Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs rRNA
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000129824 Gene ID 6192 Accession 10425
Symbol RPS4Y1 Alias S4;RPS4Y Full Name ribosomal protein S4 Y-linked 1
Status Confidence Length 25667 bases Strand Plus strand
Position Y : 2841602 - 2867268 RNA binding domain Ribosomal_S4e , KOW , RS4NT
Summary Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000415317 KOW PF00467 0.00013 1
ENSP00000415317 RS4NT PF08071 2.2e-20 2
ENSP00000415317 Ribosomal_S4e PF00900 2.3e-35 3
ENSP00000250784 KOW PF00467 0.00013 1
ENSP00000250784 RS4NT PF08071 2.1e-20 2
ENSP00000250784 Ribosomal_S4e PF00900 1.8e-35 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31448102 Sex differences in gene expression patterns associated with the APOE4 allele. Michelle Hsu 2019-01-01 F1000Research
34594098 Biomarkers of Blood from Patients with Atherosclerosis Based on Bioinformatics Analysis. Yongjiang Qian 2021-01-01 Evolutionary bioinformatics online

Transcripts

Name Transcript ID bp Protein Translation ID
RPS4Y1-201 ENST00000250784 1189 263aa ENSP00000250784
RPS4Y1-202 ENST00000430575 811 262aa ENSP00000415317
RPS4Y1-203 ENST00000477725 998 No protein -
RPS4Y1-204 ENST00000515575 454 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129824homo_sapiensENSP0000048625297.338493.9164homo_sapiensENSP0000025078497.338493.9164
ENSG00000129824homo_sapiensENSP0000036274496.577992.7757homo_sapiensENSP0000025078496.577992.7757

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129824homo_sapiensENSP0000025078499.619899.6198pan_troglodytesENSPTRP0000003874899.619899.6198
ENSG00000129824homo_sapiensENSP0000025078495.817593.1559ornithorhynchus_anatinusENSOANP0000000468495.817593.1559
ENSG00000129824homo_sapiensENSP0000025078496.197793.1559sarcophilus_harrisiiENSSHAP0000000648896.197793.1559
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361sarcophilus_harrisiiENSSHAP0000000932796.197793.5361
ENSG00000129824homo_sapiensENSP0000025078494.676889.7338sarcophilus_harrisiiENSSHAP0000000713593.962389.0566
ENSG00000129824homo_sapiensENSP0000025078493.155987.4525notamacropus_eugeniiENSMEUP0000000727393.869788.1226
ENSG00000129824homo_sapiensENSP0000025078496.577990.1141callithrix_jacchusENSCJAP0000008159396.577990.1141
ENSG00000129824homo_sapiensENSP0000025078410096.5779macaca_fascicularisENSMFAP0000004683010096.5779
ENSG00000129824homo_sapiensENSP0000025078410096.5779macaca_mulattaENSMMUP0000004254510096.5779
ENSG00000129824homo_sapiensENSP0000025078491.254886.692papio_anubisENSPANP0000004969590.56686.0377
ENSG00000129824homo_sapiensENSP0000025078444.486743.346ailuropoda_melanoleucaENSAMEP0000004127495.121992.6829
ENSG00000129824homo_sapiensENSP0000025078444.866943.7262ailuropoda_melanoleucaENSAMEP0000002272895.93593.4959
ENSG00000129824homo_sapiensENSP0000025078493.916489.7338monodelphis_domesticaENSMODP0000001386193.560689.3939
ENSG00000129824homo_sapiensENSP0000025078495.817593.1559monodelphis_domesticaENSMODP0000003365695.817593.1559
ENSG00000129824homo_sapiensENSP0000025078496.197793.1559monodelphis_domesticaENSMODP0000003524696.197793.1559
ENSG00000129824homo_sapiensENSP0000025078410096.5779chlorocebus_sabaeusENSCSAP0000001433410096.5779
ENSG00000129824homo_sapiensENSP0000025078493.155988.5932prolemur_simusENSPSMP0000001075693.511588.9313
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361vombatus_ursinusENSVURP0001002885296.197793.5361
ENSG00000129824homo_sapiensENSP0000025078493.916490.4943vombatus_ursinusENSVURP0001000335193.916490.4943
ENSG00000129824homo_sapiensENSP0000025078495.817593.5361vombatus_ursinusENSVURP0001002358395.817593.5361
ENSG00000129824homo_sapiensENSP0000025078499.239597.3384rhinopithecus_bietiENSRBIP0000001862597.388195.5224
ENSG00000129824homo_sapiensENSP0000025078490.114187.8327phascolarctos_cinereusENSPCIP0000002541193.675991.3043
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361phascolarctos_cinereusENSPCIP0000001288096.197793.5361
ENSG00000129824homo_sapiensENSP0000025078495.817593.5361phascolarctos_cinereusENSPCIP0000003501372.832471.0983
ENSG00000129824homo_sapiensENSP0000025078496.958291.635cebus_imitatorENSCCAP0000002459496.958291.635
ENSG00000129824homo_sapiensENSP0000025078499.619897.7186rhinopithecus_roxellanaENSRROP0000000709699.619897.7186
ENSG00000129824homo_sapiensENSP0000025078476.806161.597caenorhabditis_elegansY43B11AR.4.177.992362.5483
ENSG00000129824homo_sapiensENSP0000025078486.69273.0038drosophila_melanogasterFBpp031208087.356373.5632
ENSG00000129824homo_sapiensENSP0000025078434.600831.1787ciona_intestinalisENSCINP0000001555089.215780.3922
ENSG00000129824homo_sapiensENSP0000025078427.376422.0532ciona_intestinalisENSCINP000000155619072.5
ENSG00000129824homo_sapiensENSP0000025078493.155987.4525petromyzon_marinusENSPMAP0000000812593.155987.4525
ENSG00000129824homo_sapiensENSP0000025078444.486738.403petromyzon_marinusENSPMAP0000000862175.483965.1613
ENSG00000129824homo_sapiensENSP0000025078490.874582.1293eptatretus_burgeriENSEBUP0000000895065.659359.3407
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943callorhinchus_miliiENSCMIP0000000633393.962389.8113
ENSG00000129824homo_sapiensENSP0000025078496.197793.1559latimeria_chalumnaeENSLACP0000000336296.197793.1559
ENSG00000129824homo_sapiensENSP0000025078493.536189.3536lepisosteus_oculatusENSLOCP0000001777993.893189.6947
ENSG00000129824homo_sapiensENSP0000025078493.916487.4525clupea_harengusENSCHAP0000005902093.916487.4525
ENSG00000129824homo_sapiensENSP0000025078494.676887.8327danio_rerioENSDARP0000010808994.676887.8327
ENSG00000129824homo_sapiensENSP0000025078494.296687.8327carassius_auratusENSCARP0000002222294.296687.8327
ENSG00000129824homo_sapiensENSP0000025078494.296688.2129carassius_auratusENSCARP0000001410485.223479.7251
ENSG00000129824homo_sapiensENSP0000025078483.650277.9468carassius_auratusENSCARP0000003853589.430983.3333
ENSG00000129824homo_sapiensENSP0000025078492.775786.3118astyanax_mexicanusENSAMXP0000001365392.775786.3118
ENSG00000129824homo_sapiensENSP0000025078493.916488.2129ictalurus_punctatusENSIPUP0000000121893.560687.8788
ENSG00000129824homo_sapiensENSP0000025078491.254885.5513esox_luciusENSELUP0000001359890.909185.2273
ENSG00000129824homo_sapiensENSP0000025078494.296688.9734electrophorus_electricusENSEEEP0000002179694.296688.9734
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316oncorhynchus_kisutchENSOKIP0000507150692.015285.9316
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316oncorhynchus_kisutchENSOKIP0000510422292.015285.9316
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316oncorhynchus_mykissENSOMYP0000007866792.015285.9316
ENSG00000129824homo_sapiensENSP0000025078490.114184.0304oncorhynchus_mykissENSOMYP0000007866089.772783.7121
ENSG00000129824homo_sapiensENSP0000025078484.790978.327salmo_salarENSSSAP0000003750983.834677.4436
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316salmo_salarENSSSAP0000008155986.738381.0036
ENSG00000129824homo_sapiensENSP0000025078492.395486.692salmo_truttaENSSTUP0000007349792.395486.692
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316salmo_truttaENSSTUP0000009577392.015285.9316
ENSG00000129824homo_sapiensENSP0000025078494.296687.4525gadus_morhuaENSGMOP0000002043080.781874.9186
ENSG00000129824homo_sapiensENSP0000025078494.296688.9734fundulus_heteroclitusENSFHEP0000001779293.939488.6364
ENSG00000129824homo_sapiensENSP0000025078493.916489.7338poecilia_reticulataENSPREP0000000851093.916489.7338
ENSG00000129824homo_sapiensENSP0000025078493.916489.3536xiphophorus_maculatusENSXMAP0000001487093.916489.3536
ENSG00000129824homo_sapiensENSP0000025078494.676890.8745oryzias_latipesENSORLP0000001201594.676890.8745
ENSG00000129824homo_sapiensENSP0000025078493.916488.2129cyclopterus_lumpusENSCLMP0000502007293.916488.2129
ENSG00000129824homo_sapiensENSP0000025078493.536188.9734oreochromis_niloticusENSONIP0000007815182.550378.5235
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141haplochromis_burtoniENSHBUP0000002839094.676890.1141
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141astatotilapia_callipteraENSACLP0000002804494.676890.1141
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943sparus_aurataENSSAUP0001002549394.676890.4943
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141lates_calcariferENSLCAP0001005209694.676890.1141
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361xenopus_tropicalisENSXETP0000005675596.197793.5361
ENSG00000129824homo_sapiensENSP0000025078495.817593.1559chrysemys_picta_belliiENSCPBP0000001092392.647190.0735
ENSG00000129824homo_sapiensENSP0000025078496.577993.9164anas_platyrhynchos_platyrhynchosENSAPLP0000000646478.395176.2346
ENSG00000129824homo_sapiensENSP0000025078496.577993.9164gallus_gallusENSGALP0001002264674.26972.2222
ENSG00000129824homo_sapiensENSP0000025078485.551383.6502meleagris_gallopavoENSMGAP0000003190596.566594.4206
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361meleagris_gallopavoENSMGAP0000000999793.357990.7749
ENSG00000129824homo_sapiensENSP0000025078491.63586.692parus_majorENSPMJP0000001624880.066475.7475
ENSG00000129824homo_sapiensENSP0000025078481.74976.4259neolamprologus_brichardiENSNBRP0000001526787.755182.0408
ENSG00000129824homo_sapiensENSP0000025078494.296690.8745erpetoichthys_calabaricusENSECRP0000001431593.939490.5303
ENSG00000129824homo_sapiensENSP0000025078430.798527.7567kryptolebias_marmoratusENSKMAP000000200307567.5926
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943oryzias_javanicusENSOJAP0000003390494.676890.4943
ENSG00000129824homo_sapiensENSP0000025078493.916488.9734amphilophus_citrinellusENSACIP0000001638093.916488.9734
ENSG00000129824homo_sapiensENSP0000025078493.916488.9734dicentrarchus_labraxENSDLAP0000508203476.708172.6708
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141amphiprion_perculaENSAPEP0000002074394.676890.1141
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943oryzias_sinensisENSOSIP0000003380494.676890.4943
ENSG00000129824homo_sapiensENSP0000025078489.353686.692pelodiscus_sinensisENSPSIP0000000441795.918493.0612
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361gopherus_evgoodeiENSGEVP0000501540196.197793.5361
ENSG00000129824homo_sapiensENSP0000025078489.353686.692chelonoidis_abingdoniiENSCABP0000001860195.918493.0612
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141seriola_dumeriliENSSDUP0000002048694.676890.1141
ENSG00000129824homo_sapiensENSP0000025078486.69284.0304struthio_camelus_australisENSSCUP0000002243093.061290.2041
ENSG00000129824homo_sapiensENSP0000025078487.832785.1711anser_brachyrhynchusENSABRP0000000309092.771189.9598
ENSG00000129824homo_sapiensENSP0000025078493.536188.9734gasterosteus_aculeatusENSGACP0000002477593.893189.313
ENSG00000129824homo_sapiensENSP0000025078494.296689.3536cynoglossus_semilaevisENSCSEP0000000092994.296689.3536
ENSG00000129824homo_sapiensENSP0000025078493.916489.3536poecilia_formosaENSPFOP0000000694793.916489.3536
ENSG00000129824homo_sapiensENSP0000025078493.916489.7338myripristis_murdjanENSMMDP0000502469293.916489.7338
ENSG00000129824homo_sapiensENSP0000025078494.676888.2129sander_luciopercaENSSLUP0000000329694.676888.2129
ENSG00000129824homo_sapiensENSP0000025078495.817593.5361strigops_habroptilaENSSHBP0000500833986.006883.959
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141amphiprion_ocellarisENSAOCP0000002919494.676890.1141
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361terrapene_carolina_triunguisENSTMTP0000000605896.197793.5361
ENSG00000129824homo_sapiensENSP0000025078490.874585.1711hucho_huchoENSHHUP0000003999390.188784.5283
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316hucho_huchoENSHHUP0000000953392.015285.9316
ENSG00000129824homo_sapiensENSP0000025078493.536187.8327betta_splendensENSBSLP0000002967493.536187.8327
ENSG00000129824homo_sapiensENSP0000025078493.536186.692pygocentrus_nattereriENSPNAP0000002540589.454582.9091
ENSG00000129824homo_sapiensENSP0000025078495.437389.3536anabas_testudineusENSATEP0000002025395.437389.3536
ENSG00000129824homo_sapiensENSP0000025078486.311873.384ciona_savignyiENSCSAVP0000000886287.644874.5174
ENSG00000129824homo_sapiensENSP0000025078482.889769.5817saccharomyces_cerevisiaeYJR145C83.524970.1149
ENSG00000129824homo_sapiensENSP0000025078482.889769.5817saccharomyces_cerevisiaeYHR203C83.524970.1149
ENSG00000129824homo_sapiensENSP0000025078489.353685.5513seriola_lalandi_dorsalisENSSLDP000000041299490
ENSG00000129824homo_sapiensENSP0000025078494.676888.9734labrus_bergyltaENSLBEP0000000224894.676888.9734
ENSG00000129824homo_sapiensENSP0000025078475.665470.3422labrus_bergyltaENSLBEP0000002200293.427286.8545
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141pundamilia_nyerereiENSPNYP0000002312894.676890.1141
ENSG00000129824homo_sapiensENSP0000025078494.676889.7338mastacembelus_armatusENSMAMP0000001536294.676889.7338
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943stegastes_partitusENSSPAP0000002989894.676890.4943
ENSG00000129824homo_sapiensENSP0000025078484.030480.6084stegastes_partitusENSSPAP0000002141885.992282.4903
ENSG00000129824homo_sapiensENSP0000025078492.015285.9316oncorhynchus_tshawytschaENSOTSP0000502319692.015285.9316
ENSG00000129824homo_sapiensENSP0000025078484.410677.5665oncorhynchus_tshawytschaENSOTSP0000503845884.090977.2727
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141acanthochromis_polyacanthusENSAPOP0000000485494.676890.1141
ENSG00000129824homo_sapiensENSP0000025078495.817593.5361aquila_chrysaetos_chrysaetosENSACCP0002001208495.817593.5361
ENSG00000129824homo_sapiensENSP0000025078487.832782.8897nothobranchius_furzeriENSNFUP0001503065583.695778.9855
ENSG00000129824homo_sapiensENSP0000025078494.676889.7338cyprinodon_variegatusENSCVAP0000001085694.676889.7338
ENSG00000129824homo_sapiensENSP0000025078493.916488.2129denticeps_clupeoidesENSDCDP0000000901693.916488.2129
ENSG00000129824homo_sapiensENSP0000025078494.296689.7338larimichthys_croceaENSLCRP0000501670792.883988.3895
ENSG00000129824homo_sapiensENSP0000025078494.296688.5932takifugu_rubripesENSTRUP0000007273894.296688.5932
ENSG00000129824homo_sapiensENSP0000025078494.296690.1141hippocampus_comesENSHCOP0000001591294.296690.1141
ENSG00000129824homo_sapiensENSP0000025078491.254884.7909cyprinus_carpio_carpioENSCCRP0000005045689.887683.5206
ENSG00000129824homo_sapiensENSP0000025078494.676888.5932cyprinus_carpio_carpioENSCCRP0000005044994.676888.5932
ENSG00000129824homo_sapiensENSP0000025078496.197793.5361coturnix_japonicaENSCJPP0000501224896.197793.5361
ENSG00000129824homo_sapiensENSP0000025078493.916489.3536poecilia_latipinnaENSPLAP0000000256793.916489.3536
ENSG00000129824homo_sapiensENSP0000025078493.916488.2129sinocyclocheilus_grahamiENSSGRP0000010926293.916488.2129
ENSG00000129824homo_sapiensENSP0000025078463.117957.4144sinocyclocheilus_grahamiENSSGRP0000010994690.217482.0652
ENSG00000129824homo_sapiensENSP0000025078494.676890.1141maylandia_zebraENSMZEP0000502677494.676890.1141
ENSG00000129824homo_sapiensENSP0000025078494.296688.5932tetraodon_nigroviridisENSTNIP0000000543994.656588.9313
ENSG00000129824homo_sapiensENSP0000025078487.832781.3688paramormyrops_kingsleyaeENSPKIP0000000179294.285787.3469
ENSG00000129824homo_sapiensENSP0000025078488.593280.6084paramormyrops_kingsleyaeENSPKIP0000001451764.902559.0529
ENSG00000129824homo_sapiensENSP0000025078493.536187.4525scleropages_formosusENSSFOP0001501539492.830286.7924
ENSG00000129824homo_sapiensENSP0000025078494.676888.5932scleropages_formosusENSSFOP0001501537294.676888.5932
ENSG00000129824homo_sapiensENSP0000025078439.163534.981leptobrachium_leishanenseENSLLEP0000000288469.594662.1622
ENSG00000129824homo_sapiensENSP0000025078495.817593.1559leptobrachium_leishanenseENSLLEP0000004233595.817593.1559
ENSG00000129824homo_sapiensENSP0000025078493.155987.4525scophthalmus_maximusENSSMAP0000006868685.664380.4196
ENSG00000129824homo_sapiensENSP0000025078494.676890.4943oryzias_melastigmaENSOMEP0000001841394.676890.4943

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1IBAHomo_sapiens(9606)Function
GO:0003735enables structural constituent of ribosome2IBA,IMPHomo_sapiens(9606)Function
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005844part_of polysome1IDAHomo_sapiens(9606)Component
GO:0006412involved_in translation2IBA,IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0019843enables rRNA binding1IEAHomo_sapiens(9606)Function
GO:0022627part_of cytosolic small ribosomal subunit2IBA,NASHomo_sapiens(9606)Component

Expression