RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000126653	Gene ID	84081	Accession	25305
Symbol	NSRP1	Alias	CCDC55;NSrp70;HSPC095;NEDSSBA	Full Name	nuclear speckle splicing regulatory protein 1
Status	Confidence	Length	69695 bases	Strand	Plus strand
Position	17 : 30116781 - 30186475	RNA binding domain	NSRP1_N , NRP1_C
Summary	Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000247026	NSRP1_N	PF09745	1.5e-35	1
ENSP00000247026	NRP1_C	PF20427	1.2e-73	2
ENSP00000465442	NSRP1_N	PF09745	6.1e-17	1
ENSP00000466463	NSRP1_N	PF09745	5.6e-34	1
ENSP00000468327	NSRP1_N	PF09745	6.1e-37	1
ENSP00000477862	NSRP1_N	PF09745	1.2e-35	1
ENSP00000477862	NRP1_C	PF20427	9.8e-74	2

Showing 1 to 7 of 7 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30607034	RIC_PMID_30607034_Hs_HEK293	HEK293	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30607034	RIC_PMID30607034_Hs_OOPS_MCF10A	MCF10A	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30607034	RIC_PMID30607034_Hs_OOPS_U2OS		Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y

Showing 1 to 8 of 8 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
31311520	New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report.	Ken-Ichi Aoyama	2019-07-16	BMC medical genetics

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
NSRP1-201	ENST00000247026	2506	558aa	ENSP00000247026
NSRP1-202	ENST00000394826	1800	50aa	ENSP00000378303
NSRP1-203	ENST00000467446	548	No protein	-
NSRP1-204	ENST00000475652	1242	41aa	ENSP00000464569
NSRP1-205	ENST00000479218	540	41aa	ENSP00000466640
NSRP1-206	ENST00000540900	2057	No protein	-
NSRP1-207	ENST00000577289	562	No protein	-
NSRP1-208	ENST00000580103	774	157aa	ENSP00000468327
NSRP1-209	ENST00000581048	547	No protein	-
NSRP1-210	ENST00000583301	684	No protein	-

Showing 1 to 10 of 17 entries

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Gene Model

Click here to download ENSG00000126653's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
74233	Electrocardiography	6E-9	27659466

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000126653	rs7211246	17	30158744	QRS complex (12-leadsum)	27659466	115.62	EFO_0007742\|EFO_0005054

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000126653's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000126653	homo_sapiens	ENSP00000378312	13.6394	5.65536	homo_sapiens	ENSP00000247026	36.7383	15.233

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000126653	homo_sapiens	ENSP00000247026	99.1039	97.6702	nomascus_leucogenys	ENSNLEP00000004399	99.1039	97.6702
ENSG00000126653	homo_sapiens	ENSP00000247026	99.2832	99.1039	pan_paniscus	ENSPPAP00000000846	99.2832	99.1039
ENSG00000126653	homo_sapiens	ENSP00000247026	98.3871	97.1326	pongo_abelii	ENSPPYP00000028919	96.6549	95.4225
ENSG00000126653	homo_sapiens	ENSP00000247026	99.4624	99.2832	pan_troglodytes	ENSPTRP00000015293	99.4624	99.2832
ENSG00000126653	homo_sapiens	ENSP00000247026	99.2832	98.9247	gorilla_gorilla	ENSGGOP00000019255	99.2832	98.9247
ENSG00000126653	homo_sapiens	ENSP00000247026	61.6487	50.5376	sarcophilus_harrisii	ENSSHAP00000030969	70.7819	58.0247
ENSG00000126653	homo_sapiens	ENSP00000247026	71.5054	57.8853	notamacropus_eugenii	ENSMEUP00000011392	77.6265	62.8405
ENSG00000126653	homo_sapiens	ENSP00000247026	45.5197	41.9355	choloepus_hoffmanni	ENSCHOP00000008014	63.6591	58.6466
ENSG00000126653	homo_sapiens	ENSP00000247026	70.7885	60.2151	dasypus_novemcinctus	ENSDNOP00000028308	78.0632	66.4032
ENSG00000126653	homo_sapiens	ENSP00000247026	89.7849	83.3333	dasypus_novemcinctus	ENSDNOP00000011419	89.6243	83.1843

Showing 1 to 10 of 201 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0000381	involved_in regulation of alternative mRNA splicing, via spliceosome	1	IDA	Homo_sapiens(9606)	Process
GO:0001701	involved_in in utero embryonic development	1	IEA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	1	IEA	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	IEA	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component

Showing 1 to 10 of 12 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression