RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000129473	Gene ID	599	Accession	995
Symbol	BCL2L2	Alias	BCLW;BCL-W;PPP1R51;BCL2-L-2	Full Name	BCL2 like 2
Status	Confidence	Length	12962 bases	Strand	Plus strand
Position	14 : 23298790 - 23311751	RNA binding domain	N.A.
Summary	This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
BCL2L2-202	ENST00000553824	548	51aa	ENSP00000451148
BCL2L2-210	ENST00000679219	3557	193aa	ENSP00000503012
BCL2L2-208	ENST00000678311	3568	193aa	ENSP00000504570
BCL2L2-207	ENST00000557579	762	185aa	ENSP00000452265
BCL2L2-201	ENST00000250405	3526	193aa	ENSP00000250405
BCL2L2-209	ENST00000679000	3539	193aa	ENSP00000503368
BCL2L2-206	ENST00000557236	1245	168aa	ENSP00000451701
BCL2L2-204	ENST00000556100	1368	193aa	ENSP00000503091
BCL2L2-203	ENST00000554635	545	71aa	ENSP00000451234
BCL2L2-205	ENST00000556599	548	167aa	ENSP00000451197

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002931	involved_in response to ischemia	1	IEA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005741	is_active_in mitochondrial outer membrane	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IEA	Homo_sapiens(9606)	Component
GO:0007283	involved_in spermatogenesis	1	TAS	Homo_sapiens(9606)	Process
GO:0008630	involved_in intrinsic apoptotic signaling pathway in response to DNA damage	1	IBA	Homo_sapiens(9606)	Process
GO:0035795	involved_in negative regulation of mitochondrial membrane permeability	1	IEA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042803	enables protein homodimerization activity	1	IBA	Homo_sapiens(9606)	Function
GO:0042981	involved_in regulation of apoptotic process	1	IDA	Homo_sapiens(9606)	Process
GO:0043066	involved_in negative regulation of apoptotic process	1	IMP	Homo_sapiens(9606)	Process
GO:0044877	enables protein-containing complex binding	1	IEA	Homo_sapiens(9606)	Function
GO:0046982	enables protein heterodimerization activity	1	IBA	Homo_sapiens(9606)	Function
GO:0051400	enables BH domain binding	1	IEA	Homo_sapiens(9606)	Function
GO:0060011	involved_in Sertoli cell proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0071392	involved_in cellular response to estradiol stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0090201	involved_in negative regulation of release of cytochrome c from mitochondria	1	IEA	Homo_sapiens(9606)	Process
GO:0097136	part_of Bcl-2 family protein complex	2	IMP,IPI	Homo_sapiens(9606)	Component
GO:0097192	involved_in extrinsic apoptotic signaling pathway in absence of ligand	1	IBA	Homo_sapiens(9606)	Process
GO:0097718	enables disordered domain specific binding	1	IPI	Homo_sapiens(9606)	Function
GO:1904646	involved_in cellular response to amyloid-beta	1	IEA	Homo_sapiens(9606)	Process
GO:1905430	involved_in cellular response to glycine	1	IEA	Homo_sapiens(9606)	Process
GO:2001243	involved_in negative regulation of intrinsic apoptotic signaling pathway	1	IBA	Homo_sapiens(9606)	Process