RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000124713	Gene ID	27232	Accession	4415
Symbol	GNMT	Alias	HEL-S-182mP	Full Name	glycine N-methyltransferase
Status	Confidence	Length	3127 bases	Strand	Plus strand
Position	6 : 42960754 - 42963880	RNA binding domain	Methyltransf_31
Summary	The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000361894	Methyltransf_31	PF13847	3.6e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
30115977	MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.	Jung-Hsien Hung	2018-08-16	Scientific reports

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005542	enables folic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005977	involved_in glycogen metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006111	involved_in regulation of gluconeogenesis	1	IBA	Homo_sapiens(9606)	Process
GO:0006555	involved_in methionine metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006730	involved_in one-carbon metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0016594	enables glycine binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0017174	enables glycine N-methyltransferase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0032259	involved_in methylation	1	IEA	Homo_sapiens(9606)	Process
GO:0036211	involved_in protein modification process	1	NAS	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0046498	involved_in S-adenosylhomocysteine metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0046500	involved_in S-adenosylmethionine metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0051289	involved_in protein homotetramerization	2	IBA,IPI	Homo_sapiens(9606)	Process
GO:1901052	involved_in sarcosine metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:1904047	enables S-adenosyl-L-methionine binding	1	IBA	Homo_sapiens(9606)	Function