RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligaseKinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000127334	Gene ID	8445	Accession	3093
Symbol	DYRK2	Alias	NA	Full Name	dual specificity tyrosine phosphorylation regulated kinase 2
Status	Confidence	Length	17069 bases	Strand	Plus strand
Position	12 : 67648338 - 67665406	RNA binding domain	N.A.
Summary	DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32213288	An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei.	Mathieu Cayla	2020-03-26	eLife
36934104	FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.	Rafael Jiménez-Izquierdo	2023-03-18	Cell death & disease

Name	Transcript ID	bp	Protein	Translation ID
DYRK2-206	ENST00000543747	568	156aa	ENSP00000440839
DYRK2-202	ENST00000344096	8888	601aa	ENSP00000342105
DYRK2-203	ENST00000393555	2209	528aa	ENSP00000377186
DYRK2-204	ENST00000537632	411	No protein	-
DYRK2-201	ENST00000319833	566	93aa	ENSP00000324733
DYRK2-205	ENST00000542503	560	167aa	ENSP00000443314

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
11717	Hand Strength	4.0782724970212E-5	17903295
11733	Hand Strength	4.0782724970212E-5	17903295
33113	Urine	4.8427976E-005	-
33148	Urine	6.5025970E-005	-
33162	Urine	8.0259131E-005	-
35074	Platelet Function Tests	1.7548500E-005	-
35075	Platelet Function Tests	1.7548500E-005	-
57952	Myocardial Infarction	1.4690000E-005	-
73330	Rest	9E-6	27126917
74509	Alzheimer Disease	4E-6	27770636

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000151	part_of ubiquitin ligase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0004712	enables protein serine/threonine/tyrosine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0004713	enables protein tyrosine kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005856	is_active_in cytoskeleton	1	IBA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IEP	Homo_sapiens(9606)	Process
GO:0007224	involved_in smoothened signaling pathway	1	IMP	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0018107	involved_in peptidyl-threonine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0030145	enables manganese ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0042771	involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	1	IDA	Homo_sapiens(9606)	Process
GO:0045725	involved_in positive regulation of glycogen biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0070885	involved_in negative regulation of calcineurin-NFAT signaling cascade	1	IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1901796	involved_in regulation of signal transduction by p53 class mediator	1	TAS	Homo_sapiens(9606)	Process
GO:1990904	part_of ribonucleoprotein complex	1	IEA	Homo_sapiens(9606)	Component