RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000126883	Gene ID	8021	Accession	8064
Symbol	NUP214	Alias	CAN;CAIN;IIAE9	Full Name	nucleoporin 214
Status	Confidence	Length	109091 bases	Strand	Plus strand
Position	9 : 131125573 - 131234663	RNA binding domain	N.A.
Summary	The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
19219046	The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.	Holger H von	2009-03-01	Nature structural & molecular biology
29809148	Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore.	X Xun Bao	2018-05-29	eLife
37254647	Nucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly.	Laura Thomas	2023-07-03	The EMBO journal
35974102	Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults.	Silvia Arniani	2022-11-01	Leukemia
36288392	Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.	Claudia Chiriches	2022-10-01	PLoS genetics
31755865	Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells.	Masahiro Oka	2019-11-22	eLife
30883195	The Structure of the Nuclear Pore Complex (An Update).	H Daniel Lin	2019-06-20	Annual review of biochemistry

Name	Transcript ID	bp	Protein	Translation ID
NUP214-232	ENST00000695493	3697	No protein	-
NUP214-233	ENST00000695494	2487	No protein	-
NUP214-234	ENST00000695495	5402	No protein	-
NUP214-235	ENST00000695496	4266	No protein	-
NUP214-236	ENST00000695497	7272	1145aa	ENSP00000511963
NUP214-237	ENST00000695498	7506	1848aa	ENSP00000511964
NUP214-201	ENST00000359428	7568	2090aa	ENSP00000352400
NUP214-202	ENST00000411637	7538	2080aa	ENSP00000396576
NUP214-213	ENST00000525561	3399	No protein	-
NUP214-231	ENST00000652454	6537	2078aa	ENSP00000499001
NUP214-228	ENST00000651022	2160	720aa	ENSP00000498226
NUP214-230	ENST00000651639	907	187aa	ENSP00000498545
NUP214-224	ENST00000531584	545	52aa	ENSP00000435874
NUP214-238	ENST00000695499	1583	No protein	-
NUP214-216	ENST00000526412	551	No protein	-
NUP214-222	ENST00000530843	189	No protein	-
NUP214-223	ENST00000530863	560	187aa	ENSP00000434223
NUP214-214	ENST00000525980	2274	No protein	-
NUP214-221	ENST00000530630	536	No protein	-
NUP214-208	ENST00000489260	649	No protein	-
NUP214-215	ENST00000526346	577	140aa	ENSP00000437139
NUP214-226	ENST00000531929	593	No protein	-
NUP214-229	ENST00000651334	609	203aa	ENSP00000498792
NUP214-211	ENST00000524578	6939	No protein	-
NUP214-203	ENST00000453861	3208	967aa	ENSP00000416934
NUP214-205	ENST00000470765	620	No protein	-
NUP214-207	ENST00000483497	3275	916aa	ENSP00000436793
NUP214-204	ENST00000465486	1068	No protein	-
NUP214-225	ENST00000531600	1775	495aa	ENSP00000435364
NUP214-217	ENST00000528114	575	No protein	-
NUP214-212	ENST00000525384	840	No protein	-
NUP214-239	ENST00000695500	4052	No protein	-
NUP214-219	ENST00000529286	493	No protein	-
NUP214-227	ENST00000650694	1655	437aa	ENSP00000498774
NUP214-240	ENST00000695501	4405	No protein	-
NUP214-220	ENST00000530491	502	No protein	-
NUP214-210	ENST00000498010	388	113aa	ENSP00000435583
NUP214-206	ENST00000476004	502	145aa	ENSP00000433606
NUP214-218	ENST00000528406	393	78aa	ENSP00000433654
NUP214-209	ENST00000496921	2977	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005049	enables nuclear export signal receptor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005635	located_in nuclear envelope	1	IDA	Homo_sapiens(9606)	Component
GO:0005643	part_of nuclear pore	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006405	involved_in RNA export from nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0006406	involved_in mRNA export from nucleus	1	IMP	Homo_sapiens(9606)	Process
GO:0006606	involved_in protein import into nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0006611	acts_upstream_of_or_within protein export from nucleus	1	IMP	Homo_sapiens(9606)	Process
GO:0006913	involved_in nucleocytoplasmic transport	1	NAS	Homo_sapiens(9606)	Process
GO:0008139	enables nuclear localization sequence binding	1	IBA	Homo_sapiens(9606)	Function
GO:0017056	enables structural constituent of nuclear pore	1	IBA	Homo_sapiens(9606)	Function
GO:0046822	involved_in regulation of nucleocytoplasmic transport	1	IMP	Homo_sapiens(9606)	Process
GO:0051726	involved_in regulation of cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:1990876	located_in cytoplasmic side of nuclear pore	1	IDA	Homo_sapiens(9606)	Component