Functions and Diseases

RBP Type Canonical_RBPs
Diseases SARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000126945 Gene ID 3188 Accession 5042
Symbol HNRNPH2 Alias FTP3;MRXSB;NRPH2;HNRPH';HNRPH2;hnRNPH' Full Name heterogeneous nuclear ribonucleoprotein H2
Status Confidence Length 5912 bases Strand Plus strand
Position X : 101408222 - 101414133 RNA binding domain zf-RNPHF , RRM_1
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000361927 RRM_1 PF00076 3.6e-31 1
ENSP00000361927 RRM_1 PF00076 3.6e-31 2
ENSP00000361927 RRM_1 PF00076 3.6e-31 3
ENSP00000361927 zf-RNPHF PF08080 3.8e-22 4

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37372334 Rett-like Phenotypes in HNRNPH2-Related Neurodevelopmental Disorder. Nicho Joseph Gonzalez 2023-05-26 Genes
35910704 The potential consequences of bidirectional promoter methylation on GLA and HNRNPH2 expression in Fabry disease phenotypes in a family of patients carrying a GLA deletion variant. A Mohammed Al-Obaide 2022-08-01 Biomedical reports
27088854 A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Xinjian Li 2016-05-01 Nature cell biology
32531916 The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics. L Aaron Slusher 2020-06-10 Cancers

Transcripts

Name Transcript ID bp Protein Translation ID
HNRNPH2-201 ENST00000316594 2296 449aa ENSP00000361927

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000126945homo_sapiensENSP0000040573827.900118.7959homo_sapiensENSP0000036192742.316328.5078
ENSG00000126945homo_sapiensENSP0000041874825.52316.8759homo_sapiensENSP0000036192740.757226.9488
ENSG00000126945homo_sapiensENSP0000026586672.254364.1618homo_sapiensENSP0000036192755.679349.4432
ENSG00000126945homo_sapiensENSP0000042980716.68339.39061homo_sapiensENSP0000036192737.193820.9354
ENSG00000126945homo_sapiensENSP0000050778786.50675.9036homo_sapiensENSP0000036192779.955570.1559
ENSG00000126945homo_sapiensENSP0000025479945.416731.0417homo_sapiensENSP0000036192748.552333.1849
ENSG00000126945homo_sapiensENSP0000036322818.45499.87124homo_sapiensENSP0000036192738.307420.49
ENSG00000126945homo_sapiensENSP0000037708298.218396.2138homo_sapiensENSP0000036192798.218396.2138

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000126945homo_sapiensENSP0000036192790.868690.8686pan_paniscusENSPPAP0000001046899.512299.5122
ENSG00000126945homo_sapiensENSP0000036192797.327497.3274pan_paniscusENSPPAP0000003662999.771799.7717
ENSG00000126945homo_sapiensENSP00000361927100100pongo_abeliiENSPPYP00000045041100100
ENSG00000126945homo_sapiensENSP0000036192772.828568.3742pan_troglodytesENSPTRP0000006297585.156279.9479
ENSG00000126945homo_sapiensENSP0000036192796.213894.4321ornithorhynchus_anatinusENSOANP0000003407991.525489.8305
ENSG00000126945homo_sapiensENSP0000036192775.278465.2561sarcophilus_harrisiiENSSHAP0000001500473.799163.9738
ENSG00000126945homo_sapiensENSP0000036192796.213894.4321sarcophilus_harrisiiENSSHAP0000004389591.525489.8305
ENSG00000126945homo_sapiensENSP0000036192775.946567.0379sarcophilus_harrisiiENSSHAP0000002760073.333364.7312
ENSG00000126945homo_sapiensENSP0000036192749.220548.1069notamacropus_eugeniiENSMEUP0000001331250.456649.3151
ENSG00000126945homo_sapiensENSP0000036192710099.7773dasypus_novemcinctusENSDNOP0000002231210099.7773
ENSG00000126945homo_sapiensENSP0000036192755.011152.784erinaceus_europaeusENSEEUP0000001433055.133952.9018
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546echinops_telfairiENSETEP0000000684099.777399.5546
ENSG00000126945homo_sapiensENSP00000361927100100callithrix_jacchusENSCJAP00000008959100100
ENSG00000126945homo_sapiensENSP0000036192775.723874.833cercocebus_atysENSCATP0000001048895.774794.6479
ENSG00000126945homo_sapiensENSP00000361927100100macaca_fascicularisENSMFAP00000063732100100
ENSG00000126945homo_sapiensENSP00000361927100100macaca_mulattaENSMMUP00000025720100100
ENSG00000126945homo_sapiensENSP0000036192787.750686.637macaca_nemestrinaENSMNEP0000000365289.545588.4091
ENSG00000126945homo_sapiensENSP00000361927100100papio_anubisENSPANP00000029000100100
ENSG00000126945homo_sapiensENSP0000036192775.501174.833mandrillus_leucophaeusENSMLEP0000003501795.49394.6479
ENSG00000126945homo_sapiensENSP0000036192710099.5546tursiops_truncatusENSTTRP0000001212810099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546vulpes_vulpesENSVVUP0000000686799.777399.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091mus_spretusMGP_SPRETEiJ_P009644399.777399.1091
ENSG00000126945homo_sapiensENSP0000036192710099.7773equus_asinusENSEASP0000506163710099.7773
ENSG00000126945homo_sapiensENSP0000036192710099.3318capra_hircusENSCHIP0000000661110099.3318
ENSG00000126945homo_sapiensENSP0000036192710099.5546capra_hircusENSCHIP0000002160110099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546panthera_leoENSPLOP0000002667699.777399.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773ailuropoda_melanoleucaENSAMEP0000001979910099.7773
ENSG00000126945homo_sapiensENSP0000036192710099.5546bos_indicus_hybridENSBIXP0000501179210099.5546
ENSG00000126945homo_sapiensENSP0000036192757.46156.1247oryctolagus_cuniculusENSOCUP0000004168995.202992.9889
ENSG00000126945homo_sapiensENSP0000036192710099.7773oryctolagus_cuniculusENSOCUP0000002517510099.7773
ENSG00000126945homo_sapiensENSP0000036192794.432193.7639oryctolagus_cuniculusENSOCUP0000002359197.025296.3387
ENSG00000126945homo_sapiensENSP0000036192710099.7773equus_caballusENSECAP0000006391310099.7773
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546canis_lupus_familiarisENSCAFP0084502719199.777399.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546panthera_pardusENSPPRP0000001964899.777399.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773marmota_marmota_marmotaENSMMMP0000001775110099.7773
ENSG00000126945homo_sapiensENSP0000036192710099.5546balaenoptera_musculusENSBMSP0001002792810099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546cavia_porcellusENSCPOP0000001711299.777399.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546felis_catusENSFCAP0000001427999.777399.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773ursus_americanusENSUAMP0000002752610099.7773
ENSG00000126945homo_sapiensENSP0000036192777.95177.5056bison_bison_bisonENSBBBP0000002518377.95177.5056
ENSG00000126945homo_sapiensENSP0000036192710099.5546monodon_monocerosENSMMNP0001501499410099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.5546sus_scrofaENSSSCP0000007582410099.5546
ENSG00000126945homo_sapiensENSP0000036192776.837474.3875octodon_degusENSODEP0000000958889.378286.5285
ENSG00000126945homo_sapiensENSP0000036192761.469957.6837jaculus_jaculusENSJJAP0000000486186.792481.4465
ENSG00000126945homo_sapiensENSP0000036192788.864186.4143jaculus_jaculusENSJJAP0000001340494.326291.7258
ENSG00000126945homo_sapiensENSP0000036192798.44197.7728jaculus_jaculusENSJJAP0000000268998.44197.7728
ENSG00000126945homo_sapiensENSP0000036192710099.5546ovis_aries_rambouilletENSOARP0002002216410099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773ursus_maritimusENSUMAP0000001651010099.7773
ENSG00000126945homo_sapiensENSP0000036192710099.5546ochotona_princepsENSOPRP0000000729410099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.5546delphinapterus_leucasENSDLEP0000000223810099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.5546physeter_catodonENSPCTP0000500918210099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091mus_caroliMGP_CAROLIEiJ_P009268199.777399.1091
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091mus_musculusENSMUSP0000010882899.777399.1091
ENSG00000126945homo_sapiensENSP0000036192799.109198.8864dipodomys_ordiiENSDORP0000001948899.109198.8864
ENSG00000126945homo_sapiensENSP0000036192710099.7773mustela_putorius_furoENSMPUP0000001901610099.7773
ENSG00000126945homo_sapiensENSP0000036192799.777399.7773chlorocebus_sabaeusENSCSAP0000001793699.777399.7773
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091mesocricetus_auratusENSMAUP0000000233699.777399.1091
ENSG00000126945homo_sapiensENSP0000036192710099.5546phocoena_sinusENSPSNP0000002764110099.5546
ENSG00000126945homo_sapiensENSP0000036192799.109197.9955camelus_dromedariusENSCDRP0000501926599.109197.9955
ENSG00000126945homo_sapiensENSP0000036192799.331899.1091panthera_tigris_altaicaENSPTIP0000000047599.331899.1091
ENSG00000126945homo_sapiensENSP0000036192799.554698.8864rattus_norvegicusENSRNOP0000008958199.554698.8864
ENSG00000126945homo_sapiensENSP0000036192763.02962.3608prolemur_simusENSPSMP0000002968898.95197.9021
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091microtus_ochrogasterENSMOCP0000001232599.777399.1091
ENSG00000126945homo_sapiensENSP0000036192710099.7773sorex_araneusENSSARP0000001282210099.7773
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091peromyscus_maniculatus_bairdiiENSPEMP0000002271699.777399.1091
ENSG00000126945homo_sapiensENSP0000036192710099.5546bos_mutusENSBMUP0000001514810099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091cricetulus_griseus_chok1gshdENSCGRP0000100653699.777399.1091
ENSG00000126945homo_sapiensENSP0000036192710099.7773pteropus_vampyrusENSPVAP0000000148010099.7773
ENSG00000126945homo_sapiensENSP0000036192799.554699.3318myotis_lucifugusENSMLUP0000002061499.554699.3318
ENSG00000126945homo_sapiensENSP0000036192777.95169.4877vombatus_ursinusENSVURP0001002895877.262768.8742
ENSG00000126945homo_sapiensENSP0000036192796.213894.4321vombatus_ursinusENSVURP0001000983991.525489.8305
ENSG00000126945homo_sapiensENSP0000036192710099.5546rhinolophus_ferrumequinumENSRFEP0001000147810099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773neovison_visonENSNVIP0000001859410099.7773
ENSG00000126945homo_sapiensENSP0000036192710099.5546bos_taurusENSBTAP0000000986410099.5546
ENSG00000126945homo_sapiensENSP0000036192799.554698.8864heterocephalus_glaber_femaleENSHGLP0000005362699.776899.1071
ENSG00000126945homo_sapiensENSP0000036192774.610273.0512rhinopithecus_bietiENSRBIP0000001797883.959982.2055
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546canis_lupus_dingoENSCAFP0002000910999.777399.5546
ENSG00000126945homo_sapiensENSP0000036192710099.7773sciurus_vulgarisENSSVLP0000502245810099.7773
ENSG00000126945homo_sapiensENSP0000036192753.897548.5523phascolarctos_cinereusENSPCIP0000003691975.862168.3386
ENSG00000126945homo_sapiensENSP0000036192796.213894.4321phascolarctos_cinereusENSPCIP0000000973388.163386.5306
ENSG00000126945homo_sapiensENSP0000036192799.777399.3318procavia_capensisENSPCAP0000000308399.777399.3318
ENSG00000126945homo_sapiensENSP0000036192799.554698.6637nannospalax_galiliENSNGAP0000002127999.554698.6637
ENSG00000126945homo_sapiensENSP0000036192797.327496.882bos_grunniensENSBGRP0000003136110099.5423
ENSG00000126945homo_sapiensENSP0000036192782.850878.6192chinchilla_lanigeraENSCLAP0000002103090.731786.0976
ENSG00000126945homo_sapiensENSP0000036192799.554699.3318chinchilla_lanigeraENSCLAP0000000272599.554699.3318
ENSG00000126945homo_sapiensENSP0000036192792.873191.5368cervus_hanglu_yarkandensisENSCHYP0000002487390.455589.154
ENSG00000126945homo_sapiensENSP0000036192710099.3318catagonus_wagneriENSCWAP0000002237010099.3318
ENSG00000126945homo_sapiensENSP0000036192710099.7773ictidomys_tridecemlineatusENSSTOP0000001977610099.7773
ENSG00000126945homo_sapiensENSP0000036192799.777399.5546otolemur_garnettiiENSOGAP0000001556499.777399.5546
ENSG00000126945homo_sapiensENSP0000036192710099.5546urocitellus_parryiiENSUPAP0001001245410099.5546
ENSG00000126945homo_sapiensENSP0000036192710099.5546moschus_moschiferusENSMMSP0000001782610099.5546
ENSG00000126945homo_sapiensENSP0000036192799.777399.1091mus_pahariMGP_PahariEiJ_P009029499.777399.1091
ENSG00000126945homo_sapiensENSP0000036192753.674841.2027ciona_intestinalisENSCINP0000000363266.027450.6849
ENSG00000126945homo_sapiensENSP0000036192769.933257.9065petromyzon_marinusENSPMAP0000000085566.525455.0847
ENSG00000126945homo_sapiensENSP0000036192758.351947.216eptatretus_burgeriENSEBUP0000001447672.980559.0529
ENSG00000126945homo_sapiensENSP0000036192765.033451.6704eptatretus_burgeriENSEBUP0000000371367.436553.5797
ENSG00000126945homo_sapiensENSP0000036192780.178271.7149callorhinchus_miliiENSCMIP0000001309981.44872.8507
ENSG00000126945homo_sapiensENSP0000036192784.409878.1737latimeria_chalumnaeENSLACP0000002287885.360479.0541
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871chrysemys_picta_belliiENSCPBP0000001262275.428672
ENSG00000126945homo_sapiensENSP0000036192728.507825.6125sphenodon_punctatusENSSPUP0000000312173.988466.474
ENSG00000126945homo_sapiensENSP0000036192785.523481.5145crocodylus_porosusENSCPRP0000501668977.732874.0891
ENSG00000126945homo_sapiensENSP0000036192789.309685.5234laticauda_laticaudataENSLLTP0000001086478.781975.442
ENSG00000126945homo_sapiensENSP0000036192789.309685.5234notechis_scutatusENSNSUP0000000016078.781975.442
ENSG00000126945homo_sapiensENSP0000036192789.309685.5234pseudonaja_textilisENSPTXP0000001949278.781975.442
ENSG00000126945homo_sapiensENSP0000036192788.19684.4098anas_platyrhynchos_platyrhynchosENSAPLP0000001009273.469470.3154
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871gallus_gallusENSGALP000100209057571.5909
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871meleagris_gallopavoENSMGAP0000000747081.818278.0992
ENSG00000126945homo_sapiensENSP0000036192787.527883.2962serinus_canariaENSSCAP0000001569171.846468.3729
ENSG00000126945homo_sapiensENSP0000036192787.527882.6281parus_majorENSPMJP0000001040967.525863.7457
ENSG00000126945homo_sapiensENSP0000036192727.171520.9354naja_najaENSNNAP0000002315273.053956.2874
ENSG00000126945homo_sapiensENSP0000036192789.309685.5234podarcis_muralisENSPMRP0000000904582.004178.5276
ENSG00000126945homo_sapiensENSP0000036192787.305183.2962geospiza_fortisENSGFOP0000000754879.032375.4032
ENSG00000126945homo_sapiensENSP0000036192787.527883.2962taeniopygia_guttataENSTGUP0000002898969.190165.8451
ENSG00000126945homo_sapiensENSP0000036192789.309685.5234salvator_merianaeENSSMRP0000002225282.004178.5276
ENSG00000126945homo_sapiensENSP0000036192789.086984.6325pelodiscus_sinensisENSPSIP0000000335177.669973.7864
ENSG00000126945homo_sapiensENSP0000036192787.973383.9644gopherus_evgoodeiENSGEVP0000500651575.238171.8095
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871chelonoidis_abingdoniiENSCABP0000001798075.428672
ENSG00000126945homo_sapiensENSP0000036192789.086985.0779struthio_camelus_australisENSSCUP0000000392577.669974.1748
ENSG00000126945homo_sapiensENSP0000036192782.850878.8419anser_brachyrhynchusENSABRP0000000065978.315874.5263
ENSG00000126945homo_sapiensENSP0000036192787.750683.5189strigops_habroptilaENSSHBP0000500957278.019874.2574
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871terrapene_carolina_triunguisENSTMTP0000003028675.428672
ENSG00000126945homo_sapiensENSP0000036192788.19684.1871aquila_chrysaetos_chrysaetosENSACCP0002002206376.300672.8324
ENSG00000126945homo_sapiensENSP0000036192787.305182.4053ficedula_albicollisENSFALP0000003075270.250966.3082
ENSG00000126945homo_sapiensENSP0000036192787.973383.0735coturnix_japonicaENSCJPP0000500550476.107971.869
ENSG00000126945homo_sapiensENSP0000036192743.652639.1982tetraodon_nigroviridisENSTNIP0000001185175.675767.9537
ENSG00000126945homo_sapiensENSP0000036192782.182674.833leptobrachium_leishanenseENSLLEP0000003527880.217473.0435

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1TASHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0014069located_in postsynaptic density1IEAHomo_sapiens(9606)Component
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0043484involved_in regulation of RNA splicing1IBAHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex2IBA,IDAHomo_sapiens(9606)Component

Expression