Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000121236 Gene ID 117854 Accession 16277
Symbol TRIM6 Alias RNF89 Full Name tripartite motif containing 6
Status Confidence Length 16850 bases Strand Plus strand
Position 11 : 5596109 - 5612958 RNA binding domain SPRY
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000399215 SPRY PF00622 7.6e-10 1
ENSP00000421079 SPRY PF00622 7.6e-10 1
ENSP00000421802 SPRY PF00622 7.6e-10 1
ENSP00000427704 SPRY PF00622 7.6e-10 1
ENSP00000369450 SPRY PF00622 1.4e-09 1
ENSP00000484009 SPRY PF00622 1.4e-09 1
ENSP00000278302 SPRY PF00622 1.4e-09 1
ENSP00000369440 SPRY PF00622 1.6e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM6-201 ENST00000278302 3217 488aa ENSP00000278302
TRIM6-204 ENST00000424369 468 98aa ENSP00000414108
TRIM6-209 ENST00000507320 1767 313aa ENSP00000427704
TRIM6-203 ENST00000380107 2590 462aa ENSP00000369450
TRIM6-202 ENST00000380097 3422 516aa ENSP00000369440
TRIM6-210 ENST00000511284 740 No protein -
TRIM6-205 ENST00000445329 2951 313aa ENSP00000399215
TRIM6-211 ENST00000515022 1060 313aa ENSP00000421802
TRIM6-208 ENST00000506134 1398 313aa ENSP00000421079
TRIM6-212 ENST00000621176 3005 462aa ENSP00000484009
TRIM6-206 ENST00000469187 1050 No protein -
TRIM6-207 ENST00000481603 2482 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
30257Calcium1.3960000E-005-
72623Immunoglobulins3E-623382691

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000209involved_in protein polyubiquitination1IBAHomo_sapiens(9606)Process
GO:0002230involved_in positive regulation of defense response to virus by host1IMPHomo_sapiens(9606)Process
GO:0002720involved_in positive regulation of cytokine production involved in immune response1IMPHomo_sapiens(9606)Process
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654is_active_in nucleoplasm1IBAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol1IBAHomo_sapiens(9606)Component
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0010508involved_in positive regulation of autophagy1IBAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0010800involved_in positive regulation of peptidyl-threonine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0010994involved_in free ubiquitin chain polymerization2IDA,IMPHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding2IBA,IPIHomo_sapiens(9606)Function
GO:0030674enables protein-macromolecule adaptor activity1IPIHomo_sapiens(9606)Function
GO:0032496involved_in response to lipopolysaccharide1IMPHomo_sapiens(9606)Process
GO:0032880involved_in regulation of protein localization1IBAHomo_sapiens(9606)Process
GO:0033138involved_in positive regulation of peptidyl-serine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0035458involved_in cellular response to interferon-beta1IMPHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IBAHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IBAHomo_sapiens(9606)Process
GO:0045071involved_in negative regulation of viral genome replication1IMPHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IBAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046596involved_in regulation of viral entry into host cell1IBAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IBAHomo_sapiens(9606)Process
GO:0060340involved_in positive regulation of type I interferon-mediated signaling pathway2IDA,IMPHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0070936involved_in protein K48-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0098586involved_in cellular response to virus1IEAHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding1IEAHomo_sapiens(9606)Function
GO:0140374involved_in antiviral innate immune response1IDAHomo_sapiens(9606)Process
GO:1901222NOT involved_in regulation of NIK/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:1990782enables protein tyrosine kinase binding1IPIHomo_sapiens(9606)Function
GO:2000679involved_in positive regulation of transcription regulatory region DNA binding1IMPHomo_sapiens(9606)Process
GO:2000737involved_in negative regulation of stem cell differentiation1IEAHomo_sapiens(9606)Process

Expression