Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000129566 Gene ID 7011 Accession 11726
Symbol TEP1 Alias TP1;TLP1;p240;TROVE1;VAULT2 Full Name telomerase associated protein 1
Status Confidence Length 47835 bases Strand Minus strand
Position 14 : 20365667 - 20413501 RNA binding domain TROVE
Summary This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000451634 TROVE PF05731 1.5e-205 1
ENSP00000262715 TROVE PF05731 2.4e-205 1
ENSP00000452574 TROVE PF05731 1.8e-137 1
ENSP00000452574 TROVE PF05731 1.8e-137 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
28623509 Telomerase and drug resistance in cancer. Natalia Lipinska 2017-11-01 Cellular and molecular life sciences : CMLS
11027287 Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Y Liu 2000-11-01 Molecular and cellular biology
33572350 The Vault Nanoparticle: A Gigantic Ribonucleoprotein Assembly Involved in Diverse Physiological and Pathological Phenomena and an Ideal Nanovector for Drug Delivery and Therapy. Gianni Frascotti 2021-02-09 Cancers
32090359 A guide to naming human non-coding RNA genes. L Ruth Seal 2020-03-16 The EMBO journal
23060231 Structural studies of large nucleoprotein particles, vaults. Hideaki Tanaka 2012-01-01 Proceedings of the Japan Academy. Series B, Physical and biological sciences
10477748 The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. A V Kickhoefer 1999-09-06 The Journal of cell biology

Transcripts

Name Transcript ID bp Protein Translation ID
TEP1-203 ENST00000553365 2967 250aa ENSP00000450475
TEP1-201 ENST00000262715 10775 2627aa ENSP00000262715
TEP1-205 ENST00000555008 6697 1904aa ENSP00000450541
TEP1-206 ENST00000555727 7832 1481aa ENSP00000451634
TEP1-209 ENST00000556935 7643 2519aa ENSP00000452574
TEP1-204 ENST00000553984 602 201aa ENSP00000450508
TEP1-210 ENST00000557314 2698 70aa ENSP00000450830
TEP1-207 ENST00000556488 1055 102aa ENSP00000451409
TEP1-202 ENST00000471684 732 78aa ENSP00000451919
TEP1-211 ENST00000557627 1081 No protein -
TEP1-208 ENST00000556549 581 166aa ENSP00000452240

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
3298Cholesterol, HDL6.52425684686264E-517903299
35038Platelet Function Tests2.6838500E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129566homo_sapiensENSP0000042276333.982920.1091homo_sapiensENSP0000026271516.59699.82109
ENSG00000129566homo_sapiensENSP0000026369434.733918.4874homo_sapiensENSP000002627154.720212.51237
ENSG00000129566homo_sapiensENSP0000032779623.232311.3636homo_sapiensENSP000002627153.502091.71298
ENSG00000129566homo_sapiensENSP0000042857928.35215.852homo_sapiensENSP0000026271515.45498.64104
ENSG00000129566homo_sapiensENSP0000026560219.31448.27759homo_sapiensENSP000002627158.79333.76856
ENSG00000129566homo_sapiensENSP0000038660921.329211.798homo_sapiensENSP0000026271515.75948.71717
ENSG00000129566homo_sapiensENSP0000036888727.295912.7551homo_sapiensENSP000002627154.073091.90331
ENSG00000129566homo_sapiensENSP0000036267742.675226.7516homo_sapiensENSP000002627155.100883.19756
ENSG00000129566homo_sapiensENSP0000038037833.658517.561homo_sapiensENSP000002627155.253142.74077
ENSG00000129566homo_sapiensENSP0000029648439.557722.3587homo_sapiensENSP000002627156.128663.46403
ENSG00000129566homo_sapiensENSP0000035144643.712626.6467homo_sapiensENSP000002627155.557673.38789
ENSG00000129566homo_sapiensENSP0000033038143.636427.8788homo_sapiensENSP000002627155.481543.50209
ENSG00000129566homo_sapiensENSP0000031189933.734918.7952homo_sapiensENSP000002627155.329272.96917
ENSG00000129566homo_sapiensENSP0000035114724.646513.9394homo_sapiensENSP000002627154.644082.62657
ENSG00000129566homo_sapiensENSP0000031649623.291110.8861homo_sapiensENSP000002627153.502091.63685
ENSG00000129566homo_sapiensENSP0000031419321.807211.2048homo_sapiensENSP000002627156.889993.54016
ENSG00000129566homo_sapiensENSP0000034812927.542414.1949homo_sapiensENSP000002627154.948612.55044
ENSG00000129566homo_sapiensENSP0000032330237.866123.2218homo_sapiensENSP000002627156.889994.22535
ENSG00000129566homo_sapiensENSP0000041628923.128512.8492homo_sapiensENSP000002627157.879714.37762
ENSG00000129566homo_sapiensENSP0000026674224.242410.6061homo_sapiensENSP000002627156.09062.66464
ENSG00000129566homo_sapiensENSP0000025444218.389310.0671homo_sapiensENSP0000026271510.43015.70994
ENSG00000129566homo_sapiensENSP0000038430222.304312.7031homo_sapiensENSP000002627155.7483.2737
ENSG00000129566homo_sapiensENSP0000039757016.77728.81963homo_sapiensENSP000002627159.630765.06281
ENSG00000129566homo_sapiensENSP0000035664125.17113.4063homo_sapiensENSP000002627157.004193.73049
ENSG00000129566homo_sapiensENSP0000030726030.425114.7651homo_sapiensENSP000002627155.177012.51237
ENSG00000129566homo_sapiensENSP0000038479217.39997.94485homo_sapiensENSP0000026271510.08764.60601
ENSG00000129566homo_sapiensENSP00000517324100100homo_sapiensENSP00000262715100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129566homo_sapiensENSP0000026271593.604991.8919nomascus_leucogenysENSNLEP0000001314196.318194.5554
ENSG00000129566homo_sapiensENSP0000026271599.048398.3632pan_paniscusENSPPAP0000001984199.086198.4006
ENSG00000129566homo_sapiensENSP0000026271594.442393.2623pongo_abeliiENSPPYP0000000633297.792796.5708
ENSG00000129566homo_sapiensENSP0000026271599.200698.6296pan_troglodytesENSPTRP0000001034099.200698.6296
ENSG00000129566homo_sapiensENSP0000026271599.314898.9722gorilla_gorillaENSGGOP0000000020699.314898.9722
ENSG00000129566homo_sapiensENSP0000026271571.86959.8401sarcophilus_harrisiiENSSHAP0000002241172.531760.3919
ENSG00000129566homo_sapiensENSP0000026271561.096352.1888notamacropus_eugeniiENSMEUP0000000987773.623962.8899
ENSG00000129566homo_sapiensENSP0000026271585.763278.721dasypus_novemcinctusENSDNOP0000001539467.922862.3455
ENSG00000129566homo_sapiensENSP0000026271565.169457.3278erinaceus_europaeusENSEEUP0000001117665.493557.6129
ENSG00000129566homo_sapiensENSP0000026271574.800266.8062echinops_telfairiENSETEP0000001358176.877968.662
ENSG00000129566homo_sapiensENSP0000026271595.432192.539callithrix_jacchusENSCJAP0000001811995.577692.6801
ENSG00000129566homo_sapiensENSP0000026271596.840595.0514cercocebus_atysENSCATP0000003230297.025295.2326
ENSG00000129566homo_sapiensENSP0000026271597.183195.4701macaca_fascicularisENSMFAP0000000864797.368495.6522
ENSG00000129566homo_sapiensENSP0000026271597.14595.3559macaca_mulattaENSMMUP0000008037697.330395.5378
ENSG00000129566homo_sapiensENSP0000026271597.183195.394macaca_nemestrinaENSMNEP0000001600397.368495.5759
ENSG00000129566homo_sapiensENSP0000026271597.068995.2037papio_anubisENSPANP0000005647297.25495.3852
ENSG00000129566homo_sapiensENSP0000026271588.960886.9433mandrillus_leucophaeusENSMLEP0000002257995.621993.4534
ENSG00000129566homo_sapiensENSP0000026271584.392877.8074tursiops_truncatusENSTTRP0000001184084.392877.8074
ENSG00000129566homo_sapiensENSP0000026271556.947151.3514vulpes_vulpesENSVVUP0000001218381.216173.2356
ENSG00000129566homo_sapiensENSP0000026271584.088374.9524mus_spretusMGP_SPRETEiJ_P003818784.056374.9239
ENSG00000129566homo_sapiensENSP0000026271589.113182.9083equus_asinusENSEASP0000502561889.045382.8452
ENSG00000129566homo_sapiensENSP0000026271585.192278.4926capra_hircusENSCHIP0000003289084.998178.3137
ENSG00000129566homo_sapiensENSP0000026271585.534878.3784loxodonta_africanaENSLAFP0000000208186.290379.0707
ENSG00000129566homo_sapiensENSP0000026271584.164477.5409panthera_leoENSPLOP0000001055885.964279.1991
ENSG00000129566homo_sapiensENSP0000026271585.230377.9216ailuropoda_melanoleucaENSAMEP0000000583985.917178.5495
ENSG00000129566homo_sapiensENSP0000026271583.936177.3506bos_indicus_hybridENSBIXP0000503752186.402879.6238
ENSG00000129566homo_sapiensENSP0000026271584.583277.5029oryctolagus_cuniculusENSOCUP0000003932385.560378.3982
ENSG00000129566homo_sapiensENSP0000026271588.580182.2992equus_caballusENSECAP0000000929989.396983.058
ENSG00000129566homo_sapiensENSP0000026271580.738571.9071canis_lupus_familiarisENSCAFP0084503041981.514272.598
ENSG00000129566homo_sapiensENSP0000026271585.763278.9494panthera_pardusENSPPRP0000002209086.921380.0154
ENSG00000129566homo_sapiensENSP0000026271587.133679.9772marmota_marmota_marmotaENSMMMP0000000129788.106280.8699
ENSG00000129566homo_sapiensENSP0000026271587.628581.043balaenoptera_musculusENSBMSP0001001195387.628581.043
ENSG00000129566homo_sapiensENSP0000026271579.177870.689cavia_porcellusENSCPOP0000000096182.835573.9546
ENSG00000129566homo_sapiensENSP0000026271585.953679.7107felis_catusENSFCAP0000005623084.065577.9598
ENSG00000129566homo_sapiensENSP0000026271586.143979.0636ursus_americanusENSUAMP0000001418386.572379.4568
ENSG00000129566homo_sapiensENSP0000026271569.623158.2794monodelphis_domesticaENSMODP0000004443476.240163.8183
ENSG00000129566homo_sapiensENSP0000026271562.238357.8987bison_bison_bisonENSBBBP0000000167787.85681.7303
ENSG00000129566homo_sapiensENSP0000026271583.821977.3887monodon_monocerosENSMMNP0001501313383.853877.4181
ENSG00000129566homo_sapiensENSP0000026271587.514380.5482sus_scrofaENSSSCP0000000234187.647780.671
ENSG00000129566homo_sapiensENSP0000026271588.884783.0225microcebus_murinusENSMICP0000002378190.503984.5349
ENSG00000129566homo_sapiensENSP0000026271573.886664.9029octodon_degusENSODEP0000000228081.043871.19
ENSG00000129566homo_sapiensENSP0000026271585.192276.7796jaculus_jaculusENSJJAP0000000005685.095176.692
ENSG00000129566homo_sapiensENSP0000026271586.105879.33ovis_aries_rambouilletENSOARP0002001453986.138679.3602
ENSG00000129566homo_sapiensENSP0000026271584.392877.0461ursus_maritimusENSUMAP0000001222685.334977.9061
ENSG00000129566homo_sapiensENSP0000026271576.018369.3567ochotona_princepsENSOPRP0000001273777.643970.8398
ENSG00000129566homo_sapiensENSP0000026271586.143979.5204delphinapterus_leucasENSDLEP0000000215487.00580.3153
ENSG00000129566homo_sapiensENSP0000026271584.126475.1808mus_caroliMGP_CAROLIEiJ_P003646984.126475.1808
ENSG00000129566homo_sapiensENSP0000026271584.354875.295mus_musculusENSMUSP0000000644484.290675.2377
ENSG00000129566homo_sapiensENSP0000026271563.266157.4039dipodomys_ordiiENSDORP0000000237887.61279.4939
ENSG00000129566homo_sapiensENSP0000026271585.61178.3784mustela_putorius_furoENSMPUP0000001801385.578478.3486
ENSG00000129566homo_sapiensENSP0000026271595.470192.6152aotus_nancymaaeENSANAP0000002318295.615792.7564
ENSG00000129566homo_sapiensENSP0000026271592.272689.3415saimiri_boliviensis_boliviensisENSSBOP0000000544894.798691.7873
ENSG00000129566homo_sapiensENSP0000026271596.878694.9372chlorocebus_sabaeusENSCSAP0000001275296.989395.0457
ENSG00000129566homo_sapiensENSP0000026271580.776671.0316mesocricetus_auratusENSMAUP0000001397682.825972.8337
ENSG00000129566homo_sapiensENSP0000026271587.285980.7766phocoena_sinusENSPSNP0000001623187.285980.7766
ENSG00000129566homo_sapiensENSP0000026271586.18279.5584camelus_dromedariusENSCDRP0000500202087.14480.4465
ENSG00000129566homo_sapiensENSP0000026271588.656382.9083carlito_syrichtaENSTSYP0000000366689.888184.0602
ENSG00000129566homo_sapiensENSP0000026271584.659378.0358panthera_tigris_altaicaENSPTIP0000002066486.807280.0156
ENSG00000129566homo_sapiensENSP0000026271584.164474.686rattus_norvegicusENSRNOP0000007802883.718374.29
ENSG00000129566homo_sapiensENSP0000026271583.441278.2642prolemur_simusENSPSMP0000002971588.780983.2726
ENSG00000129566homo_sapiensENSP0000026271582.565773.3156microtus_ochrogasterENSMOCP0000001626482.065872.8717
ENSG00000129566homo_sapiensENSP0000026271568.633460.2969sorex_araneusENSSARP0000001310470.789262.1908
ENSG00000129566homo_sapiensENSP0000026271584.849675.7899peromyscus_maniculatus_bairdiiENSPEMP0000001141084.914375.8476
ENSG00000129566homo_sapiensENSP0000026271581.00574.0008bos_mutusENSBMUP0000001714285.737378.3239
ENSG00000129566homo_sapiensENSP0000026271584.278675.257mus_spicilegusENSMSIP0000002281884.214575.1997
ENSG00000129566homo_sapiensENSP0000026271584.278674.686cricetulus_griseus_chok1gshdENSCGRP0000101398484.439474.8284
ENSG00000129566homo_sapiensENSP0000026271576.893871.0697pteropus_vampyrusENSPVAP0000001011077.128771.2868
ENSG00000129566homo_sapiensENSP0000026271587.476280.5482myotis_lucifugusENSMLUP0000001401188.316781.3221
ENSG00000129566homo_sapiensENSP0000026271565.169455.4625vombatus_ursinusENSVURP0001002588275.920264.612
ENSG00000129566homo_sapiensENSP0000026271586.714980.2436rhinolophus_ferrumequinumENSRFEP0001002401888.157981.5789
ENSG00000129566homo_sapiensENSP0000026271585.458778.2261neovison_visonENSNVIP0000001912585.296478.0775
ENSG00000129566homo_sapiensENSP0000026271586.867179.901bos_taurusENSBTAP0000000156486.900279.9315
ENSG00000129566homo_sapiensENSP0000026271583.288975.0285heterocephalus_glaber_femaleENSHGLP0000000570485.003976.5734
ENSG00000129566homo_sapiensENSP0000026271596.193493.8333rhinopithecus_bietiENSRBIP0000001419295.974293.6194
ENSG00000129566homo_sapiensENSP0000026271560.068553.8257canis_lupus_dingoENSCAFP0002001792981.256472.8115
ENSG00000129566homo_sapiensENSP0000026271587.590480.7766sciurus_vulgarisENSSVLP0000500330288.43281.5527
ENSG00000129566homo_sapiensENSP0000026271568.40557.0994phascolarctos_cinereusENSPCIP0000004813875.535963.0517
ENSG00000129566homo_sapiensENSP0000026271560.525355.158procavia_capensisENSPCAP0000000941963.906858.2396
ENSG00000129566homo_sapiensENSP0000026271585.763277.8455nannospalax_galiliENSNGAP0000002667885.665477.7567
ENSG00000129566homo_sapiensENSP0000026271577.122268.7857chinchilla_lanigeraENSCLAP0000000285582.057573.1875
ENSG00000129566homo_sapiensENSP0000026271585.230378.0738cervus_hanglu_yarkandensisENSCHYP0000002358785.100777.9551
ENSG00000129566homo_sapiensENSP0000026271586.562679.4823catagonus_wagneriENSCWAP0000001505985.746678.733
ENSG00000129566homo_sapiensENSP0000026271587.36280.434ictidomys_tridecemlineatusENSSTOP0000000902387.998581.0199
ENSG00000129566homo_sapiensENSP0000026271586.867180.8146otolemur_garnettiiENSOGAP0000001193788.142182.0008
ENSG00000129566homo_sapiensENSP0000026271595.051491.968cebus_imitatorENSCCAP0000003524395.196392.1083
ENSG00000129566homo_sapiensENSP0000026271586.79179.8249urocitellus_parryiiENSUPAP0001001005587.423380.4064
ENSG00000129566homo_sapiensENSP0000026271585.991679.1397moschus_moschiferusENSMMSP0000001536886.155679.2906
ENSG00000129566homo_sapiensENSP0000026271597.525795.2798rhinopithecus_roxellanaENSRROP0000002659397.488695.2435
ENSG00000129566homo_sapiensENSP0000026271583.212874.4195mus_pahariMGP_PahariEiJ_P008458783.915675.048
ENSG00000129566homo_sapiensENSP0000026271588.123383.1367propithecus_coquereliENSPCOP0000002609790.359185.2459
ENSG00000129566homo_sapiensENSP000002627155.405413.08336ciona_intestinalisENSCINP0000000912742.771124.3976
ENSG00000129566homo_sapiensENSP0000026271512.98068.86943petromyzon_marinusENSPMAP0000000422552.140735.6269
ENSG00000129566homo_sapiensENSP0000026271521.81213.209eptatretus_burgeriENSEBUP0000002749532.299919.5603
ENSG00000129566homo_sapiensENSP0000026271511.07737.99391latimeria_chalumnaeENSLACP0000000183060.248443.4783
ENSG00000129566homo_sapiensENSP0000026271510.04955.748astyanax_mexicanusENSAMXP0000004367439.81922.7753
ENSG00000129566homo_sapiensENSP0000026271552.569535.4397xenopus_tropicalisENSXETP0000003524451.858834.9606
ENSG00000129566homo_sapiensENSP0000026271521.8515.8356sphenodon_punctatusENSSPUP0000000145458.511742.4057
ENSG00000129566homo_sapiensENSP000002627159.478496.69966laticauda_laticaudataENSLLTP0000000988156.979440.2746
ENSG00000129566homo_sapiensENSP000002627159.783027.00419notechis_scutatusENSNSUP0000000292458.675842.0091
ENSG00000129566homo_sapiensENSP0000026271531.366622.1545pseudonaja_textilisENSPTXP0000002248059.025841.6905
ENSG00000129566homo_sapiensENSP0000026271555.805139.056anolis_carolinensisENSACAP0000000812057.131739.9844
ENSG00000129566homo_sapiensENSP0000026271514.046410.2779naja_najaENSNNAP0000001300659.0443.2
ENSG00000129566homo_sapiensENSP0000026271542.634230.5291podarcis_muralisENSPMRP0000001957160.279943.1647
ENSG00000129566homo_sapiensENSP0000026271543.890427.8264erpetoichthys_calabaricusENSECRP0000000167953.354933.8269
ENSG00000129566homo_sapiensENSP0000026271555.310239.3224salvator_merianaeENSSMRP0000000831156.935740.4781
ENSG00000129566homo_sapiensENSP0000026271532.660822.5733paramormyrops_kingsleyaeENSPKIP0000002570052.158136.0486

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000722involved_in telomere maintenance via recombination2IBA,IDAHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1IEAHomo_sapiens(9606)Component
GO:0002039enables p53 binding1IPIHomo_sapiens(9606)Function
GO:0003720contributes_to telomerase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005697part_of telomerase holoenzyme complex2IBA,IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0006278involved_in RNA-templated DNA biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0016363located_in nuclear matrix1IDAHomo_sapiens(9606)Component
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0070034enables telomerase RNA binding2IBA,ISSHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1TASHomo_sapiens(9606)Component

Expression