Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000120727 Gene ID 51247 Accession 17970
Symbol PAIP2 Alias PAIP-2;PAIP2A Full Name poly(A) binding protein interacting protein 2
Status Confidence Length 28134 bases Strand Plus strand
Position 5 : 139341587 - 139369720 RNA binding domain PAM2
Summary Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000422821 PAM2 PF07145 3.4e-07 1
ENSP00000265192 PAM2 PF07145 8.3e-07 1
ENSP00000378275 PAM2 PF07145 8.3e-07 1
ENSP00000422508 PAM2 PF07145 8.3e-07 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PAIP2-204 ENST00000507755 776 93aa ENSP00000423084
PAIP2-201 ENST00000265192 1456 127aa ENSP00000265192
PAIP2-206 ENST00000510409 815 No protein -
PAIP2-207 ENST00000511381 365 No protein -
PAIP2-208 ENST00000511706 468 67aa ENSP00000422821
PAIP2-203 ENST00000507415 423 No protein -
PAIP2-202 ENST00000394795 2297 127aa ENSP00000378275
PAIP2-205 ENST00000510080 858 127aa ENSP00000422508

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000120727homo_sapiensENSP0000024422179.674859.3496homo_sapiensENSP0000026519277.165457.4803

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378nomascus_leucogenysENSNLEP00000011128100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378pan_paniscusENSPPAP00000033753100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504pongo_abeliiENSPPYP0000001770710099.1936
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378pan_troglodytesENSPTRP00000048000100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378gorilla_gorillaENSGGOP00000006246100100
ENSG00000120727homo_sapiensENSP0000026519296.06392.9134ornithorhynchus_anatinusENSOANP0000005270996.06392.9134
ENSG00000120727homo_sapiensENSP0000026519296.850496.8504sarcophilus_harrisiiENSSHAP0000004307899.193699.1936
ENSG00000120727homo_sapiensENSP0000026519262.204762.2047notamacropus_eugeniiENSMEUP0000000678698.7598.75
ENSG00000120727homo_sapiensENSP0000026519291.338690.5512choloepus_hoffmanniENSCHOP0000001011096.666795.8333
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378dasypus_novemcinctusENSDNOP00000025382100100
ENSG00000120727homo_sapiensENSP0000026519262.992162.9921erinaceus_europaeusENSEEUP0000001055998.765498.7654
ENSG00000120727homo_sapiensENSP0000026519262.204762.2047echinops_telfairiENSETEP0000000864398.7598.75
ENSG00000120727homo_sapiensENSP0000026519299.212698.4252callithrix_jacchusENSCJAP0000001295310099.2064
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378cercocebus_atysENSCATP00000039550100100
ENSG00000120727homo_sapiensENSP0000026519295.275694.4882macaca_fascicularisENSMFAP0000001918069.142968.5714
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378macaca_mulattaENSMMUP00000062637100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378macaca_nemestrinaENSMNEP00000007980100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126papio_anubisENSPANP00000024681100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378mandrillus_leucophaeusENSMLEP00000031562100100
ENSG00000120727homo_sapiensENSP0000026519296.06396.063tursiops_truncatusENSTTRP0000000351399.18799.187
ENSG00000120727homo_sapiensENSP0000026519288.976486.6142vulpes_vulpesENSVVUP0000001345672.435970.5128
ENSG00000120727homo_sapiensENSP0000026519297.637896.063mus_spretusMGP_SPRETEiJ_P004826410098.3871
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378equus_asinusENSEASP00005054995100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378capra_hircusENSCHIP00000002034100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504loxodonta_africanaENSLAFP0000002894010099.1936
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126panthera_leoENSPLOP00000004117100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126ailuropoda_melanoleucaENSAMEP00000011925100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126bos_indicus_hybridENSBIXP00005032831100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126oryctolagus_cuniculusENSOCUP00000005991100100
ENSG00000120727homo_sapiensENSP0000026519289.763889.7638equus_caballusENSECAP0000000987066.279166.2791
ENSG00000120727homo_sapiensENSP0000026519287.401685.8268canis_lupus_familiarisENSCAFP0084500081766.867565.6627
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126panthera_pardusENSPPRP00000010390100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378marmota_marmota_marmotaENSMMMP00000011034100100
ENSG00000120727homo_sapiensENSP0000026519287.401686.6142marmota_marmota_marmotaENSMMMP0000001613295.689794.8276
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378balaenoptera_musculusENSBMSP00010004245100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378cavia_porcellusENSCPOP00000023519100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126felis_catusENSFCAP00000039208100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378ursus_americanusENSUAMP00000035147100100
ENSG00000120727homo_sapiensENSP0000026519287.401685.8268monodelphis_domesticaENSMODP0000004513582.222280.7407
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126bison_bison_bisonENSBBBP00000003721100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126monodon_monocerosENSMMNP00015006046100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378sus_scrofaENSSSCP00000021401100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504microcebus_murinusENSMICP0000001899010099.1936
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378octodon_degusENSODEP00000003909100100
ENSG00000120727homo_sapiensENSP0000026519282.677274.8031jaculus_jaculusENSJJAP0000001487289.743681.1966
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378jaculus_jaculusENSJJAP00000014343100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126ovis_aries_rambouilletENSOARP00020022893100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378ursus_maritimusENSUMAP0000002160347.692347.6923
ENSG00000120727homo_sapiensENSP0000026519262.992162.9921ochotona_princepsENSOPRP00000000235100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378delphinapterus_leucasENSDLEP00000006987100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378physeter_catodonENSPCTP00005024310100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.063mus_caroliMGP_CAROLIEiJ_P004633510098.3871
ENSG00000120727homo_sapiensENSP0000026519297.637896.063mus_musculusENSMUSP0000015849610098.3871
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378dipodomys_ordiiENSDORP00000018598100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378mustela_putorius_furoENSMPUP00000009213100100
ENSG00000120727homo_sapiensENSP0000026519288.976486.6142aotus_nancymaaeENSANAP0000001509593.388490.9091
ENSG00000120727homo_sapiensENSP0000026519251.968551.9685saimiri_boliviensis_boliviensisENSSBOP00000014042100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126vicugna_pacosENSVPAP00000005881100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378chlorocebus_sabaeusENSCSAP00000009247100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126tupaia_belangeriENSTBEP00000003549100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378mesocricetus_auratusENSMAUP00000010699100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378phocoena_sinusENSPSNP00000019603100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378camelus_dromedariusENSCDRP00005000803100100
ENSG00000120727homo_sapiensENSP0000026519274.803169.2913carlito_syrichtaENSTSYP0000002494087.96381.4815
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378carlito_syrichtaENSTSYP00000019106100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126panthera_tigris_altaicaENSPTIP00000023948100100
ENSG00000120727homo_sapiensENSP0000026519293.700891.3386rattus_norvegicusENSRNOP0000006615495.967793.5484
ENSG00000120727homo_sapiensENSP0000026519291.338686.6142rattus_norvegicusENSRNOP0000002698981.118976.9231
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126prolemur_simusENSPSMP00000027258100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378microtus_ochrogasterENSMOCP00000012146100100
ENSG00000120727homo_sapiensENSP0000026519299.212698.4252sorex_araneusENSSARP0000000355610099.2064
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504peromyscus_maniculatus_bairdiiENSPEMP0000003696410099.1936
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378bos_mutusENSBMUP00000019025100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.063mus_spicilegusENSMSIP0000001163210098.3871
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378cricetulus_griseus_chok1gshdENSCGRP00001003118100100
ENSG00000120727homo_sapiensENSP0000026519298.425298.4252pteropus_vampyrusENSPVAP0000001455299.206499.2064
ENSG00000120727homo_sapiensENSP0000026519296.850496.8504myotis_lucifugusENSMLUP0000000272699.193699.1936
ENSG00000120727homo_sapiensENSP0000026519287.401685.8268vombatus_ursinusENSVURP0001001218882.222280.7407
ENSG00000120727homo_sapiensENSP0000026519288.18987.4016rhinolophus_ferrumequinumENSRFEP0001001417085.496284.7328
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378neovison_visonENSNVIP00000018352100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378bos_taurusENSBTAP00000010815100100
ENSG00000120727homo_sapiensENSP0000026519285.826885.0394heterocephalus_glaber_femaleENSHGLP0000005582793.965593.1034
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378rhinopithecus_bietiENSRBIP00000031457100100
ENSG00000120727homo_sapiensENSP0000026519293.700892.126rhinopithecus_bietiENSRBIP0000003400293.700892.126
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504canis_lupus_dingoENSCAFP0002000386910099.1936
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378sciurus_vulgarisENSSVLP00005014819100100
ENSG00000120727homo_sapiensENSP0000026519287.401685.8268phascolarctos_cinereusENSPCIP0000002101982.222280.7407
ENSG00000120727homo_sapiensENSP0000026519299.212698.4252procavia_capensisENSPCAP0000000644410099.2064
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378nannospalax_galiliENSNGAP00000015186100100
ENSG00000120727homo_sapiensENSP0000026519299.212699.2126bos_grunniensENSBGRP00000017969100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378chinchilla_lanigeraENSCLAP00000009608100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378cervus_hanglu_yarkandensisENSCHYP00000023776100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378catagonus_wagneriENSCWAP00000002110100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378ictidomys_tridecemlineatusENSSTOP00000013215100100
ENSG00000120727homo_sapiensENSP0000026519269.291361.4173otolemur_garnettiiENSOGAP0000000949868.7560.9375
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378cebus_imitatorENSCCAP00000024019100100
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378urocitellus_parryiiENSUPAP00010027927100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.8504moschus_moschiferusENSMMSP0000000460510099.1936
ENSG00000120727homo_sapiensENSP0000026519297.637897.6378rhinopithecus_roxellanaENSRROP00000035560100100
ENSG00000120727homo_sapiensENSP0000026519297.637896.063mus_pahariMGP_PahariEiJ_P003894010098.3871
ENSG00000120727homo_sapiensENSP0000026519288.18985.8268propithecus_coquereliENSPCOP0000003015491.803389.3443
ENSG00000120727homo_sapiensENSP0000026519250.393737.0079drosophila_melanogasterFBpp008216151.612937.9032
ENSG00000120727homo_sapiensENSP0000026519267.716550.3937petromyzon_marinusENSPMAP0000000377174.137955.1724
ENSG00000120727homo_sapiensENSP0000026519259.842549.6063eptatretus_burgeriENSEBUP000000026125041.4474
ENSG00000120727homo_sapiensENSP0000026519289.763878.7402callorhinchus_miliiENSCMIP0000000027391.935580.6452
ENSG00000120727homo_sapiensENSP0000026519296.06388.9764latimeria_chalumnaeENSLACP0000000715896.06388.9764
ENSG00000120727homo_sapiensENSP0000026519276.37863.7795gadus_morhuaENSGMOP0000004158074.045861.8321
ENSG00000120727homo_sapiensENSP0000026519296.850496.8504chrysemys_picta_belliiENSCPBP0000000801799.193699.1936
ENSG00000120727homo_sapiensENSP0000026519296.06396.063sphenodon_punctatusENSSPUP0000002509798.387198.3871
ENSG00000120727homo_sapiensENSP0000026519296.850496.063crocodylus_porosusENSCPRP0000500410988.489287.7698
ENSG00000120727homo_sapiensENSP0000026519296.06393.7008laticauda_laticaudataENSLLTP0000001966998.387195.9677
ENSG00000120727homo_sapiensENSP0000026519296.06393.7008notechis_scutatusENSNSUP0000000260498.387195.9677
ENSG00000120727homo_sapiensENSP0000026519295.275692.9134pseudonaja_textilisENSPTXP0000000796297.580695.1613
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378anas_platyrhynchos_platyrhynchosENSAPLP0000003167598.425297.6378
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378gallus_gallusENSGALP0001001149762.562
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378meleagris_gallopavoENSMGAP0000000075498.425297.6378
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378serinus_canariaENSSCAP0000002325598.425297.6378
ENSG00000120727homo_sapiensENSP0000026519297.637895.2756parus_majorENSPMJP0000001023340.390939.4137
ENSG00000120727homo_sapiensENSP0000026519287.401681.1024anolis_carolinensisENSACAP0000002776564.912360.2339
ENSG00000120727homo_sapiensENSP0000026519296.06393.7008naja_najaENSNNAP0000001598698.387195.9677
ENSG00000120727homo_sapiensENSP0000026519295.275694.4882podarcis_muralisENSPMRP0000000022997.580696.7742
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378geospiza_fortisENSGFOP0000000840383.892683.2215
ENSG00000120727homo_sapiensENSP0000026519296.06395.2756salvator_merianaeENSSMRP0000002958298.387197.5806
ENSG00000120727homo_sapiensENSP0000026519280.31561.4173amphilophus_citrinellusENSACIP0000002895779.687560.9375
ENSG00000120727homo_sapiensENSP0000026519296.850496.063pelodiscus_sinensisENSPSIP0000001677299.193698.3871
ENSG00000120727homo_sapiensENSP0000026519298.425298.4252gopherus_evgoodeiENSGEVP0000500649199.206499.2064
ENSG00000120727homo_sapiensENSP0000026519296.850496.8504chelonoidis_abingdoniiENSCABP0000002905499.193699.1936
ENSG00000120727homo_sapiensENSP0000026519296.850496.8504struthio_camelus_australisENSSCUP0000000585899.193699.1936
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378anser_brachyrhynchusENSABRP0000002567098.425297.6378
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378strigops_habroptilaENSSHBP0000501545598.425297.6378
ENSG00000120727homo_sapiensENSP0000026519241.732337.7953terrapene_carolina_triunguisENSTMTP0000001624774.647967.6056
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378aquila_chrysaetos_chrysaetosENSACCP0002001758198.425297.6378
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378ficedula_albicollisENSFALP0000003206066.844966.3102
ENSG00000120727homo_sapiensENSP0000026519298.425297.6378coturnix_japonicaENSCJPP0000501350798.425297.6378

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000900enables mRNA regulatory element binding translation repressor activity1IEAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0006412involved_in translation1IEAHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis1IEAHomo_sapiens(9606)Process
GO:0007613involved_in memory1IEAHomo_sapiens(9606)Process
GO:0017148involved_in negative regulation of translation1IBAHomo_sapiens(9606)Process
GO:0030371enables translation repressor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0045947involved_in negative regulation of translational initiation1IDAHomo_sapiens(9606)Process
GO:1900271involved_in regulation of long-term synaptic potentiation1IEAHomo_sapiens(9606)Process

Expression