Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000124766 Gene ID 6659 Accession 11200
Symbol SOX4 Alias CSS10;EVI16 Full Name SRY-box transcription factor 4
Status Confidence Length 4869 bases Strand Plus strand
Position 6 : 21593751 - 21598619 RNA binding domain N.A.
Summary This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36305754 hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway. Xiaoyu Sui 2023-03-01 Cancer medicine
32266420 LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia. Xiaoyang Ying 2020-06-01 Inflammation research : official journal of the European Histamine Research Society ... [et al.]
26514989 Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR. Lei Zhang 2015-12-01 Journal of molecular histology
31911754 Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway. Nan Gao 2020-01-01 Cancer cell international
31268162 SOX4 regulates invasion of bladder cancer cells via repression of WNT5a. D Josue Moran 2019-08-01 International journal of oncology
32256813 MicroRNA-132-3p regulates cell proliferation, apoptosis, migration and invasion of liver cancer by targeting Sox4. Jiansheng Huang 2020-04-01 Oncology letters

Transcripts

Name Transcript ID bp Protein Translation ID
SOX4-201 ENST00000244745 4869 474aa ENSP00000244745

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
78685Endometrial Neoplasms2E-827008869

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1ISSHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific1ISAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific3IBA,IDA,ISSHomo_sapiens(9606)Function
GO:0001666involved_in response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0002328involved_in pro-B cell differentiation1ISSHomo_sapiens(9606)Process
GO:0003183involved_in mitral valve morphogenesis1ISSHomo_sapiens(9606)Process
GO:0003215involved_in cardiac right ventricle morphogenesis1ISSHomo_sapiens(9606)Process
GO:0003289involved_in atrial septum primum morphogenesis1ISSHomo_sapiens(9606)Process
GO:0003357involved_in noradrenergic neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0003700NOT enables DNA-binding transcription factor activity3IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding2IDA,IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005667part_of transcription regulator complex1IEAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0006355involved_in regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0007399involved_in nervous system development1ISSHomo_sapiens(9606)Process
GO:0007507involved_in heart development1ISSHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0009653involved_in anatomical structure morphogenesis1IBAHomo_sapiens(9606)Process
GO:0010467involved_in gene expression1IEAHomo_sapiens(9606)Process
GO:0014009involved_in glial cell proliferation1ISSHomo_sapiens(9606)Process
GO:0021510involved_in spinal cord development1ISSHomo_sapiens(9606)Process
GO:0021782involved_in glial cell development1IEAHomo_sapiens(9606)Process
GO:0030154involved_in cell differentiation1IBAHomo_sapiens(9606)Process
GO:0030217involved_in T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0031018involved_in endocrine pancreas development1IEAHomo_sapiens(9606)Process
GO:0031397involved_in negative regulation of protein ubiquitination1IMPHomo_sapiens(9606)Process
GO:0031647involved_in regulation of protein stability1IMPHomo_sapiens(9606)Process
GO:0032024involved_in positive regulation of insulin secretion1ISSHomo_sapiens(9606)Process
GO:0035019involved_in somatic stem cell population maintenance1IEAHomo_sapiens(9606)Process
GO:0035198enables miRNA binding1IEAHomo_sapiens(9606)Function
GO:0035910involved_in ascending aorta morphogenesis1ISSHomo_sapiens(9606)Process
GO:0042593involved_in glucose homeostasis1ISSHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043516involved_in regulation of DNA damage response, signal transduction by p53 class mediator1IMPHomo_sapiens(9606)Process
GO:0045588involved_in positive regulation of gamma-delta T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0045662involved_in negative regulation of myoblast differentiation1IDAHomo_sapiens(9606)Process
GO:0045663involved_in positive regulation of myoblast differentiation1IDAHomo_sapiens(9606)Process
GO:0045727involved_in positive regulation of translation1IMPHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0048485involved_in sympathetic nervous system development1ISSHomo_sapiens(9606)Process
GO:0050821involved_in protein stabilization1IMPHomo_sapiens(9606)Process
GO:0060412involved_in ventricular septum morphogenesis1ISSHomo_sapiens(9606)Process
GO:0060485involved_in mesenchyme development1ISSHomo_sapiens(9606)Process
GO:0060563involved_in neuroepithelial cell differentiation1ISSHomo_sapiens(9606)Process
GO:0060993involved_in kidney morphogenesis1ISSHomo_sapiens(9606)Process
GO:0061484involved_in hematopoietic stem cell homeostasis1IEAHomo_sapiens(9606)Process
GO:0071333involved_in cellular response to glucose stimulus1ISSHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway1ISSHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:2000761involved_in positive regulation of N-terminal peptidyl-lysine acetylation1IDAHomo_sapiens(9606)Process

Expression