RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000124256 Gene ID
81030 Accession
16176
Symbol
ZBP1
Alias
DAI;DLM1;DLM-1;C20orf183
Full Name
Z-DNA binding protein 1
Status
Confidence
Length
16731 bases
Strand
Minus strand
Position
20 : 57603846 - 57620576
RNA binding domain
z-alpha
Summary
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000440552
z-alpha
PF02295 1.5e-13
1
ENSP00000440552
z-alpha
PF02295 1.5e-13
2
ENSP00000360215
z-alpha
PF02295 8e-13
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
35203445 Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response.
Mateusz Szczerba
2022-01-22
Biomedicines
37450010 The Z-nucleic acid sensor ZBP1 in health and disease.
Jonathan Maelfait
2023-08-07
The Journal of experimental medicine
26512708 Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function.
S Amy Gardiner
2015-10-23
Biomolecules
30915105 Detection of Differentially Expressed Cleavage Site Intervals Within 3' Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs.
J Benjamin Harrison
2019-01-01
Frontiers in genetics
37047816 Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells.
Fauziah F Mohd
2023-04-06
International journal of molecular sciences
28716805 Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Jonathan Maelfait
2017-09-01
The EMBO journal
31440477 Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs.
Yun Wang
2019-01-01
Frontiers in cellular and infection microbiology
Name
Transcript ID
bp
Protein
Translation ID
ZBP1-202
ENST00000395822
2073
354aa
ENSP00000379167
ZBP1-201
ENST00000371173
2142
429aa
ENSP00000360215
ZBP1-205
ENST00000461547
4213
No protein
-
ZBP1-204
ENST00000453793
357
119aa
ENSP00000404620
ZBP1-208
ENST00000541799
1041
248aa
ENSP00000440552
ZBP1-206
ENST00000480037
1737
No protein
-
ZBP1-209
ENST00000546110
558
No protein
-
ZBP1-207
ENST00000538947
589
No protein
-
ZBP1-203
ENST00000432548
573
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
24112 Body Fat Distribution 6.1800000E-005 - 24206 Body Fat Distribution 3.4780000E-005 - 27710 Coronary Disease 8.0190000E-005 - 62620 Hippocampus 2E-6 19668339
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000124256
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000124256 homo_sapiens ENSP00000360215 95.5711 91.1422 nomascus_leucogenys ENSNLEP00000008611 95.5711 91.1422 ENSG00000124256 homo_sapiens ENSP00000360215 98.1352 97.4359 pan_paniscus ENSPPAP00000029845 98.1352 97.4359 ENSG00000124256 homo_sapiens ENSP00000360215 96.2704 94.4056 pongo_abelii ENSPPYP00000012472 96.2704 94.4056 ENSG00000124256 homo_sapiens ENSP00000360215 98.3683 97.9021 pan_troglodytes ENSPTRP00000088120 98.3683 97.9021 ENSG00000124256 homo_sapiens ENSP00000360215 99.0676 97.9021 gorilla_gorilla ENSGGOP00000010722 99.0676 97.9021 ENSG00000124256 homo_sapiens ENSP00000360215 64.1026 51.7483 dasypus_novemcinctus ENSDNOP00000001894 61.3839 49.5536 ENSG00000124256 homo_sapiens ENSP00000360215 47.7855 37.296 erinaceus_europaeus ENSEEUP00000001872 65.0794 50.7937 ENSG00000124256 homo_sapiens ENSP00000360215 85.7809 79.021 callithrix_jacchus ENSCJAP00000035442 87.619 80.7143 ENSG00000124256 homo_sapiens ENSP00000360215 90.4429 87.1795 cercocebus_atys ENSCATP00000003367 92.381 89.0476 ENSG00000124256 homo_sapiens ENSP00000360215 90.676 87.4126 macaca_fascicularis ENSMFAP00000015377 92.619 89.2857 ENSG00000124256 homo_sapiens ENSP00000360215 90.2098 86.9464 macaca_mulatta ENSMMUP00000029733 92.1429 88.8095 ENSG00000124256 homo_sapiens ENSP00000360215 89.9767 86.7133 macaca_nemestrina ENSMNEP00000042463 91.9048 88.5714 ENSG00000124256 homo_sapiens ENSP00000360215 81.352 76.9231 papio_anubis ENSPANP00000051258 78.2511 73.991 ENSG00000124256 homo_sapiens ENSP00000360215 87.4126 84.1492 mandrillus_leucophaeus ENSMLEP00000014699 92.5926 89.1358 ENSG00000124256 homo_sapiens ENSP00000360215 56.1772 44.7552 tursiops_truncatus ENSTTRP00000000646 68.272 54.3909 ENSG00000124256 homo_sapiens ENSP00000360215 62.9371 50.3497 vulpes_vulpes ENSVVUP00000023493 61.3636 49.0909 ENSG00000124256 homo_sapiens ENSP00000360215 55.711 45.2214 mus_spretus MGP_SPRETEiJ_P0058657 58.1509 47.2019 ENSG00000124256 homo_sapiens ENSP00000360215 61.3054 50.8158 equus_asinus ENSEASP00005034018 57.8022 47.9121 ENSG00000124256 homo_sapiens ENSP00000360215 62.2378 48.7179 capra_hircus ENSCHIP00000002930 62.5293 48.9461 ENSG00000124256 homo_sapiens ENSP00000360215 45.2214 36.8298 loxodonta_africana ENSLAFP00000009285 61.5873 50.1587 ENSG00000124256 homo_sapiens ENSP00000360215 54.7786 44.9883 panthera_leo ENSPLOP00000014957 50.7559 41.6847 ENSG00000124256 homo_sapiens ENSP00000360215 63.8695 51.9814 ailuropoda_melanoleuca ENSAMEP00000028942 56.8465 46.2656 ENSG00000124256 homo_sapiens ENSP00000360215 64.1026 51.049 bos_indicus_hybrid ENSBIXP00005040285 65.6325 52.2673 ENSG00000124256 homo_sapiens ENSP00000360215 62.9371 51.5152 equus_caballus ENSECAP00000043423 63.981 52.3697 ENSG00000124256 homo_sapiens ENSP00000360215 62.9371 49.6503 canis_lupus_familiaris ENSCAFP00845018130 53.7849 42.4303 ENSG00000124256 homo_sapiens ENSP00000360215 38.9277 31.7016 panthera_pardus ENSPPRP00000020109 73.2456 59.6491 ENSG00000124256 homo_sapiens ENSP00000360215 63.8695 53.6131 marmota_marmota_marmota ENSMMMP00000009894 64.9289 54.5024 ENSG00000124256 homo_sapiens ENSP00000360215 59.9068 47.0862 balaenoptera_musculus ENSBMSP00010021689 62.5304 49.1484 ENSG00000124256 homo_sapiens ENSP00000360215 63.4033 50.8158 cavia_porcellus ENSCPOP00000007699 67.6617 54.2289 ENSG00000124256 homo_sapiens ENSP00000360215 64.8019 53.1469 felis_catus ENSFCAP00000059181 62.3318 51.1211 ENSG00000124256 homo_sapiens ENSP00000360215 64.3357 52.2145 ursus_americanus ENSUAMP00000025389 62.0225 50.3371 ENSG00000124256 homo_sapiens ENSP00000360215 60.373 48.2517 bison_bison_bison ENSBBBP00000028107 66.0714 52.8061 ENSG00000124256 homo_sapiens ENSP00000360215 40.5594 32.8671 monodon_monoceros ENSMMNP00015006224 73.7288 59.7458 ENSG00000124256 homo_sapiens ENSP00000360215 65.5012 52.9138 sus_scrofa ENSSSCP00000008004 64.1553 51.8265 ENSG00000124256 homo_sapiens ENSP00000360215 61.0723 50.3497 microcebus_murinus ENSMICP00000040709 61.215 50.4673 ENSG00000124256 homo_sapiens ENSP00000360215 59.4406 46.1538 ovis_aries_rambouillet ENSOARP00020016946 63.75 49.5 ENSG00000124256 homo_sapiens ENSP00000360215 64.1026 51.9814 ursus_maritimus ENSUMAP00000002975 61.9369 50.2252 ENSG00000124256 homo_sapiens ENSP00000360215 65.9674 52.4476 delphinapterus_leucas ENSDLEP00000001464 65.9674 52.4476 ENSG00000124256 homo_sapiens ENSP00000360215 61.3054 50.1166 physeter_catodon ENSPCTP00005029869 73.4637 60.0559 ENSG00000124256 homo_sapiens ENSP00000360215 54.7786 45.2214 mus_caroli MGP_CAROLIEiJ_P0056479 58.0247 47.9012 ENSG00000124256 homo_sapiens ENSP00000360215 56.1772 45.9207 mus_musculus ENSMUSP00000029018 58.6375 47.9319 ENSG00000124256 homo_sapiens ENSP00000360215 61.5385 50.8158 mustela_putorius_furo ENSMPUP00000006616 59.4595 49.0991 ENSG00000124256 homo_sapiens ENSP00000360215 87.4126 81.1189 aotus_nancymaae ENSANAP00000041420 88.4434 82.0755 ENSG00000124256 homo_sapiens ENSP00000360215 85.7809 79.021 saimiri_boliviensis_boliviensis ENSSBOP00000033103 86.9976 80.1418 ENSG00000124256 homo_sapiens ENSP00000360215 45.9207 37.0629 vicugna_pacos ENSVPAP00000001542 73.7828 59.5506 ENSG00000124256 homo_sapiens ENSP00000360215 62.0047 51.049 tupaia_belangeri ENSTBEP00000005659 73.8889 60.8333 ENSG00000124256 homo_sapiens ENSP00000360215 50.5828 41.0256 mesocricetus_auratus ENSMAUP00000001471 53.317 43.2432 ENSG00000124256 homo_sapiens ENSP00000360215 40.0932 32.1678 phocoena_sinus ENSPSNP00000025492 72.8814 58.4746 ENSG00000124256 homo_sapiens ENSP00000360215 63.8695 51.049 camelus_dromedarius ENSCDRP00005026865 67.1569 53.6765 ENSG00000124256 homo_sapiens ENSP00000360215 70.3963 58.9744 carlito_syrichta ENSTSYP00000026433 68.4807 57.3696 ENSG00000124256 homo_sapiens ENSP00000360215 39.8601 33.1002 panthera_tigris_altaica ENSPTIP00000010874 73.0769 60.6838 ENSG00000124256 homo_sapiens ENSP00000360215 57.1096 45.2214 rattus_norvegicus ENSRNOP00000071089 59.9022 47.4328 ENSG00000124256 homo_sapiens ENSP00000360215 41.0256 33.5664 prolemur_simus ENSPSMP00000001000 72.1311 59.0164 ENSG00000124256 homo_sapiens ENSP00000360215 59.4406 49.1842 microtus_ochrogaster ENSMOCP00000021837 61.1511 50.5995 ENSG00000124256 homo_sapiens ENSP00000360215 58.7413 49.6503 peromyscus_maniculatus_bairdii ENSPEMP00000017020 61.0169 51.5738 ENSG00000124256 homo_sapiens ENSP00000360215 63.1702 50.5828 bos_mutus ENSBMUP00000022551 67.0792 53.7129 ENSG00000124256 homo_sapiens ENSP00000360215 55.2448 45.4545 mus_spicilegus ENSMSIP00000031951 54.9884 45.2436 ENSG00000124256 homo_sapiens ENSP00000360215 56.6434 47.0862 cricetulus_griseus_chok1gshd ENSCGRP00001014737 59.7052 49.6315 ENSG00000124256 homo_sapiens ENSP00000360215 58.9744 47.3193 pteropus_vampyrus ENSPVAP00000013848 68.9373 55.3134 ENSG00000124256 homo_sapiens ENSP00000360215 55.4779 43.1235 myotis_lucifugus ENSMLUP00000015517 57.767 44.9029 ENSG00000124256 homo_sapiens ENSP00000360215 58.042 46.8531 rhinolophus_ferrumequinum ENSRFEP00010032199 60 48.4337 ENSG00000124256 homo_sapiens ENSP00000360215 52.9138 44.289 neovison_vison ENSNVIP00000028828 55.774 46.683 ENSG00000124256 homo_sapiens ENSP00000360215 63.6364 51.049 bos_taurus ENSBTAP00000036951 67.5743 54.2079 ENSG00000124256 homo_sapiens ENSP00000360215 92.5408 89.7436 rhinopithecus_bieti ENSRBIP00000043074 88.0266 85.3659 ENSG00000124256 homo_sapiens ENSP00000360215 64.1026 50.8158 canis_lupus_dingo ENSCAFP00020028048 62.6424 49.6583 ENSG00000124256 homo_sapiens ENSP00000360215 39.3939 31.9347 sciurus_vulgaris ENSSVLP00005002146 70.4167 57.0833 ENSG00000124256 homo_sapiens ENSP00000360215 50.8158 39.1608 procavia_capensis ENSPCAP00000006466 64.1176 49.4118 ENSG00000124256 homo_sapiens ENSP00000360215 60.6061 51.9814 nannospalax_galili ENSNGAP00000025474 62.5 53.6058 ENSG00000124256 homo_sapiens ENSP00000360215 63.1702 50.5828 bos_grunniens ENSBGRP00000014766 67.0792 53.7129 ENSG00000124256 homo_sapiens ENSP00000360215 64.1026 53.6131 chinchilla_lanigera ENSCLAP00000017724 67.9012 56.7901 ENSG00000124256 homo_sapiens ENSP00000360215 63.8695 49.8834 cervus_hanglu_yarkandensis ENSCHYP00000027094 67.8218 52.9703 ENSG00000124256 homo_sapiens ENSP00000360215 63.8695 50.8158 catagonus_wagneri ENSCWAP00000015854 63.1336 50.2304 ENSG00000124256 homo_sapiens ENSP00000360215 64.3357 52.6807 otolemur_garnettii ENSOGAP00000013144 68.8279 56.3591 ENSG00000124256 homo_sapiens ENSP00000360215 85.7809 79.2541 cebus_imitator ENSCCAP00000001497 85.9813 79.4393 ENSG00000124256 homo_sapiens ENSP00000360215 63.6364 53.1469 urocitellus_parryii ENSUPAP00010005869 63.1944 52.7778 ENSG00000124256 homo_sapiens ENSP00000360215 61.5385 47.5524 moschus_moschiferus ENSMMSP00000028054 66 51 ENSG00000124256 homo_sapiens ENSP00000360215 92.5408 89.2774 rhinopithecus_roxellana ENSRROP00000029448 92.5408 89.2774 ENSG00000124256 homo_sapiens ENSP00000360215 44.7552 36.5967 mus_pahari MGP_PahariEiJ_P0067464 57.6577 47.1471 ENSG00000124256 homo_sapiens ENSP00000360215 70.3963 58.9744 propithecus_coquereli ENSPCOP00000029430 72.7711 60.9639 ENSG00000124256 homo_sapiens ENSP00000360215 42.4242 26.5734 chrysemys_picta_bellii ENSCPBP00000034313 41.5525 26.0274 ENSG00000124256 homo_sapiens ENSP00000360215 44.0559 25.4079 crocodylus_porosus ENSCPRP00005007126 43.5484 25.1152 ENSG00000124256 homo_sapiens ENSP00000360215 34.4988 22.6107 chelonoidis_abingdonii ENSCABP00000016805 45.8204 30.031 ENSG00000124256 homo_sapiens ENSP00000360215 35.1981 21.2121 terrapene_carolina_triunguis ENSTMTP00000001629 41.9444 25.2778
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0002218 involved_in activation of innate immune response 1 ISS Homo_sapiens(9606) Process GO:0003677 enables DNA binding 2 IBA,IDA Homo_sapiens(9606) Function GO:0003692 enables left-handed Z-DNA binding 1 NAS Homo_sapiens(9606) Function GO:0003723 enables RNA binding 1 IDA Homo_sapiens(9606) Function GO:0003725 enables double-stranded RNA binding 1 ISS Homo_sapiens(9606) Function GO:0003726 enables double-stranded RNA adenosine deaminase activity 1 IEA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 2 IC,IDA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 2 IDA,TAS Homo_sapiens(9606) Component GO:0006915 involved_in apoptotic process 1 IEA Homo_sapiens(9606) Process GO:0043065 involved_in positive regulation of apoptotic process 1 ISS Homo_sapiens(9606) Process GO:0050727 involved_in regulation of inflammatory response 1 ISS Homo_sapiens(9606) Process GO:0050729 involved_in positive regulation of inflammatory response 1 ISS Homo_sapiens(9606) Process GO:0050832 involved_in defense response to fungus 1 ISS Homo_sapiens(9606) Process GO:0051607 involved_in defense response to virus 2 IMP,ISS Homo_sapiens(9606) Process GO:0060340 involved_in positive regulation of type I interferon-mediated signaling pathway 1 IBA Homo_sapiens(9606) Process GO:0060545 involved_in positive regulation of necroptotic process 2 IMP,ISS Homo_sapiens(9606) Process GO:0070269 involved_in pyroptosis 1 ISS Homo_sapiens(9606) Process GO:0140374 involved_in antiviral innate immune response 1 IDA Homo_sapiens(9606) Process GO:2000659 involved_in regulation of interleukin-1-mediated signaling pathway 1 ISS Homo_sapiens(9606) Process
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