RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000132274	Gene ID	10346	Accession	16379
Symbol	TRIM22	Alias	RNF94;STAF50;GPSTAF50	Full Name	tripartite motif containing 22
Status	Confidence	Length	47393 bases	Strand	Plus strand
Position	11 : 5689697 - 5737089	RNA binding domain	SPRY
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000514104	SPRY	PF00622	1.1e-07	1
ENSP00000393250	SPRY	PF00622	1.6e-07	1
ENSP00000369299	SPRY	PF00622	1.8e-07	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
19624813	Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells.	Michael Gurevich	2009-07-22	BMC medical genomics

Name	Transcript ID	bp	Protein	Translation ID
TRIM22-209	ENST00000460454	4528	No protein	-
TRIM22-212	ENST00000699052	2708	No protein	-
TRIM22-204	ENST00000425490	812	203aa	ENSP00000400417
TRIM22-213	ENST00000699053	2062	277aa	ENSP00000514103
TRIM22-214	ENST00000699054	4185	No protein	-
TRIM22-210	ENST00000480395	3750	No protein	-
TRIM22-201	ENST00000379965	2888	498aa	ENSP00000369299
TRIM22-215	ENST00000699055	3355	No protein	-
TRIM22-216	ENST00000699056	5084	No protein	-
TRIM22-208	ENST00000454828	2684	466aa	ENSP00000393250
TRIM22-202	ENST00000414641	897	227aa	ENSP00000396849
TRIM22-217	ENST00000699057	1699	387aa	ENSP00000514104
TRIM22-203	ENST00000414897	655	143aa	ENSP00000388994
TRIM22-218	ENST00000699058	5395	No protein	-
TRIM22-211	ENST00000493494	460	No protein	-
TRIM22-207	ENST00000450670	508	63aa	ENSP00000406412
TRIM22-205	ENST00000429063	1241	37aa	ENSP00000409991
TRIM22-206	ENST00000444844	1244	38aa	ENSP00000404204

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
26830	Blood Pressure	9.3910000E-005	-
41772	Platelet Function Tests	1.1102600E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000209	involved_in protein polyubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0002230	involved_in positive regulation of defense response to virus by host	1	IDA	Homo_sapiens(9606)	Process
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0003714	enables transcription corepressor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	is_active_in nucleoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0006355	involved_in regulation of DNA-templated transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0006955	involved_in immune response	1	TAS	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0009615	involved_in response to virus	1	TAS	Homo_sapiens(9606)	Process
GO:0010508	involved_in positive regulation of autophagy	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0015030	located_in Cajal body	1	IEA	Homo_sapiens(9606)	Component
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component
GO:0016607	located_in nuclear speck	1	IEA	Homo_sapiens(9606)	Component
GO:0019901	enables protein kinase binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0030674	enables protein-macromolecule adaptor activity	1	IPI	Homo_sapiens(9606)	Function
GO:0032880	involved_in regulation of protein localization	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IBA	Homo_sapiens(9606)	Function
GO:0043123	involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0045087	involved_in innate immune response	1	IBA	Homo_sapiens(9606)	Process
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0046596	involved_in regulation of viral entry into host cell	1	IBA	Homo_sapiens(9606)	Process
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IDA	Homo_sapiens(9606)	Process
GO:0051092	involved_in positive regulation of NF-kappaB transcription factor activity	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0051607	involved_in defense response to virus	1	IEA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0070534	involved_in protein K63-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process