Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000123143 Gene ID 5585 Accession 9405
Symbol PKN1 Alias DBK;PKN;PAK1;PRK1;PAK-1;PRKCL1;PKN-ALPHA Full Name protein kinase N1
Status Confidence Length 38814 bases Strand Plus strand
Position 19 : 14433053 - 14471866 RNA binding domain N.A.
Summary The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PKN1-203 ENST00000585619 582 14aa ENSP00000467422
PKN1-204 ENST00000585839 3518 No protein -
PKN1-201 ENST00000242783 3120 942aa ENSP00000242783
PKN1-207 ENST00000586557 899 255aa ENSP00000465842
PKN1-210 ENST00000587429 562 No protein -
PKN1-212 ENST00000590097 848 263aa ENSP00000466367
PKN1-202 ENST00000342216 2960 948aa ENSP00000343325
PKN1-214 ENST00000592794 322 No protein -
PKN1-211 ENST00000588200 548 No protein -
PKN1-208 ENST00000586900 550 No protein -
PKN1-206 ENST00000586237 529 151aa ENSP00000466819
PKN1-209 ENST00000587215 363 No protein -
PKN1-213 ENST00000591461 867 198aa ENSP00000465867
PKN1-205 ENST00000586039 686 No protein -
PKN1-215 ENST00000592960 677 226aa ENSP00000468497

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
24413Rotator Cuff5.9470000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001782involved_in B cell homeostasis1IEAHomo_sapiens(9606)Process
GO:0001783involved_in B cell apoptotic process1IEAHomo_sapiens(9606)Process
GO:0002634involved_in regulation of germinal center formation1IEAHomo_sapiens(9606)Process
GO:0002637involved_in regulation of immunoglobulin production1IEAHomo_sapiens(9606)Process
GO:0003014involved_in renal system process1IEAHomo_sapiens(9606)Process
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity1TASHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0004697enables protein kinase C activity2EXP,TASHomo_sapiens(9606)Function
GO:0004698enables calcium-dependent protein kinase C activity1IEAHomo_sapiens(9606)Function
GO:0005080enables protein kinase C binding1IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005768located_in endosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II2IDA,IMPHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0006469involved_in negative regulation of protein kinase activity1IEAHomo_sapiens(9606)Process
GO:0006972involved_in hyperosmotic response1IEAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0010631involved_in epithelial cell migration1IMPHomo_sapiens(9606)Process
GO:0018105involved_in peptidyl-serine phosphorylation1IBAHomo_sapiens(9606)Process
GO:0030374enables nuclear receptor coactivator activity2IDA,IMPHomo_sapiens(9606)Function
GO:0030496located_in midbody1IDAHomo_sapiens(9606)Component
GO:0030889involved_in negative regulation of B cell proliferation1IEAHomo_sapiens(9606)Process
GO:0031267enables small GTPase binding1IDAHomo_sapiens(9606)Function
GO:0032154located_in cleavage furrow1IDAHomo_sapiens(9606)Component
GO:0032991part_of protein-containing complex1IEAHomo_sapiens(9606)Component
GO:0035402enables histone H3T11 kinase activity1IDAHomo_sapiens(9606)Function
GO:0035556involved_in intracellular signal transduction1IBAHomo_sapiens(9606)Process
GO:0042393enables histone binding1IDAHomo_sapiens(9606)Function
GO:0042826enables histone deacetylase binding1IDAHomo_sapiens(9606)Function
GO:0043687involved_in post-translational protein modification1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0048536involved_in spleen development1IEAHomo_sapiens(9606)Process
GO:0050681enables nuclear androgen receptor binding1IDAHomo_sapiens(9606)Function
GO:0060765involved_in regulation of androgen receptor signaling pathway1TASHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:2000145involved_in regulation of cell motility1IMPHomo_sapiens(9606)Process

Expression