RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	snRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000131876	Gene ID	6627	Accession	11152
Symbol	SNRPA1	Alias	Lea1;U2A'	Full Name	small nuclear ribonucleoprotein polypeptide A'
Status	Confidence	Length	13739 bases	Strand	Minus strand
Position	15 : 101281510 - 101295248	RNA binding domain	N.A.
Summary	Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
No data available in table

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_MCF7	MCF7	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30799147	cRIC_PMID30799147._Hs_HEK293	HEK293	Manuel Garcia-Moreno	2019 Apr 4	doi: 10.1016/j.molcel.2019.01.017.?Epub 2019 Feb 21
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

Showing 1 to 9 of 9 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
33460399	Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer.	Penghui Yuan	2021-01-15	Aging
33986153	A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.	Lisa Fish	2021-05-14	Science (New York, N.Y.)
37277111	High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.	Juan Juan Yang	2023-08-01	The clinical respiratory journal

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
SNRPA1-201	ENST00000254193	1052	255aa	ENSP00000254193
SNRPA1-202	ENST00000394082	556	No protein	-
SNRPA1-203	ENST00000540017	506	No protein	-
SNRPA1-204	ENST00000558020	466	No protein	-
SNRPA1-205	ENST00000558036	2108	No protein	-
SNRPA1-206	ENST00000558059	678	No protein	-
SNRPA1-207	ENST00000559309	924	154aa	ENSP00000452836
SNRPA1-208	ENST00000559686	625	142aa	ENSP00000453521
SNRPA1-209	ENST00000560307	433	No protein	-
SNRPA1-210	ENST00000560383	565	No protein	-

Showing 1 to 10 of 15 entries

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Gene Model

Click here to download ENSG00000131876's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000131876	rs56377826	15	101287286	Lung cancer	28604730	1.0730215	EFO_0001071

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Protein-Protein Interaction (PPI)

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Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000131876	homo_sapiens	ENSP00000384971	28.9199	18.4669	homo_sapiens	ENSP00000254193	32.549	20.7843
ENSG00000131876	homo_sapiens	ENSP00000480240	44.6903	26.9911	homo_sapiens	ENSP00000254193	39.6078	23.9216

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000131876	homo_sapiens	ENSP00000254193	100	100	nomascus_leucogenys	ENSNLEP00000000576	100	100
ENSG00000131876	homo_sapiens	ENSP00000254193	100	100	pan_paniscus	ENSPPAP00000017914	100	100
ENSG00000131876	homo_sapiens	ENSP00000254193	100	100	pongo_abelii	ENSPPYP00000007744	100	100
ENSG00000131876	homo_sapiens	ENSP00000254193	100	100	pan_troglodytes	ENSPTRP00000041754	100	100
ENSG00000131876	homo_sapiens	ENSP00000254193	100	100	gorilla_gorilla	ENSGGOP00000021155	100	100
ENSG00000131876	homo_sapiens	ENSP00000254193	98.4314	95.6863	ornithorhynchus_anatinus	ENSOANP00000018632	98.4314	95.6863
ENSG00000131876	homo_sapiens	ENSP00000254193	92.1569	87.8431	sarcophilus_harrisii	ENSSHAP00000026557	82.4561	78.5965
ENSG00000131876	homo_sapiens	ENSP00000254193	97.2549	94.902	notamacropus_eugenii	ENSMEUP00000011830	98.8048	96.4143
ENSG00000131876	homo_sapiens	ENSP00000254193	88.6274	87.8431	choloepus_hoffmanni	ENSCHOP00000005628	99.5595	98.6784
ENSG00000131876	homo_sapiens	ENSP00000254193	99.2157	99.2157	dasypus_novemcinctus	ENSDNOP00000031080	99.2157	99.2157

Showing 1 to 10 of 231 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000398	involved_in mRNA splicing, via spliceosome	4	IBA,IC,IDA,NAS	Homo_sapiens(9606)	Process
GO:0005634	located_in nucleus	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005681	part_of spliceosomal complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005686	part_of U2 snRNP	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0007283	involved_in spermatogenesis	1	IGI	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	TAS	Homo_sapiens(9606)	Process
GO:0016604	located_in nuclear body	1	IDA	Homo_sapiens(9606)	Component

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression