Welcome to
RBP World!
Functions and Diseases
| RBP Type | Canonical_RBPs |
| Diseases | N.A. |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | TF |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000126456 | Gene ID | 3661 | Accession | 6118 |
| Symbol | IRF3 | Alias | IIAE7 | Full Name | interferon regulatory factor 3 |
| Status | Confidence | Length | 6306 bases | Strand | Minus strand |
| Position | 19 : 49659570 - 49665875 | RNA binding domain | IRF-3 | ||
| Summary | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|---|---|---|---|
| ENSP00000366339 | IRF-3 | PF10401 | 8.3e-53 | 1 |
| ENSP00000470069 | IRF-3 | PF10401 | 8.3e-53 | 1 |
| ENSP00000472582 | IRF-3 | PF10401 | 8.3e-53 | 1 |
| ENSP00000472601 | IRF-3 | PF10401 | 8.3e-53 | 1 |
| ENSP00000310127 | IRF-3 | PF10401 | 1.8e-52 | 1 |
| ENSP00000366344 | IRF-3 | PF10401 | 1.8e-52 | 1 |
| ENSP00000469113 | IRF-3 | PF10401 | 1.8e-52 | 1 |
| ENSP00000470431 | IRF-3 | PF10401 | 5.9e-30 | 1 |
| ENSP00000470436 | IRF-3 | PF10401 | 9.5e-30 | 1 |
| ENSP00000471896 | IRF-3 | PF10401 | 1.7e-29 | 1 |
| ENSP00000472223 | IRF-3 | PF10401 | 8.5e-20 | 1 |
| ENSP00000470512 | IRF-3 | PF10401 | 5.4e-15 | 1 |
| ENSP00000472700 | IRF-3 | PF10401 | 5.4e-15 | 1 |
| ENSP00000473128 | IRF-3 | PF10401 | 9.4e-15 | 1 |
| ENSP00000471358 | IRF-3 | PF10401 | 1.2e-14 | 1 |
| ENSP00000469067 | IRF-3 | PF10401 | 2e-10 | 1 |
| ENSP00000471517 | IRF-3 | PF10401 | 1.6e-07 | 1 |
| ENSP00000471402 | IRF-3 | PF10401 | 7.2e-06 | 1 |
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 21782231 | MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. | Fajian Hou | 2011-08-05 | Cell |
| 28592649 | Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross. | Richard Green | 2017-06-07 | G3 (Bethesda, Md.) |
| 35617432 | A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain. | Weiguang Liu | 2022-05-31 | Proceedings of the National Academy of Sciences of the United States of America |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| IRF3-224 | ENST00000599680 | 472 | No protein | - |
| IRF3-202 | ENST00000377135 | 1442 | 281aa | ENSP00000366339 |
| IRF3-201 | ENST00000309877 | 1691 | 427aa | ENSP00000310127 |
| IRF3-227 | ENST00000600911 | 1637 | 408aa | ENSP00000470431 |
| IRF3-215 | ENST00000596822 | 823 | 135aa | ENSP00000468911 |
| IRF3-228 | ENST00000601291 | 1556 | 452aa | ENSP00000471896 |
| IRF3-203 | ENST00000377139 | 1595 | 427aa | ENSP00000366344 |
| IRF3-217 | ENST00000597198 | 1741 | 427aa | ENSP00000469113 |
| IRF3-211 | ENST00000596644 | 550 | No protein | - |
| IRF3-219 | ENST00000597636 | 2874 | 329aa | ENSP00000470436 |
| IRF3-207 | ENST00000593922 | 1494 | 281aa | ENSP00000472601 |
| IRF3-213 | ENST00000596765 | 710 | 154aa | ENSP00000470512 |
| IRF3-223 | ENST00000599223 | 1055 | 300aa | ENSP00000471358 |
| IRF3-225 | ENST00000600022 | 882 | 154aa | ENSP00000472700 |
| IRF3-222 | ENST00000599144 | 1117 | 281aa | ENSP00000470069 |
| IRF3-221 | ENST00000598808 | 1468 | 281aa | ENSP00000472582 |
| IRF3-212 | ENST00000596756 | 931 | 264aa | ENSP00000473128 |
| IRF3-231 | ENST00000602190 | 413 | No protein | - |
| IRF3-220 | ENST00000598108 | 1118 | 287aa | ENSP00000472223 |
| IRF3-209 | ENST00000595034 | 739 | 119aa | ENSP00000469067 |
| IRF3-206 | ENST00000593818 | 924 | 105aa | ENSP00000471517 |
| IRF3-229 | ENST00000601373 | 680 | 84aa | ENSP00000471402 |
| IRF3-205 | ENST00000593337 | 633 | 153aa | ENSP00000473176 |
| IRF3-210 | ENST00000595240 | 567 | No protein | - |
| IRF3-208 | ENST00000594387 | 800 | No protein | - |
| IRF3-230 | ENST00000601809 | 768 | 190aa | ENSP00000470140 |
| IRF3-204 | ENST00000442265 | 315 | 104aa | ENSP00000400378 |
| IRF3-214 | ENST00000596788 | 447 | 71aa | ENSP00000473232 |
| IRF3-218 | ENST00000597369 | 550 | No protein | - |
| IRF3-226 | ENST00000600453 | 700 | 102aa | ENSP00000470905 |
| IRF3-216 | ENST00000597180 | 301 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000122 | involved_in negative regulation of transcription by RNA polymerase II | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0000785 | part_of chromatin | 2 | IDA,ISA | Homo_sapiens(9606) | Component |
| GO:0000978 | enables RNA polymerase II cis-regulatory region sequence-specific DNA binding | 3 | IBA,IDA,IMP | Homo_sapiens(9606) | Function |
| GO:0000981 | enables DNA-binding transcription factor activity, RNA polymerase II-specific | 3 | IBA,IDA,ISA | Homo_sapiens(9606) | Function |
| GO:0001216 | enables DNA-binding transcription activator activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0001227 | enables DNA-binding transcription repressor activity, RNA polymerase II-specific | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0001228 | enables DNA-binding transcription activator activity, RNA polymerase II-specific | 1 | IMP | Homo_sapiens(9606) | Function |
| GO:0002376 | involved_in immune system process | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0002753 | involved_in cytosolic pattern recognition receptor signaling pathway | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0003677 | enables DNA binding | 1 | NAS | Homo_sapiens(9606) | Function |
| GO:0003700 | enables DNA-binding transcription factor activity | 2 | IC,IDA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 2 | IDA,IPI | Homo_sapiens(9606) | Function |
| GO:0005634 | is_active_in nucleus | 3 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005737 | is_active_in cytoplasm | 3 | IDA,IGI | Homo_sapiens(9606) | Component |
| GO:0005739 | located_in mitochondrion | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0006357 | involved_in regulation of transcription by RNA polymerase II | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0006915 | involved_in apoptotic process | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0006974 | involved_in DNA damage response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0019904 | enables protein domain specific binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0031663 | involved_in lipopolysaccharide-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0032481 | involved_in positive regulation of type I interferon production | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0032727 | involved_in positive regulation of interferon-alpha production | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0032728 | involved_in positive regulation of interferon-beta production | 2 | ISS,TAS | Homo_sapiens(9606) | Process |
| GO:0035666 | involved_in TRIF-dependent toll-like receptor signaling pathway | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0039530 | involved_in MDA-5 signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0042802 | enables identical protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0042803 | enables protein homodimerization activity | 2 | IDA,IPI | Homo_sapiens(9606) | Function |
| GO:0042981 | involved_in regulation of apoptotic process | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0043123 | involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0043565 | enables sequence-specific DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 2 | IDA,IMP | Homo_sapiens(9606) | Process |
| GO:0050727 | involved_in regulation of inflammatory response | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0051607 | involved_in defense response to virus | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0060337 | involved_in type I interferon-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0060340 | involved_in positive regulation of type I interferon-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0071360 | involved_in cellular response to exogenous dsRNA | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0071888 | involved_in macrophage apoptotic process | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0097300 | involved_in programmed necrotic cell death | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0098586 | involved_in cellular response to virus | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:1990837 | enables sequence-specific double-stranded DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:1990841 | enables promoter-specific chromatin binding | 1 | IEA | Homo_sapiens(9606) | Function |