.700790.9335jaculus_jaculusENSJJAP0000002202096.5294.68
ENSG00000132466homo_sapiensENSP0000035141694.621694.0069ovis_aries_rambouilletENSOARP0002000315898.598997.9584
ENSG00000132466homo_sapiensENSP0000035141695.274794.8905ursus_maritimusENSUMAP0000000860898.140197.7444
ENSG00000132466homo_sapiensENSP0000035141675.528274.7215ochotona_princepsENSOPRP0000001298882.190681.3127
ENSG00000132466homo_sapiensENSP0000035141694.698494.1222delphinapterus_leucasENSDLEP0000002030498.639598.0392
ENSG00000132466homo_sapiensENSP0000035141698.117697.5029physeter_catodonENSPCTP0000500462898.648198.0301
ENSG00000132466homo_sapiensENSP0000035141697.925596.5809mus_caroliMGP_CAROLIEiJ_P006900796.589695.2634
ENSG00000132466homo_sapiensENSP0000035141697.887196.4656mus_musculusENSMUSP0000001442197.887196.4656
ENSG00000132466homo_sapiensENSP0000035141697.810297.1571dipodomys_ordiiENSDORP0000001048798.07497.4191
ENSG00000132466homo_sapiensENSP0000035141694.813794.1222mustela_putorius_furoENSMPUP0000000922999.076798.3541
ENSG00000132466homo_sapiensENSP0000035141696.96596.7345aotus_nancymaaeENSANAP0000003213199.409299.1729
ENSG00000132466homo_sapiensENSP0000035141698.309698.0407saimiri_boliviensis_boliviensisENSSBOP0000003682899.727299.4544
ENSG00000132466homo_sapiensENSP0000035141682.673882.3281vicugna_pacosENSVPAP0000000122988.052487.6841
ENSG00000132466homo_sapiensENSP0000035141695.159494.9289chlorocebus_sabaeusENSCSAP0000000114299.477999.2369
ENSG00000132466homo_sapiensENSP0000035141667.537567.0764tupaia_belangeriENSTBEP0000000720867.928967.4652
ENSG00000132466homo_sapiensENSP0000035141695.850994.7368mesocricetus_auratusENSMAUP0000002082798.616697.4704
ENSG00000132466homo_sapiensENSP0000035141694.583294.0453phocoena_sinusENSPSNP0000000870199.114398.5507
ENSG00000132466homo_sapiensENSP0000035141694.467994.0069camelus_dromedariusENSCDRP0000502882798.438897.9584
ENSG00000132466homo_sapiensENSP0000035141694.19993.6612carlito_syrichtaENSTSYP0000002528698.355497.7938
ENSG00000132466homo_sapiensENSP0000035141695.389994.9289panthera_tigris_altaicaENSPTIP0000001645995.610395.1482
ENSG00000132466homo_sapiensENSP0000035141698.040796.8114rattus_norvegicusENSRNOP0000008665197.330396.1098
ENSG00000132466homo_sapiensENSP0000035141696.350495.8894prolemur_simusENSPSMP0000001918698.934998.4615
ENSG00000132466homo_sapiensENSP0000035141697.848696.9266microtus_ochrogasterENSMOCP0000002617198.415897.4884
ENSG00000132466homo_sapiensENSP0000035141691.740390.8183sorex_araneusENSSARP0000000058296.484895.5152
ENSG00000132466homo_sapiensENSP0000035141694.391193.3154peromyscus_maniculatus_bairdiiENSPEMP0000001534798.714397.5894
ENSG00000132466homo_sapiensENSP0000035141693.661293.1617bos_mutusENSBMUP0000000201498.664598.1384
ENSG00000132466homo_sapiensENSP0000035141694.045392.5471mus_spicilegusENSMSIP0000002098798.155696.5918
ENSG00000132466homo_sapiensENSP0000035141698.424997.3492cricetulus_griseus_chok1gshdENSCGRP0000101770698.614397.5366
ENSG00000132466homo_sapiensENSP0000035141693.200292.6239pteropus_vampyrusENSPVAP0000000172793.200292.6239
ENSG00000132466homo_sapiensENSP0000035141693.930193.3538myotis_lucifugusENSMLUP0000000465099.068198.4603
ENSG00000132466homo_sapiensENSP0000035141691.048888.6285vombatus_ursinusENSVURP0001001210294.686492.1694
ENSG00000132466homo_sapiensENSP0000035141698.61797.9255rhinolophus_ferrumequinumENSRFEP0001002922398.806898.1139
ENSG00000132466homo_sapiensENSP0000035141691.855691.5098neovison_visonENSNVIP0000002016394.20893.8534
ENSG00000132466homo_sapiensENSP0000035141699.001298.6938bos_taurusENSBTAP0000000646798.546898.2409
ENSG00000132466homo_sapiensENSP0000035141697.041995.9278heterocephalus_glaber_femaleENSHGLP0000002637797.793396.6705
ENSG00000132466homo_sapiensENSP0000035141698.463398.2712rhinopithecus_bietiENSRBIP0000003733099.650199.4557
ENSG00000132466homo_sapiensENSP0000035141698.924398.5401canis_lupus_dingoENSCAFP0002003486598.282497.9008
ENSG00000132466homo_sapiensENSP0000035141698.693898.3481sciurus_vulgarisENSSVLP0000502342999.112798.7654
ENSG00000132466homo_sapiensENSP0000035141691.240988.859phascolarctos_cinereusENSPCIP0000000855595.03892.557
ENSG00000132466homo_sapiensENSP0000035141657.664257.4721procavia_capensisENSPCAP0000000871357.819757.6271
ENSG00000132466homo_sapiensENSP0000035141698.540197.8486nannospalax_galiliENSNGAP0000001077499.07398.3778
ENSG00000132466homo_sapiensENSP0000035141693.622793.3538bos_grunniensENSBGRP0000004152398.743998.4603
ENSG00000132466homo_sapiensENSP0000035141694.045393.1233chinchilla_lanigeraENSCLAP0000000574598.352897.3885
ENSG00000132466homo_sapiensENSP0000035141694.621694.199cervus_hanglu_yarkandensisENSCHYP0000000267298.559498.1192
ENSG00000132466homo_sapiensENSP0000035141694.467993.8532catagonus_wagneriENSCWAP0000002684598.715498.0731
ENSG00000132466homo_sapiensENSP0000035141696.427296.043ictidomys_tridecemlineatusENSSTOP0000000814599.052998.6582
ENSG00000132466homo_sapiensENSP0000035141697.310896.6961otolemur_garnettiiENSOGAP0000000026899.138998.5127
ENSG00000132466homo_sapiensENSP0000035141699.577499.3853cebus_imitatorENSCCAP0000003239599.424699.2328
ENSG00000132466homo_sapiensENSP0000035141694.698494.199urocitellus_parryiiENSUPAP0001001456898.99698.4739
ENSG00000132466homo_sapiensENSP0000035141694.6694.199moschus_moschiferusENSMMSP0000002671898.599498.1192
ENSG00000132466homo_sapiensENSP0000035141699.769599.5774rhinopithecus_roxellanaENSRROP0000000988699.769599.5774
ENSG00000132466homo_sapiensENSP0000035141694.314392.7776mus_pahariMGP_PahariEiJ_P003217397.266295.6815
ENSG00000132466homo_sapiensENSP0000035141689.78188.8974propithecus_coquereliENSPCOP0000001522597.741596.7796
ENSG00000132466homo_sapiensENSP0000035141612.792911.4483ciona_intestinalisENSCINP0000001346883.2574.5
ENSG00000132466homo_sapiensENSP000003514164.610073.76489ciona_intestinalisENSCINP0000003619971.856358.6826
ENSG00000132466homo_sapiensENSP0000035141642.91240.0307petromyzon_marinusENSPMAP0000000203883.296177.7032
ENSG00000132466homo_sapiensENSP0000035141662.197553.8993eptatretus_burgeriENSEBUP0000000313073.758563.918
ENSG00000132466homo_sapiensENSP0000035141679.139573.7995latimeria_chalumnaeENSLACP0000001718086.048580.2423
ENSG00000132466homo_sapiensENSP0000035141689.166383.6727xenopus_tropicalisENSXETP0000008884689.097983.6084
ENSG00000132466homo_sapiensENSP0000035141686.899784.0184chrysemys_picta_belliiENSCPBP0000002769494.093290.9734
ENSG00000132466homo_sapiensENSP0000035141685.555182.6354sphenodon_punctatusENSSPUP0000001107293.88790.683
ENSG00000132466homo_sapiensENSP0000035141690.088487.6297crocodylus_porosusENSCPRP0000500982095.016292.423
ENSG00000132466homo_sapiensENSP0000035141686.707681.7518laticauda_laticaudataENSLLTP0000001794691.265786.0493
ENSG00000132466homo_sapiensENSP0000035141688.666983.9032notechis_scutatusENSNSUP0000002486588.598883.8388
ENSG00000132466homo_sapiensENSP0000035141687.706583.0196pseudonaja_textilisENSPTXP0000002432391.3286.44
ENSG00000132466homo_sapiensENSP0000035141676.142973.8763anas_platyrhynchos_platyrhynchosENSAPLP0000001056594.51691.7024
ENSG00000132466homo_sapiensENSP0000035141693.73891.0872gallus_gallusENSGALP0001000606894.063291.4032
ENSG00000132466homo_sapiensENSP0000035141690.549488.3212meleagris_gallopavoENSMGAP0000001054495.696393.3415
ENSG00000132466homo_sapiensENSP0000035141687.322385.2478serinus_canariaENSSCAP0000000603593.500691.2793
ENSG00000132466homo_sapiensENSP0000035141692.892890.3957parus_majorENSPMJP000000008869390.5
ENSG00000132466homo_sapiensENSP0000035141686.746183.3653anolis_carolinensisENSACAP0000001111190.901887.3591
ENSG00000132466homo_sapiensENSP0000035141684.402679.5236naja_najaENSNNAP0000000521590.897885.6434
ENSG00000132466homo_sapiensENSP0000035141688.666985.4783podarcis_muralisENSPMRP0000003036093.139689.7902
ENSG00000132466homo_sapiensENSP0000035141688.590185.7088geospiza_fortisENSGFOP0000001033993.549790.5071
ENSG00000132466homo_sapiensENSP0000035141690.933588.4748taeniopygia_guttataENSTGUP0000000163595.136792.5643
ENSG00000132466homo_sapiensENSP0000035141687.168683.5958salvator_merianaeENSSMRP0000002271191.418287.6712
ENSG00000132466homo_sapiensENSP0000035141691.010488.2828pelodiscus_sinensisENSPSIP0000001198394.949992.1042
ENSG00000132466homo_sapiensENSP0000035141690.933588.4748gopherus_evgoodeiENSGEVP0000500731094.755892.1938
ENSG00000132466homo_sapiensENSP0000035141691.548289.32struthio_camelus_australisENSSCUP0000002354795.472893.149
ENSG00000132466homo_sapiensENSP0000035141693.584391.1256anser_brachyrhynchusENSABRP0000000802894.308991.8312
ENSG00000132466homo_sapiensENSP0000035141690.395787.5912strigops_habroptilaENSSHBP0000501913792.930590.0474
ENSG00000132466homo_sapiensENSP0000035141691.240988.5901terrapene_carolina_triunguisENSTMTP0000000838595.114192.3508
ENSG00000132466homo_sapiensENSP0000035141640.184435.4207ciona_savignyiENSCSAVP0000000613577.424168.2457
ENSG00000132466homo_sapiensENSP0000035141691.548289.32aquila_chrysaetos_chrysaetosENSACCP0002000044995.779793.4486
ENSG00000132466homo_sapiensENSP0000035141686.861384.0569ficedula_albicollisENSFALP0000001639893.545790.5254
ENSG00000132466homo_sapiensENSP0000035141691.279388.8974coturnix_japonicaENSCJPP0000500160795.4692.9691
ENSG00000132466homo_sapiensENSP0000035141688.244382.7891leptobrachium_leishanenseENSLLEP0000000057288.380182.9165

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000785part_of chromatin1IDAHomo_sapiens(9606)Component
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0001955involved_in blood vessel maturation1IEAHomo_sapiens(9606)Process
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0006275involved_in regulation of DNA replication1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0031965located_in nuclear membrane1IDAHomo_sapiens(9606)Component
GO:0042742involved_in defense response to bacterium1IDAHomo_sapiens(9606)Process
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response2IBA,IDAHomo_sapiens(9606)Process
GO:0045787involved_in positive regulation of cell cycle1IMPHomo_sapiens(9606)Process
GO:0051151involved_in negative regulation of smooth muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:1900087involved_in positive regulation of G1/S transition of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:1900245involved_in positive regulation of MDA-5 signaling pathway1IDAHomo_sapiens(9606)Process
GO:1900246involved_in positive regulation of RIG-I signaling pathway1IDAHomo_sapiens(9606)Process

Expression