RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	rRNA
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000132275	Gene ID	23378	Accession	29030
Symbol	RRP8	Alias	NML;KIAA0409	Full Name	ribosomal RNA processing 8
Status	Confidence	Length	8545 bases	Strand	Minus strand
Position	11 : 6595072 - 6603616	RNA binding domain	Methyltransf_8
Summary	Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000254605	Methyltransf_8	PF05148	5.9e-106	1
ENSP00000436246	Methyltransf_8	PF05148	6.5e-30	1
ENSP00000436960	Methyltransf_8	PF05148	2.9e-47	1

Showing 1 to 3 of 3 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

Showing 1 to 10 of 24 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
25594003	SirT1 and rRNA in the nucleolus: regulating the regulator.	Leixiang Yang	2014-01-01	Oncoscience
29385568	rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans.	Wataru Yokoyama	2018-06-01	Journal of biochemistry

Showing 1 to 2 of 2 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
RRP8-201	ENST00000254605	6559	456aa	ENSP00000254605
RRP8-202	ENST00000526352	1126	No protein	-
RRP8-203	ENST00000530762	956	78aa	ENSP00000435873
RRP8-204	ENST00000533907	1989	306aa	ENSP00000436246
RRP8-205	ENST00000534343	726	140aa	ENSP00000436960

Showing 1 to 5 of 5 entries

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Gene Model

Click here to download ENSG00000132275's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000132275's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000132275	homo_sapiens	ENSP00000254605	95.8333	94.5175	nomascus_leucogenys	ENSNLEP00000021169	97.7629	96.4206
ENSG00000132275	homo_sapiens	ENSP00000254605	99.3421	99.3421	pan_paniscus	ENSPPAP00000036049	99.3421	99.3421
ENSG00000132275	homo_sapiens	ENSP00000254605	99.3421	98.4649	pongo_abelii	ENSPPYP00000004057	99.3421	98.4649
ENSG00000132275	homo_sapiens	ENSP00000254605	99.3421	99.1228	pan_troglodytes	ENSPTRP00000005772	99.3421	99.1228
ENSG00000132275	homo_sapiens	ENSP00000254605	99.7807	99.3421	gorilla_gorilla	ENSGGOP00000000382	99.7807	99.3421
ENSG00000132275	homo_sapiens	ENSP00000254605	64.9123	54.386	ornithorhynchus_anatinus	ENSOANP00000051027	60.5317	50.7157
ENSG00000132275	homo_sapiens	ENSP00000254605	64.693	52.8509	sarcophilus_harrisii	ENSSHAP00000010755	69.74	56.974
ENSG00000132275	homo_sapiens	ENSP00000254605	45.1754	39.4737	notamacropus_eugenii	ENSMEUP00000004524	78.0303	68.1818
ENSG00000132275	homo_sapiens	ENSP00000254605	87.5	82.6754	dasypus_novemcinctus	ENSDNOP00000000612	79.4821	75.0996
ENSG00000132275	homo_sapiens	ENSP00000254605	84.4298	78.9474	echinops_telfairi	ENSETEP00000007216	84.989	79.4702

Showing 1 to 10 of 195 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000183	involved_in rDNA heterochromatin formation	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005677	part_of chromatin silencing complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0033553	part_of rDNA heterochromatin	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0035064	enables methylated histone binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0042149	involved_in cellular response to glucose starvation	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0046015	involved_in regulation of transcription by glucose	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function

Showing 1 to 10 of 23 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression