RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	KinaseTF
Localizations	N.A.
BulkPerturb-seq	DataSet_01_137 DataSet_01_354

Description

Ensembl ID	ENSG00000125651	Gene ID	2962	Accession	4652
Symbol	GTF2F1	Alias	BTF4;RAP74;TF2F1;TFIIF	Full Name	general transcription factor IIF subunit 1
Status	Confidence	Length	14410 bases	Strand	Minus strand
Position	19 : 6379572 - 6393981	RNA binding domain	N.A.
Summary	Enables several functions, including RNA polymerase II general transcription initiation factor activity; phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; response to virus; and transcription initiation from RNA polymerase II promoter. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_MCF7	MCF7	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30607034	RIC_PMID_30607034_Hs_HEK293	HEK293	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30607034	RIC_PMID30607034_Hs_OOPS_MCF10A	MCF10A	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y

Showing 1 to 8 of 8 entries

Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
25990731	Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.	Toon Verheyen	2015-07-13	Nucleic acids research
31185018	Genome-wide analysis identifies rare copy number variations associated with inflammatory bowel disease.	Svetlana Frenkel	2019-01-01	PloS one
37205561	A Bayesian Noisy Logic Model for Inference of Transcription Factor Activity from Single Cell and Bulk Transcriptomic Data.	Argenis Arriojas	2023-05-05	bioRxiv : the preprint server for biology

Showing 1 to 3 of 3 entries

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
GTF2F1-201	ENST00000394456	2432	517aa	ENSP00000377969
GTF2F1-202	ENST00000593678	1705	433aa	ENSP00000469091
GTF2F1-203	ENST00000594213	1002	No protein	-
GTF2F1-204	ENST00000594965	762	No protein	-
GTF2F1-205	ENST00000595047	1382	381aa	ENSP00000471403
GTF2F1-206	ENST00000598607	568	127aa	ENSP00000471542

Showing 1 to 6 of 6 entries

Gene Model

Click here to download ENSG00000125651's gene model file

Protein-Protein Interaction (PPI)

Click here to download ENSG00000125651's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000125651	homo_sapiens	ENSP00000377969	96.1315	95.5513	nomascus_leucogenys	ENSNLEP00000019300	97.2603	96.6732
ENSG00000125651	homo_sapiens	ENSP00000377969	99.4197	98.8395	pan_paniscus	ENSPPAP00000001443	99.6124	99.031
ENSG00000125651	homo_sapiens	ENSP00000377969	99.8066	99.4197	pan_troglodytes	ENSPTRP00000017625	99.8066	99.4197
ENSG00000125651	homo_sapiens	ENSP00000377969	99.8066	99.6132	gorilla_gorilla	ENSGGOP00000046119	99.8066	99.6132
ENSG00000125651	homo_sapiens	ENSP00000377969	91.4894	83.9458	ornithorhynchus_anatinus	ENSOANP00000009747	91.3127	83.7838
ENSG00000125651	homo_sapiens	ENSP00000377969	88.9749	81.4313	sarcophilus_harrisii	ENSSHAP00000012674	90.7298	83.0375
ENSG00000125651	homo_sapiens	ENSP00000377969	86.8472	75.8221	sarcophilus_harrisii	ENSSHAP00000000434	85.1992	74.3833
ENSG00000125651	homo_sapiens	ENSP00000377969	79.6905	71.3733	sarcophilus_harrisii	ENSSHAP00000034931	85.8333	76.875
ENSG00000125651	homo_sapiens	ENSP00000377969	93.0368	85.2998	notamacropus_eugenii	ENSMEUP00000005930	93.3981	85.6311
ENSG00000125651	homo_sapiens	ENSP00000377969	59.9613	56.2863	erinaceus_europaeus	ENSEEUP00000013263	59.7303	56.0694

Showing 1 to 10 of 213 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005674	part_of transcription factor TFIIF complex	2	IBA,IPI	Homo_sapiens(9606)	Component
GO:0006367	involved_in transcription initiation at RNA polymerase II promoter	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0016251	enables RNA polymerase II general transcription initiation factor activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0001091	enables RNA polymerase II general transcription initiation factor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0001096	enables TFIIF-class transcription factor complex binding	1	IBA	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function

Showing 1 to 10 of 24 entries

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Expression

Contents

Description
RBPomes
Literatures
Transcripts
Gene Model
PPI
Orthologs
Gene Ontology
Expression