Functions and Diseases

RBP Type Canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000132376 Gene ID 51763 Accession 33882
Symbol INPP5K Alias PPS;SKIP;MDCCAID Full Name inositol polyphosphate-5-phosphatase K
Status Confidence Length 22166 bases Strand Minus strand
Position 17 : 1494577 - 1516742 RNA binding domain Exo_endo_phos
Summary This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000413937 Exo_endo_phos PF03372 1.4e-07 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
INPP5K-204 ENST00000421807 2706 448aa ENSP00000413937
INPP5K-203 ENST00000406424 3194 372aa ENSP00000385177
INPP5K-201 ENST00000320345 2880 372aa ENSP00000318476
INPP5K-202 ENST00000350761 1505 63aa ENSP00000254712
INPP5K-212 ENST00000487039 482 No protein -
INPP5K-217 ENST00000574561 591 154aa ENSP00000461105
INPP5K-208 ENST00000461552 581 No protein -
INPP5K-213 ENST00000495339 406 No protein -
INPP5K-206 ENST00000449479 949 229aa ENSP00000413259
INPP5K-211 ENST00000481867 558 No protein -
INPP5K-209 ENST00000477115 770 No protein -
INPP5K-219 ENST00000575172 594 158aa ENSP00000459758
INPP5K-220 ENST00000576646 629 38aa ENSP00000466632
INPP5K-216 ENST00000573790 635 99aa ENSP00000461846
INPP5K-207 ENST00000460733 554 No protein -
INPP5K-215 ENST00000571274 571 84aa ENSP00000458413
INPP5K-205 ENST00000445774 565 52aa ENSP00000389334
INPP5K-210 ENST00000477910 739 50aa ENSP00000467376
INPP5K-214 ENST00000498390 622 23aa ENSP00000466929
INPP5K-218 ENST00000574955 566 51aa ENSP00000459029

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001701involved_in in utero embryonic development1IEAHomo_sapiens(9606)Process
GO:0001726is_active_in ruffle2IBA,IDAHomo_sapiens(9606)Component
GO:0001933involved_in negative regulation of protein phosphorylation1ISSHomo_sapiens(9606)Process
GO:0004439enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity2IBA,IMPHomo_sapiens(9606)Function
GO:0004445enables inositol-polyphosphate 5-phosphatase activity1IEAHomo_sapiens(9606)Function
GO:0005000enables vasopressin receptor activity1ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,ISSHomo_sapiens(9606)Component
GO:0005783is_active_in endoplasmic reticulum2IBA,IDAHomo_sapiens(9606)Component
GO:0005802located_in trans-Golgi network1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0005979involved_in regulation of glycogen biosynthetic process1ISSHomo_sapiens(9606)Process
GO:0006469involved_in negative regulation of protein kinase activity1IDAHomo_sapiens(9606)Process
GO:0006661involved_in phosphatidylinositol biosynthetic process1TASHomo_sapiens(9606)Process
GO:0007186involved_in G protein-coupled receptor signaling pathway1ISSHomo_sapiens(9606)Process
GO:0010801involved_in negative regulation of peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0010829involved_in negative regulation of glucose transmembrane transport1IDAHomo_sapiens(9606)Process
GO:0016020located_in membrane2HDA,IDAHomo_sapiens(9606)Component
GO:0016311involved_in dephosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0016312enables inositol bisphosphate phosphatase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0030036involved_in actin cytoskeleton organization1NASHomo_sapiens(9606)Process
GO:0032587located_in ruffle membrane1IDAHomo_sapiens(9606)Component
GO:0032869involved_in cellular response to insulin stimulus1IDAHomo_sapiens(9606)Process
GO:0032870involved_in cellular response to hormone stimulus1ISSHomo_sapiens(9606)Process
GO:0033137involved_in negative regulation of peptidyl-serine phosphorylation2IBA,IDAHomo_sapiens(9606)Process
GO:0034485enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0034594enables phosphatidylinositol trisphosphate phosphatase activity1IDAHomo_sapiens(9606)Function
GO:0034595enables phosphatidylinositol phosphate 5-phosphatase activity1IMPHomo_sapiens(9606)Function
GO:0035305involved_in negative regulation of dephosphorylation1ISSHomo_sapiens(9606)Process
GO:0035810involved_in positive regulation of urine volume1ISSHomo_sapiens(9606)Process
GO:0042577enables lipid phosphatase activity1NASHomo_sapiens(9606)Function
GO:0042593involved_in glucose homeostasis1ISSHomo_sapiens(9606)Process
GO:0043005located_in neuron projection1IDAHomo_sapiens(9606)Component
GO:0043407involved_in negative regulation of MAP kinase activity1IDAHomo_sapiens(9606)Process
GO:0043922involved_in negative regulation by host of viral transcription1IDAHomo_sapiens(9606)Process
GO:0045719involved_in negative regulation of glycogen biosynthetic process2IBA,IDAHomo_sapiens(9606)Process
GO:0045869involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate1IDAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1ISSHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1ISSHomo_sapiens(9606)Process
GO:0046030enables inositol trisphosphate phosphatase activity1IDAHomo_sapiens(9606)Function
GO:0046627involved_in negative regulation of insulin receptor signaling pathway2IBA,IDAHomo_sapiens(9606)Process
GO:0046856involved_in phosphatidylinositol dephosphorylation3IBA,IDAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0051497involved_in negative regulation of stress fiber assembly1IDAHomo_sapiens(9606)Process
GO:0051898involved_in negative regulation of protein kinase B signaling2IBA,IDAHomo_sapiens(9606)Process
GO:0051926involved_in negative regulation of calcium ion transport1IDAHomo_sapiens(9606)Process
GO:0052658enables inositol-1,4,5-trisphosphate 5-phosphatase activity1IEAHomo_sapiens(9606)Function
GO:0052659enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity1IEAHomo_sapiens(9606)Function
GO:0071320involved_in cellular response to cAMP1ISSHomo_sapiens(9606)Process
GO:0071356involved_in cellular response to tumor necrosis factor1IDAHomo_sapiens(9606)Process
GO:0071364involved_in cellular response to epidermal growth factor stimulus1IDAHomo_sapiens(9606)Process
GO:0072659involved_in protein localization to plasma membrane1ISSHomo_sapiens(9606)Process
GO:0090315involved_in negative regulation of protein targeting to membrane1IDAHomo_sapiens(9606)Process
GO:0097178involved_in ruffle assembly1IDAHomo_sapiens(9606)Process
GO:2000466involved_in negative regulation of glycogen (starch) synthase activity1ISSHomo_sapiens(9606)Process
GO:2001153involved_in positive regulation of renal water transport1ISSHomo_sapiens(9606)Process

Expression