RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	DUB
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000121022	Gene ID	10987	Accession	2240
Symbol	COPS5	Alias	CSN5;JAB1;SGN5;MOV-34	Full Name	COP9 signalosome subunit 5
Status	Confidence	Length	21865 bases	Strand	Minus strand
Position	8 : 67043079 - 67064943	RNA binding domain	N.A.
Summary	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
27903243	Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components.	A Christina Wicker	2016-12-01	BMC genomics

Name	Transcript ID	bp	Protein	Translation ID
COPS5-212	ENST00000523086	717	No protein	-
COPS5-201	ENST00000357849	1296	334aa	ENSP00000350512
COPS5-211	ENST00000521509	3826	No protein	-
COPS5-203	ENST00000517736	1621	197aa	ENSP00000429774
COPS5-210	ENST00000521386	5691	No protein	-
COPS5-205	ENST00000518374	1451	68aa	ENSP00000427869
COPS5-213	ENST00000523890	1086	57aa	ENSP00000427997
COPS5-206	ENST00000518747	676	151aa	ENSP00000428586
COPS5-204	ENST00000517793	657	No protein	-
COPS5-202	ENST00000517406	474	78aa	ENSP00000428124
COPS5-209	ENST00000519963	764	No protein	-
COPS5-208	ENST00000519057	566	No protein	-
COPS5-207	ENST00000518768	565	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000338	involved_in protein deneddylation	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0003713	enables transcription coactivator activity	1	TAS	Homo_sapiens(9606)	Function
GO:0003743	enables translation initiation factor activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	3	IBA,IDA,ISS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005852	part_of eukaryotic translation initiation factor 3 complex	1	TAS	Homo_sapiens(9606)	Component
GO:0006412	involved_in translation	1	TAS	Homo_sapiens(9606)	Process
GO:0006413	involved_in translational initiation	1	IEA	Homo_sapiens(9606)	Process
GO:0008021	located_in synaptic vesicle	1	IDA	Homo_sapiens(9606)	Component
GO:0008180	part_of COP9 signalosome	4	IBA,IDA,IPI,ISS	Homo_sapiens(9606)	Component
GO:0008237	enables metallopeptidase activity	2	IBA,IMP	Homo_sapiens(9606)	Function
GO:0016579	involved_in protein deubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0019784	enables deNEDDylase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0019899	enables enzyme binding	1	IEA	Homo_sapiens(9606)	Function
GO:0035718	enables macrophage migration inhibitory factor binding	1	IEA	Homo_sapiens(9606)	Function
GO:0043066	involved_in negative regulation of apoptotic process	1	IMP	Homo_sapiens(9606)	Process
GO:0043687	involved_in post-translational protein modification	1	TAS	Homo_sapiens(9606)	Process
GO:0045116	involved_in protein neddylation	1	NAS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0046328	involved_in regulation of JNK cascade	1	IDA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IDA	Homo_sapiens(9606)	Process
GO:0051726	involved_in regulation of cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0140492	enables metal-dependent deubiquitinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:1903894	involved_in regulation of IRE1-mediated unfolded protein response	1	IMP	Homo_sapiens(9606)	Process
GO:1990182	involved_in exosomal secretion	1	IDA	Homo_sapiens(9606)	Process
GO:2000434	involved_in regulation of protein neddylation	1	NAS	Homo_sapiens(9606)	Process