Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000123384 Gene ID 4035 Accession 6692
Symbol LRP1 Alias APR;KPA;LRP;A2MR;CD91;APOER;LRP1A;TGFBR5;IGFBP3R;IGFBP-3R;IGFBP3R1 Full Name LDL receptor related protein 1
Status Confidence Length 84879 bases Strand Plus strand
Position 12 : 57128483 - 57213361 RNA binding domain N.A.
Summary This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
LRP1-204 ENST00000553277 1693 296aa ENSP00000451449
LRP1-201 ENST00000243077 14923 4544aa ENSP00000243077
LRP1-202 ENST00000338962 2169 292aa ENSP00000341264
LRP1-207 ENST00000554174 2175 439aa ENSP00000451737
LRP1-212 ENST00000556830 1847 No protein -
LRP1-205 ENST00000553446 292 No protein -
LRP1-206 ENST00000554118 418 139aa ENSP00000451622
LRP1-209 ENST00000555941 499 No protein -
LRP1-208 ENST00000555124 550 183aa ENSP00000451012
LRP1-210 ENST00000556247 611 No protein -
LRP1-203 ENST00000451724 1284 No protein -
LRP1-211 ENST00000556356 5114 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
68908Aortic Aneurysm, Abdominal5E-1022055160
71889Migraine Disorders3E-822683712
74099Stroke3E-725420145
74430Migraine Disorders1E-623793025
76347Migraine Disorders1E-1023793025
77438Migraine Disorders6E-4927322543
81801Migraine without Aura4E-1627322543
87017Lung Volume Measurements8E-623284291
87183Lung Volume Measurements1E-821946350
87184Respiratory Function Tests1E-821946350
91852Migraine Disorders4E-921666692
92994Migraine Disorders4E-1923793025
93558Aortic Aneurysm, Abdominal6E-727899403
94628Migraine Disorders6E-3627182965

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001523involved_in retinoid metabolic process1TASHomo_sapiens(9606)Process
GO:0001540enables amyloid-beta binding1ICHomo_sapiens(9606)Function
GO:0002265involved_in astrocyte activation involved in immune response1ISSHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005041enables low-density lipoprotein particle receptor activity1TASHomo_sapiens(9606)Function
GO:0005044enables scavenger receptor activity1TASHomo_sapiens(9606)Function
GO:0005509enables calcium ion binding1ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IEAHomo_sapiens(9606)Component
GO:0005765located_in lysosomal membrane1HDAHomo_sapiens(9606)Component
GO:0005769located_in early endosome1IDAHomo_sapiens(9606)Component
GO:0005794located_in Golgi apparatus1IEAHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton1IEAHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane3IBA,ISS,TASHomo_sapiens(9606)Component
GO:0005905located_in clathrin-coated pit1IEAHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006629involved_in lipid metabolic process1TASHomo_sapiens(9606)Process
GO:0006898involved_in receptor-mediated endocytosis3IBA,IMP,ISSHomo_sapiens(9606)Process
GO:0006909involved_in phagocytosis3IBA,IMP,NASHomo_sapiens(9606)Process
GO:0007041involved_in lysosomal transport1ISSHomo_sapiens(9606)Process
GO:0007167involved_in enzyme-linked receptor protein signaling pathway1ISSHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1ISSHomo_sapiens(9606)Process
GO:0010715involved_in regulation of extracellular matrix disassembly1TASHomo_sapiens(9606)Process
GO:0010875involved_in positive regulation of cholesterol efflux1ISSHomo_sapiens(9606)Process
GO:0014912involved_in negative regulation of smooth muscle cell migration1ISSHomo_sapiens(9606)Process
GO:0016020located_in membrane1NASHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016964enables alpha-2 macroglobulin receptor activity2IMP,TASHomo_sapiens(9606)Function
GO:0030178involved_in negative regulation of Wnt signaling pathway1ISSHomo_sapiens(9606)Process
GO:0030226enables apolipoprotein receptor activity1TASHomo_sapiens(9606)Function
GO:0030666located_in endocytic vesicle membrane1TASHomo_sapiens(9606)Component
GO:0031623involved_in receptor internalization1TASHomo_sapiens(9606)Process
GO:0032050enables clathrin heavy chain binding1IPIHomo_sapiens(9606)Function
GO:0032092involved_in positive regulation of protein binding1IGIHomo_sapiens(9606)Process
GO:0032370involved_in positive regulation of lipid transport1ISSHomo_sapiens(9606)Process
GO:0032374involved_in regulation of cholesterol transport1ISSHomo_sapiens(9606)Process
GO:0032429involved_in regulation of phospholipase A2 activity1ISSHomo_sapiens(9606)Process
GO:0032956involved_in regulation of actin cytoskeleton organization1ISSHomo_sapiens(9606)Process
GO:0034185enables apolipoprotein binding3IBA,IDA,IPIHomo_sapiens(9606)Function
GO:0035909involved_in aorta morphogenesis1ISSHomo_sapiens(9606)Process
GO:0038023enables signaling receptor activity1TASHomo_sapiens(9606)Function
GO:0038024enables cargo receptor activity4IBA,IMP,ISS,NASHomo_sapiens(9606)Function
GO:0042953involved_in lipoprotein transport1NASHomo_sapiens(9606)Process
GO:0043235part_of receptor complex1IDAHomo_sapiens(9606)Component
GO:0043277involved_in apoptotic cell clearance1ISSHomo_sapiens(9606)Process
GO:0043395enables heparan sulfate proteoglycan binding1TASHomo_sapiens(9606)Function
GO:0044877enables protein-containing complex binding1IDAHomo_sapiens(9606)Function
GO:0045056involved_in transcytosis1TASHomo_sapiens(9606)Process
GO:0045807involved_in positive regulation of endocytosis1IGIHomo_sapiens(9606)Process
GO:0060392involved_in negative regulation of SMAD protein signal transduction1ISSHomo_sapiens(9606)Process
GO:0060394involved_in negative regulation of pathway-restricted SMAD protein phosphorylation1ISSHomo_sapiens(9606)Process
GO:0070325enables lipoprotein particle receptor binding1ICHomo_sapiens(9606)Function
GO:0097242involved_in amyloid-beta clearance2NAS,TASHomo_sapiens(9606)Process
GO:0098797part_of plasma membrane protein complex1TASHomo_sapiens(9606)Component
GO:0150093involved_in amyloid-beta clearance by transcytosis3IBA,IGI,ISSHomo_sapiens(9606)Process
GO:0150094involved_in amyloid-beta clearance by cellular catabolic process3IBA,IMP,ISSHomo_sapiens(9606)Process
GO:0150104involved_in transport across blood-brain barrier2ISS,NASHomo_sapiens(9606)Process
GO:1900223involved_in positive regulation of amyloid-beta clearance2ISS,TASHomo_sapiens(9606)Process
GO:1903078involved_in positive regulation of protein localization to plasma membrane1IGIHomo_sapiens(9606)Process
GO:1904300involved_in positive regulation of transcytosis1ISSHomo_sapiens(9606)Process
GO:1904646involved_in cellular response to amyloid-beta1ISSHomo_sapiens(9606)Process
GO:1905049acts_upstream_of negative regulation of metallopeptidase activity1ICHomo_sapiens(9606)Process
GO:1905167involved_in positive regulation of lysosomal protein catabolic process1IMPHomo_sapiens(9606)Process
GO:2000587involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway1ISSHomo_sapiens(9606)Process

Expression