RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000130921	Gene ID	91574	Accession	26784
Symbol	MTRFR	Alias	SPG55;COXPD7;mtRF-R;C12orf65	Full Name	mitochondrial translation release factor in rescue
Status	Confidence	Length	24695 bases	Strand	Plus strand
Position	12 : 123233385 - 123258079	RNA binding domain	RF-1
Summary	This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]