RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000124641	Gene ID	9477	Accession	16840
Symbol	MED20	Alias	SRB2;TRFP;PRO0213	Full Name	mediator complex subunit 20
Status	Confidence	Length	15786 bases	Strand	Minus strand
Position	6 : 41905354 - 41921139	RNA binding domain	Med20
Summary	This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000265350	Med20	PF08612	4.5e-48	1
ENSP00000386668	Med20	PF08612	2.5e-36	1
ENSP00000377795	Med20	PF08612	3.3e-36	1
ENSP00000386816	Med20	PF08612	1.3e-23	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
25416	Waist-Hip Ratio	4.2310000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003713	enables transcription coactivator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0003899	enables DNA-directed 5-3 RNA polymerase activity	1	NAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	1	NAS	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006366	involved_in transcription by RNA polymerase II	1	TAS	Homo_sapiens(9606)	Process
GO:0016592	part_of mediator complex	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0032968	involved_in positive regulation of transcription elongation by RNA polymerase II	1	NAS	Homo_sapiens(9606)	Process
GO:0035914	involved_in skeletal muscle cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0051123	involved_in RNA polymerase II preinitiation complex assembly	1	NAS	Homo_sapiens(9606)	Process
GO:0060261	involved_in positive regulation of transcription initiation by RNA polymerase II	1	NAS	Homo_sapiens(9606)	Process
GO:0070847	part_of core mediator complex	1	IPI	Homo_sapiens(9606)	Component