Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000130175 Gene ID 5589 Accession 9411
Symbol PRKCSH Alias GIIB;PCLD;PLD1;80K-H;G19P1;PCLD1;PKCSH;AGE-R2;GIIbeta;VASAP-60;GluIIbeta Full Name protein kinase C substrate 80K-H
Status Confidence Length 15685 bases Strand Plus strand
Position 19 : 11435284 - 11450968 RNA binding domain N.A.
Summary This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PRKCSH-221 ENST00000676823 814 171aa ENSP00000503072
PRKCSH-214 ENST00000591946 569 62aa ENSP00000464835
PRKCSH-208 ENST00000589126 625 168aa ENSP00000467566
PRKCSH-207 ENST00000588269 557 132aa ENSP00000465889
PRKCSH-206 ENST00000587509 545 140aa ENSP00000465821
PRKCSH-220 ENST00000593104 545 No protein -
PRKCSH-218 ENST00000593053 588 No protein -
PRKCSH-212 ENST00000591462 2063 525aa ENSP00000465489
PRKCSH-217 ENST00000592741 2100 535aa ENSP00000466134
PRKCSH-222 ENST00000677123 2096 535aa ENSP00000503163
PRKCSH-219 ENST00000593101 578 144aa ENSP00000465047
PRKCSH-205 ENST00000587327 2189 525aa ENSP00000466012
PRKCSH-209 ENST00000589838 1898 528aa ENSP00000465461
PRKCSH-210 ENST00000589990 567 No protein -
PRKCSH-201 ENST00000585325 598 No protein -
PRKCSH-216 ENST00000592445 598 No protein -
PRKCSH-202 ENST00000585540 501 No protein -
PRKCSH-203 ENST00000586486 1613 200aa ENSP00000465948
PRKCSH-204 ENST00000587290 780 No protein -
PRKCSH-211 ENST00000590098 795 No protein -
PRKCSH-215 ENST00000592435 358 No protein -
PRKCSH-213 ENST00000591510 591 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001889involved_in liver development1IBAHomo_sapiens(9606)Process
GO:0005080enables protein kinase C binding1IPIHomo_sapiens(9606)Function
GO:0005509enables calcium ion binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005783located_in endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005788located_in endoplasmic reticulum lumen2NAS,TASHomo_sapiens(9606)Component
GO:0006491involved_in N-glycan processing2IBA,IDAHomo_sapiens(9606)Process
GO:0017177part_of glucosidase II complex3IBA,IDA,IPIHomo_sapiens(9606)Component
GO:0035556involved_in intracellular signal transduction1NASHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1IMPHomo_sapiens(9606)Component
GO:0044325enables transmembrane transporter binding1IPIHomo_sapiens(9606)Function
GO:0051219enables phosphoprotein binding1IPIHomo_sapiens(9606)Function

Expression