RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000129484	Gene ID	10038	Accession	272
Symbol	PARP2	Alias	ARTD2;ADPRT2;PARP-2;ADPRTL2;ADPRTL3;pADPRT-2	Full Name	poly(ADP-ribose) polymerase 2
Status	Confidence	Length	14290 bases	Strand	Plus strand
Position	14 : 20343615 - 20357904	RNA binding domain	PARP
Summary	This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000250416	PARP	PF00644	6.7e-70	1
ENSP00000392972	PARP	PF00644	8.8e-70	1
ENSP00000432283	PARP	PF00644	8.5e-56	1
ENSP00000445524	PARP	PF00644	4.6e-45	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
26091344	RNA Regulation by Poly(ADP-Ribose) Polymerases.	J Florian Bock	2015-06-18	Molecular cell
32656996	The multifaceted role of PARP1 in RNA biogenesis.	Rebekah Eleazer	2021-03-01	Wiley interdisciplinary reviews. RNA
31829559	Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation.	Y Meagan Nakamoto	2019-12-24	Biochemistry
33693821	An RNA tagging approach for system-wide RNA-binding proteome profiling and dynamics investigation upon transcription inhibition.	Zheng Zhang	2021-06-21	Nucleic acids research
24928857	PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.	Marie-France Langelier	2014-07-01	Nucleic acids research
37609662	The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors.	Adèle Beneyton	2023-09-01	NAR cancer
35349716	PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.	Xiaohui Lin	2022-04-22	Nucleic acids research
32441764	Repositioning PARP inhibitors for SARS-CoV-2 infection(COVID-19); a new multi-pronged therapy for acute respiratory distress syndrome?	Nicola Curtin	2020-08-01	British journal of pharmacology
32029452	PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis.	Dae-Seok Kim	2020-03-01	Genes & development

Name	Transcript ID	bp	Protein	Translation ID
PARP2-202	ENST00000429687	1827	570aa	ENSP00000392972
PARP2-201	ENST00000250416	1886	583aa	ENSP00000250416
PARP2-206	ENST00000529465	717	110aa	ENSP00000431867
PARP2-204	ENST00000527915	1980	531aa	ENSP00000432283
PARP2-205	ENST00000528465	551	No protein	-
PARP2-211	ENST00000555140	530	No protein	-
PARP2-203	ENST00000527384	429	No protein	-
PARP2-208	ENST00000532299	876	No protein	-
PARP2-210	ENST00000539930	635	177aa	ENSP00000445524
PARP2-207	ENST00000530598	842	No protein	-
PARP2-209	ENST00000534664	566	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8428	Alcohol Drinking	1.38358566389269E-11	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003682	enables chromatin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003684	enables damaged DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006281	involved_in DNA repair	1	IDA	Homo_sapiens(9606)	Process
GO:0006284	involved_in base-excision repair	1	IEA	Homo_sapiens(9606)	Process
GO:0006302	involved_in double-strand break repair	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IDA	Homo_sapiens(9606)	Process
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0030592	involved_in DNA ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0031491	enables nucleosome binding	1	IDA	Homo_sapiens(9606)	Function
GO:0046697	involved_in decidualization	1	ISS	Homo_sapiens(9606)	Process
GO:0061051	involved_in positive regulation of cell growth involved in cardiac muscle cell development	1	IEA	Homo_sapiens(9606)	Process
GO:0070212	involved_in protein poly-ADP-ribosylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0070213	involved_in protein auto-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0072572	enables poly-ADP-D-ribose binding	1	IDA	Homo_sapiens(9606)	Function
GO:0090734	is_active_in site of DNA damage	2	IDA	Homo_sapiens(9606)	Component
GO:0097191	involved_in extrinsic apoptotic signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0140294	enables NAD DNA ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140805	enables NAD+-protein-serine ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140806	enables NAD+- protein-aspartate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140807	enables NAD+-protein-glutamate ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140861	involved_in DNA repair-dependent chromatin remodeling	1	IDA	Homo_sapiens(9606)	Process
GO:0160004	enables poly-ADP-D-ribose modification-dependent protein binding	1	IDA	Homo_sapiens(9606)	Function
GO:1901215	involved_in negative regulation of neuron death	1	IEA	Homo_sapiens(9606)	Process
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function